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WO2002060374A3 - Derives de benz-1,3-azole et leurs utilisations en tant qu'inhibiteurs de l'heparanase - Google Patents

Derives de benz-1,3-azole et leurs utilisations en tant qu'inhibiteurs de l'heparanase Download PDF

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Publication number
WO2002060374A3
WO2002060374A3 PCT/IL2002/000081 IL0200081W WO02060374A3 WO 2002060374 A3 WO2002060374 A3 WO 2002060374A3 IL 0200081 W IL0200081 W IL 0200081W WO 02060374 A3 WO02060374 A3 WO 02060374A3
Authority
WO
WIPO (PCT)
Prior art keywords
benz
azole derivatives
heparanase inhibitors
heparanase
derivatives
Prior art date
Application number
PCT/IL2002/000081
Other languages
English (en)
Other versions
WO2002060374A2 (fr
Inventor
Maty Ayal-Hershkovitz
Daphna Miron
Ofra Levy
Original Assignee
Insight Strategy And Marketing
Maty Ayal-Hershkovitz
Daphna Miron
Ofra Levy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insight Strategy And Marketing, Maty Ayal-Hershkovitz, Daphna Miron, Ofra Levy filed Critical Insight Strategy And Marketing
Priority to AU2002228317A priority Critical patent/AU2002228317A1/en
Publication of WO2002060374A2 publication Critical patent/WO2002060374A2/fr
Publication of WO2002060374A3 publication Critical patent/WO2002060374A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/84—Naphthothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des dérivés de benz-1,3-azole, à savoir des dérivés de benzimidazole, de benzoxazole et de benzthiazole en tant qu'inhibiteurs de l'héparanase convenant pour le traitement de maladies et de troubles causés par ou associés à l'activité catalytique de l'héparanase tels que le cancer, les troubles inflammatoires et les maladies auto-immunes.
PCT/IL2002/000081 2001-01-29 2002-01-29 Derives de benz-1,3-azole et leurs utilisations en tant qu'inhibiteurs de l'heparanase WO2002060374A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002228317A AU2002228317A1 (en) 2001-01-29 2002-01-29 Benz-1,3-azole derivatives and their uses as heparanase inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26430601P 2001-01-29 2001-01-29
US60/264,306 2001-01-29

Publications (2)

Publication Number Publication Date
WO2002060374A2 WO2002060374A2 (fr) 2002-08-08
WO2002060374A3 true WO2002060374A3 (fr) 2003-02-27

Family

ID=23005454

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2002/000081 WO2002060374A2 (fr) 2001-01-29 2002-01-29 Derives de benz-1,3-azole et leurs utilisations en tant qu'inhibiteurs de l'heparanase

Country Status (2)

Country Link
AU (1) AU2002228317A1 (fr)
WO (1) WO2002060374A2 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60329513D1 (de) * 2002-07-30 2009-11-12 Banyu Pharma Co Ltd Antagonist des melanin-concentrating-hormone-rezeptors, enthaltend ein benzimidazolderivat als wirkstoff
EP1547996A4 (fr) * 2002-08-30 2006-08-02 Bf Res Inst Inc Sondes de diagnostic et remedes contre des maladies presentant une accumulation de la proteine du prion et methode de marquage
GB0226822D0 (en) * 2002-11-16 2002-12-24 Oxford Glycosciences Uk Ltd Novel compounds
WO2004046122A2 (fr) * 2002-11-16 2004-06-03 Oxford Glycosciences (Uk) Ltd Derives d'acides de benzoxazole, de benzothiazole, et de benzimidazole pharmaceutiquement actifs
BRPI0416639A (pt) 2003-11-19 2007-01-16 Metabasis Therapeutics Inc tiromiméticos contendo fósforo
AU2006249350B2 (en) 2003-11-19 2012-02-16 Metabasis Therapeutics, Inc. Thyromimetics for the treatment of fatty liver diseases
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
BRPI0511834A (pt) 2004-07-14 2008-01-08 Ptc Therapeutics Inc métodos por tratar hepatite c
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
CA2578636A1 (fr) 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines utilisees pour traiter l'hepatite c
CN101588808A (zh) * 2006-10-20 2009-11-25 澳大利亚国立大学 对细胞外基质降解的抑制
US7906655B2 (en) * 2008-08-07 2011-03-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
GB0821913D0 (en) * 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
CN101735152A (zh) * 2009-12-18 2010-06-16 长沙理工大学 2,2'-(1,4-亚苯基)二(苯并咪唑-5-羧酸)及其制备方法
US8686048B2 (en) * 2010-05-06 2014-04-01 Rhizen Pharmaceuticals Sa Immunomodulator and anti-inflammatory compounds
EP2575968B1 (fr) 2010-06-01 2016-03-09 Summit Therapeutics plc Composés pour le traitement d'une maladie associée à clostridium difficile
US11202789B2 (en) 2016-11-21 2021-12-21 Viking Therapeutics, Inc. Method of treating glycogen storage disease
US11718609B2 (en) 2016-12-13 2023-08-08 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
US11787783B2 (en) 2016-12-13 2023-10-17 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
EP3381907A1 (fr) 2017-03-27 2018-10-03 Leadiant Biosciences SA Composés de 2-aminophényl-benzazolyl-5-acétate symétriques et leur utilisation comme anti-héparanase
EP3381906A1 (fr) * 2017-03-27 2018-10-03 Leadiant Biosciences SA Composes utiles comme inhibiteurs d'heparanase
BR112019025659A2 (pt) 2017-06-05 2020-08-25 Viking Therapeutics, Inc. composições para o tratamento de fibrose
EP3768690B1 (fr) 2018-03-22 2025-08-27 Viking Therapeutics, Inc. Formes cristallines et procédés de production de formes cristallines d'un composé
US12102646B2 (en) 2018-12-05 2024-10-01 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation

Citations (3)

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Publication number Priority date Publication date Assignee Title
US5932600A (en) * 1997-03-14 1999-08-03 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6153631A (en) * 1996-10-23 2000-11-28 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
WO2001027088A1 (fr) * 1999-10-12 2001-04-19 Japan Tobacco Inc. Potentialisateurs de lpl

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153631A (en) * 1996-10-23 2000-11-28 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US5932600A (en) * 1997-03-14 1999-08-03 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
WO2001027088A1 (fr) * 1999-10-12 2001-04-19 Japan Tobacco Inc. Potentialisateurs de lpl

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] (COLUMBUS, OH, USA); CHAUHAN ET AL.: "Synthesis of 2,5(6)-disubstituted benzimidazoles, 2-substituted 5-(4-substituted phenyl) - 1,3,4-thiadiazoles and imidazothioxanthene and their antifilarial activity, section B: organic chemistry including medicinal chemistry", XP002958527, accession no. ACS Database accession no. 1987:477754 *
DATABASE CAPLUS [online] (COLUMBUS, OH, USA); MIKROYANNIDIS ET AL.: "Heat-resistance mixture resin vbased on addition-type bismidobenzimidazoles", XP002958526, accession no. ACS Database accession no. 1991:123605 *
EUROPEAN POLYMER J., vol. 27, no. 2, 1991, pages 199 - 203 *
INDIAN JOURNAL OF CHEMISTRY, vol. 25B, no. 11, 1986, pages 1146 - 1149 *

Also Published As

Publication number Publication date
AU2002228317A1 (en) 2002-08-12
WO2002060374A2 (fr) 2002-08-08

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