[go: up one dir, main page]

WO2001059064A3 - Acides nucleiques, proteines et anticorps - Google Patents

Acides nucleiques, proteines et anticorps Download PDF

Info

Publication number
WO2001059064A3
WO2001059064A3 PCT/US2001/001342 US0101342W WO0159064A3 WO 2001059064 A3 WO2001059064 A3 WO 2001059064A3 US 0101342 W US0101342 W US 0101342W WO 0159064 A3 WO0159064 A3 WO 0159064A3
Authority
WO
WIPO (PCT)
Prior art keywords
bladder
polypeptides
antibodies
polynucleotides
treating
Prior art date
Application number
PCT/US2001/001342
Other languages
English (en)
Other versions
WO2001059064A2 (fr
Inventor
Craig A Rosen
Steven C Barash
Steven M Ruben
Original Assignee
Human Genome Sciences Inc
Craig A Rosen
Steven C Barash
Steven M Ruben
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc, Craig A Rosen, Steven C Barash, Steven M Ruben filed Critical Human Genome Sciences Inc
Priority to EP01912656A priority Critical patent/EP1252176A2/fr
Publication of WO2001059064A2 publication Critical patent/WO2001059064A2/fr
Publication of WO2001059064A3 publication Critical patent/WO2001059064A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne de nouveaux polynucléotides liés à la vessie, les polypeptides codés par ces polynucléotides appelés ici collectivement 'antigènes de la vessie', ainsi que des anticorps fixant de manière immunospécifique ces polypeptides, et l'utilisation de ces polynucléotide, antigènes et anticorps de la vessie pour détecter, traiter, prévenir et/ou pronostiquer des troubles du système vésical, notamment, de façon non exhaustive, la présence d'un cancer de la vessie et de métastases de la vessie. Plus spécifiquement, l'invention concerne des molécules d'acides nucléiques de la vessie isolées codant les nouveaux polypeptides de la vessie. L'invention a trait à de nouveaux polypeptides de la vessie ainsi qu'à des anticorps se fixant à ces polypeptides. L'invention a également trait à des vecteurs, des cellules hôtes ainsi que des méthodes de recombinaison et de synthèse permettant de produire des polynucléotides, des polypeptides et/ou des anticorps de la vessie. L'invention concerne aussi des méthodes diagnostiques et thérapeutiques utiles pour diagnostiquer, traiter, prévenir et/ou pronostiquer des troubles liés à la vessie, notamment le cancer de la vessie ainsi que des méthodes thérapeutiques de traitement de ces troubles. L'invention porte également sur des méthodes de criblage permettant d'identifier des agonistes et des antagonistes de polynucléotides et de polypeptides de l'invention. Enfin, l'invention concerne des méthodes et/ou des compositions permettant d'inhiber ou de stimuler la production et/ou la fonction des polypeptides de l'invention.
PCT/US2001/001342 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps WO2001059064A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP01912656A EP1252176A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps

Applications Claiming Priority (235)

Application Number Priority Date Filing Date Title
US17906500P 2000-01-31 2000-01-31
US60/179,065 2000-01-31
US18062800P 2000-02-04 2000-02-04
US60/180,628 2000-02-04
US18466400P 2000-02-24 2000-02-24
US60/184,664 2000-02-24
US18635000P 2000-03-02 2000-03-02
US60/186,350 2000-03-02
US18987400P 2000-03-16 2000-03-16
US60/189,874 2000-03-16
US19007600P 2000-03-17 2000-03-17
US60/190,076 2000-03-17
US19812300P 2000-04-18 2000-04-18
US60/198,123 2000-04-18
US20551500P 2000-05-19 2000-05-19
US60/205,515 2000-05-19
US20946700P 2000-06-07 2000-06-07
US60/209,467 2000-06-07
US21488600P 2000-06-28 2000-06-28
US60/214,886 2000-06-28
US21513500P 2000-06-30 2000-06-30
US60/215,135 2000-06-30
US21688000P 2000-07-07 2000-07-07
US21664700P 2000-07-07 2000-07-07
US60/216,647 2000-07-07
US60/216,880 2000-07-07
US21748700P 2000-07-11 2000-07-11
US21749600P 2000-07-11 2000-07-11
US60/217,487 2000-07-11
US60/217,496 2000-07-11
US21829000P 2000-07-14 2000-07-14
US60/218,290 2000-07-14
US22096400P 2000-07-26 2000-07-26
US22096300P 2000-07-26 2000-07-26
US60/220,963 2000-07-26
US60/220,964 2000-07-26
US22526700P 2000-08-14 2000-08-14
US22521300P 2000-08-14 2000-08-14
US22575700P 2000-08-14 2000-08-14
US22521400P 2000-08-14 2000-08-14
US22527000P 2000-08-14 2000-08-14
US22575900P 2000-08-14 2000-08-14
US22526600P 2000-08-14 2000-08-14
US22451900P 2000-08-14 2000-08-14
US22544700P 2000-08-14 2000-08-14
US22526800P 2000-08-14 2000-08-14
US22575800P 2000-08-14 2000-08-14
US22451800P 2000-08-14 2000-08-14
US60/224,519 2000-08-14
US60/225,270 2000-08-14
US60/225,268 2000-08-14
US60/225,213 2000-08-14
US60/225,758 2000-08-14
US60/225,759 2000-08-14
US60/225,447 2000-08-14
US60/225,214 2000-08-14
US60/224,518 2000-08-14
US60/225,267 2000-08-14
US60/225,757 2000-08-14
US60/225,266 2000-08-14
US22627900P 2000-08-18 2000-08-18
US60/226,279 2000-08-18
US22686800P 2000-08-22 2000-08-22
US22668100P 2000-08-22 2000-08-22
US22718200P 2000-08-22 2000-08-22
US60/226,868 2000-08-22
US60/226,681 2000-08-22
US60/227,182 2000-08-22
US22700900P 2000-08-23 2000-08-23
US60/227,009 2000-08-23
US22892400P 2000-08-30 2000-08-30
US60/228,924 2000-08-30
US22934500P 2000-09-01 2000-09-01
US22928700P 2000-09-01 2000-09-01
US22934300P 2000-09-01 2000-09-01
US22934400P 2000-09-01 2000-09-01
US60/229,287 2000-09-01
US60/229,343 2000-09-01
US60/229,344 2000-09-01
US60/229,345 2000-09-01
US22950900P 2000-09-05 2000-09-05
US22951300P 2000-09-05 2000-09-05
US60/229,513 2000-09-05
US60/229,509 2000-09-05
US23043700P 2000-09-06 2000-09-06
US23043800P 2000-09-06 2000-09-06
US60/230,437 2000-09-06
US60/230,438 2000-09-06
US23208000P 2000-09-08 2000-09-08
US23124200P 2000-09-08 2000-09-08
US23124300P 2000-09-08 2000-09-08
US23141400P 2000-09-08 2000-09-08
US23208100P 2000-09-08 2000-09-08
US23124400P 2000-09-08 2000-09-08
US23141300P 2000-09-08 2000-09-08
US60/232,081 2000-09-08
US60/231,243 2000-09-08
US60/231,414 2000-09-08
US60/231,244 2000-09-08
US60/232,080 2000-09-08
US60/231,413 2000-09-08
US60/231,242 2000-09-08
US23196800P 2000-09-12 2000-09-12
US60/231,968 2000-09-12
US23240100P 2000-09-14 2000-09-14
US23306400P 2000-09-14 2000-09-14
US23306300P 2000-09-14 2000-09-14
US23239800P 2000-09-14 2000-09-14
US23306500P 2000-09-14 2000-09-14
US23239700P 2000-09-14 2000-09-14
US23239900P 2000-09-14 2000-09-14
US23240000P 2000-09-14 2000-09-14
US60/232,399 2000-09-14
US60/232,398 2000-09-14
US60/233,064 2000-09-14
US60/232,400 2000-09-14
US60/233,063 2000-09-14
US60/233,065 2000-09-14
US60/232,397 2000-09-14
US60/232,401 2000-09-14
US23427400P 2000-09-21 2000-09-21
US23422300P 2000-09-21 2000-09-21
US60/234,274 2000-09-21
US60/234,223 2000-09-21
US23499700P 2000-09-25 2000-09-25
US23499800P 2000-09-25 2000-09-25
US60/234,998 2000-09-25
US60/234,997 2000-09-25
US23548400P 2000-09-26 2000-09-26
US60/235,484 2000-09-26
US23583600P 2000-09-27 2000-09-27
US23583400P 2000-09-27 2000-09-27
US60/235,836 2000-09-27
US60/235,834 2000-09-27
US23636800P 2000-09-29 2000-09-29
US23637000P 2000-09-29 2000-09-29
US23636900P 2000-09-29 2000-09-29
US23632700P 2000-09-29 2000-09-29
US23636700P 2000-09-29 2000-09-29
US60/236,370 2000-09-29
US60/236,369 2000-09-29
US60/236,367 2000-09-29
US60/236,327 2000-09-29
US60/236,368 2000-09-29
US23704000P 2000-10-02 2000-10-02
US23680200P 2000-10-02 2000-10-02
US23703700P 2000-10-02 2000-10-02
US23703900P 2000-10-02 2000-10-02
US23703800P 2000-10-02 2000-10-02
US60/237,037 2000-10-02
US60/237,039 2000-10-02
US60/237,040 2000-10-02
US60/236,802 2000-10-02
US60/237,038 2000-10-02
US23993500P 2000-10-13 2000-10-13
US23993700P 2000-10-13 2000-10-13
US60/239,935 2000-10-13
US60/239,937 2000-10-13
US24180800P 2000-10-20 2000-10-20
US24182600P 2000-10-20 2000-10-20
US24096000P 2000-10-20 2000-10-20
US24178500P 2000-10-20 2000-10-20
US24178700P 2000-10-20 2000-10-20
US24178600P 2000-10-20 2000-10-20
US24180900P 2000-10-20 2000-10-20
US24122100P 2000-10-20 2000-10-20
US60/241,809 2000-10-20
US60/241,785 2000-10-20
US60/241,221 2000-10-20
US60/241,808 2000-10-20
US60/241,787 2000-10-20
US60/241,786 2000-10-20
US60/240,960 2000-10-20
US60/241,826 2000-10-20
US24461700P 2000-11-01 2000-11-01
US60/244,617 2000-11-01
US24647500P 2000-11-08 2000-11-08
US24652600P 2000-11-08 2000-11-08
US24652700P 2000-11-08 2000-11-08
US24661100P 2000-11-08 2000-11-08
US24647700P 2000-11-08 2000-11-08
US24647400P 2000-11-08 2000-11-08
US24661000P 2000-11-08 2000-11-08
US24652500P 2000-11-08 2000-11-08
US24647600P 2000-11-08 2000-11-08
US24652800P 2000-11-08 2000-11-08
US24653200P 2000-11-08 2000-11-08
US60/246,476 2000-11-08
US60/246,611 2000-11-08
US60/246,525 2000-11-08
US60/246,523 2000-11-08
US60/246,613 2000-11-08
US60/246,478 2000-11-08
US60/246,528 2000-11-08
US60/246,532 2000-11-08
US60/246,609 2000-11-08
US60/246,524 2000-11-08
US60/246,526 2000-11-08
US60/246,474 2000-11-08
US60/246,475 2000-11-08
US60/246,477 2000-11-08
US60/246,527 2000-11-08
US60/246,610 2000-11-08
US60/249,211 2000-11-17
US60/249,207 2000-11-17
US60/249,213 2000-11-17
US60/249,209 2000-11-17
US60/249,212 2000-11-17
US60/249,299 2000-11-17
US60/249,300 2000-11-17
US60/249,216 2000-11-17
US60/249,218 2000-11-17
US60/249,217 2000-11-17
US60/249,245 2000-11-17
US60/249,214 2000-11-17
US60/249,208 2000-11-17
US60/249,210 2000-11-17
US60/249,215 2000-11-17
US60/249,265 2000-11-17
US60/249,244 2000-11-17
US60/249,297 2000-11-17
US60/249,264 2000-11-17
US60/250,160 2000-12-01
US60/250,391 2000-12-01
US60/256,719 2000-12-05
US60/251,988 2000-12-05
US60/251,030 2000-12-05
US60/251,479 2000-12-06
US60/251,990 2000-12-08
US60/251,989 2000-12-08
US60/251,856 2000-12-08
US60/251,869 2000-12-08
US60/251,868 2000-12-08
US60/254,097 2000-12-11
US60/259,678 2001-01-05

Publications (2)

Publication Number Publication Date
WO2001059064A2 WO2001059064A2 (fr) 2001-08-16
WO2001059064A3 true WO2001059064A3 (fr) 2002-03-14

Family

ID=27587117

Family Applications (48)

Application Number Title Priority Date Filing Date
PCT/US2001/001239 WO2001055301A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001326 WO2001055315A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines, et anticorps
PCT/US2001/001345 WO2001055325A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001309 WO2001055308A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001314 WO2001055310A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001356 WO2001055173A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001310 WO2001055387A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001349 WO2001054474A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001321 WO2001055312A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001339 WO2001055320A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001240 WO2001055302A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001325 WO2001055202A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001311 WO2001055309A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001308 WO2001055364A2 (fr) 2000-01-31 2001-01-17 Acides nucléiques, protéines et anticorps
PCT/US2001/001317 WO2001055201A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001351 WO2001055355A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001328 WO2001055316A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001344 WO2001055324A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001350 WO2001055350A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001313 WO2001055200A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001315 WO2001055311A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001322 WO2001055343A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001302 WO2001055304A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001336 WO2001055204A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001301 WO2001055303A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001343 WO2001055323A2 (fr) 2000-01-31 2001-01-17 Acides ncleiques, proteines et anticorps
PCT/US2001/001340 WO2001055321A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001358 WO2001055163A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines, et anticorps
PCT/US2001/001332 WO2001055318A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001306 WO2001055307A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001335 WO2001055319A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001312 WO2001054733A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001330 WO2001055447A1 (fr) 2000-01-31 2001-01-17 Acides nucléiques, proteines et anticorps
PCT/US2001/001327 WO2001055203A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001342 WO2001059064A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001353 WO2001055206A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001341 WO2001055322A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001338 WO2001055367A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et antigenes
PCT/US2001/001354 WO2001057182A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001348 WO2001055368A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001359 WO2001055328A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001337 WO2001055205A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001324 WO2001055314A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001333 WO2001055448A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001357 WO2001055208A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001352 WO2001055327A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001355 WO2001055207A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001316 WO2001054473A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps

Family Applications Before (34)

Application Number Title Priority Date Filing Date
PCT/US2001/001239 WO2001055301A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001326 WO2001055315A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines, et anticorps
PCT/US2001/001345 WO2001055325A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001309 WO2001055308A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001314 WO2001055310A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001356 WO2001055173A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001310 WO2001055387A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001349 WO2001054474A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001321 WO2001055312A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001339 WO2001055320A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001240 WO2001055302A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001325 WO2001055202A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001311 WO2001055309A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001308 WO2001055364A2 (fr) 2000-01-31 2001-01-17 Acides nucléiques, protéines et anticorps
PCT/US2001/001317 WO2001055201A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001351 WO2001055355A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001328 WO2001055316A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001344 WO2001055324A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001350 WO2001055350A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001313 WO2001055200A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001315 WO2001055311A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001322 WO2001055343A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001302 WO2001055304A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001336 WO2001055204A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001301 WO2001055303A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001343 WO2001055323A2 (fr) 2000-01-31 2001-01-17 Acides ncleiques, proteines et anticorps
PCT/US2001/001340 WO2001055321A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001358 WO2001055163A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines, et anticorps
PCT/US2001/001332 WO2001055318A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001306 WO2001055307A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001335 WO2001055319A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001312 WO2001054733A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001330 WO2001055447A1 (fr) 2000-01-31 2001-01-17 Acides nucléiques, proteines et anticorps
PCT/US2001/001327 WO2001055203A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps

Family Applications After (13)

Application Number Title Priority Date Filing Date
PCT/US2001/001353 WO2001055206A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001341 WO2001055322A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001338 WO2001055367A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et antigenes
PCT/US2001/001354 WO2001057182A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001348 WO2001055368A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001359 WO2001055328A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001337 WO2001055205A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001324 WO2001055314A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001333 WO2001055448A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001357 WO2001055208A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001352 WO2001055327A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001355 WO2001055207A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
PCT/US2001/001316 WO2001054473A2 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps

Country Status (3)

Country Link
AU (16) AU2001241416A1 (fr)
CA (37) CA2395885A1 (fr)
WO (48) WO2001055301A2 (fr)

Families Citing this family (284)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070982A2 (fr) * 2000-03-23 2001-09-27 Immusol Incorporated Regulateurs de brca-1 et procedes d'utilisation
US20020137890A1 (en) 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6706262B1 (en) 1998-03-18 2004-03-16 Corixa Corporation Compounds and methods for therapy and diagnosis of lung cancer
US6960570B2 (en) 1998-03-18 2005-11-01 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US7579160B2 (en) 1998-03-18 2009-08-25 Corixa Corporation Methods for the detection of cervical cancer
US7258860B2 (en) 1998-03-18 2007-08-21 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US7771719B1 (en) 2000-01-11 2010-08-10 Genentech, Inc. Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E
EP2333069A3 (fr) 1998-05-15 2011-09-14 Genentech, Inc. Utilisations therapeutiques de polypeptides homologues de il-17
US6929938B2 (en) 2001-08-15 2005-08-16 Millennium Pharmaceuticals, Inc. 25501, a human transferase family member and uses therefor
WO2000050565A2 (fr) * 1999-02-25 2000-08-31 Thomas Jefferson University Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs
US7141417B1 (en) 1999-02-25 2006-11-28 Thomas Jefferson University Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
WO2000050458A1 (fr) * 1999-02-26 2000-08-31 Smithkline Beecham Corporation Clonage du recepteur 7tm (axor 17) du type p2y
AU3885400A (en) * 1999-03-23 2000-10-09 Human Genome Sciences, Inc. 48 human secreted proteins
CA2365601A1 (fr) 1999-03-29 2000-10-05 Kansai Technology Licensing Organization Co., Ltd. Nouvelle cytidine desaminase
AU774436B2 (en) 1999-08-12 2004-06-24 Agensys, Inc. C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof
EP1892249A1 (fr) * 1999-09-01 2008-02-27 Genentech, Inc. Polypeptides sécrétés et transmembranaires, et acides nucléiques les codant
US20020151047A1 (en) * 2001-01-08 2002-10-17 Yi Hu Novel human protease and polynucleotides encoding the same
US6617147B2 (en) 2000-04-25 2003-09-09 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
US7083944B1 (en) * 1999-10-27 2006-08-01 Millennium Pharmaceuticals, Inc. Molecules of the card-related protein family and uses thereof
US6893818B1 (en) 1999-10-28 2005-05-17 Agensys, Inc. Gene upregulated in cancers of the prostate
US7005499B1 (en) * 1999-11-18 2006-02-28 Genentech, Inc. Wnt-regulated cytokine-like polypeptide and nucleic acids encoding same
EP1878794A3 (fr) * 1999-11-30 2008-01-23 Genentech, Inc. Compositions et procédés pour le traitement de maladies liées au système immunitaire
EP1690873A3 (fr) * 1999-12-01 2006-08-23 Genentech, Inc. Composition et procédés de diagnostic de tumeurs
CN1300781A (zh) * 1999-12-22 2001-06-27 上海博德基因开发有限公司 一种新的多肽-人shc蛋白43和编码这种多肽的多核苷酸
US20040043397A1 (en) 2000-01-11 2004-03-04 Genentech, Inc. IL-17 homologous polypeptides and therapeutic uses thereof
ES2304126T3 (es) 2000-01-26 2008-09-16 Agensys, Inc. 84p2a9: una proteina especifica de prostata y testiculos altamente expresada en el cancer de prostata.
US6953682B2 (en) 2000-02-10 2005-10-11 Millennium Pharmaceuticals, Inc. Nucleic acid sequences encoding adenylate kinase, phospholipid scramblase-like, DNA fragmentation factor-like, phosphatidylserine synthase-like, and atpase-like molecules and uses therefor
US7078205B2 (en) 2000-02-17 2006-07-18 Millennium Pharmaceuticals, Inc. Nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecules, atpase molecules, acyltransferase molecules, pyridoxal-phosphate dependent enzyme molecules and uses therefor
US20020082212A1 (en) * 2000-07-20 2002-06-27 Millennium Pharmaceuticals, Inc. 7716, a novel human ATPase and uses therefor
US7718397B2 (en) 2000-03-21 2010-05-18 Genentech, Inc. Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof
EP1272640A2 (fr) 2000-03-24 2003-01-08 Millennium Pharmaceuticals, Inc. 3714, 16742, 23546, et 13887 nouvelles molecules de proteine kinase et leurs utilisations
US20030198953A1 (en) * 2000-03-30 2003-10-23 Spytek Kimberly A. Novel proteins and nucleic acids encoding same
US7632929B2 (en) 2000-04-20 2009-12-15 The Board Of Trustees Of The University Of Arkansas Methamphetamine-like hapten compounds, linkers, carriers and compositions and uses thereof
EP1280917A2 (fr) * 2000-04-26 2003-02-05 Millennium Pharmaceuticals, Inc. 21657, deshydrogenase humaine a chaine courte et ses utilisations
US6808876B1 (en) 2000-05-02 2004-10-26 Immusol, Inc. Cellular regulators of infectious agents and methods of use
US20030096313A1 (en) * 2000-05-12 2003-05-22 Burkhard Scharm Novel serine-threonine kinase-4
EP1158001B1 (fr) * 2000-05-26 2007-11-14 F. Hoffmann-La Roche Ag Un acide nucléique produit excessivement dans des cellules tumorales humaines, une protéine codée par ledit acide nucléique et un procédé de diagnose de tumeurs
US20040175815A1 (en) * 2000-05-26 2004-09-09 Yonghong Xiao Regulation of human p78-like serube/threonine kinase
DE10027170A1 (de) * 2000-05-31 2001-12-13 Schering Ag Humanes PEM als Target für die Fertilitätskontrolle
US20030096969A1 (en) 2000-06-02 2003-05-22 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7098311B2 (en) * 2000-06-02 2006-08-29 Brigham And Women's Hospital Fusion of jAZF1 and jjAZ1 genes in endometrial stromal tumors
AU6531101A (en) * 2000-06-02 2001-12-17 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU6604901A (en) * 2000-06-05 2001-12-17 Bayer Aktiengesellschaft Regulation of human hm74-like g protein coupled receptor
EP1287029A2 (fr) * 2000-06-09 2003-03-05 Corixa Corporation Compositions et procedes pour la therapie et le diagnostic du cancer du colon
US6323016B1 (en) 2000-06-09 2001-11-27 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
AU2001268435A1 (en) * 2000-06-15 2001-12-24 Millennium Pharmaceuticals, Inc. 23680, a novel human aminotransferase and uses therefor
WO2001096546A2 (fr) * 2000-06-16 2001-12-20 Incyte Genomics, Inc. Proteine-phosphatases
CA2709771A1 (fr) * 2000-06-23 2002-01-03 Genentech, Inc. Compositions et methode de diagnostic et de traitement des troubles mettant en cause l'angiogenese
EP1325114A2 (fr) * 2000-06-26 2003-07-09 Millennium Pharmaceuticals, Inc. 46619, une nouvelle synthase beta-cetoacyle et utilisations de cette derniere
US7094587B2 (en) 2000-06-27 2006-08-22 Millennium Pharmaceuticals, Inc. 16002 Molecules and uses therefor
WO2002000691A2 (fr) * 2000-06-27 2002-01-03 Curagen Corporation Nouveaux polynucleotides et polypeptides codes par ceux-ci
WO2002000939A2 (fr) 2000-06-28 2002-01-03 Diadexus, Inc. Procede de diagnostic, de surveillance, de determination du stade, d'imagerie et de traitement du cancer du colon
US6900303B2 (en) 2000-06-30 2005-05-31 Millennium Pharmaceuticals, Inc. 57658, a novel human uridine kinase and uses thereof
AU2001273239A1 (en) * 2000-07-07 2002-01-21 Incyte Genomics, Inc. Transporters and ion channels
AU2001271843A1 (en) * 2000-07-07 2002-01-21 Incyte Genomics, Inc. Gtp-binding proteins
AU2001275944A1 (en) * 2000-07-14 2002-01-30 Millennium Pharmaceuticals, Inc. 62088, a human nucleoside phosphatase family member and uses thereof
WO2002006318A2 (fr) 2000-07-18 2002-01-24 Board Of Regents, The University Of Texas System Procedes et compositions permettant de stabiliser des microtubules et des filaments intermediaires dans des cellules de muscle strie
US20030171324A1 (en) * 2000-07-18 2003-09-11 Shyam Ramakrishnan Regulation of human desc1-like serine protease
AU2001273150A1 (en) * 2000-07-20 2002-02-05 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20060252034A1 (en) * 2000-07-25 2006-11-09 Klaus Duecker Novel protein containing ring finger domaine r1p4
WO2002008282A2 (fr) * 2000-07-26 2002-01-31 Stanford University Proteine bstp-ras/rerg et reactifs apparentes, procedes d'utilisation de ces derniers
AU2001277200A1 (en) * 2000-07-26 2002-02-05 Applied Genomics, Inc. Bstp-cad protein and related reagents and methods of use thereof
EP1657254A3 (fr) * 2000-08-01 2006-06-07 Genentech, Inc. Polypeptide, acides nucléiques le codant, et leur utilisation pour le diagnostic du cancer
US7335732B2 (en) 2000-08-01 2008-02-26 Genentech, Inc. PRO9799 polypeptides
EP1315431A1 (fr) * 2000-08-02 2003-06-04 Millennium Pharmaceuticals, Inc. Membre de la famille du facteur de liberation du gtp humain (15368) et ses utilisations
AU2001283062A1 (en) 2000-08-02 2002-02-13 The Johns Hopkins University Endothelial cell expression patterns
US6924364B2 (en) 2000-08-04 2005-08-02 Zymogenetics, Inc. Human secreted protein, Zzp1
AU2001281252A1 (en) 2000-08-10 2002-02-18 Board Of Regents, The University Of Texas System The tumor suppressor car-1
CA2418266A1 (fr) * 2000-08-11 2002-02-21 Merck Patent Gesellschaft Mit Beschraenkter Haftung Nouvelles proteines mekk
EP1326985A1 (fr) * 2000-08-18 2003-07-16 MERCK PATENT GmbH Identification d'un gene d'acetyltransferase n-terminale humaine
US6706513B2 (en) 2000-08-21 2004-03-16 Bristol-Myers Squibb Company Adenosine deaminase homolog
JP2004519217A (ja) * 2000-08-21 2004-07-02 インサイト・ゲノミックス・インコーポレイテッド 微小管関連タンパク質およびチューブリン
WO2002016579A2 (fr) * 2000-08-24 2002-02-28 Eli Lilly And Company Acides nucleiques, vecteurs, cellules hotes, polypeptides et utilisations de ces derniers
WO2002018578A2 (fr) 2000-08-28 2002-03-07 Agensys, Inc. Acide nucleique et proteine correspondante denommes 85p1b3 utilises dans le traitement et la detection de cancers
US20040096842A1 (en) * 2000-08-28 2004-05-20 Peter Brodin Molecules involved in the regulation of insulin resistance syndrome (irs)
AU2001232835A1 (en) * 2000-08-28 2002-03-13 Human Genome Sciences, Inc. 18 human secreted proteins
AU2002210464A1 (en) * 2000-08-30 2002-03-13 Bayer Aktiengesellschaft Regulation of human aminotransferase-like enzyme
WO2002018573A2 (fr) * 2000-08-30 2002-03-07 Millennium Pharmaceuticals, Inc. Nouveau transporteur humain de sulfate: la proteine 54370, et utilisations associees
WO2002018552A2 (fr) * 2000-08-30 2002-03-07 Bayer Aktiengesellschaft Regulation d'enzyme humaine de type aminotransferase
AU2001286815A1 (en) * 2000-08-30 2002-03-13 Millennium Pharmaceuticals, Inc. 48921, a novel human gtp releasing factor and uses therefor
US7166428B2 (en) 2000-08-31 2007-01-23 Millennium Pharmaceuticals, Inc. 62112, a novel human dehydrogenase and uses thereof
US7153669B2 (en) 2000-09-05 2006-12-26 Amgen Inc. Nucleic acids encoding MK61 receptors
WO2002020754A2 (fr) * 2000-09-05 2002-03-14 Incyte Genomics, Inc. Molecules utilisees a des fins diagnostiques et therapeutiques
AU2001288999A1 (en) * 2000-09-08 2002-03-22 Millennium Pharmaceuticals, Inc. 38646, a guanine nucleotide exchange factor and uses therefor
US6372468B1 (en) * 2000-09-14 2002-04-16 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US6391606B1 (en) * 2000-09-14 2002-05-21 Pe Corporation Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
CA2424199A1 (fr) * 2000-10-05 2002-04-11 Curagen Corporation Nouvelles proteines humaines, polynucleotides codant pour ces proteines et methodes d'utilisation associees
WO2002031126A2 (fr) * 2000-10-11 2002-04-18 Bayer Aktiengesellschaft Regulation d'une peptidyl-prolyl cis-trans isomerase de type cyclophiline humaine
AU2002211597A1 (en) * 2000-10-11 2002-04-22 Millennium Pharmaceuticals, Inc. 8843, a human dual specificity phosphatase family member and uses therefor
AU2002211715A1 (en) * 2000-10-12 2002-04-22 The Texas A And M University System Nucleic acid sequences encoding cmg proteins cmg proteins and methods for their use
WO2002030268A2 (fr) * 2000-10-13 2002-04-18 Eos Biotechnology, Inc. Procedes de diagnostic du cancer de la prostate, compositions et procedes de criblage de modulateurs du cancer de la prostate
US6531297B2 (en) * 2000-10-20 2003-03-11 Applera Corporation Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
AU2002249787A1 (en) 2000-10-25 2002-08-19 Diadexus, Inc. Compositions and methods relating to lung specific genes and proteins
AU2002220668A1 (en) * 2000-10-31 2002-05-15 Bayer Aktiengesellschaft Regulation of human glutathione-s-transferase
WO2002038743A2 (fr) * 2000-11-09 2002-05-16 Glaxo Group Limited Enzyme
AU2002219988A1 (en) 2000-11-20 2002-05-27 Diadexus, Inc. Compositions and methods relating to breast specific genes and proteins
AU2001297765A1 (en) * 2000-12-05 2002-10-21 Incyte Genomics, Inc. Ligases
EP1339845A2 (fr) 2000-12-07 2003-09-03 ZymoGenetics, Inc. Proteine associee au complement adipocyte zacrp3x2
US7776523B2 (en) 2000-12-07 2010-08-17 Novartis Vaccines And Diagnostics, Inc. Endogenous retroviruses up-regulated in prostate cancer
AU2002211305A1 (en) * 2000-12-14 2002-06-24 Pe Corporation (Ny) Isolated human kinase proteins, their encoding nucleic acid molecules, and uses thereof
US20020142376A1 (en) * 2000-12-20 2002-10-03 Gennady Merkulov Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
EP1409673B1 (fr) 2000-12-22 2006-06-07 Brystol-Myers Squibb Company Proteine humaine contenant une sequence repetee riche en leucine exprimee principalement dans l'intestin grele, hlrrsi1
US7892730B2 (en) * 2000-12-22 2011-02-22 Sagres Discovery, Inc. Compositions and methods for cancer
US6423521B1 (en) * 2000-12-28 2002-07-23 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
WO2002053591A1 (fr) * 2000-12-30 2002-07-11 Lion Bioscience Ag Cofacteur de recepteur nucleaire mammalien cf12 et ses procedes d'utilisation
EP1425289A4 (fr) * 2001-01-30 2004-10-13 Regeneron Pharma Nouvelles molecules d'acide nucleique et polypeptidiques
EP1409536A2 (fr) * 2001-02-12 2004-04-21 Curagen Corporation Proteines, polynucleotides codant pour lesdites proteines et methodes d'utilisation desdites proteines
EP1637601A3 (fr) * 2001-02-21 2006-03-29 Curagen Corporation Protéines , polynucléotides codant pour ces protéines et procédés d'utilisation
AU2002305052A1 (en) 2001-03-13 2002-09-24 Corvas International, Inc. Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
WO2002074906A2 (fr) * 2001-03-16 2002-09-26 Eli Lilly And Company Proteines de mammiferes lp et reactifs associes
EP1383884A4 (fr) 2001-03-22 2004-12-15 Dendreon Corp Molecules d'acide nucleique codant la serine protease cvsp14, polypeptides codes et procedes
WO2002077267A2 (fr) 2001-03-27 2002-10-03 Dendreon San Diego Llc Molecules d'acide nucleique codant une serine protease transmembranaire 9, polypeptides codes et procedes fondes sur ces derniers
US6913904B2 (en) * 2001-03-27 2005-07-05 Applera Corporation Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof
US7033790B2 (en) 2001-04-03 2006-04-25 Curagen Corporation Proteins and nucleic acids encoding same
US7736654B2 (en) 2001-04-10 2010-06-15 Agensys, Inc. Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers
CA2443147A1 (fr) 2001-04-10 2002-10-24 Agensys, Inc. Acide nucleique et proteine correspondante intitulee 184p1e2, utilises dans le traitement et la detection de cancers
AU2002258626B2 (en) 2001-04-10 2007-01-18 Agensys, Inc. Nucleid acid and corresponding protein entitled 158P3D2 useful in treatment and detection of cancer
KR20040015128A (ko) * 2001-04-24 2004-02-18 오츠카 세이야쿠 가부시키가이샤 크론병 항체 결합성 펩티드 및 크론병의 검사 방법
EP1383883A2 (fr) * 2001-04-24 2004-01-28 Isis Innovation Limited Snps asthme-associes autour du marqueur d2s308 de microsatellite et de l'identification de prolyl-oligopeptidase-dpp10 humain
US20050158719A1 (en) * 2001-05-07 2005-07-21 Yasufumi Sato Polypeptide serving as angiogenic marker and dna thereof
AU2002314048A1 (en) * 2001-05-09 2002-11-18 Bayer Aktiengesellschaft Regulation of human phosphatidic acid phosphatase type 2c-like protein
CA2447050A1 (fr) 2001-05-14 2002-11-21 Dendreon San Diego Llc Molecules d'acides nucleiques codant pour une serine protease transmembranaire 10, polypeptides codes et methodes associees
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
WO2003000901A2 (fr) * 2001-06-26 2003-01-03 Decode Genetics Ehf. Acides nucleiques codant des proteines kinases
US20030120040A1 (en) 2001-06-29 2003-06-26 Genentech, Inc. Secreted and Transmembrane polypeptides and nucleic acids encoding the same
GB2399086A (en) * 2001-08-02 2004-09-08 Aeomica Inc Human zinc finger containing gene MDZ4
CA2458645A1 (fr) * 2001-08-17 2003-04-17 Incyte Genomics, Inc. Molecules de signalisation intracellulaire
US7270960B2 (en) * 2001-08-29 2007-09-18 Pacific Northwest Research Institute Diagnosis of ovarian carcinomas
WO2003023063A1 (fr) * 2001-09-07 2003-03-20 Sankyo Company, Limited Methode d'estimation du risque d'apparition de diabetes
WO2003040369A2 (fr) * 2001-09-17 2003-05-15 Molecular Engines Laboratories Sequences impliquees dans les phenomenes de suppression tumorale, reversion tumorale, apoptose et/ou resistance aux virus et leur utilisation comme medicaments
WO2003025175A2 (fr) * 2001-09-17 2003-03-27 Molecular Engines Laboratories Sequences impliquees dans les phenomenes de suppression tumorale, reversion tumorale, apoptose et/ou resistance aux virus et leur utilisation comme medicaments
WO2003029411A2 (fr) 2001-09-28 2003-04-10 Brigham Young University Nouveaux variants de la cyclooxygenase et methodes d'utilisation
US20040248132A1 (en) 2001-10-04 2004-12-09 Toshiyuki Sakai DR5 gene promoter and siah-1 gene promoter
US7084257B2 (en) 2001-10-05 2006-08-01 Amgen Inc. Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
WO2003031607A1 (fr) * 2001-10-10 2003-04-17 Bayer Healthcare Ag Regulation de deshydrogenase/reductase des chaines courtes humaine
ATE364690T1 (de) 2001-11-09 2007-07-15 Proteologics Inc Posh nukleinsäure, polypeptide und darauf bezogene verfahren
US7491690B2 (en) 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
JPWO2003044197A1 (ja) * 2001-11-21 2005-03-24 独立行政法人科学技術振興機構 ハンチントン病遺伝子転写因子
US7151162B2 (en) 2001-12-06 2006-12-19 The University Of Children's Hospital Of Both Cantons Of Basel Nuclear protein
AU2002339697A1 (en) * 2001-12-19 2003-06-30 Genset S.A. Gmg-5 polynucleotides and polypeptides and uses thereof
JP2003245084A (ja) 2001-12-20 2003-09-02 Morinaga Milk Ind Co Ltd 脳梁又は精子の形成不全の診断及び治療に有用な新規遺伝子、並びにその用途
DE10163467A1 (de) * 2001-12-21 2003-11-27 Axaron Bioscience Ag Protein 24B2 und zugrundliegende DNA-Sequenz
US6759222B2 (en) 2002-01-02 2004-07-06 Millennium Pharmaceuticals, Inc. 14815, a human kinase family member and uses therefor
AU2003202543A1 (en) * 2002-01-07 2003-07-24 Bayer Aktiengesellschaft Human phosphatidic acid phosphatase type 2-like protein
AU2003235631A1 (en) * 2002-01-15 2003-07-30 Bayer Aktiengesellschaft Human subtilisin/kexin-like convertase
WO2003059948A1 (fr) * 2002-01-15 2003-07-24 Medigene Ag Gene-2 associe a la myocardiopathie dilatee (dcmag-2) : inducteur cytoplasmique du remodelage sarcomerique de cardiomyocytes
WO2003062429A1 (fr) * 2002-01-23 2003-07-31 Yamanouchi Pharmaceutical Co., Ltd. Nouvelle serine protease
WO2003070749A2 (fr) 2002-02-15 2003-08-28 Northwestern University Auto-assemblage de nanofibres amphiphiles peptidiques dans des conditions physiologiques
EP1338609A1 (fr) * 2002-02-21 2003-08-27 MEMOREC Stoffel GmbH-Medizinisch-Molekulare Entwicklung, Köln Un outre récepteur KDR et son utilisation
WO2003076645A2 (fr) * 2002-03-05 2003-09-18 Applera Corporation Proteines transporteuses humaines isolees, molecules d'acide nucleique codant celles-ci, et utilisations associees
WO2003074557A1 (fr) * 2002-03-06 2003-09-12 Oxford Glycosciences (Uk) Ltd Nouvelle proteine associée à la malignité de lymphocyte b
AU2003253986A1 (en) 2002-03-13 2003-09-29 Genomic Health Gene expression profiling in biopsied tumor tissues
US7527935B2 (en) 2002-03-19 2009-05-05 Mitsubishi Tanabe Pharma Corporation G-protein coupled receptor having eicosanoid as ligand and gene thereof
AU2003220913A1 (en) * 2002-03-19 2003-09-29 Tanabe Seiyaku Co., Ltd. Novel g protein-coupled recepotrs and genes thereof
GB0206684D0 (en) * 2002-03-21 2002-05-01 Babraham Inst Novel proteins
US7193069B2 (en) 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
CA2413475C (fr) 2002-04-25 2010-07-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Expression de zap-70 en tant que marqueur de la leucemie chronique lymphoide/du lymphome a petits lymphocytes (lcl/lpl)
JP2004041003A (ja) * 2002-05-17 2004-02-12 Takeda Chem Ind Ltd 新規タンパク質、そのｄｎａおよびその用途
EP2269628A3 (fr) 2002-05-29 2011-04-20 DeveloGen Aktiengesellschaft Proteines specifiques du pancreas
WO2003101401A2 (fr) 2002-06-03 2003-12-11 Chiron Corporation Utilisation de nrg4, ou d'inhibiteurs de nrg4, dans le traitement du cancer du colon et du pancreas
EP2275544A3 (fr) 2002-06-06 2011-03-30 Oncotherapy Science, Inc. Gènes et polypeptides en rapport avec les cancers du colon chez l'homme
EP1532161B1 (fr) 2002-06-13 2012-02-15 Novartis Vaccines and Diagnostics, Inc. Vecteurs pour l'expression de polypeptides hml-2
US20060172296A1 (en) * 2002-07-22 2006-08-03 Masahiro Takeuchi Novel gene associated with rheumatoid arthritis
ATE419360T1 (de) 2002-08-14 2009-01-15 Nat Inst Of Advanced Ind Scien Neue n-acetylgalactosamin-transferasen und diese codierende nukleinsäuren
WO2004016733A2 (fr) 2002-08-16 2004-02-26 Agensys, Inc. Acides nucleiques et proteines correspondantes connues sous 251p5g2 que l'on utilise dans le traitement et la detection de cancers
WO2004018518A1 (fr) * 2002-08-23 2004-03-04 Japan Science And Technology Agency Peptides antigeniques de tumeur cancereuse solide humains, polynucleotides codant pour ceux-ci et utilisation de ceux-ci
EP1540014A2 (fr) * 2002-08-27 2005-06-15 Epigenomics AG Procede et acides nucleiques servant a l'analyse de troubles lies a la proliferation des cellules mammaires
US7452969B2 (en) 2002-08-30 2008-11-18 Licentia Ltd Neurotrophic factor protein and uses thereof
JP4679149B2 (ja) 2002-09-30 2011-04-27 オンコセラピー・サイエンス株式会社 ヒト膵癌に関連する遺伝子およびポリペプチド
EP1552310A2 (fr) * 2002-10-17 2005-07-13 EVOTEC Neurosciences GmbH L'utilisation de la proteine et du gene de la nicotinamide mononucleotide adenylyltransferase 2 (nmnat-2) pour le diagnostique et la therapie des maladies neurodegeneratives
AU2002952216A0 (en) * 2002-10-23 2002-11-07 The Walter And Eliza Hall Institute Of Medical Research Novel therapeutic molecules
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
EP1570080A4 (fr) 2002-11-15 2006-03-01 Genomic Health Inc Etablissement de profils d'expressions genetique du cancer a recepteur de facteur de croissance epidermique positif
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
AU2002953341A0 (en) * 2002-12-13 2003-01-09 The Walter And Eliza Hall Institute Of Medical Research A novel phosphoprotein
AU2003287764B2 (en) * 2002-12-13 2010-01-21 The Walter And Eliza Hall Institute Of Medical Research A novel phosphoprotein
US20040231909A1 (en) 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
WO2004070025A2 (fr) * 2003-02-05 2004-08-19 Juan Saus Nouvelles isoformes de la proteine liant l'antigene de goodpasture et troubles induits par une proteine incorrectement repliee
EP1445614A1 (fr) * 2003-02-06 2004-08-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Méthodes d'évaluation in vitro de l'état de progression d'un virus HIV chez un individu
US7074891B2 (en) 2003-02-07 2006-07-11 Posco Leukocyte stimulating peptides
JP4568716B2 (ja) 2003-02-20 2010-10-27 ジェノミック ヘルス， インコーポレイテッド 遺伝子発現を測定するためのイントロンｒｎａの使用
JPWO2004078784A1 (ja) * 2003-03-04 2006-06-08 アステラス製薬株式会社 線維化病態に関連する新規遺伝子
RS54160B1 (sr) * 2003-03-19 2015-12-31 Biogen Idec Ma Inc. Protein koji se vezuje za nogo receptor
ITRM20030149A1 (it) 2003-04-02 2004-10-03 Giuliani Spa Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
EP3170906B1 (fr) 2003-06-24 2018-08-22 Genomic Health, Inc. Prédiction de probabilité de récurrence de cancer
CA2531967C (fr) 2003-07-10 2013-07-16 Genomic Health, Inc. Algorithme de profile d'expression et test du pronostic du cancer
EP2311468B1 (fr) 2003-08-08 2014-01-15 Perseus Proteomics Inc. Gène surexprimé dans le cancer
WO2005018554A2 (fr) * 2003-08-12 2005-03-03 Washington University In St. Louis Proteine de surface cellulaire isolee inductible par la chaleur et therapie d'immunociblage de tumeurs basee sur l'hyperthermie
US20070178458A1 (en) * 2003-09-05 2007-08-02 O'brien Philippa Methods of diagnosis and prognosis of ovarian cancer II
WO2005026314A2 (fr) * 2003-09-10 2005-03-24 Japan Science And Technology Agency Groupe de genes exprimes de facon differentielle dans des cellules de sang peripherique ainsi que procede de diagnostic et procede d'analyse mettant en oeuvre ce groupe
DE602004028262D1 (de) * 2003-10-02 2010-09-02 Glaxosmithkline Biolog Sa B. pertussis antigene und ihre verwendung bei der vakzinierung
CA2541006C (fr) 2003-10-03 2015-02-17 Brigham And Women's Hospital Ligands de tim-3 et methodes associees
WO2005040791A2 (fr) * 2003-10-21 2005-05-06 Bayer Healthcare Ag Diagnostics et therapeutiques pour maladies liees au recepteur de peptides similaire a la somatostatine et a l'angiogenine (salpr)
US20050255560A1 (en) * 2003-11-21 2005-11-17 Zeren Gao Ztnf11, a tumor necrosis factor
EP1696945B1 (fr) * 2003-12-05 2012-01-18 Northwestern University Amphiphiles peptidiques a assemblage automatique et procedes associes d'administration de facteur de croissance
EP1699936B1 (fr) 2003-12-23 2011-02-09 Genomic Health, Inc. Amplification universelle d'arn fragmente
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
EP3556866B1 (fr) 2004-03-02 2021-04-07 The Johns Hopkins University Mutations du gène pik3ca dans les cancers humains
TW200539890A (en) 2004-03-12 2005-12-16 Brigham & Womens Hospital Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function
WO2005090569A1 (fr) * 2004-03-24 2005-09-29 The Council Of The Queensland Institute Of Medical Research Cancer et acides nucleiques et proteines de testicule vsm1 et vsm2, et leurs utilisations
CA2561577A1 (fr) * 2004-03-30 2005-10-13 Nsgene A/S Utilisation therapeutique d'un facteur de croissance, nsg33
WO2005100606A2 (fr) 2004-04-09 2005-10-27 Genomic Health, Inc. Marqueurs d'expression genique permettant de predire la reponse a la chimiotherapie
DE102004024617A1 (de) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
WO2005118832A2 (fr) * 2004-06-01 2005-12-15 Bayer Healthcare Ag Agents diagnostiques et therapeutiques pour des maladies associees a une proteine de type kinase regulee par serum/glucocorticoide (sgkl)
BRPI0512500A (pt) 2004-06-24 2008-03-11 Biogen Idec Inc tratamento ou condições envolvendo desmielinação
US7587279B2 (en) 2004-07-06 2009-09-08 Genomic Health Method for quantitative PCR data analysis system (QDAS)
EP1780215B1 (fr) * 2004-08-05 2009-06-17 Toagosei Co., Ltd. Peptide determinant antigenique d'un anticorps de la maladie de crohn et reactif pour test de la maladie de crohn
DK1815014T3 (da) 2004-11-05 2012-06-18 Genomic Health Inc Molekylære indikatorer for brystcancerprognose og forudsigelse af behandlingsrespons
AU2005304824B2 (en) 2004-11-05 2011-12-22 Genomic Health, Inc. Predicting response to chemotherapy using gene expression markers
EP2845865A1 (fr) 2004-11-12 2015-03-11 Xencor Inc. Variantes Fc avec liaison altérée en FcRn
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
CN101184995A (zh) 2005-03-04 2008-05-21 西北大学 生血管肝素结合肽两亲物
EP1880005B1 (fr) * 2005-05-13 2012-11-07 Centre National de la Recherche Scientifique Utilisation de nouveau codage genique pour nouvel element de la famille mcm2-8 dans les compositions pharmaceutiques
DK1904104T3 (da) 2005-07-08 2013-11-11 Biogen Idec Inc SP35-antistoffer og anvendelser heraf
EP1907589A4 (fr) * 2005-07-26 2010-11-24 Siemens Healthcare Diagnostics Polymorphismes de nucleotides uniques a susceptibilite par rapport a une maladie cardio-vasculaire
US8207128B2 (en) * 2005-09-28 2012-06-26 Supadelixir Inc. Polypeptide inhibiting transmigration of leukocytes or growth and/or metastasis of cancer cells, and fusion protein thereof
EP1790664A1 (fr) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Anticorps monoclonaux contre claudin-18 pour le traitement du cancer
EP1969003B8 (fr) 2005-12-14 2010-11-10 Hermo Pharma Ltd. Utilisations d'un FACTEUR NEUROTROPHIQUE
US20120141376A1 (en) * 2006-07-03 2012-06-07 Richard Einstein Prostate specific transcripts and the use thereof for prostate cancer therapeutics and diagnostics
US20080108070A1 (en) * 2006-09-08 2008-05-08 Corixa Corporation Methods, compositions, and kits for the detection and monitoring of colon cancer
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
US8999634B2 (en) * 2007-04-27 2015-04-07 Quest Diagnostics Investments Incorporated Nucleic acid detection combining amplification with fragmentation
GB0805159D0 (en) * 2008-03-19 2008-04-23 Sancho Madrid David Immune modulation via C-type lectin
PL2565204T3 (pl) * 2007-07-27 2016-03-31 Immatics Biotechnologies Gmbh Nowe immunogenne epitopy do immunoterapii
US7863021B2 (en) 2007-09-05 2011-01-04 Celera Corporation Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
WO2009034661A1 (fr) * 2007-09-12 2009-03-19 Toppan Printing Co., Ltd. Procédé de diagnostic et induction d'une résistance à un virus
WO2009050309A1 (fr) 2007-10-17 2009-04-23 Universidad De Cordoba Isoformes du récepteur de la somatostatine humaine de type 5 produites par traitement alternatif et paires d'oligonucléotides permettant de les détecter par pcr
ES2742268T3 (es) 2007-12-26 2020-02-13 Xencor Inc Variantes de Fc con unión alterada a FcRn
GB0803352D0 (en) * 2008-02-22 2008-04-02 Ntnu Technology Transfer As Oligopeptidic compounds and uses thereof
WO2009115612A1 (fr) * 2008-03-21 2009-09-24 Universiteit Hasselt Biomarqueurs de la polyarthrite rhumatoïde
AU2009269099B2 (en) 2008-07-09 2016-03-10 Biogen Ma Inc. Compositions comprising antibodies to LINGO or fragments thereof
US8334264B2 (en) 2008-07-24 2012-12-18 NsGenee A/S Therapeutic use of a growth factor, METRNL
SI2172211T1 (sl) 2008-10-01 2015-03-31 Immatics Biotechnologies Gmbh Sestavek s tumorjem povezanih peptidov in zadevnih cepiv proti raku za zdravljenje glioblastoma (GBM) in drugih vrst raka
WO2010057069A1 (fr) 2008-11-14 2010-05-20 Gen-Probe Incorporated Compositions, kits et procédés pour la détection d’acide nucléique de campylobacter
WO2010062960A2 (fr) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center Méthodes de détermination d'une réceptivité à une thérapie par anti-tnfα lors d’une maladie intestinale inflammatoire
US20110286924A1 (en) * 2008-12-09 2011-11-24 Alethia Biotherapeutics Inc Novel human endogenous retroviral erv3 variant and uses thereof in the diagnosing ovarian cancer
KR20120012811A (ko) 2009-04-13 2012-02-10 노오쓰웨스턴 유니버시티 신규한 연골 재생용 펩티드-기반 스카폴드 및 이들의 사용 방법
WO2011028952A1 (fr) 2009-09-02 2011-03-10 Xencor, Inc. Compositions et procédés pour une co-liaison bivalente et monovalente simultanée d'antigènes
JP6210685B2 (ja) 2010-01-27 2017-10-11 マサチューセッツ インスティテュート オブ テクノロジー 標的化された広域スペクトルのインフルエンザ中和のための操作されたポリペプチド剤
DK2621526T3 (en) 2010-09-29 2018-08-06 Agensys Inc ANTIBODY-PHARMACEUTICAL CONJUGATES (ADC) BINDING TO 191P4D12 PROTEINS
AU2011307488B2 (en) 2010-10-01 2015-08-20 Hoba Therapeutics Aps Use of meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain
WO2012081040A1 (fr) * 2010-12-14 2012-06-21 Hananja Ehf. Activité biologique de la protéine placentaire 13
CN107596346A (zh) 2011-09-05 2018-01-19 霍巴治疗公司 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗
WO2013068445A1 (fr) * 2011-11-09 2013-05-16 Sanofi Diacylglycérol lipase et applications associées
PL2844667T3 (pl) 2012-04-30 2018-10-31 Biocon Limited Ukierunkowane/immunomodulujące białka fuzyjne i sposoby ich otrzymywania
WO2013167153A1 (fr) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Anticorps utiles dans le diagnostic du cancer
KR102142161B1 (ko) 2012-05-14 2020-08-06 바이오젠 엠에이 인코포레이티드 운동 뉴런 관련 병태 치료용 lingo-2 길항제
WO2013174404A1 (fr) 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer
CA3169263A1 (fr) 2012-11-13 2014-05-22 Astellas Pharma Inc. Agents de traitement de maladies cancereuses exprimant claudine
WO2014127785A1 (fr) 2013-02-20 2014-08-28 Ganymed Pharmaceuticals Ag Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer
NZ711445A (en) 2013-03-12 2018-06-29 Biocon Ltd Fusion immunomodulatory proteins and methods for making same
US9023353B2 (en) * 2013-03-13 2015-05-05 The Board Of Trustees Of The University Of Arkansas Anti-(+)—methamphetamine monoclonal antibodies
WO2014146672A1 (fr) 2013-03-18 2014-09-25 Ganymed Pharmaceuticals Ag Thérapie comprenant des anticorps dirigés contre cldn 18.2 pour le traitement du cancer
KR20210157418A (ko) 2013-03-27 2021-12-28 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
DK3019619T3 (da) 2013-07-11 2021-10-11 Modernatx Inc Sammensætninger, der omfatter syntetiske polynukleotider, som koder for crispr-beslægtede proteiner, og syntetiske sgrna'er, og anvendelsesfremgangsmåder
EP4105236A1 (fr) 2013-07-19 2022-12-21 Cedars-Sinai Medical Center Anticorps contre tl1a (tnfsf15) pour le traitement des maladies inflammatoires de l'intestin
KR102790260B1 (ko) 2013-09-25 2025-04-01 싸이톰스 테라퓨틱스, 인크. 매트릭스 메탈로프로테이나제 기질 및 다른 절단성 모이어티 및 이의 사용 방법
US20160367651A1 (en) * 2013-10-01 2016-12-22 Mie University T cell inducing vaccine containing an interepitope sequence that promotes antigen presentation
US9562073B2 (en) 2014-01-31 2017-02-07 Cytomx Therapeutics, Inc. Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
CA2973266A1 (fr) 2015-01-08 2016-07-14 Biogen Ma Inc. Antagonistes de lingo-1 et leurs utilisations pour le traitement de troubles de demyelinisation
IL300408B1 (en) 2015-01-20 2025-07-01 Cytomx Therapeutics Inc Penitentiary substrates for cleavage by metalloferon protease and serine protease and their uses
US11124766B2 (en) * 2015-06-12 2021-09-21 Emory University Growth and survival compositions for cells capable of producing antibodies and methods related thereto
PT3344776T (pt) * 2015-09-04 2021-08-03 Synthetic Genomics Inc Microorganismos recombinantes de algas com aumento de produtividade
CN109462996A (zh) 2016-03-17 2019-03-12 西达-赛奈医疗中心 通过rnaset2诊断炎性肠病的方法
EP3436069A4 (fr) * 2016-03-29 2019-12-18 Valkyrie Therapeutics Inc. Modulation de l'entretien structural de l'expression du chromosome-1
US9611297B1 (en) 2016-08-26 2017-04-04 Thrasos Therapeutics Inc. Compositions and methods for the treatment of cast nephropathy and related conditions
US11125757B2 (en) 2017-05-26 2021-09-21 Emory University Methods of culturing and characterizing antibody secreting cells
EP3508499A1 (fr) 2018-01-08 2019-07-10 iOmx Therapeutics AG Anticorps ciblant et d'autres modulateurs d'un gène d'immunoglobuline associé à une résistance contre des réponses immunitaires antitumorales et leurs utilisations
CN113677364B (zh) 2018-12-03 2024-07-05 艾更斯司股份有限公司 包含抗191p4d12抗体药物偶联物的药物组合物及其使用方法
BR112021010433A2 (pt) 2018-12-06 2021-08-24 Cytomx Therapeutics, Inc. Substratos cliváveis de metaloprotease de matriz e de serina ou cisteína protease e métodos de uso destes
JP2022530457A (ja) * 2019-04-26 2022-06-29 サンガモ セラピューティクス， インコーポレイテッド 遺伝子操作ａａｖ
CA3146023A1 (fr) 2019-07-05 2021-01-14 Iomx Therapeutics Ag Anticorps de liant a l'igc2 de l'igsf11 (vsig3) et leurs utilisations
WO2021083958A1 (fr) * 2019-10-29 2021-05-06 Specialites Pet Food Nouveaux peptides induisant la satiété
BR112022019454A2 (pt) * 2020-03-27 2022-12-13 Onecuregen Co Ltd Composição compreendendo peptídeo vgll1 para tratamento de câncer
EP4149952A1 (fr) * 2020-05-12 2023-03-22 Institut Curie Épitopes néo-antigéniques associés à des mutations sf3b1
US12188060B2 (en) 2020-05-15 2025-01-07 Crispr Therapeutics Ag Messenger RNA encoding Cas9 for use in genome-editing systems
WO2022008027A1 (fr) 2020-07-06 2022-01-13 Iomx Therapeutics Ag Anticorps de liaison à l'igv d'igsf11 (vsig3) et leurs utilisations
CN117529492A (zh) * 2021-01-21 2024-02-06 鹿特丹伊拉斯谟大学医疗中心 用于治疗的t细胞
WO2022178318A1 (fr) * 2021-02-18 2022-08-25 Beren Therapeutics P.B.C. Méthodes de traitement de l'hypercholestérolémie familiale hétérozygote et homozygote avec des cyclodextrines
WO2023287726A1 (fr) 2021-07-12 2023-01-19 Penland Foundation Traitement du cancer à l'aide de toxine botulique et d'oxyde nitreux
US20240158457A1 (en) * 2022-05-20 2024-05-16 Medikine, Inc. Interleukin-18 receptor binding polypeptides and uses thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446240A (en) * 1981-01-30 1984-05-01 Nerenberg Samuel T Pancreas specific protein systems
US5457038A (en) * 1988-11-10 1995-10-10 Genetics Institute, Inc. Natural killer stimulatory factor
US6080540A (en) * 1990-04-20 2000-06-27 Cold Spring Harbor Laboratory Cloning of mammalian genes in microbial organisms and methods for pharmacological screening
AU656350B2 (en) * 1990-11-26 1995-02-02 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Cell stress transcriptional factors
US5721352A (en) * 1991-02-19 1998-02-24 University Of Florida Research Foundation Entomopoxvirus expression system
US5840870A (en) * 1995-12-29 1998-11-24 Incyte Pharmaceuticals, Inc. Polynucleotides PANC1A and PANC1B associated with pancreatic cancer
WO1999014234A2 (fr) * 1997-09-17 1999-03-25 Genentech, Inc. Stimulation ou inhibition de l'angiogenese et de la cardiovascularisation
US5912160A (en) * 1995-08-22 1999-06-15 Thomas Jefferson University Gab1, Grb2 binding protein, and compositions for making and methods of using the same
JP3462313B2 (ja) * 1995-08-24 2003-11-05 キッコーマン株式会社 変異型ウリカーゼ、変異型ウリカーゼ遺伝子、新規な組み換え体ｄｎａ及び変異型ウリカーゼの製造法
US5998165A (en) * 1995-12-29 1999-12-07 Incyte Pharmaceuticals, Inc. Polynucleotides encoding a protein associated with pancreatic cancer
EP0927046A4 (fr) * 1996-04-29 2002-10-02 Univ Johns Hopkins Med Regulateur de la degradation de l'arn chez les mammiferes induite par des transcrits non-sens
US6500934B1 (en) * 1996-07-24 2002-12-31 Michael Rush Lerner Bivalent agonists for G-protein coupled receptors
US5976834A (en) * 1997-01-09 1999-11-02 Smithkline Beecham Corporation cDNA clone HNFJD15 that encodes a novel human 7-transmembrane receptor
US5925521A (en) * 1997-03-31 1999-07-20 Incyte Pharmaceuticals, Inc. Human serine carboxypeptidase
CA2232743A1 (fr) * 1997-04-02 1998-10-02 Smithkline Beecham Corporation Tl5, homologue tnf
WO1998045435A2 (fr) * 1997-04-10 1998-10-15 Genetics Institute, Inc. MARQUEURS SECRETES DE SEQUENCE EXPRIMEE (sEST)
IT1291110B1 (it) * 1997-04-15 1998-12-29 Istituto Europ Di Oncologia S Interattori intracellulari e specificita' di legame del dominio eh
US5948641A (en) * 1997-05-29 1999-09-07 Incyte Pharmaceuticals, Inc. Polynucleotides encoding a metal response element binding protein
IL133315A0 (en) * 1997-06-06 2001-04-30 Regeneron Pharma Ntn-2 member of tnf ligand family
US5932442A (en) * 1997-09-23 1999-08-03 Incyte Pharmaceuticals, Inc. Human regulatory molecules
US5972660A (en) * 1997-10-22 1999-10-26 Incyte Pharmaceuticals, Inc. Human hydroxypyruvate reductase
DE19818598A1 (de) * 1998-04-19 1999-10-21 Metagen Gesellschaft Fuer Genomforschung Mbh Menschliche Nukleinsäuresequenzen aus Pankreasnormalgewebe
CA2327317A1 (fr) * 1998-04-29 1999-11-04 Genesis Research And Development Corporation Limited Polynucleotides isoles de cellules de la peau et leurs procedes d'utilisation
US6262249B1 (en) * 1998-06-23 2001-07-17 Chiron Corporation Pancreatic cancer genes
CA2296792A1 (fr) * 1999-02-26 2000-08-26 Genset S.A. Sequences marqueurs exprimees et proteines humaines codees

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE GENEMBL [online] 31 July 1998 (1998-07-31), STONE N.E. ET AL.: "Direct submission", XP002945285, Database accession no. AC004049 *

Also Published As

Publication number Publication date
WO2001055204A1 (fr) 2001-08-02
AU2001241417A1 (en) 2001-08-07
CA2394039A1 (fr) 2001-08-02
WO2001055307A2 (fr) 2001-08-02
WO2001054733A1 (fr) 2001-08-02
WO2001055318A2 (fr) 2001-08-02
WO2001055315A2 (fr) 2001-08-02
WO2001055350A8 (fr) 2001-09-07
AU2001241405A1 (en) 2001-08-07
WO2001055325A8 (fr) 2001-12-13
WO2001055311A8 (fr) 2001-09-07
WO2001055303A2 (fr) 2001-08-02
AU2001241406A1 (en) 2001-08-07
AU2001241415A1 (en) 2001-08-07
AU2001241412A1 (en) 2001-08-07
WO2001055311A2 (fr) 2001-08-02
WO2001055303A3 (fr) 2001-12-20
WO2001055328A3 (fr) 2002-07-04
CA2398411A1 (fr) 2001-08-02
WO2001055311A3 (fr) 2002-07-04
WO2001055322A2 (fr) 2001-08-02
WO2001055318A3 (fr) 2002-07-04
WO2001055308A8 (fr) 2001-09-07
WO2001055309A2 (fr) 2001-08-02
WO2001055207A8 (fr) 2001-09-07
WO2001055321A8 (fr) 2001-09-07
WO2001055320A8 (fr) 2001-09-07
WO2001055309A3 (fr) 2002-07-18
CA2395699A1 (fr) 2001-08-02
CA2395738A1 (fr) 2002-08-02
WO2001055307A3 (fr) 2002-01-10
CA2395403A1 (fr) 2001-08-02
CA2392757A1 (fr) 2001-08-02
WO2001055319A2 (fr) 2001-08-02
CA2392398A1 (fr) 2001-08-02
WO2001055318A8 (fr) 2001-09-07
CA2392438A1 (fr) 2001-08-02
WO2001055325A2 (fr) 2001-08-02
WO2001055308A3 (fr) 2002-07-04
WO2001055173A2 (fr) 2001-08-02
WO2001055314A2 (fr) 2001-08-02
WO2001055343A1 (fr) 2001-08-02
CA2395178A1 (fr) 2001-08-02
WO2001055203A1 (fr) 2001-08-02
WO2001057182A3 (fr) 2002-03-28
WO2001055355A8 (fr) 2001-09-07
WO2001055206A1 (fr) 2001-08-02
WO2001055368A1 (fr) 2001-08-02
WO2001055302A2 (fr) 2001-08-02
WO2001055202A8 (fr) 2001-09-07
CA2395827A1 (fr) 2001-08-02
WO2001055301A8 (fr) 2001-09-07
WO2001055328A8 (fr) 2001-09-07
AU2001250770A1 (en) 2001-08-07
CA2392450A1 (fr) 2001-08-16
WO2001055301A2 (fr) 2001-08-02
WO2001055343A8 (fr) 2001-09-07
WO2001055367A8 (fr) 2001-12-20
AU2001241409A1 (en) 2001-08-07
CA2398877A1 (fr) 2001-08-09
WO2001054473A8 (fr) 2001-09-07
WO2001055208A1 (fr) 2001-08-02
WO2001055310A3 (fr) 2001-12-27
CA2395671A1 (fr) 2001-08-02
CA2395872A1 (fr) 2001-08-02
WO2001055327A2 (fr) 2001-08-02
WO2001055387A8 (fr) 2001-12-06
WO2001055163A8 (fr) 2001-09-07
WO2001055316A8 (fr) 2001-09-07
CA2393912A1 (fr) 2001-08-02
WO2001055208A8 (fr) 2001-09-07
WO2001055321A2 (fr) 2001-08-02
WO2001055367A1 (fr) 2001-08-02
WO2001055302A8 (fr) 2001-09-07
WO2001055204A8 (fr) 2001-09-07
AU4141101A (en) 2001-08-20
CA2393002A1 (fr) 2001-08-02
WO2001055206A8 (fr) 2001-12-13
WO2001054473A2 (fr) 2001-08-02
WO2001055303A8 (fr) 2001-09-07
WO2001055323A2 (fr) 2001-08-02
CA2395693A1 (fr) 2001-08-02
CA2395666A1 (fr) 2001-08-02
CA2395295A1 (fr) 2001-08-02
WO2001055324A8 (fr) 2001-09-07
WO2001055316A3 (fr) 2002-04-11
CA2393652A1 (fr) 2001-08-02
CA2395734A1 (fr) 2001-08-02
WO2001055304A8 (fr) 2001-09-07
WO2001055327A3 (fr) 2002-02-28
WO2001055201A8 (fr) 2001-09-07
WO2001055201A1 (fr) 2001-08-02
WO2001055173A8 (fr) 2001-11-29
WO2001055202A1 (fr) 2001-08-02
CA2395885A1 (fr) 2001-08-02
AU2001241410A1 (en) 2001-08-07
WO2001055312A2 (fr) 2001-08-02
WO2001055448A8 (fr) 2001-09-07
WO2001054733A8 (fr) 2001-09-07
WO2001055207A1 (fr) 2001-08-02
WO2001055302A3 (fr) 2002-02-14
WO2001055323A3 (fr) 2002-05-10
AU2001241413A1 (en) 2001-08-07
AU2001241408A1 (en) 2001-08-07
WO2001055319A8 (fr) 2001-09-07
WO2001055368A8 (fr) 2001-09-07
WO2001055447A1 (fr) 2001-08-02
WO2001055325A3 (fr) 2002-07-04
WO2001055312A3 (fr) 2002-03-14
AU2001241416A1 (en) 2001-08-07
CA2397407A1 (fr) 2001-08-02
CA2395849A1 (fr) 2001-08-02
WO2001055315A3 (fr) 2002-02-07
WO2001055205A8 (fr) 2001-12-13
WO2001055309A8 (fr) 2001-09-07
WO2001055324A3 (fr) 2002-01-24
WO2001059064A2 (fr) 2001-08-16
WO2001055315A8 (fr) 2001-09-07
CA2393618A1 (fr) 2001-08-02
CA2392751A1 (fr) 2001-08-02
CA2395858A1 (fr) 2001-08-02
CA2395729A1 (fr) 2001-08-02
CA2392428A1 (fr) 2001-08-02
CA2395654A1 (fr) 2001-08-02
WO2001055310A8 (fr) 2001-09-07
WO2001055327A8 (fr) 2001-09-07
CA2395787A1 (fr) 2001-08-02
AU4313701A (en) 2001-08-14
AU2001241407A1 (en) 2001-08-07
WO2001055387A1 (fr) 2001-08-02
CA2395816A1 (fr) 2001-08-02
WO2001054474A8 (fr) 2001-12-20
WO2001055310A2 (fr) 2001-08-02
WO2001055364A2 (fr) 2001-08-02
WO2001055323A8 (fr) 2001-09-07
WO2001057182A2 (fr) 2001-08-09
WO2001055314A3 (fr) 2002-05-02
WO2001055203A8 (fr) 2001-09-07
WO2001055316A2 (fr) 2001-08-02
WO2001055304A3 (fr) 2002-07-18
AU2001241414A1 (en) 2001-08-07
WO2001055364A8 (fr) 2001-09-07
WO2001055205A1 (fr) 2001-08-02
WO2001055355A1 (fr) 2001-08-02
WO2001055324A2 (fr) 2001-08-02
WO2001055308A2 (fr) 2001-08-02
WO2001055322A3 (fr) 2002-07-04
WO2001055320A2 (fr) 2001-08-02
WO2001055321A3 (fr) 2002-07-04
WO2001055322A8 (fr) 2001-09-07
WO2001055447A8 (fr) 2001-09-07
WO2001055319A3 (fr) 2002-02-21
CA2397839A1 (fr) 2001-08-02
CA2392422A1 (fr) 2001-08-02
WO2001055312A8 (fr) 2001-09-07
WO2001054474A2 (fr) 2001-08-02
WO2001055320A3 (fr) 2002-04-11
WO2001055304A2 (fr) 2001-08-02
CA2395724A1 (fr) 2001-08-02
CA2395398A1 (fr) 2001-08-02
CA2394841A1 (fr) 2001-08-02
WO2001055314A8 (fr) 2001-09-07
WO2001055301A3 (fr) 2009-06-04
WO2001055448A1 (fr) 2001-08-02
WO2001055163A1 (fr) 2001-08-02
AU2001241418A1 (en) 2001-08-07
WO2001055350A1 (fr) 2001-08-02
WO2001055307A8 (fr) 2001-09-07
WO2001055200A8 (fr) 2001-09-07
WO2001055200A1 (fr) 2001-08-02
WO2001055364A3 (fr) 2002-07-04
WO2001055328A2 (fr) 2001-08-02

Similar Documents

Publication Publication Date Title
WO2001059064A3 (fr) Acides nucleiques, proteines et anticorps
WO2001059063A3 (fr) Acides nucleiques, proteines et anticorps
WO2001055317A3 (fr) Acides nucleiques, proteines et anticorps
WO2002000677A8 (fr) Acides nucleiques, proteines et anticorps
WO2001055300A3 (fr) Acides nucleiques, proteines et anticorps
WO2001055313A3 (fr) Acides nucleiques, proteines et anticorps
WO2001055167A8 (fr) Acides nucleiques, proteines et anticorps
WO2001055329A8 (fr) Acides nucleiques, proteines et anticorps

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2392450

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001912656

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001912656

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2001912656

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: JP

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)