[go: up one dir, main page]

WO2002067969A3 - Compositions d'insuline stabilisees - Google Patents

Compositions d'insuline stabilisees Download PDF

Info

Publication number
WO2002067969A3
WO2002067969A3 PCT/US2002/005013 US0205013W WO02067969A3 WO 2002067969 A3 WO2002067969 A3 WO 2002067969A3 US 0205013 W US0205013 W US 0205013W WO 02067969 A3 WO02067969 A3 WO 02067969A3
Authority
WO
WIPO (PCT)
Prior art keywords
insulin
compositions
species
stabilized
complexes
Prior art date
Application number
PCT/US2002/005013
Other languages
English (en)
Other versions
WO2002067969A2 (fr
Inventor
Antwerp William Peter Van
Poonam S Gulati
Original Assignee
Medtronic Minimed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Minimed Inc filed Critical Medtronic Minimed Inc
Priority to AU2002248464A priority Critical patent/AU2002248464A1/en
Publication of WO2002067969A2 publication Critical patent/WO2002067969A2/fr
Publication of WO2002067969A3 publication Critical patent/WO2002067969A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des compositions d'insuline stabilisées comprenant un mélange de types d'insuline tels que l'insuline et un analogue de l'insuline. Ces compositions d'insuline comportant un mélange d'insuline et d'analogues de l'insuline constituent des complexes hétérodimères plus stables que les complexes hétérodimères formés dans des compositions contenant un seul type d'insuline. Par conséquent, la présente invention porte également sur des procédés pour stabiliser les molécules d'insuline, sur des procédés pour identifier les complexes d'insuline hétérodimères stables et les compositions d'insuline stabilisées.
PCT/US2002/005013 2001-02-21 2002-02-21 Compositions d'insuline stabilisees WO2002067969A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002248464A AU2002248464A1 (en) 2001-02-21 2002-02-21 Stabilized insulin formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27037401P 2001-02-21 2001-02-21
US60/270,374 2001-02-21

Publications (2)

Publication Number Publication Date
WO2002067969A2 WO2002067969A2 (fr) 2002-09-06
WO2002067969A3 true WO2002067969A3 (fr) 2003-04-10

Family

ID=23031089

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/005013 WO2002067969A2 (fr) 2001-02-21 2002-02-21 Compositions d'insuline stabilisees

Country Status (3)

Country Link
US (1) US6852694B2 (fr)
AU (1) AU2002248464A1 (fr)
WO (1) WO2002067969A2 (fr)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US7041468B2 (en) 2001-04-02 2006-05-09 Therasense, Inc. Blood glucose tracking apparatus and methods
AU2003303597A1 (en) 2002-12-31 2004-07-29 Therasense, Inc. Continuous glucose monitoring system and methods of use
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
CA2556331A1 (fr) 2004-02-17 2005-09-29 Therasense, Inc. Procede et systeme de communication de donnees dans un systeme de controle et de gestion de glucose en continu
US8112240B2 (en) 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US7620438B2 (en) 2006-03-31 2009-11-17 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US8927015B2 (en) * 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
WO2007143225A2 (fr) 2006-06-07 2007-12-13 Abbott Diabetes Care, Inc. Système et procédé de surveillance d'un analyte
US8732188B2 (en) 2007-02-18 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing contextual based medication dosage determination
US8930203B2 (en) 2007-02-18 2015-01-06 Abbott Diabetes Care Inc. Multi-function analyte test device and methods therefor
US8123686B2 (en) 2007-03-01 2012-02-28 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
US20100286467A1 (en) * 2007-03-19 2010-11-11 Benny Pesach Device for drug delivery and associated connections thereto
US9220837B2 (en) * 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
EP2131900B1 (fr) * 2007-03-19 2018-05-30 Insuline Medical Ltd. Dispositif d'administration de médicaments
US8665091B2 (en) 2007-05-08 2014-03-04 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US8461985B2 (en) 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8456301B2 (en) 2007-05-08 2013-06-04 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8409133B2 (en) 2007-12-18 2013-04-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
MY152979A (en) 2008-01-09 2014-12-15 Sanofi Aventis Deutschland Novel insulin derivatives having an extremely delayed time-action profile
US8632803B2 (en) * 2008-02-27 2014-01-21 Ramot At Tel-Aviv University Ltd. System for delivery of protein in insoluble fibrillar or aggregate form
EP2910571B1 (fr) 2008-03-18 2016-10-05 Novo Nordisk A/S Analogues de l'insuline acylés, stabilisés à la protéase
CN102088997A (zh) * 2008-04-07 2011-06-08 国家免疫研究所 用于治疗糖尿病和其他慢性疾病的组合物
US20100069292A1 (en) * 2008-09-02 2010-03-18 Biodel, Inc. Insulin with a basal release profile
EP3677275B1 (fr) 2008-10-17 2024-06-12 Sanofi-Aventis Deutschland GmbH Combinaison d'une insuline et d'un antagoniste glp 1
RU2532893C2 (ru) 2008-11-07 2014-11-10 Инсьюлин Медикал Лтд. Устройство и способ доставки лекарственных средств
US8103456B2 (en) 2009-01-29 2012-01-24 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
US9226701B2 (en) 2009-04-28 2016-01-05 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
WO2010138856A1 (fr) 2009-05-29 2010-12-02 Abbott Diabetes Care Inc. Systèmes d'antenne de dispositif médical comportant des configurations d'antenne externe
BR112012000177B1 (pt) * 2009-07-06 2021-06-01 Sanofi-Aventis Deutschland Gmbh Formulação farmacêutica aquosa contendo metionina, processo para sua preparação, uso da mesma e medicamento para tratar diabetes mellitus
US20120232002A1 (en) * 2009-07-06 2012-09-13 Sanofi-Aventis Deutschland Gmbh Slow-acting insulin preparations
US8993331B2 (en) 2009-08-31 2015-03-31 Abbott Diabetes Care Inc. Analyte monitoring system and methods for managing power and noise
EP2473098A4 (fr) 2009-08-31 2014-04-09 Abbott Diabetes Care Inc Dispositif et procédés de traitement de signal d'analyte
US8618049B2 (en) 2009-09-08 2013-12-31 Stephen B. H. Kent Ester insulin
EP2482720A4 (fr) 2009-09-29 2014-04-23 Abbott Diabetes Care Inc Procédé et appareil de fourniture de fonction de notification dans des systèmes de surveillance de substance à analyser
EP3831402A1 (fr) * 2009-11-13 2021-06-09 Sanofi-Aventis Deutschland GmbH Composition pharmaceutique comprenant un agoniste du glp-1, une insuline et de la méthionine
UY33025A (es) 2009-11-13 2011-06-30 Sanofi Aventis Deustschland Gmbh Composicion farmaceutica que comprende un agonista de glp-1 metionina
US8637458B2 (en) 2010-05-12 2014-01-28 Biodel Inc. Insulin with a stable basal release profile
AU2011202239C1 (en) 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins
RU2546520C2 (ru) 2010-08-30 2015-04-10 Санофи-Авентис Дойчланд Гмбх Применение ave0010 для производства лекарственного средства для лечения сахарного диабета 2 типа
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
HUE027989T2 (en) 2011-08-29 2016-11-28 Sanofi Aventis Deutschland A pharmaceutical composition for use in glycemic control in patients with type 2 diabetes
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
US9980669B2 (en) 2011-11-07 2018-05-29 Abbott Diabetes Care Inc. Analyte monitoring device and methods
EP2836508B1 (fr) * 2012-04-11 2016-06-29 Novo Nordisk A/S Formulations à base d'insuline
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
TWI641381B (zh) 2013-02-04 2018-11-21 法商賽諾菲公司 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
CN110354255B (zh) 2013-04-03 2024-05-14 赛诺菲 通过长效胰岛素制剂治疗糖尿病
CA2932877A1 (fr) 2014-01-09 2015-07-16 Sanofi Formulations pharmaceutiques stabilisees d'analogues de l'insuline et/ou de derives de l'insuline
US9895424B2 (en) 2014-01-09 2018-02-20 Sanofi Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
JP6735674B2 (ja) 2014-01-09 2020-08-05 サノフイＳａｎｏｆｉ インスリンアスパルトの安定化された医薬製剤
WO2015120457A1 (fr) * 2014-02-10 2015-08-13 Biodel Inc. Formulations d'insuline à action ultrarapide stabilisées
EP3660040B1 (fr) 2014-11-21 2025-06-18 Merck Sharp & Dohme LLC Agonistes partiels du récepteur d'insuline
PE20171622A1 (es) 2014-12-12 2017-11-02 Sanofi Aventis Deutschland Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
US10689430B2 (en) 2016-05-25 2020-06-23 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
CN115154591B (zh) 2016-12-16 2023-04-14 诺和诺德股份有限公司 含胰岛素的药物组合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012988A1 (fr) * 1995-10-06 1997-04-10 Pence Procede et compositions faisant intervenir un heterodimere bispirale pour la detection et la purification de proteines exprimees
EP0837072A2 (fr) * 1988-12-23 1998-04-22 Novo Nordisk A/S Insulines Lys(B28). Analogues de l'insuline humane
DE19908041A1 (de) * 1999-02-24 2000-08-31 Hoecker Hartwig Kovalent verbrückte Insulindimere

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652525A (en) 1978-04-19 1987-03-24 The Regents Of The University Of California Recombinant bacterial plasmids containing the coding sequences of insulin genes
DE3064888D1 (en) 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
US4783441A (en) 1979-04-30 1988-11-08 Hoechst Aktiengesellschaft Aqueous protein solutions stable to denaturation
US4431740A (en) 1979-09-12 1984-02-14 The Regents Of The University Of California DNA Transfer vector and transformed microorganism containing human proinsulin and pre-proinsulin genes
US4652548A (en) 1981-08-27 1987-03-24 Eli Lilly And Company Pharmaceutical formulations comprising human insulin, human C-peptide, and human proinsulin
DE3326472A1 (de) 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3326473A1 (de) 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3501641A1 (de) 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
GB8720115D0 (en) 1987-08-26 1987-09-30 Cooper G J S Treatment of diabetes mellitus
US4988675A (en) 1988-02-05 1991-01-29 Ciba-Geigy Corporation Method for preventing secondary effects
EP0425482B1 (fr) * 1988-07-20 1993-08-18 Novo Nordisk A/S Analogues d'insuline humaine et preparations les contenant
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
DE69231583T2 (de) 1991-05-24 2001-03-29 Amylin Pharmaceuticals, Inc. Zusammensetzung zur Behandlung des Insulinmangels bei Säugetieren, die Amylin und Insulin enthält.
US5527307A (en) 1994-04-01 1996-06-18 Minimed Inc. Implantable medication infusion pump with discharge side port
US5569186A (en) 1994-04-25 1996-10-29 Minimed Inc. Closed loop infusion pump system with removable glucose sensor
AUPM678294A0 (en) 1994-07-13 1994-08-04 Gropep Pty Ltd Use of insulin-like growth factor in combination with insulin
WO1996010417A1 (fr) 1994-10-04 1996-04-11 Novo Nordisk A/S Preparations contenant l'insuline humaine aspb28 et du nicotinamide
US5637095A (en) 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
TW438587B (en) 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
IL120443A (en) 1996-03-18 2000-07-16 Sankyo Co Use of an insulin sensitizer for the manufacture of a medicament for the treatment or prophylaxis of pancreatitis
US5783556A (en) 1996-08-13 1998-07-21 Genentech, Inc. Formulated insulin-containing composition
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6136784A (en) 1997-01-08 2000-10-24 Amylin Pharmaceuticals, Inc. Amylin agonist pharmaceutical compositions containing insulin
US6153632A (en) 1997-02-24 2000-11-28 Rieveley; Robert B. Method and composition for the treatment of diabetes
US6514937B1 (en) * 1997-02-25 2003-02-04 Celtrix Pharmaceuticals, Inc. Method of treating psychological and metabolic disorders using IGF or IGF/IGFBP-3
ZA984697B (en) 1997-06-13 1999-12-01 Lilly Co Eli Stable insulin formulations.
GB9712866D0 (en) 1997-06-18 1997-08-20 Smithkline Beecham Plc Novel method of treatment
WO1999043705A1 (fr) 1998-02-27 1999-09-02 Novo Nordisk A/S Derives de glp-1 tronques a l'extremite n-terminale
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
JP2003503356A (ja) 1999-06-25 2003-01-28 メドトロニック ミニメド インコーポレイテッド 多剤糖尿病治療

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0837072A2 (fr) * 1988-12-23 1998-04-22 Novo Nordisk A/S Insulines Lys(B28). Analogues de l'insuline humane
WO1997012988A1 (fr) * 1995-10-06 1997-04-10 Pence Procede et compositions faisant intervenir un heterodimere bispirale pour la detection et la purification de proteines exprimees
DE19908041A1 (de) * 1999-02-24 2000-08-31 Hoecker Hartwig Kovalent verbrückte Insulindimere

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BRANGE J ET AL: "Chemical stability of insulin. 5. Isolation, characterization and identification of insulin transformation products.", ACTA PHARMACEUTICA NORDICA. SWEDEN 1992, vol. 4, no. 4, 1992, pages 223 - 232, XP001085437, ISSN: 1100-1801 *

Also Published As

Publication number Publication date
US6852694B2 (en) 2005-02-08
WO2002067969A2 (fr) 2002-09-06
US20020132760A1 (en) 2002-09-19
AU2002248464A1 (en) 2002-09-12

Similar Documents

Publication Publication Date Title
WO2002067969A3 (fr) Compositions d'insuline stabilisees
BR0213541A (pt) Composição alimentìcia que compreende um isolado de proteìna de canola
WO2004010941A3 (fr) Compositions pharmaceutiques de 2,6-diisopropylphenol aqueux
EP1478322A4 (fr) Beta-2'-OU 3'-HALONUCLEOSIDES
PL354486A1 (en) Method and composition for the control of arthropods
WO2004075919A3 (fr) Composes destines a la stabilisation des proteines et procedes d'utilisation associes
WO2001044272A3 (fr) Nouveaux lipopeptides utilises comme agents antibacteriens
AU2002235994A1 (en) Method for producing proteins by fermentation of microorganisms from the thermus family, the protein mixture thus obtained and cosmetic compositions containing same
MY127953A (en) Gabapentin-containing solid compositions and process for preparing the same
EP2298287A3 (fr) Compositions stabilisees de polypeptides de facteur VII
MXPA03011793A (es) Formulaciones de interferon.
ATE278322T1 (de) Mittel zur bekämpfung von pflanzenschädlingen
EA200301275A1 (ru) Капсулы для ингаляции
DE60110054D1 (en) Cardioprotektive phosphonate
EP1446010A4 (fr) Compositions d'azithromycine stabilisees
IL160171A0 (en) Depsipeptide derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
BR0210098A (pt) Compostos de fragrância
AU9624198A (en) Quinoline and quinazoline derivatives having corticotropin releasing factor (crf) antagonist activity
WO2002077017A3 (fr) Nouvelles utilisations medicales de composes facilitant la communication
BRPI0403461A (pt) composições estabilizadas contendo um agente ativo lábil ao oxigênio
AU7320300A (en) Means of stabilizing thrombin and compositions
GB0104371D0 (en) Color improving stabilizing compositions comprising leucine
WO2002059322A3 (fr) Compositions et methodes liees a la famille de genes biosynthetiques de la daptomycine
EE05182B1 (et) Asendatud homopiperidlbensimidasooli analoog, meetod selle valmistamiseks ning seda sisaldav farmatseutiline kompositsioon
WO2003014297A3 (fr) Compositions et procedes relatifs a la famille multigenique biosynthetique de la daptomycine

Legal Events

Date Code Title Description
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP