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WO2001090374A3 - 26493, a novel human must dgtpase family member and uses thereof - Google Patents

26493, a novel human must dgtpase family member and uses thereof Download PDF

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Publication number
WO2001090374A3
WO2001090374A3 PCT/US2001/016424 US0116424W WO0190374A3 WO 2001090374 A3 WO2001090374 A3 WO 2001090374A3 US 0116424 W US0116424 W US 0116424W WO 0190374 A3 WO0190374 A3 WO 0190374A3
Authority
WO
WIPO (PCT)
Prior art keywords
dgtpase
nucleic acid
acid molecules
family member
expression vectors
Prior art date
Application number
PCT/US2001/016424
Other languages
English (en)
Other versions
WO2001090374A2 (fr
Inventor
Rachel A Meyers
Original Assignee
Millenium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millenium Pharmaceuticals Inc filed Critical Millenium Pharmaceuticals Inc
Priority to AU2001261798A priority Critical patent/AU2001261798A1/en
Publication of WO2001090374A2 publication Critical patent/WO2001090374A2/fr
Publication of WO2001090374A3 publication Critical patent/WO2001090374A3/fr
Priority to US11/591,659 priority patent/US20070048784A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides isolated nucleic acids molecules, designated 26493 nucleic acid molecules, which encode novel muT dGTPase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26493 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26493 gene has been introduced or disrupted. The invention still further provides isolated 26493 proteins, fusion proteins, antigenic peptides and anti-26493 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2001/016424 2000-03-24 2001-05-22 26493, a novel human must dgtpase family member and uses thereof WO2001090374A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001261798A AU2001261798A1 (en) 2000-05-22 2001-05-22 26493, a novel human must dgtpase family member and uses thereof
US11/591,659 US20070048784A1 (en) 2000-03-24 2006-11-01 Novel human hydrolase family members and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20603600P 2000-05-22 2000-05-22
US60/206,036 2000-05-22

Publications (2)

Publication Number Publication Date
WO2001090374A2 WO2001090374A2 (fr) 2001-11-29
WO2001090374A3 true WO2001090374A3 (fr) 2002-04-25

Family

ID=22764715

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/016424 WO2001090374A2 (fr) 2000-03-24 2001-05-22 26493, a novel human must dgtpase family member and uses thereof

Country Status (2)

Country Link
AU (1) AU2001261798A1 (fr)
WO (1) WO2001090374A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047540A1 (fr) * 1998-03-19 1999-09-23 Human Genome Sciences, Inc. 95 proteines humaines secretees
WO2001064839A2 (fr) * 2000-02-28 2001-09-07 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides exprimes par des macrophages

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047540A1 (fr) * 1998-03-19 1999-09-23 Human Genome Sciences, Inc. 95 proteines humaines secretees
WO2001064839A2 (fr) * 2000-02-28 2001-09-07 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides exprimes par des macrophages

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 14 February 2000 (2000-02-14), ABOLA A.P. ET AL: "Homo sapiens chromosome 8 clone RP11-67H12, WORKING DRAFT SEQUENCE, 15 unordered pieces.", XP002190558 *
DATABASE EMBL 28 July 1999 (1999-07-28), STRAUSBERG, R.: "wl93d05.x1 NCI_CGAP_Brn25 Homo sapiens cDNA clone IMAGE:2432457 3', mRNA", XP002190557 *
DATABASE EMBL 29 September 2000 (2000-09-29), SUGANO S. ET AL.: "Homo sapiens cDNA: FLJ22494 fis, clone HRC11131.", XP002190559 *
DATABASE EMBL 8 February 2000 (2000-02-08), STRAUSBERG, R.: "UI-HF-BK0-aaj-a-06-0-UI.r1 NIH_MGC_36 Homo sapiens cDNA clone IMAGE:3053843 5', mRNA sequence.", XP002190556 *
KENNEDY C H ET AL: "Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 429, no. 1, 5 June 1998 (1998-06-05), pages 17 - 20, XP004257965, ISSN: 0014-5793 *
KOONIN EUGENE V: "A highly conserved sequence motif defining the family of MuT-related proteins from eubacteria, eukaryotes and viruses.", NUCLEIC ACIDS RESEARCH, vol. 21, no. 20, 1993, pages 4847, XP002190555, ISSN: 0305-1048 *

Also Published As

Publication number Publication date
AU2001261798A1 (en) 2001-12-03
WO2001090374A2 (fr) 2001-11-29

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