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WO2000077167A3 - Systeme de ciblage par vecteur d'amplicon du virus herpes simplex et technique d'utilisation - Google Patents

Systeme de ciblage par vecteur d'amplicon du virus herpes simplex et technique d'utilisation Download PDF

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Publication number
WO2000077167A3
WO2000077167A3 PCT/US2000/016050 US0016050W WO0077167A3 WO 2000077167 A3 WO2000077167 A3 WO 2000077167A3 US 0016050 W US0016050 W US 0016050W WO 0077167 A3 WO0077167 A3 WO 0077167A3
Authority
WO
WIPO (PCT)
Prior art keywords
herpes simplex
simplex virus
same
targeting system
vector targeting
Prior art date
Application number
PCT/US2000/016050
Other languages
English (en)
Other versions
WO2000077167A2 (fr
Inventor
Matthew A Spear
Xandra O Breakefield
Original Assignee
Gen Hospital Corp
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp, Univ California filed Critical Gen Hospital Corp
Priority to EP00938260A priority Critical patent/EP1444353A4/fr
Publication of WO2000077167A2 publication Critical patent/WO2000077167A2/fr
Publication of WO2000077167A3 publication Critical patent/WO2000077167A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16645—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des vecteurs d'amplicon du virus herpès simplex (HSV), et en particulier, des vecteurs d'amplicon HSV-1, qui ont été génétiquement modifiés et utilisés seuls ou avec un virus HSV génétiquement modifié en conséquence, de façon à cibler un type de cellule sélectionné, tel que des cellules néoplastiques. Cette invention concerne aussi des techniques d'utilisation de ces vecteurs destinés à cibler une cellule, de façon à traiter un état pathologique, tel qu'un cancer.
PCT/US2000/016050 1999-06-11 2000-06-12 Systeme de ciblage par vecteur d'amplicon du virus herpes simplex et technique d'utilisation WO2000077167A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP00938260A EP1444353A4 (fr) 1999-06-11 2000-06-12 Systeme de ciblage par vecteur d'amplicon du virus herpes simplex et technique d'utilisation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13896399P 1999-06-11 1999-06-11
US60/138,963 1999-06-11

Publications (2)

Publication Number Publication Date
WO2000077167A2 WO2000077167A2 (fr) 2000-12-21
WO2000077167A3 true WO2000077167A3 (fr) 2004-05-06

Family

ID=22484469

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/016050 WO2000077167A2 (fr) 1999-06-11 2000-06-12 Systeme de ciblage par vecteur d'amplicon du virus herpes simplex et technique d'utilisation

Country Status (2)

Country Link
EP (1) EP1444353A4 (fr)
WO (1) WO2000077167A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
US8216564B2 (en) 2002-05-02 2012-07-10 Ramot At Tel-Aviv University Ltd. Composite oncolytic herpes virus vectors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5501979A (en) * 1989-02-01 1996-03-26 The General Hospital Corporation Herpes simplex virus type I expression vector
US5869331A (en) * 1992-11-20 1999-02-09 University Of Medicine & Dentistry Of New Jersey Cell type specific gene transfer using retroviral vectors containing antibody-envelope fusion proteins and wild-type envelope fusion proteins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5851826A (en) * 1995-07-26 1998-12-22 Children's Medical Center Corporation Helper virus-free herpesvirus vector packaging system
EP1002119A1 (fr) * 1997-07-31 2000-05-24 University Of Pittsburgh Of The Commonwealth System Of Higher Education Vecteurs de virus d'herpes simplex (hsv) cibles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5501979A (en) * 1989-02-01 1996-03-26 The General Hospital Corporation Herpes simplex virus type I expression vector
US5869331A (en) * 1992-11-20 1999-02-09 University Of Medicine & Dentistry Of New Jersey Cell type specific gene transfer using retroviral vectors containing antibody-envelope fusion proteins and wild-type envelope fusion proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
See also references of EP1444353A4 *
TAL-SINGER ET AL.: "Interaction of herpes simplex virus glycoprotein gC with mammalian cell surface molecules", JOURNAL OF VIROLOGY, vol. 69, no. 7, July 1995 (1995-07-01), pages 4471 - 4483, XP000946705 *
WANG ET AL.: "A hybrid herpesvirus infectious vector based on epstein-barr virus and herpes simplex virus type 1 for gene transfer into human cells in vitro and in vivo", JOURNAL OF VIROLOGY, vol. 70, December 1996 (1996-12-01), pages 8422 - 8430, XP000946704 *

Also Published As

Publication number Publication date
EP1444353A2 (fr) 2004-08-11
WO2000077167A2 (fr) 2000-12-21
EP1444353A4 (fr) 2004-08-11

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