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WO2002008949A3 - Methods and systems for evaluating a matching between measured data and standards - Google Patents

Methods and systems for evaluating a matching between measured data and standards Download PDF

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Publication number
WO2002008949A3
WO2002008949A3 PCT/US2001/023630 US0123630W WO0208949A3 WO 2002008949 A3 WO2002008949 A3 WO 2002008949A3 US 0123630 W US0123630 W US 0123630W WO 0208949 A3 WO0208949 A3 WO 0208949A3
Authority
WO
WIPO (PCT)
Prior art keywords
measured data
matching
data points
evaluating
standards
Prior art date
Application number
PCT/US2001/023630
Other languages
French (fr)
Other versions
WO2002008949A2 (en
Inventor
Heinz Breu
Hugh J Pasika
Original Assignee
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applera Corp filed Critical Applera Corp
Priority to AU2001283003A priority Critical patent/AU2001283003B2/en
Priority to EP01961761A priority patent/EP1350179A2/en
Priority to AU8300301A priority patent/AU8300301A/en
Priority to JP2002514583A priority patent/JP2004505254A/en
Priority to CA002416611A priority patent/CA2416611A1/en
Publication of WO2002008949A2 publication Critical patent/WO2002008949A2/en
Publication of WO2002008949A3 publication Critical patent/WO2002008949A3/en

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/18—Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00—Computing arrangements using knowledge-based models
    • G06N5/02—Knowledge representation; Symbolic representation
    • G06N5/022—Knowledge engineering; Knowledge acquisition

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Theoretical Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Mathematical Physics (AREA)
  • Databases & Information Systems (AREA)
  • Pure & Applied Mathematics (AREA)
  • Mathematical Optimization (AREA)
  • Medical Informatics (AREA)
  • Mathematical Analysis (AREA)
  • Software Systems (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Computational Mathematics (AREA)
  • Evolutionary Biology (AREA)
  • Signal Processing (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Evolutionary Computation (AREA)
  • Operations Research (AREA)
  • Probability & Statistics with Applications (AREA)
  • Epidemiology (AREA)
  • Algebra (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)

Abstract

The present invention proposes an approach to matching measured data points representative of a physical property (for instance the measured peak location or positions of an in-lane size standard which represent DNA fragment length) to a set of standard values of that property (for instance a size standard definition). The matching is evaluated by comparing ratios of intervals between selected pairs of the measured data points with ratios of the intervals between adjacent pairs of the standard values, to find the measured data points that best match the standard values.
PCT/US2001/023630 2000-07-21 2001-07-23 Methods and systems for evaluating a matching between measured data and standards WO2002008949A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001283003A AU2001283003B2 (en) 2000-07-21 2001-07-23 Methods and systems for evaluating a matching between measured data and standards
EP01961761A EP1350179A2 (en) 2000-07-21 2001-07-23 Methods and systems for evaluating a matching between measured data and standards
AU8300301A AU8300301A (en) 2000-07-21 2001-07-23 Methods and systems for evaluating a matching between measured data and standards
JP2002514583A JP2004505254A (en) 2000-07-21 2001-07-23 Method and system for evaluating the match between measured data and a standard
CA002416611A CA2416611A1 (en) 2000-07-21 2001-07-23 Methods and systems for evaluating a matching between measured data and standards

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21969700P 2000-07-21 2000-07-21
US60/219,697 2000-07-21

Publications (2)

Publication Number Publication Date
WO2002008949A2 WO2002008949A2 (en) 2002-01-31
WO2002008949A3 true WO2002008949A3 (en) 2003-07-31

Family

ID=22820389

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/023630 WO2002008949A2 (en) 2000-07-21 2001-07-23 Methods and systems for evaluating a matching between measured data and standards

Country Status (5)

Country Link
EP (1) EP1350179A2 (en)
JP (1) JP2004505254A (en)
AU (2) AU8300301A (en)
CA (1) CA2416611A1 (en)
WO (1) WO2002008949A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2588982A1 (en) * 2010-06-29 2013-05-08 Analogic Corporation Internal sizing/lane standard signal verification
GB201511508D0 (en) * 2015-07-01 2015-08-12 Ge Healthcare Bio Sciences Ab Method for determining a size of biomolecules

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993014224A1 (en) * 1992-01-14 1993-07-22 Applied Biosystems, Inc. Size-calibration dna fragment mixture and method
US5876933A (en) * 1994-09-29 1999-03-02 Perlin; Mark W. Method and system for genotyping
WO2000016087A1 (en) * 1998-09-16 2000-03-23 The Perkin-Elmer Corporation Spectral calibration of fluorescent polynucleotide separation apparatus
US6054268A (en) * 1994-06-17 2000-04-25 Perlin; Mark W. Method and system for genotyping
EP1128311A2 (en) * 2000-02-15 2001-08-29 Mark W. Perlin A method and system for DNA analysis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993014224A1 (en) * 1992-01-14 1993-07-22 Applied Biosystems, Inc. Size-calibration dna fragment mixture and method
US6054268A (en) * 1994-06-17 2000-04-25 Perlin; Mark W. Method and system for genotyping
US5876933A (en) * 1994-09-29 1999-03-02 Perlin; Mark W. Method and system for genotyping
WO2000016087A1 (en) * 1998-09-16 2000-03-23 The Perkin-Elmer Corporation Spectral calibration of fluorescent polynucleotide separation apparatus
EP1128311A2 (en) * 2000-02-15 2001-08-29 Mark W. Perlin A method and system for DNA analysis

Also Published As

Publication number Publication date
JP2004505254A (en) 2004-02-19
WO2002008949A2 (en) 2002-01-31
AU2001283003B2 (en) 2004-04-08
AU8300301A (en) 2002-02-05
CA2416611A1 (en) 2002-01-31
EP1350179A2 (en) 2003-10-08

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