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WO2000045799A3 - Utilisation d'acides isoxazolcarboxyliques substitues et de leurs derives, et nouvelles substances - Google Patents

Utilisation d'acides isoxazolcarboxyliques substitues et de leurs derives, et nouvelles substances Download PDF

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Publication number
WO2000045799A3
WO2000045799A3 PCT/EP2000/000517 EP0000517W WO0045799A3 WO 2000045799 A3 WO2000045799 A3 WO 2000045799A3 EP 0000517 W EP0000517 W EP 0000517W WO 0045799 A3 WO0045799 A3 WO 0045799A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
carboxylic acids
novel substances
substituted isoxazol
isoxazol carboxylic
Prior art date
Application number
PCT/EP2000/000517
Other languages
German (de)
English (en)
Other versions
WO2000045799A2 (fr
Inventor
Juergen Stoltefuss
Gabriele Braeunlich
Berthold Hinzen
Thomas Kraemer
Josef Pernerstorfer
Thomas Stuedemann
Ulrich Nielsch
Martin Bechem
Emanuel Lohrmann
Christoph Gerdes
Michael Sperzel
Klemens Lustig
Lorenz Mayr
Original Assignee
Bayer Ag
Juergen Stoltefuss
Gabriele Braeunlich
Berthold Hinzen
Thomas Kraemer
Josef Pernerstorfer
Thomas Stuedemann
Ulrich Nielsch
Martin Bechem
Emanuel Lohrmann
Christoph Gerdes
Michael Sperzel
Klemens Lustig
Lorenz Mayr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Juergen Stoltefuss, Gabriele Braeunlich, Berthold Hinzen, Thomas Kraemer, Josef Pernerstorfer, Thomas Stuedemann, Ulrich Nielsch, Martin Bechem, Emanuel Lohrmann, Christoph Gerdes, Michael Sperzel, Klemens Lustig, Lorenz Mayr filed Critical Bayer Ag
Priority to AU21100/00A priority Critical patent/AU2110000A/en
Publication of WO2000045799A2 publication Critical patent/WO2000045799A2/fr
Publication of WO2000045799A3 publication Critical patent/WO2000045799A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

L'invention concerne l'utilisation d'acides isoxazolcarboxyliques substitués et de leurs dérivés, de formule générale (I), pour le traitement et la prophylaxie d'anémies. Elle concerne également de nouvelles substances de formule générale (Ia) et de nouveaux procédés pour leur production.
PCT/EP2000/000517 1999-02-04 2000-01-24 Utilisation d'acides isoxazolcarboxyliques substitues et de leurs derives, et nouvelles substances WO2000045799A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU21100/00A AU2110000A (en) 1999-02-04 2000-01-24 Use of substituted isoxazol carboxylic acids and derivatives and novel substances

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19904389A DE19904389A1 (de) 1999-02-04 1999-02-04 Verwendung von substituierten Isoxazolcarbonsäuren und Derivate und neue Stoffe
DE19904389.2 1999-02-04

Publications (2)

Publication Number Publication Date
WO2000045799A2 WO2000045799A2 (fr) 2000-08-10
WO2000045799A3 true WO2000045799A3 (fr) 2002-01-24

Family

ID=7896332

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/000517 WO2000045799A2 (fr) 1999-02-04 2000-01-24 Utilisation d'acides isoxazolcarboxyliques substitues et de leurs derives, et nouvelles substances

Country Status (5)

Country Link
AR (1) AR022469A1 (fr)
AU (1) AU2110000A (fr)
DE (1) DE19904389A1 (fr)
GT (1) GT200000011A (fr)
WO (1) WO2000045799A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8884034B2 (en) 2009-07-08 2014-11-11 Dermira (Canada), Inc. TOFA analogs useful in treating dermatological disorders or conditions

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WO1998037068A1 (fr) 1997-02-21 1998-08-27 Bristol-Myers Squibb Company Derives d'acide benzoïque et composes apparentes utilises comme agents antiarythmiques
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
PL374536A1 (en) 2002-08-23 2005-10-31 Rigel Pharmaceuticals, Inc. Pyridyl substituted heterocycles useful for treating or preventing hcv infection
US7115642B2 (en) 2003-05-02 2006-10-03 Rigel Pharmaceuticals, Inc. Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection
WO2004099165A2 (fr) 2003-05-02 2004-11-18 Rigel Pharmaceuticals, Inc. Composes heterocycliques et certains de leurs hydro-isomeres
US7220745B2 (en) 2003-05-15 2007-05-22 Rigel Pharmaceuticals Heterocyclic compounds useful to treat HCV
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
WO2005049065A2 (fr) 2003-11-19 2005-06-02 Rigel Pharmaceuticals, Inc. Combinaisons efficaces d'un point de vue synergique de composes dihaloacetamide et d'interferon ou de ribavirine contre les infections par le virus de l'hepatite c (vhc)
US7514434B2 (en) 2004-02-23 2009-04-07 Rigel Pharmaceuticals, Inc. Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
WO2006044503A2 (fr) * 2004-10-13 2006-04-27 Ptc Therapeutics, Inc. Composes pour la suppression de mutations non-sens et procedes d'utilisation associes
CA2606106A1 (fr) 2005-05-02 2007-03-08 Rigel Pharmaceuticals, Inc. Composes heterocycliques antiviraux comprenant des groupes metabolisables et leurs utilisations
US20080306124A1 (en) * 2005-06-08 2008-12-11 Rainer Albert Polycyclic Oxadiazoles or I Soxazoles and Their Use as Sip Receptor Ligands
GB0601744D0 (en) * 2006-01-27 2006-03-08 Novartis Ag Organic compounds
PT2069336E (pt) 2006-09-07 2013-03-07 Actelion Pharmaceuticals Ltd Derivados de piridin-4-ilo como agentes imunomoduladores
KR101454937B1 (ko) * 2006-09-08 2014-10-27 액테리온 파마슈티칼 리미티드 면역조절제로서 피리딘-3-일 유도체
US8486979B2 (en) 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
UY30846A1 (es) 2006-12-30 2008-07-31 Abbott Gmbh & Amp Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
NZ580454A (en) 2007-03-16 2011-05-27 Actelion Pharmaceuticals Ltd Amino- pyridine derivatives as s1p1 /edg1 receptor agonists
EP2182809B1 (fr) 2007-08-27 2018-01-17 Dart Neuroscience (Cayman) Ltd Composés isoxazole thérapeutiques
WO2010009775A1 (fr) 2007-12-07 2010-01-28 Abbott Gmbh & Co. Kg Dérivés d'oxindole à substitution carbamate et utilisation de ceux-ci pour traiter des maladies dépendant de la vasopressine
JP5645217B2 (ja) 2007-12-07 2014-12-24 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー ５，６−二置換オキシンドール誘導体およびバソプレッシン依存性疾患を治療するためのこれらの使用
WO2009071687A1 (fr) 2007-12-07 2009-06-11 Abbott Gmbh & Co. Kg Dérivés oxindoliques substitués par amidométhyle et leur utilisation dans le traitement de maladies vasopressine-dépendantes
JP5595926B2 (ja) 2007-12-07 2014-09-24 アボット ゲーエムベーハー ウント カンパニー カーゲー ５−ハロゲン−置換オキシインドール誘導体およびバソプレッシン依存性疾患の治療へのこれらの使用
US9040568B2 (en) 2009-05-29 2015-05-26 Abbvie Inc. Pharmaceutical compositions for the treatment of pain
CN102471328B (zh) 2009-07-16 2015-04-01 埃科特莱茵药品有限公司 吡啶-4-基衍生物
SI2665720T1 (sl) 2011-01-19 2015-08-31 Actelion Pharmaceuticals Ltd. Derivati 2-metoksi-piridin-4-ila
CN102329277B (zh) * 2011-10-24 2013-08-07 海南霞迪药业有限公司 一种制备帕瑞昔布的方法
CN107667104B (zh) 2015-05-20 2022-03-22 爱杜西亚药品有限公司 (s)-3-{4-[5-(2-环戊基-6-甲氧基-吡啶-4-基)-[1,2,4]噁二唑-3-基]-2-乙基-6-甲基-苯氧基}-丙烷-1,2-二醇的结晶形式
CN116535399B (zh) * 2022-01-25 2024-02-27 中国药科大学 3-羟基-5-(异噁唑-5-基)吡啶甲酰甘氨酸类化合物、制法、药物组合物和应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB149877A (en) * 1919-11-22 1920-08-26 Arthur William Wells Improvements in and in connection with safety razors
EP0015140A1 (fr) * 1979-02-22 1980-09-03 Monsanto Company Préparation thermolytique d'acides 2-(3-aryl-isoxazol-5-yl) benzoiques, de leurs sels et d'halogénures à partir de 3'-(aryl)-spiro(isobenzofuran-1(3H),5'(4'H)isoxazol)-3-ones
WO1993019062A1 (fr) * 1992-03-24 1993-09-30 Warner-Lambert Company Derives de tetrahydropyridine isoxazoline
DE4314966A1 (de) * 1993-05-06 1994-11-10 Fahlberg List Pharma Gmbh 2-Hydroxyphenylsubstituierte Isoxazole, ihre Verwendung als pharmazeutische Wirkstoffe und sie enthaltende Arzneimittel
WO1997019039A1 (fr) * 1995-11-17 1997-05-29 Novartis Ag Synthese en phase solide de composes heterocycliques et d'une banque combinatoire de composes
EP0838543A1 (fr) * 1996-09-30 1998-04-29 Lindauer Dornier Gesellschaft M.B.H Métier à tisser avec dispositifs pour recevoir et guider des bielles de commande de cadres
WO1998057923A1 (fr) * 1997-06-18 1998-12-23 Fujisawa Pharmaceutical Co., Ltd. Nouveau procede de preparation

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB149877A (en) * 1919-11-22 1920-08-26 Arthur William Wells Improvements in and in connection with safety razors
EP0015140A1 (fr) * 1979-02-22 1980-09-03 Monsanto Company Préparation thermolytique d'acides 2-(3-aryl-isoxazol-5-yl) benzoiques, de leurs sels et d'halogénures à partir de 3'-(aryl)-spiro(isobenzofuran-1(3H),5'(4'H)isoxazol)-3-ones
WO1993019062A1 (fr) * 1992-03-24 1993-09-30 Warner-Lambert Company Derives de tetrahydropyridine isoxazoline
DE4314966A1 (de) * 1993-05-06 1994-11-10 Fahlberg List Pharma Gmbh 2-Hydroxyphenylsubstituierte Isoxazole, ihre Verwendung als pharmazeutische Wirkstoffe und sie enthaltende Arzneimittel
WO1997019039A1 (fr) * 1995-11-17 1997-05-29 Novartis Ag Synthese en phase solide de composes heterocycliques et d'une banque combinatoire de composes
EP0838543A1 (fr) * 1996-09-30 1998-04-29 Lindauer Dornier Gesellschaft M.B.H Métier à tisser avec dispositifs pour recevoir et guider des bielles de commande de cadres
WO1998057923A1 (fr) * 1997-06-18 1998-12-23 Fujisawa Pharmaceutical Co., Ltd. Nouveau procede de preparation
EP0994101A1 (fr) * 1997-06-18 2000-04-19 Fujisawa Pharmaceutical Co., Ltd. Nouveau procede de preparation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8884034B2 (en) 2009-07-08 2014-11-11 Dermira (Canada), Inc. TOFA analogs useful in treating dermatological disorders or conditions
US9434718B2 (en) 2009-07-08 2016-09-06 Dermira (Canada), Inc. TOFA analogs useful in treating dermatological disorders or conditions
US9782382B2 (en) 2009-07-08 2017-10-10 Dermira (Canada), Inc. TOFA analogs useful in treating dermatological disorders or conditions

Also Published As

Publication number Publication date
AR022469A1 (es) 2002-09-04
WO2000045799A2 (fr) 2000-08-10
DE19904389A1 (de) 2000-08-10
GT200000011A (es) 2001-07-27
AU2110000A (en) 2000-08-25

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