[go: up one dir, main page]

WO2001011371A3 - Diagnosis of inflammation measuring il-8 in urine - Google Patents

Diagnosis of inflammation measuring il-8 in urine Download PDF

Info

Publication number
WO2001011371A3
WO2001011371A3 PCT/GB2000/002971 GB0002971W WO0111371A3 WO 2001011371 A3 WO2001011371 A3 WO 2001011371A3 GB 0002971 W GB0002971 W GB 0002971W WO 0111371 A3 WO0111371 A3 WO 0111371A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosis
mammal
level
urine
interleukin
Prior art date
Application number
PCT/GB2000/002971
Other languages
French (fr)
Other versions
WO2001011371A2 (en
Inventor
Ali Said Assad Taha
Original Assignee
Ali Said Assad Taha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9918589.4A external-priority patent/GB9918589D0/en
Application filed by Ali Said Assad Taha filed Critical Ali Said Assad Taha
Priority to AU64550/00A priority Critical patent/AU6455000A/en
Publication of WO2001011371A2 publication Critical patent/WO2001011371A2/en
Publication of WO2001011371A3 publication Critical patent/WO2001011371A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A method of diagnosis of a medical condition of a mammal comprising detection of the level of Interleukin-8 (IL-8) in excreted urine of the mammal is described. The use of a detected level of Interleukin-8 in excreted urine of a mammal in the diagnosis of a medical condition of the mammal is also described. The method and use are particularly applicable in the diagnosis of inflammatory conditions such as ulcerative colitis, Crohn's disease, arthritis, cholecystitis, appendicitis, and urinary tract infections. The present invention provides a simple and non-invasive method and apparatus for detecting the level of IL-8 in a mammal, and using the detected level to diagnose, or in the diagnosis of, various medical conditions, particularly but not exclusively inflammatory conditions.
PCT/GB2000/002971 1999-08-07 2000-08-07 Diagnosis of inflammation measuring il-8 in urine WO2001011371A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU64550/00A AU6455000A (en) 1999-08-07 2000-08-07 Method and apparatus for diagnosis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9918589.4 1999-08-07
GBGB9918589.4A GB9918589D0 (en) 1999-08-07 1999-08-07 Method and apparatus for diagnosis
GBGB9925246.2A GB9925246D0 (en) 1999-08-07 1999-10-27 Method and apparatus for diagnosis
GB9925246.2 1999-10-27

Publications (2)

Publication Number Publication Date
WO2001011371A2 WO2001011371A2 (en) 2001-02-15
WO2001011371A3 true WO2001011371A3 (en) 2001-09-07

Family

ID=26315830

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/002971 WO2001011371A2 (en) 1999-08-07 2000-08-07 Diagnosis of inflammation measuring il-8 in urine

Country Status (2)

Country Link
AU (1) AU6455000A (en)
WO (1) WO2001011371A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040175754A1 (en) 2002-10-09 2004-09-09 David Bar-Or Diagnosis and monitoring of inflammation, ischemia and appendicitis
US7560244B2 (en) 2003-06-04 2009-07-14 Joslin Diabetes Center, Inc. Method of evaluating a subject for risk or predisposition of reduced renal function over time
US20100166739A1 (en) * 2008-12-30 2010-07-01 Lipella Paharmaceuticals Inc. Methods and Compositions for Diagnosing Urological Disorders
RU2615353C1 (en) * 2016-02-24 2017-04-04 федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Западный государственный медицинский университет имени И.И. Мечникова" Министерства здравоохранения Российской Федерации Method for determination of degree of activity of exacerbation of chronic obstructive pyelonephritis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041194A1 (en) * 1995-06-07 1996-12-19 The Children's Medical Center Corporation Diagnosis, prognosis and monitoring of angiogenesis dependent diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041194A1 (en) * 1995-06-07 1996-12-19 The Children's Medical Center Corporation Diagnosis, prognosis and monitoring of angiogenesis dependent diseases

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BENSON MIKAEL ET AL: "Interleukin (IL)-6 and IL-8 in children with febrile urinary tract infection and asymptomatic bacteriuria.", JOURNAL OF INFECTIOUS DISEASES, vol. 174, no. 5, 1996, pages 1080 - 1084, XP000992537, ISSN: 0022-1899 *
FLORENT C H: "Inflammatory bowel disease (IBD): Therapeutic actualities.", ACTA ENDOSCOPICA, vol. 25, no. 5 SUPPL., 1995, pages 571 - 574, XP000992520, ISSN: 0240-642X *
GENDREL D: "Urinary infection and biological markers.", ARCHIVES DE PEDIATRIE, vol. 5, no. SUPPL. 3, 1998, pages 269S - 273S, XP000992530, ISSN: 0929-693X *
JACOBSON, S. ET AL.: "Interleukin-6 and Interleukin-8 in Serum and Urine in Patients with Acute Pyelonephritis in Relation to Bacterial-Virulence-Associated Traits and Renal Function", NEPHRON, vol. 67, no. 2, 1994, pages 172 - 179, XP000992531 *
MOUTABARRIK ABDELHAKIM ET AL: "Interleukin-8 in patients with glomerulonephritis.", JN JOURNAL OF NEPHROLOGY, vol. 8, no. 6, 1995, pages 325 - 330, XP000992536, ISSN: 1121-8428 *
STIEMER BEATE ET AL: "Interleukin-8 in urine: A new diagnostic parameter for intra-amniotic infection after premature rupture of the membranes.", BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol. 104, no. 4, 1997, pages 499 - 502, XP000992558, ISSN: 0306-5456 *
TAKAYAMA FUMIO ET AL: "Involvement of interleukin-8 in dialysis-related arthritis.", KIDNEY INTERNATIONAL, vol. 53, no. 4, April 1998 (1998-04-01), pages 1007 - 1013, XP000992528, ISSN: 0085-2538 *
TESAR VLADIMIR ET AL: "Cytokines and adhesion molecules in renal vasculitis and lupus nephritis.", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 13, no. 7, July 1998 (1998-07-01), pages 1662 - 1667, XP000992542, ISSN: 0931-0509 *
TIKHONOV I ET AL: "A study of interleukin-8 and defensins in urine and plasma of patients with pyelonephritis and glomerulonephritis.", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 12, no. 12, December 1997 (1997-12-01), pages 2557 - 2561, XP000992540, ISSN: 0931-0509 *
YASUMOTO RYOJI ET AL: "Urinary interleukin-6 and interleukin-8 in females with urethral syndrome.", ACTA UROLOGICA JAPONICA, vol. 43, no. 4, 1997, pages 267 - 270, XP000992534, ISSN: 0018-1994 *

Also Published As

Publication number Publication date
AU6455000A (en) 2001-03-05
WO2001011371A2 (en) 2001-02-15

Similar Documents

Publication Publication Date Title
WO2003001966A3 (en) Diagnostic capsule and method of use
WO2003075745A3 (en) Detection, diagnosis, and monitoring of a medical condition or disease with artificial olfactometry
Meddings et al. Sucrose: a novel permeability marker for gastroduodenal disease
WO2001065263A3 (en) Sensor device for diarrhea diagnosis using fecal markers
GB2413078C (en) A system or method for assessing a subject's pedalblood circulation.
WO2002018652A3 (en) Method for detection of htr and htert telomerase-associated rna in plasma or serum
DE69924749D1 (en) GENERICALLY INTEGRATED IMPLANT POTENTIOSTAT REMOTE MEASURING ARRANGEMENT FOR ELECTROCHEMICAL SENSORS
CA2622125C (en) Detection of drastic blood pressure changes
EP1757937A3 (en) Use of HMG1 in the diagnosis of inflammatory conditions
WO1998004182A3 (en) Diagnosing medical conditions by monitoring arterial tone
AU2002365107A8 (en) An intelligent system for detecting errors and determining failure modes in noninvasive measurement of blood and tissue analytes
EP0826391A3 (en) Apparatus and method for detecting progression of AV nodal block and atrial capture using atrial lead
FR2801106B1 (en) METHOD FOR DIAGNOSING AN ATNC STRAIN-INDUCED TEST IN A BIOLOGICAL SAMPLE AND ITS USE IN THE DIFFERENTIAL DIAGNOSIS OF DIFFERENT ATNC STRAINS
AU1726797A (en) A method for monitoring the health of a patient by measuring and predicting the glucose level of the patient's blood sample
EP0808605A3 (en) An optimal diagnosis point detector for noninvasive diagnosis of blood constituents and a noninvasive diagnostic device
WO1999016351A8 (en) Methods and apparatus for r-wave detection
WO2002098280A3 (en) Method for detecting infectious agents using computer controlled automated image analysis
WO2001089359A3 (en) A system and method for detection of fetal heartbeat
Male et al. Diagnosis of venous thromboembolism in children
EP1558134A4 (en) METHOD AND DEVICE FOR THE USE OF PROBES FOR NON-INVASIVE DETECTION OF BODILY CONDITIONS
WO2001011371A3 (en) Diagnosis of inflammation measuring il-8 in urine
EP1224319A4 (en) Diagnostic assays of secreted biological fluids for detection of infection and inflammatory conditions
WO2009014342A3 (en) Markers and kit for diagnosis of alzheimer's disease
Schwab et al. Evidence for mast cell activation in collagenous colitis
WO2001088544A3 (en) Proteolytic enzymes in diagnosis of kidney disorders

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2000951690

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWW Wipo information: withdrawn in national office

Ref document number: 2000951690

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP