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WO2002002598A3 - HUMAN G PROTEIN-COUPLED RECEPTOR IGPcR18, AND USES THEROF - Google Patents

HUMAN G PROTEIN-COUPLED RECEPTOR IGPcR18, AND USES THEROF Download PDF

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Publication number
WO2002002598A3
WO2002002598A3 PCT/EP2001/007530 EP0107530W WO0202598A3 WO 2002002598 A3 WO2002002598 A3 WO 2002002598A3 EP 0107530 W EP0107530 W EP 0107530W WO 0202598 A3 WO0202598 A3 WO 0202598A3
Authority
WO
WIPO (PCT)
Prior art keywords
igpcr18
protein
coupled receptor
disorders
receptor
Prior art date
Application number
PCT/EP2001/007530
Other languages
French (fr)
Other versions
WO2002002598A2 (en
Inventor
Frank Wattler
Sigrid Wattler
Paul Trommler
Michael C Nehls
Original Assignee
Ingenium Pharmaceuticals Ag
Frank Wattler
Sigrid Wattler
Paul Trommler
Michael C Nehls
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ingenium Pharmaceuticals Ag, Frank Wattler, Sigrid Wattler, Paul Trommler, Michael C Nehls filed Critical Ingenium Pharmaceuticals Ag
Priority to AU2001269114A priority Critical patent/AU2001269114A1/en
Priority to PCT/EP2002/000021 priority patent/WO2003004528A1/en
Publication of WO2002002598A2 publication Critical patent/WO2002002598A2/en
Publication of WO2002002598A3 publication Critical patent/WO2002002598A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A novel human G protein-coupled receptor (GPcR) protein, IGPcR18, is identified and characterized. IGPcR18-encoding nucleotides, IGPcR18 proteins and fusion proteins, antibodies to the receptor, host cell expression systems, animal models in which the IGPcR18 gene is mutated, recombinant knock-out animals that do not express IGPcR18 and transgenic animals that express an IGPcR18 transgene are encompassed by the invention, as are compounds that modulate gene expression or receptor activity of IGPcR18 and their use for drug screening, and diagnosis or treatment of diseases and disorders, particularly pain, cancer, inflammatory and metabolic disorders and reproductive and gynecological disorders.
PCT/EP2001/007530 2000-06-30 2001-07-02 HUMAN G PROTEIN-COUPLED RECEPTOR IGPcR18, AND USES THEROF WO2002002598A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001269114A AU2001269114A1 (en) 2000-06-30 2001-07-02 Human g protein-coupled receptor igpcr18, and uses therof
PCT/EP2002/000021 WO2003004528A1 (en) 2001-07-02 2002-01-03 Human g protein-coupled receptors and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21587900P 2000-06-30 2000-06-30
US60/215,879 2000-06-30

Publications (2)

Publication Number Publication Date
WO2002002598A2 WO2002002598A2 (en) 2002-01-10
WO2002002598A3 true WO2002002598A3 (en) 2002-05-16

Family

ID=22804777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007530 WO2002002598A2 (en) 2000-06-30 2001-07-02 HUMAN G PROTEIN-COUPLED RECEPTOR IGPcR18, AND USES THEROF

Country Status (2)

Country Link
AU (1) AU2001269114A1 (en)
WO (1) WO2002002598A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030143668A1 (en) * 2001-06-18 2003-07-31 National Institute Of Advanced Industrial Guanosine triphosphate-binding protein coupled receptors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0711831A2 (en) * 1994-11-14 1996-05-15 Takeda Chemical Industries, Ltd. Rabbit G protein coupled receptor
WO1996016087A1 (en) * 1994-11-18 1996-05-30 Human Genome Sciences, Inc. G-protein coupled receptor
EP1067182A2 (en) * 1999-07-08 2001-01-10 Helix Research Institute Secretory protein or membrane protein

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0711831A2 (en) * 1994-11-14 1996-05-15 Takeda Chemical Industries, Ltd. Rabbit G protein coupled receptor
WO1996016087A1 (en) * 1994-11-18 1996-05-30 Human Genome Sciences, Inc. G-protein coupled receptor
EP1067182A2 (en) * 1999-07-08 2001-01-10 Helix Research Institute Secretory protein or membrane protein

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 2 January 2000 (2000-01-02), "Homo sapiens chromosome 11 clone RP11-554A11, WORKING DRAFT SEQUENCE, 27 unordered pieces", XP002192104, Database accession no. AC019124 *
DATABASE EMBL [online] 22 June 1990 (1990-06-22), "Rat pot. G protein coupled receptor, RTA protein", XP002192103, Database accession no. M35297 *
ROSS PC ET AL.: "RTA, A CANDIDATE G PROTEIN-COUPLED RECEPTOR: CLONING, SEQUENCING, AND TISSUE DISTRIBUTION", PROC NATL ACAD SCI USA, vol. 87, 1990, pages 3052 - 3056, XP002029350 *
STADEL J M ET AL: "Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 18, no. 11, 1 November 1997 (1997-11-01), pages 430 - 437, XP004099345, ISSN: 0165-6147 *

Also Published As

Publication number Publication date
AU2001269114A1 (en) 2002-01-14
WO2002002598A2 (en) 2002-01-10

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