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WO2000011461A1 - Dispositif permettant de transporter de tres petites quantites de fluide et procede de fabrication associe - Google Patents

Dispositif permettant de transporter de tres petites quantites de fluide et procede de fabrication associe Download PDF

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Publication number
WO2000011461A1
WO2000011461A1 PCT/EP1999/006044 EP9906044W WO0011461A1 WO 2000011461 A1 WO2000011461 A1 WO 2000011461A1 EP 9906044 W EP9906044 W EP 9906044W WO 0011461 A1 WO0011461 A1 WO 0011461A1
Authority
WO
WIPO (PCT)
Prior art keywords
carrier
layer
microstructured
plate
transporting
Prior art date
Application number
PCT/EP1999/006044
Other languages
German (de)
English (en)
Inventor
Wolfram Dietz
Hartmut Blum
Holger Becker
Lutz MÜLLER
Peter Dannberg
Harald Kiessling
Andreas BRÄUER
Original Assignee
Jenoptik Aktiengesellschaft
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19846958A external-priority patent/DE19846958C2/de
Application filed by Jenoptik Aktiengesellschaft, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. filed Critical Jenoptik Aktiengesellschaft
Priority to EP99944428A priority Critical patent/EP1023593A1/fr
Priority to JP2000566667A priority patent/JP2002523741A/ja
Publication of WO2000011461A1 publication Critical patent/WO2000011461A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
    • B29C65/52—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive
    • B29C65/521—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive by spin coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B29C66/1122—Single lap to lap joints, i.e. overlap joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53—Joining single elements to tubular articles, hollow articles or bars
    • B29C66/534—Joining single elements to open ends of tubular or hollow articles or to the ends of bars
    • B29C66/5346—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat
    • B29C66/53461—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat joining substantially flat covers and/or substantially flat bottoms to open ends of container bodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles

Definitions

  • the object is achieved by a device for transporting the smallest amounts of liquid, which contains a system of microstructured cavities in a carrier, in that the carrier has essentially a structure of a monolithic body except for the microstructured cavities.
  • the uniform structure of the carrier corresponding to a monolithic body, is produced in that the carrier is made from plate-shaped carrier parts with a connecting layer, the material composition of which in one

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micromachines (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'invention concerne un dispositif qui permet de transporter de très petites quantités de fluide et le procédé de fabrication associé. Le dispositif comporte un support renfermant un système de cavités microstructurées. Le but de l'invention est de satisfaire de très grandes exigences de précision pour ce qui est de la forme et de la section des microstructures, même dans le cas d'une production en grande quantité et à faible coût, ainsi que d'assurer de meilleures conditions pour les techniques optiques de mesure analytique. Pour fabriquer le support, qui présente jusque dans les cavités microstructurées la structure d'un corps monolithique, on dispose entre les éléments supports plans une couche de liaison à l'état dissous, dont la composition est similaire à celle des éléments supports et l'épaisseur sensiblement inférieure à la largeur et à la profondeur des cavités. Ce dispositif peut être utilisé principalement comme instrument analytique en médecine, en biotechnologie et en pharmacologie.
PCT/EP1999/006044 1998-08-19 1999-08-18 Dispositif permettant de transporter de tres petites quantites de fluide et procede de fabrication associe WO2000011461A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99944428A EP1023593A1 (fr) 1998-08-19 1999-08-18 Dispositif permettant de transporter de tres petites quantites de fluide et procede de fabrication associe
JP2000566667A JP2002523741A (ja) 1998-08-19 1999-08-18 極少量の液体を搬送する装置およびその製造方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19837529 1998-08-19
DE19846958.6 1998-10-12
DE19846958A DE19846958C2 (de) 1998-08-19 1998-10-12 Verfahren zur Herstellung einer Einrichtung zum Transport von kleinsten Flüssigkeitsmengen
DE19837529.8 1998-10-12

Publications (1)

Publication Number Publication Date
WO2000011461A1 true WO2000011461A1 (fr) 2000-03-02

Family

ID=26048251

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/006044 WO2000011461A1 (fr) 1998-08-19 1999-08-18 Dispositif permettant de transporter de tres petites quantites de fluide et procede de fabrication associe

Country Status (4)

Country Link
EP (1) EP1023593A1 (fr)
JP (1) JP2002523741A (fr)
CN (1) CN1275202A (fr)
WO (1) WO2000011461A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004021821B3 (de) * 2004-04-30 2005-12-08 Siemens Ag Verfahren zur Herstellung einer Lösung, zugehörige Anordnung sowie Anwendungen dieser Anordnung

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014132A1 (fr) * 1991-02-08 1992-08-20 Pharmacia Biosensor Ab Procede de production d'un moyen d'etancheite dans une structure microfluidique, et structure microfluidique le comportant
US5376252A (en) * 1990-05-10 1994-12-27 Pharmacia Biosensor Ab Microfluidic structure and process for its manufacture
WO1996004547A1 (fr) * 1994-08-01 1996-02-15 Lockheed Martin Energy Systems, Inc. Procede et dispositif de realisation de manipulations microfluides a des fins d'analyse et de synthese chimique
DE19524795A1 (de) * 1995-07-07 1997-01-09 Danfoss As Verteilervorrichtung, insbesondere für eine chemische Analysevorrichtung
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
WO1998045693A1 (fr) * 1997-04-04 1998-10-15 Aclara Biosciences Procede de fabrication de structures a microcanaux fermes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376252A (en) * 1990-05-10 1994-12-27 Pharmacia Biosensor Ab Microfluidic structure and process for its manufacture
WO1992014132A1 (fr) * 1991-02-08 1992-08-20 Pharmacia Biosensor Ab Procede de production d'un moyen d'etancheite dans une structure microfluidique, et structure microfluidique le comportant
WO1996004547A1 (fr) * 1994-08-01 1996-02-15 Lockheed Martin Energy Systems, Inc. Procede et dispositif de realisation de manipulations microfluides a des fins d'analyse et de synthese chimique
DE19524795A1 (de) * 1995-07-07 1997-01-09 Danfoss As Verteilervorrichtung, insbesondere für eine chemische Analysevorrichtung
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
WO1998045693A1 (fr) * 1997-04-04 1998-10-15 Aclara Biosciences Procede de fabrication de structures a microcanaux fermes

Also Published As

Publication number Publication date
EP1023593A1 (fr) 2000-08-02
CN1275202A (zh) 2000-11-29
JP2002523741A (ja) 2002-07-30

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