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WO2002002001A3 - Epithelial diagnostic aid - Google Patents

Epithelial diagnostic aid Download PDF

Info

Publication number
WO2002002001A3
WO2002002001A3 PCT/GB2001/003011 GB0103011W WO0202001A3 WO 2002002001 A3 WO2002002001 A3 WO 2002002001A3 GB 0103011 W GB0103011 W GB 0103011W WO 0202001 A3 WO0202001 A3 WO 0202001A3
Authority
WO
WIPO (PCT)
Prior art keywords
intensity
epithelial
lesion
variation
relates
Prior art date
Application number
PCT/GB2001/003011
Other languages
French (fr)
Other versions
WO2002002001A8 (en
WO2002002001A2 (en
Inventor
Michael Roger Cane
Symon D Oyly Cotton
Matthew Alexander Schumann
Michael Andrew Beadman
Thomas Scott Carter
Philip James Churchill White
Rebeca Lapping
Jeremy Carey
Original Assignee
Astron Clinica Ltd
Michael Roger Cane
Symon D Oyly Cotton
Matthew Alexander Schumann
Michael Andrew Beadman
Thomas Scott Carter
Philip James Churchill White
Rebeca Lapping
Jeremy Carey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0016392A external-priority patent/GB2364376A/en
Priority claimed from GB0016690A external-priority patent/GB2364567A/en
Priority claimed from GB0112501A external-priority patent/GB0112501D0/en
Application filed by Astron Clinica Ltd, Michael Roger Cane, Symon D Oyly Cotton, Matthew Alexander Schumann, Michael Andrew Beadman, Thomas Scott Carter, Philip James Churchill White, Rebeca Lapping, Jeremy Carey filed Critical Astron Clinica Ltd
Priority to EP01949639A priority Critical patent/EP1296593A2/en
Priority to US10/332,222 priority patent/US20040092802A1/en
Priority to JP2002506633A priority patent/JP2004501712A/en
Priority to AU2001270762A priority patent/AU2001270762A1/en
Publication of WO2002002001A2 publication Critical patent/WO2002002001A2/en
Publication of WO2002002001A8 publication Critical patent/WO2002002001A8/en
Publication of WO2002002001A3 publication Critical patent/WO2002002001A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/443—Evaluating skin constituents, e.g. elastin, melanin, water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

The present invention relates to devices and methodology for determining the variation in concentration of chromophores within an epithelial tissue. The devices comprise a means of illuminate the skin at one or more points and at wavelengths corresponding to specific chromophores. The device further comprises a detection means configured to detect the intensity of light remitted from the epithelial surface, a processing means configured to interpret image data sets obtained by the detection means and an output display to display the results or significance of the results. The invention further extends to a method of interpreting the distribution of chromphores within a lesion of an epithelial tissue. The method comprising the steps of illuminating an epithelial surface, determining the intensity of remitted light, analysing said intensity data to determine variation in the intensity across the lesion and providing an output corresponding to the extend of variation across the lesion. One aspec of the invention relates to a hand-held design of the device for implementing the aforementioned method. Another aspect of the invention relates to the design of the patient-contacting part of the device to prevent of contaminants and to improve the diagnostic effectiveness of the device.
PCT/GB2001/003011 2000-07-05 2001-07-04 Epithelial diagnostic aid WO2002002001A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01949639A EP1296593A2 (en) 2000-07-05 2001-07-04 Ephitelial diagnostic aid
US10/332,222 US20040092802A1 (en) 2000-07-07 2001-07-04 Epithelial diagnostic aid
JP2002506633A JP2004501712A (en) 2000-07-05 2001-07-04 Epidermis diagnosis support device
AU2001270762A AU2001270762A1 (en) 2000-07-05 2001-07-04 Epithelial diagnostic aid

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0016392.3 2000-07-05
GB0016392A GB2364376A (en) 2000-07-05 2000-07-05 Skin illumination and examination apparatus
GB0016690.0 2000-07-07
GB0016690A GB2364567A (en) 2000-07-07 2000-07-07 Determining distribution of chromophores in skin or other epithelial tissue
GB0112501.2 2001-05-23
GB0112501A GB0112501D0 (en) 2001-05-23 2001-05-23 Portable device for assessing the presence of melanin within the dermis of skin

Publications (3)

Publication Number Publication Date
WO2002002001A2 WO2002002001A2 (en) 2002-01-10
WO2002002001A8 WO2002002001A8 (en) 2002-07-04
WO2002002001A3 true WO2002002001A3 (en) 2002-10-24

Family

ID=27255793

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/003011 WO2002002001A2 (en) 2000-07-05 2001-07-04 Epithelial diagnostic aid

Country Status (4)

Country Link
EP (1) EP1296593A2 (en)
JP (1) JP2004501712A (en)
AU (1) AU2001270762A1 (en)
WO (1) WO2002002001A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7916910B2 (en) 2005-09-23 2011-03-29 Biocompatibles Uk Limited Image processing method and apparatus

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003255745B2 (en) * 2002-07-30 2007-03-22 Medx Health Corporation Method and apparatus for quantifying tissue histology
GB0217570D0 (en) 2002-07-30 2002-09-11 Univ Birmingham Method and apparatus for quantifying material or object properties
US9750449B2 (en) * 2003-12-12 2017-09-05 Johnson & Johnson Consumer Inc. Method of assessing skin
US7274453B2 (en) * 2004-10-14 2007-09-25 The Procter & Gamble Company Methods and apparatus for calibrating an electromagnetic measurement device
JP2006218291A (en) * 2005-01-13 2006-08-24 Nidec Copal Corp Skin observation apparatus
US20060244961A1 (en) * 2005-04-29 2006-11-02 Cole Curtis A Topical composition detection
GB2443389A (en) * 2006-11-03 2008-05-07 Astron Clinica Ltd Method and apparatus for obtaining a measurement of sun damage
EP2040061A1 (en) * 2007-09-24 2009-03-25 Koninklijke Philips Electronics N.V. An apparatus and method for observing the surface of a sample
JP5628180B2 (en) 2008-10-02 2014-11-19 キム グァンテKIM, Kwang Tae Cerebrovascular analyzer
JP5427388B2 (en) * 2008-10-07 2014-02-26 ショットモリテックス株式会社 Skin observation device
US20100285518A1 (en) * 2009-04-20 2010-11-11 The Curators Of The University Of Missouri Photoacoustic detection of analytes in solid tissue and detection system
JP2013132542A (en) * 2011-12-27 2013-07-08 Sharp Corp Measuring instrument

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3827457A1 (en) * 1987-11-27 1989-06-08 Bernhard Dr Ludwig Method and device for the relative quantitative determination of chromophores in surface layers
WO1991014159A1 (en) * 1990-03-08 1991-09-19 Henrik Bernhard Lemming A method of reflection measurement
WO1998022023A1 (en) * 1996-11-19 1998-05-28 Optiscan Ltd. Method for measurement of skin histology
WO1999000690A1 (en) * 1996-05-20 1999-01-07 Lucid Technologies, Inc. Confocal imaging through thick dermal tissue
US5986770A (en) * 1994-07-30 1999-11-16 Roche Diagnostics Gmbh Apparatus and method for the optical characterization of the structure and composition of a light scattering sample

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3827457A1 (en) * 1987-11-27 1989-06-08 Bernhard Dr Ludwig Method and device for the relative quantitative determination of chromophores in surface layers
WO1991014159A1 (en) * 1990-03-08 1991-09-19 Henrik Bernhard Lemming A method of reflection measurement
US5986770A (en) * 1994-07-30 1999-11-16 Roche Diagnostics Gmbh Apparatus and method for the optical characterization of the structure and composition of a light scattering sample
WO1999000690A1 (en) * 1996-05-20 1999-01-07 Lucid Technologies, Inc. Confocal imaging through thick dermal tissue
WO1998022023A1 (en) * 1996-11-19 1998-05-28 Optiscan Ltd. Method for measurement of skin histology

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7916910B2 (en) 2005-09-23 2011-03-29 Biocompatibles Uk Limited Image processing method and apparatus

Also Published As

Publication number Publication date
WO2002002001A8 (en) 2002-07-04
JP2004501712A (en) 2004-01-22
EP1296593A2 (en) 2003-04-02
AU2001270762A1 (en) 2002-01-14
WO2002002001A2 (en) 2002-01-10

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