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WO2001005389A3 - Methode de changement de la conformation d'une metalloproteinase matricielle - Google Patents

Methode de changement de la conformation d'une metalloproteinase matricielle Download PDF

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Publication number
WO2001005389A3
WO2001005389A3 PCT/US2000/016323 US0016323W WO0105389A3 WO 2001005389 A3 WO2001005389 A3 WO 2001005389A3 US 0016323 W US0016323 W US 0016323W WO 0105389 A3 WO0105389 A3 WO 0105389A3
Authority
WO
WIPO (PCT)
Prior art keywords
sulfonylaminiacid
metalloprteinase
inhibitors
derivatives
matrix metalloproteinase
Prior art date
Application number
PCT/US2000/016323
Other languages
English (en)
Other versions
WO2001005389A2 (fr
Inventor
William C Stallings
Huey S Shieh
Susan C Howard
Crecenzo Gary A De
Donald Joseph J Mc
Original Assignee
Searle & Co
William C Stallings
Huey S Shieh
Susan C Howard
Crecenzo Gary A De
Donald Joseph J Mc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co, William C Stallings, Huey S Shieh, Susan C Howard, Crecenzo Gary A De, Donald Joseph J Mc filed Critical Searle & Co
Priority to AU60498/00A priority Critical patent/AU6049800A/en
Priority to US10/031,181 priority patent/US6869951B1/en
Priority to AU2000265100A priority patent/AU2000265100A1/en
Priority to PCT/US2000/021024 priority patent/WO2002003994A1/fr
Publication of WO2001005389A2 publication Critical patent/WO2001005389A2/fr
Publication of WO2001005389A3 publication Critical patent/WO2001005389A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne un composé inhibant une métalloprotéinase matricielle ayant la structure (VIII) ou un sel, un énantiomère, un diastéréomère, un racémate ou un tautomère de celui-ci. Dans d'autres modes de réalisation, la présente invention concerne une méthode de changement de la conformation d'une métalloprotéinase matricielle, une méthode d'inhibition d'une métalloprotéinase matricielle ainsi qu'une méthode de traitement de l'ostéoarthrite.
PCT/US2000/016323 1999-07-16 2000-07-12 Methode de changement de la conformation d'une metalloproteinase matricielle WO2001005389A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU60498/00A AU6049800A (en) 1999-07-16 2000-07-12 Method of changing conformation of a matrix metalloproteinase
US10/031,181 US6869951B1 (en) 1999-07-16 2000-07-12 Method of changing conformation of a matrix metalloproteinase
AU2000265100A AU2000265100A1 (en) 2000-07-12 2000-08-01 N sulfonyl aminoacid derivatives as inhibitors of metalloproteinase
PCT/US2000/021024 WO2002003994A1 (fr) 2000-07-12 2000-08-01 Derives d'acides amines n sulfonyle inhibiteurs des metalloproteinases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14413399P 1999-07-16 1999-07-16
US60/144,133 1999-07-16

Publications (2)

Publication Number Publication Date
WO2001005389A2 WO2001005389A2 (fr) 2001-01-25
WO2001005389A3 true WO2001005389A3 (fr) 2001-08-02

Family

ID=22507217

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/016323 WO2001005389A2 (fr) 1999-07-16 2000-07-12 Methode de changement de la conformation d'une metalloproteinase matricielle

Country Status (2)

Country Link
AU (1) AU6049800A (fr)
WO (1) WO2001005389A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DOP2002000333A (es) 2001-02-14 2002-09-30 Warner Lambert Co Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
US7504431B2 (en) 2004-04-16 2009-03-17 Bristol-Myers Squibb Company Sulfonyl amide inhibitors of calcium channel function

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0757037A2 (fr) * 1995-07-28 1997-02-05 Ono Pharmaceutical Co., Ltd. Dérivés d'acide sulfonylamino comme inhibiteurs de métalloprotéinase
EP0757984A1 (fr) * 1995-08-08 1997-02-12 Ono Pharmaceutical Co., Ltd. Dérivés d'acide hydroxamique utiles pour l'inhibition gélatinase
WO1998003166A1 (fr) * 1996-07-22 1998-01-29 Monsanto Company Inhibiteurs de metalloproteases a base de sulfonamide de thiol
WO1998039329A1 (fr) * 1997-03-04 1998-09-11 Monsanto Company Composes d'acide hydroxamique sulfonamide a cycle amidoaromatique
WO1999042433A1 (fr) * 1998-02-18 1999-08-26 Inha University Foundation Nitration de composes aromatiques par un procede de nitration de type non acide
JPH11236369A (ja) * 1998-02-23 1999-08-31 Kotobuki Seiyaku Kk スルホンアミド誘導体及びその製造法並びにこれを含有する医薬組成物
JPH11246527A (ja) * 1998-03-02 1999-09-14 Shionogi & Co Ltd Ｍｍｐ−８阻害剤
EP0950656A1 (fr) * 1996-01-23 1999-10-20 Shionogi & Co., Ltd. Derives d'acides amines sulfones et inhibiteurs de metalloproteinases contenant ces derives

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0757037A2 (fr) * 1995-07-28 1997-02-05 Ono Pharmaceutical Co., Ltd. Dérivés d'acide sulfonylamino comme inhibiteurs de métalloprotéinase
EP0757984A1 (fr) * 1995-08-08 1997-02-12 Ono Pharmaceutical Co., Ltd. Dérivés d'acide hydroxamique utiles pour l'inhibition gélatinase
EP0950656A1 (fr) * 1996-01-23 1999-10-20 Shionogi & Co., Ltd. Derives d'acides amines sulfones et inhibiteurs de metalloproteinases contenant ces derives
WO1998003166A1 (fr) * 1996-07-22 1998-01-29 Monsanto Company Inhibiteurs de metalloproteases a base de sulfonamide de thiol
WO1998039329A1 (fr) * 1997-03-04 1998-09-11 Monsanto Company Composes d'acide hydroxamique sulfonamide a cycle amidoaromatique
WO1999042433A1 (fr) * 1998-02-18 1999-08-26 Inha University Foundation Nitration de composes aromatiques par un procede de nitration de type non acide
JPH11236369A (ja) * 1998-02-23 1999-08-31 Kotobuki Seiyaku Kk スルホンアミド誘導体及びその製造法並びにこれを含有する医薬組成物
JPH11246527A (ja) * 1998-03-02 1999-09-14 Shionogi & Co Ltd Ｍｍｐ−８阻害剤

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KIYAMA RYUICHI ET AL: "Homology modeling of gelatinase catalytic domains and docking simulations of novel sulfonamide inhibitors.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 10, 20 May 1999 (1999-05-20), pages 1723 - 1738, XP002159721, ISSN: 0022-2623 *
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 14 22 December 1999 (1999-12-22) *
TAMURA Y ET AL: "HIGHLY SELECTIVE AND ORALLY ACTIVE INHIBITORS OF TYPE IV COLLAGENASE (MMP-9 AND MMP-2): N-SULFONYLAMINO ACID DERIVATIVES", JOURNAL OF MEDICINAL CHEMISTRY,AMERICAN CHEMICAL SOCIETY. WASHINGTON,US, vol. 41, no. 4, 1998, pages 640 - 649, XP002072052, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
AU6049800A (en) 2001-02-05
WO2001005389A2 (fr) 2001-01-25

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