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WO2002012498A3 - Haplotypes du gene isl1 - Google Patents

Haplotypes du gene isl1 Download PDF

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Publication number
WO2002012498A3
WO2002012498A3 PCT/US2001/024664 US0124664W WO0212498A3 WO 2002012498 A3 WO2002012498 A3 WO 2002012498A3 US 0124664 W US0124664 W US 0124664W WO 0212498 A3 WO0212498 A3 WO 0212498A3
Authority
WO
WIPO (PCT)
Prior art keywords
isl1
haplotypes
gene
disclosed
isl1 gene
Prior art date
Application number
PCT/US2001/024664
Other languages
English (en)
Other versions
WO2002012498A2 (fr
Inventor
Stefanie E Kliem
Beena Koshy
Debra A Tanguay
Original Assignee
Genaissance Pharmaceuticals
Stefanie E Kliem
Beena Koshy
Debra A Tanguay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Stefanie E Kliem, Beena Koshy, Debra A Tanguay filed Critical Genaissance Pharmaceuticals
Priority to AU2001281123A priority Critical patent/AU2001281123A1/en
Publication of WO2002012498A2 publication Critical patent/WO2002012498A2/fr
Publication of WO2002012498A3 publication Critical patent/WO2002012498A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des nouveaux allèles génétiques du gène (ISL1) (ilôt-1), à homéodomaine LIM, du facteur de transcription ISL1, ainsi que divers génotypes, haplotypes et paires d'haplotypes du gène ISL1, existant dans la population des Etats-Unis d'Amérique. L'invention concerne encore des compositions et procédés d'haplotypage et/ou de génotypage du gène ISL1, chez un individu. Enfin, l'invention concerne des polynucléotides définis par les haplotypes décrits dans le corps du brevet.
PCT/US2001/024664 2000-08-04 2001-08-06 Haplotypes du gene isl1 WO2002012498A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001281123A AU2001281123A1 (en) 2000-08-04 2001-08-06 Haplotypes of the isl1 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22353500P 2000-08-04 2000-08-04
US60/223,535 2000-08-04

Publications (2)

Publication Number Publication Date
WO2002012498A2 WO2002012498A2 (fr) 2002-02-14
WO2002012498A3 true WO2002012498A3 (fr) 2003-08-28

Family

ID=22836925

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024664 WO2002012498A2 (fr) 2000-08-04 2001-08-06 Haplotypes du gene isl1

Country Status (2)

Country Link
AU (1) AU2001281123A1 (fr)
WO (1) WO2002012498A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060172297A1 (en) * 2002-08-30 2006-08-03 Riken Enhancers specific to motor nerve cells/sensory nerve cells
WO2004070013A2 (fr) 2003-01-31 2004-08-19 The Regents Of The University Of California Utilisation de l'ilot 1 comme marqueur pour isoler ou produire des cellules souches
US20080108090A1 (en) 2004-02-02 2008-05-08 The Regents Of The University Of California Methods of identifying small molecules for renewal, survival and migration of cardiac progenitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005783A1 (fr) * 1991-09-20 1993-04-01 The General Hospital Corporation Procedes de diagnostic et de traitement de la maladie de parkinson
US5972614A (en) * 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants
WO2001080156A1 (fr) * 2000-04-18 2001-10-25 Genaissance Pharmaceuticals, Inc. Procede et systeme de determination d'haplotypes a partir d'une recueil de polymorphismes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005783A1 (fr) * 1991-09-20 1993-04-01 The General Hospital Corporation Procedes de diagnostic et de traitement de la maladie de parkinson
US5972614A (en) * 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants
WO2001080156A1 (fr) * 2000-04-18 2001-10-25 Genaissance Pharmaceuticals, Inc. Procede et systeme de determination d'haplotypes a partir d'une recueil de polymorphismes

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
[online] 17 September 1999 (1999-09-17), DOE JOINT GENOME INSTITUTE STANFORD HUMAN GENOME CENTER: "Homo sapiens chromosome 5 clone CTD-2314G24, complete sequence", XP002226954, retrieved from EM_HUM Database accession no. AC010478 *
CLAIBORNE STEPHENS J: "SINGLE-NUCLEOTIDE POLYMORPHISMS, HAPLOTYPES AND THEIR RELEVANCE TO PHARMACOGENTICS", MOLECULAR DIAGNOSIS, NAPERVILLE, IL, US, vol. 4, no. 4, 1999, pages 309 - 317, XP002937520, ISSN: 1084-8592 *
CLARK A G ET AL: "HAPLOTYPE STRUCTURE AND POPULATION GENETIC INFERENCES FROM NUCLEOTIDE- SEQUENCE VARIATION IN HUMAN LIPOPROTEIN LIPASE", AMERICAN JOURNAL OF HUMAN GENETICS, UNIVERSITY OF CHICAGO PRESS, CHICAGO,, US, vol. 63, 1998, pages 595 - 612, XP002937239, ISSN: 0002-9297 *
DRYSDALE C M ET AL: "COMPLEX PROMOTER AND CODING REGION BETA2-ADRENERGIC RECEPTOR HAPLOTYPES ALTER RECEPTOR EXPRESSION AND PREDICT IN VIVO RESPONSIVENESS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 19, 12 September 2000 (2000-09-12), pages 10483 - 10488, XP002940094, ISSN: 0027-8424 *
EMILIEN G ET AL: "IMPACT OF GENOMICS ON DRUG DISCOVERY AND CLINICAL MEDICINE", QUARTERLY JOURNAL OF MEDICINE, CLARENDON PRESS, OXFORD, GB, vol. 93, no. 7, June 2000 (2000-06-01), pages 391 - 423, XP000941207, ISSN: 0033-5622 *
JUDSON R ET AL: "THE PREDICTIVE POWER OF HAPLOTYPES IN CLINICAL RESPONSE", PHARMACOGENOMICS, ASHLEY PUBLICATIONS, GB, vol. 1, no. 1, February 2000 (2000-02-01), pages 15 - 26, XP001113104, ISSN: 1462-2416 *
LU ANTONY Y H: "Drug-metabolism research challenges in the new millennium: Individual variability in drug therapy and drug safety.", DRUG METABOLISM AND DISPOSITION, vol. 26, no. 12, December 1998 (1998-12-01), pages 1217 - 1222, XP002223866, ISSN: 0090-9556 *
MAREZ D ET AL: "Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution", PHARMACOGENETICS, CHAPMAN & HALL, LONDON, GB, vol. 7, no. 3, 1997, pages 193 - 202, XP002955538, ISSN: 0960-314X *
RIGGS A C ET AL: "Characterization of the LIM/homeodomain gene islet-1 and single nucleotide screening in NIDDM.", DIABETES. UNITED STATES JUN 1995, vol. 44, no. 6, June 1995 (1995-06-01), pages 689 - 694, XP002226953, ISSN: 0012-1797 *
RUANO G ET AL: "GENOTYPING AND HAPLOTYPING OF POLYMORPHISMS DIRECTLY FROM GENOMIC DNA VIA COUPLED AMPLIFICATION AND SEQUENCING (CAS)", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 19, no. 24, 1991, pages 6877 - 6882, XP000197814, ISSN: 0305-1048 *
RUANO: "Genaissance awarded broad patent on methods for collecting genes for variation analysis across populations", GENAISSANCE PRESS RELEASE, 8 November 1999 (1999-11-08), XP002229209, Retrieved from the Internet <URL:WWW.biomedicine.ch/publications/genaissance/g111199.html> [retrieved on 20030226] *
ULBRECHT M ET AL: "Assoziation of beta 2-adrenoreceptor variants with bronchial hyperresponsiveness", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 161, no. 2, February 2000 (2000-02-01), pages 469 - 474, XP002188594, ISSN: 1073-449X *

Also Published As

Publication number Publication date
WO2002012498A2 (fr) 2002-02-14
AU2001281123A1 (en) 2002-02-18

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