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WO2000053774A3 - Metalloproteinases and methods of use therefor - Google Patents

Metalloproteinases and methods of use therefor Download PDF

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Publication number
WO2000053774A3
WO2000053774A3 PCT/US2000/006237 US0006237W WO0053774A3 WO 2000053774 A3 WO2000053774 A3 WO 2000053774A3 US 0006237 W US0006237 W US 0006237W WO 0053774 A3 WO0053774 A3 WO 0053774A3
Authority
WO
WIPO (PCT)
Prior art keywords
metalloproteinases
methods
use therefor
activity
agents
Prior art date
Application number
PCT/US2000/006237
Other languages
French (fr)
Other versions
WO2000053774A2 (en
Inventor
Gregory S Kelner
Melody Clark
Richard A Maki
Original Assignee
Neurocrine Biosciences Inc
Gregory S Kelner
Melody Clark
Richard A Maki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc, Gregory S Kelner, Melody Clark, Richard A Maki filed Critical Neurocrine Biosciences Inc
Priority to AU36226/00A priority Critical patent/AU3622600A/en
Publication of WO2000053774A2 publication Critical patent/WO2000053774A2/en
Publication of WO2000053774A3 publication Critical patent/WO2000053774A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Members of the ADAMTS family of metalloproteinases are provided, along with variants thereof and agents that modulate an activity of such metalloproteinases. The polypeptides and modulating agents may be used, for example, in the prevention and treatment of a variety of conditions associated with undesirable levels of metalloproteinase activity.
PCT/US2000/006237 1999-03-08 2000-03-08 Metalloproteinases and methods of use therefor WO2000053774A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU36226/00A AU3622600A (en) 1999-03-08 2000-03-08 Metalloproteinases and methods of use therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26458599A 1999-03-08 1999-03-08
US09/264,585 1999-03-08

Publications (2)

Publication Number Publication Date
WO2000053774A2 WO2000053774A2 (en) 2000-09-14
WO2000053774A3 true WO2000053774A3 (en) 2001-01-18

Family

ID=23006720

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006237 WO2000053774A2 (en) 1999-03-08 2000-03-08 Metalloproteinases and methods of use therefor

Country Status (2)

Country Link
AU (1) AU3622600A (en)
WO (1) WO2000053774A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7118902B2 (en) 2002-07-29 2006-10-10 Wyeth Modified ADAMTS4 molecules and method of use thereof

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220557B2 (en) 1997-04-24 2007-05-22 Human Genome Sciences, Inc. METH1 polynucleotides
US20020115842A1 (en) * 2000-09-29 2002-08-22 Friddle Carl Johan Novel human proteases and polynucleotides encoding the same
SE0100472L (en) * 2000-02-18 2001-08-19 Hoffmann La Roche New metalloproteases having thrombospondome domains and nucleic acid compositions encoding these
CA2408105A1 (en) * 2000-05-04 2001-11-08 Sugen, Inc. Novel proteases
JPWO2002031163A1 (en) * 2000-10-11 2004-02-19 財団法人かずさディー・エヌ・エー研究所 Novel ADAMTS family polypeptide and gene encoding the same
WO2002033087A2 (en) * 2000-10-17 2002-04-25 Curagen Corporation Proteins and nucleic acids encoding same
ES2212695B1 (en) * 2001-09-14 2005-10-16 Universidad De Oviedo ADAMTS-13 HUMAN PROTEIN IDENTIFICATION PROCEDURE.
ES2204250B1 (en) * 2001-09-24 2005-08-16 Universidad De Oviedo ADAMTS-16 HUMAN PROTEIN IDENTIFICATION PROCEDURE.
ES2201874B1 (en) * 2001-09-24 2005-05-16 Univesidad De Oviedo ADAMTS-17 HUMAN PROTEIN IDENTIFICATION PROCEDURE.
ES2211256B1 (en) * 2001-09-28 2005-10-16 Universidad De Oviedo. ADAMTS-19 HUMAN PROTEIN IDENTIFICATION PROCEDURE.
ES2213428B1 (en) * 2001-09-25 2005-11-16 Universidad De Oviedo. ADAMTS-19 HUMAN PROTEIN IDENTIFICATION PROCEDURE.
ES2205989B1 (en) * 2001-09-24 2005-08-16 Universidad De Oviedo ADAMTS-15 HUMAN PROTEIN IDENTIFICATION PROCEDURE.
KR20040088059A (en) 2002-02-05 2004-10-15 와이어쓰 Truncated aggrecanase molecules
AU2002314999A1 (en) * 2002-06-06 2003-12-22 The Cleveland Clinic Foundation Adamts nucleic acids and proteins
US7696307B2 (en) * 2004-04-12 2010-04-13 The Trustees Of The University Of Pennsylvania Function and regulation of ADAMTS-1
EP2298895A1 (en) * 2005-07-27 2011-03-23 Oncotherapy Science, Inc. Method of diagnosing small cell lung cancer
US8263072B2 (en) 2007-06-22 2012-09-11 Genera Istrazivanja, d.o.o. ADAMTS4 as a blood biomarker and therapeutic target for chronic renal failure
PT2650310T (en) 2012-04-13 2016-09-01 Rottapharm Biotech Srl Anti-adamts-5 antibody, derivatives and uses thereof
WO2015110707A1 (en) * 2014-01-24 2015-07-30 University Of Helsinki Methods and uses related to adamts3

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055643A1 (en) * 1997-06-03 1998-12-10 Kureha Chemical Industry Co., Ltd. Human adamts-1 protein, gene coding for the same, pharmaceutical composition, and method for immunologically assaying human adamts-1 protein

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055643A1 (en) * 1997-06-03 1998-12-10 Kureha Chemical Industry Co., Ltd. Human adamts-1 protein, gene coding for the same, pharmaceutical composition, and method for immunologically assaying human adamts-1 protein
EP1004674A1 (en) * 1997-06-03 2000-05-31 Kureha Chemical Industry Co., Ltd. Human adamts-1 protein, gene coding for the same, pharmaceutical composition, and method for immunologically assaying human adamts-1 protein

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOR LUEN TANG ET AL.: "ADAMTS: A novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats", FEBS LETTERS, vol. 445, 26 February 1999 (1999-02-26), AMSTERDAM NL, pages 223 - 225, XP002141413, Retrieved from the Internet <URL:http://gdbwww.gdb.org/gdb-bin/genera/genera/hgd/Gene?!action=query&displayName=ADAMTS2> [retrieved on 20000622] *
EMBL Database Entry AI378857 Accession number AI378857; 28 January 1999 ROBERT STRAUSBERG:"tc67h11.x1 Soares_NhHMPu_S1 Homo sapiens cDNA clone" *
FRANCISCA VÁZQUEZ ET AL.: "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 33, 13 August 1999 (1999-08-13), MD US, pages 23349 - 23357, XP002141414 *
KOUJI KUNO ET AL.: "Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 1, 3 January 1997 (1997-01-03), MD US, pages 556 - 562, XP002076038 *
KOUJI KUNO ET AL.: "The exon/intron organization and chromosomal mapping of the mouse ADAMTS-1 gene encoding an ADAM family protein with TPS motifs", GENOMICS, vol. 46, no. 3, 15 December 1997 (1997-12-15), pages 466 - 471, XP000922766 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7118902B2 (en) 2002-07-29 2006-10-10 Wyeth Modified ADAMTS4 molecules and method of use thereof

Also Published As

Publication number Publication date
WO2000053774A2 (en) 2000-09-14
AU3622600A (en) 2000-09-28

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