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WO2002011695A3 - Poudres a inhaler de proteines en faisceau a quatre helices sechees par atomisation presentant une agregation reduite au minimum - Google Patents

Poudres a inhaler de proteines en faisceau a quatre helices sechees par atomisation presentant une agregation reduite au minimum Download PDF

Info

Publication number
WO2002011695A3
WO2002011695A3 PCT/US2001/024632 US0124632W WO0211695A3 WO 2002011695 A3 WO2002011695 A3 WO 2002011695A3 US 0124632 W US0124632 W US 0124632W WO 0211695 A3 WO0211695 A3 WO 0211695A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhaleable
spray dried
helix bundle
protein powders
bundle protein
Prior art date
Application number
PCT/US2001/024632
Other languages
English (en)
Other versions
WO2002011695A2 (fr
Inventor
Cynthia Stevenson
Jayne E Hastedt
S Russ Lehrman
Hi-Shi Chiang
David B Bennett
David Lesikar
Bing Yang
David Gong
Kirsten Cabot
Original Assignee
Inhale Therapeutic Syst
Cynthia Stevenson
Jayne E Hastedt
S Russ Lehrman
Chiang Hi Shi
David B Bennett
David Lesikar
Bing Yang
David Gong
Kirsten Cabot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhale Therapeutic Syst, Cynthia Stevenson, Jayne E Hastedt, S Russ Lehrman, Chiang Hi Shi, David B Bennett, David Lesikar, Bing Yang, David Gong, Kirsten Cabot filed Critical Inhale Therapeutic Syst
Priority to EP01959572A priority Critical patent/EP1309312A2/fr
Priority to MXPA03001092A priority patent/MXPA03001092A/es
Priority to AU8111301A priority patent/AU8111301A/xx
Priority to JP2002517033A priority patent/JP2004515467A/ja
Priority to CA002418960A priority patent/CA2418960A1/fr
Priority to AU2001281113A priority patent/AU2001281113B2/en
Priority to KR10-2003-7001831A priority patent/KR20030038690A/ko
Publication of WO2002011695A2 publication Critical patent/WO2002011695A2/fr
Publication of WO2002011695A3 publication Critical patent/WO2002011695A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41J—TYPEWRITERS; SELECTIVE PRINTING MECHANISMS, i.e. MECHANISMS PRINTING OTHERWISE THAN FROM A FORME; CORRECTION OF TYPOGRAPHICAL ERRORS
    • B41J29/00—Details of, or accessories for, typewriters or selective printing mechanisms not otherwise provided for
    • B41J29/12—Guards, shields or dust excluders
    • B41J29/13—Cases or covers
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/30—Inkjet printing inks

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PCT/US2001/024632 2000-08-07 2001-08-06 Poudres a inhaler de proteines en faisceau a quatre helices sechees par atomisation presentant une agregation reduite au minimum WO2002011695A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP01959572A EP1309312A2 (fr) 2000-08-07 2001-08-06 Poudres a inhaler de proteines en faisceau a quatre helices sechees par atomisation presentant une agregation reduite au minimum
MXPA03001092A MXPA03001092A (es) 2000-08-07 2001-08-06 Polvos de proteina de haz de 4 helices secados por rocio, inhalables, que tienen agregacion minimizada.
AU8111301A AU8111301A (en) 2000-08-07 2001-08-06 Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
JP2002517033A JP2004515467A (ja) 2000-08-07 2001-08-06 吸入可能な、噴霧乾燥した、最少の凝集物を有する４−ヘリックスバンドルタンパク質粉末
CA002418960A CA2418960A1 (fr) 2000-08-07 2001-08-06 Poudres a inhaler de proteines en faisceau a quatre helices sechees par atomisation presentant une agregation reduite au minimum
AU2001281113A AU2001281113B2 (en) 2000-08-07 2001-08-06 Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
KR10-2003-7001831A KR20030038690A (ko) 2000-08-07 2001-08-06 응집이 최소화된, 흡입성 분무 건조 4-나선 다발 단백질분말

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22314400P 2000-08-07 2000-08-07
US60/223,144 2000-08-07
US22863400P 2000-08-29 2000-08-29
US60/228,634 2000-08-29
US24047800P 2000-10-13 2000-10-13
US60/240,478 2000-10-13

Publications (2)

Publication Number Publication Date
WO2002011695A2 WO2002011695A2 (fr) 2002-02-14
WO2002011695A3 true WO2002011695A3 (fr) 2002-04-25

Family

ID=27397184

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024632 WO2002011695A2 (fr) 2000-08-07 2001-08-06 Poudres a inhaler de proteines en faisceau a quatre helices sechees par atomisation presentant une agregation reduite au minimum

Country Status (10)

Country Link
US (3) US6569406B2 (fr)
EP (1) EP1309312A2 (fr)
JP (1) JP2004515467A (fr)
KR (1) KR20030038690A (fr)
CN (1) CN1446077A (fr)
AU (2) AU2001281113B2 (fr)
CA (1) CA2418960A1 (fr)
MX (1) MXPA03001092A (fr)
TW (1) TWI283182B (fr)
WO (1) WO2002011695A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
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US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US7182961B2 (en) 2001-11-20 2007-02-27 Advanced Inhalation Research, Inc. Particulate compositions for pulmonary delivery

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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
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US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7442388B2 (en) 2000-05-10 2008-10-28 Weers Jeffry G Phospholipid-based powders for drug delivery
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KR20030038690A (ko) 2003-05-16
US20030190291A1 (en) 2003-10-09
WO2002011695A2 (fr) 2002-02-14
JP2004515467A (ja) 2004-05-27
TWI283182B (en) 2007-07-01
CA2418960A1 (fr) 2002-02-14
US6569406B2 (en) 2003-05-27
US6838075B2 (en) 2005-01-04
MXPA03001092A (es) 2003-09-25
EP1309312A2 (fr) 2003-05-14
US20020065399A1 (en) 2002-05-30
AU2001281113B2 (en) 2006-07-20
US20050186143A1 (en) 2005-08-25
CN1446077A (zh) 2003-10-01
AU8111301A (en) 2002-02-18

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