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WO2000073789A3 - Procede d'estimation pronostique du risque de reductions cognitives par mesure de la longueur des telomeres - Google Patents

Procede d'estimation pronostique du risque de reductions cognitives par mesure de la longueur des telomeres Download PDF

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Publication number
WO2000073789A3
WO2000073789A3 PCT/DE2000/001811 DE0001811W WO0073789A3 WO 2000073789 A3 WO2000073789 A3 WO 2000073789A3 DE 0001811 W DE0001811 W DE 0001811W WO 0073789 A3 WO0073789 A3 WO 0073789A3
Authority
WO
WIPO (PCT)
Prior art keywords
length
telemers
cognitive
onset
restrictions
Prior art date
Application number
PCT/DE2000/001811
Other languages
German (de)
English (en)
Other versions
WO2000073789A2 (fr
Inventor
Zglinicki Thomas Von
Original Assignee
Universitaetsklinikum Charite
Zglinicki Thomas Von
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitaetsklinikum Charite, Zglinicki Thomas Von filed Critical Universitaetsklinikum Charite
Publication of WO2000073789A2 publication Critical patent/WO2000073789A2/fr
Publication of WO2000073789A3 publication Critical patent/WO2000073789A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Medical Treatment And Welfare Office Work (AREA)

Abstract

Procédé d'estimation pronostique du risque d'apparition de réductions cognitives (démence) et de maladies dégénératives chez les personnes âgées par la mesure de la longueur des télomères de cellules de patients/sujets d'expérience. La présente invention concerne en outre l'utilisation de la mesure de la longueur des télomères pour contrôler la réussite d'interventions médicamenteuses ou nutritives ou de mesures prophylactiques.
PCT/DE2000/001811 1999-06-01 2000-05-31 Procede d'estimation pronostique du risque de reductions cognitives par mesure de la longueur des telomeres WO2000073789A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19925839A DE19925839A1 (de) 1999-06-01 1999-06-01 Verfahren zur prognostischen Abschätzung des Risikos kognitiver Einschränkungen durch Messung der Telomerenlänge
DE19925839.2 1999-06-01

Publications (2)

Publication Number Publication Date
WO2000073789A2 WO2000073789A2 (fr) 2000-12-07
WO2000073789A3 true WO2000073789A3 (fr) 2001-05-03

Family

ID=7910375

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/001811 WO2000073789A2 (fr) 1999-06-01 2000-05-31 Procede d'estimation pronostique du risque de reductions cognitives par mesure de la longueur des telomeres

Country Status (2)

Country Link
DE (1) DE19925839A1 (fr)
WO (1) WO2000073789A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023572A1 (fr) * 1992-05-13 1993-11-25 University Of Texas Southwestern Medical Center At Dallas Therapie et diagnostic des etats pathologiques lies a la longueur du telomere et/ou a l'activite de la telomerase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023572A1 (fr) * 1992-05-13 1993-11-25 University Of Texas Southwestern Medical Center At Dallas Therapie et diagnostic des etats pathologiques lies a la longueur du telomere et/ou a l'activite de la telomerase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALVAREZ-LEEFMANS F.J.: "[Cellular and molecular biology of neural aging. Actual situation and perspectives]. BIOLOGIA CELULAR Y MOLECULAR DEL ENVEJECIMIENTO NEURONAL. ESTADO ACTUAL Y PERSPECTIVAS.", SALUD MENTAL, (1999) 22/5 (6-16)., XP000979632 *
FOSSEL M: "Telomerase and the aging cell: implications for human health.", JAMA, (1998 JUN 3) 279 (21) 1732-5. REF: 82, XP000978538 *
KORMANN-BORTOLOTTO MARIA HELENA ET AL: "Telomere shortening, ageing, and chromosome damage.", MECHANISMS OF AGEING AND DEVELOPMENT, vol. 89, no. 1, 1996, pages 45 - 49, XP000978486, ISSN: 0047-6374 *
KRUK PATRICIA A ET AL: "DNA damage and repair in telomeres: Relation to aging.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 92, no. 1, 1995, 1995, pages 258 - 262, XP000971997, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2000073789A2 (fr) 2000-12-07
DE19925839A1 (de) 2000-12-07

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