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WO1999039743A3 - Procede de stimulation de la proliferation des cellules hepatiques - Google Patents

Procede de stimulation de la proliferation des cellules hepatiques Download PDF

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Publication number
WO1999039743A3
WO1999039743A3 PCT/US1999/002618 US9902618W WO9939743A3 WO 1999039743 A3 WO1999039743 A3 WO 1999039743A3 US 9902618 W US9902618 W US 9902618W WO 9939743 A3 WO9939743 A3 WO 9939743A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell proliferation
hepatic cell
analogues
aii
promoting hepatic
Prior art date
Application number
PCT/US1999/002618
Other languages
English (en)
Other versions
WO1999039743A2 (fr
Inventor
Kathleen E Rodgers
Gere Dizerega
Original Assignee
Univ Southern California
Kathleen E Rodgers
Gere Dizerega
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southern California, Kathleen E Rodgers, Gere Dizerega filed Critical Univ Southern California
Priority to AU25903/99A priority Critical patent/AU2590399A/en
Publication of WO1999039743A2 publication Critical patent/WO1999039743A2/fr
Publication of WO1999039743A3 publication Critical patent/WO1999039743A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/085—Angiotensins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/32—Angiotensins [AT], angiotensinogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne un milieu de culture cellulaire amélioré ainsi que des procédés et des kits destinés à stimuler la prolifération et la différentiation des cellules hépatiques par une croissance en présence de l'angiotensinogène, l'angiotensine I (AI), des analogues de AI, et/ou des fragments de AI et des analogues de ceux-ci, des analogues de l'angiotensine II (AII), des fragments de AII ou des analogues de ceux-ci, et/ou des agonistes du récepteur de AII du type 2 (AT2), seuls ou en association avec d'autres facteurs de croissance et de cytokines.
PCT/US1999/002618 1998-02-09 1999-02-08 Procede de stimulation de la proliferation des cellules hepatiques WO1999039743A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU25903/99A AU2590399A (en) 1998-02-09 1999-02-08 Method of promoting hepatic cell proliferation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7410498P 1998-02-09 1998-02-09
US60/074,104 1998-02-09
US10841298P 1998-11-13 1998-11-13
US60/108,412 1998-11-13

Publications (2)

Publication Number Publication Date
WO1999039743A2 WO1999039743A2 (fr) 1999-08-12
WO1999039743A3 true WO1999039743A3 (fr) 1999-09-30

Family

ID=26755260

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/002618 WO1999039743A2 (fr) 1998-02-09 1999-02-08 Procede de stimulation de la proliferation des cellules hepatiques

Country Status (2)

Country Link
AU (1) AU2590399A (fr)
WO (1) WO1999039743A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3376300A (en) * 1999-02-26 2000-09-14 University Of Pittsburgh Bone marrow transplantation for hepatic regeneration and repair
US6730775B1 (en) 1999-03-23 2004-05-04 University Of Southern California Methods for limiting scar and adhesion formation
CN1529697B (zh) 2001-05-31 2010-09-22 维科尔药物公司 用作血管紧张素ⅱ激动剂的三环化合物
EP2455388A1 (fr) 2010-11-23 2012-05-23 LanthioPep B.V. Nouveaux agonistes du récepteur 2 (AT2) de type angiotensine et leurs utilisations
WO2021023698A1 (fr) 2019-08-02 2021-02-11 Lanthiopep B.V Agonistes du récepteur de l'angiotensine 2 (at2) destinés à être utilisés dans le traitement du cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014858A1 (fr) * 1994-11-14 1996-05-23 University Of Southern California Utilisation de fragments d'angiotensine ii et d'analogues de celle-ci pour la reparation des tissus
WO1996039164A1 (fr) * 1995-06-06 1996-12-12 The University Of Southern California Utilisation d'agonistes du recepteur type 2 de l'angiotensine ii dans la reparation des tissus
WO1998032457A2 (fr) * 1997-01-28 1998-07-30 University Of Southern California Procede stimulant la proliferation et la differentiation de cellules hematopoietiques et mesenchymateuses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014858A1 (fr) * 1994-11-14 1996-05-23 University Of Southern California Utilisation de fragments d'angiotensine ii et d'analogues de celle-ci pour la reparation des tissus
WO1996039164A1 (fr) * 1995-06-06 1996-12-12 The University Of Southern California Utilisation d'agonistes du recepteur type 2 de l'angiotensine ii dans la reparation des tissus
WO1998032457A2 (fr) * 1997-01-28 1998-07-30 University Of Southern California Procede stimulant la proliferation et la differentiation de cellules hematopoietiques et mesenchymateuses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DAJANI, OLAV F. ET AL: "Growth-promoting effects of Ca2+-mobilizing agents in hepatocytes: lack of correlation between the acute activation of phosphoinositide-specific phospholipase C and the stimulation of DNA synthesis by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2.alpha.", XP002111087, retrieved from STN Database accession no. 125:213302 HCA *
J. CELL. PHYSIOL. (1996), 168(3), 608-617 *

Also Published As

Publication number Publication date
WO1999039743A2 (fr) 1999-08-12
AU2590399A (en) 1999-08-23

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