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WO2002036066A3 - Compositions pharmaceutiques comprenant des complexes de vanadium organiques pour le traitement de l'ischemie - Google Patents

Compositions pharmaceutiques comprenant des complexes de vanadium organiques pour le traitement de l'ischemie Download PDF

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Publication number
WO2002036066A3
WO2002036066A3 PCT/IL2001/001004 IL0101004W WO0236066A3 WO 2002036066 A3 WO2002036066 A3 WO 2002036066A3 IL 0101004 W IL0101004 W IL 0101004W WO 0236066 A3 WO0236066 A3 WO 0236066A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
ischemia
pharmaceutical compositions
vanadium
oxovanadium
Prior art date
Application number
PCT/IL2001/001004
Other languages
English (en)
Other versions
WO2002036066A2 (fr
Inventor
Yoram Shechter
Matityahu Fridkin
Itzhak Goldwaser
Original Assignee
Yeda Res & Dev
Yoram Shechter
Matityahu Fridkin
Itzhak Goldwaser
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL13939900A external-priority patent/IL139399A0/xx
Priority claimed from IL14118201A external-priority patent/IL141182A0/xx
Application filed by Yeda Res & Dev, Yoram Shechter, Matityahu Fridkin, Itzhak Goldwaser filed Critical Yeda Res & Dev
Priority to AU2002214222A priority Critical patent/AU2002214222A1/en
Publication of WO2002036066A2 publication Critical patent/WO2002036066A2/fr
Publication of WO2002036066A3 publication Critical patent/WO2002036066A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Des complexes de vanadium organiques peuvent être utilisés dans la prévention et/ou le traitement de l'ischémie cérébrale. Le complexe de vanadium peut être du bis(N-octyl cystéine amide) oxovanadium (IV), bis(maltolato)oxovanadium (IV), bis(picolinato) oxovanadium (IV) ou un complexe de vanadium d'un hydroxamate, de préférence un monohydroxamate, et est de préférence également un complexe de vanadium d'un monohydroxamate de formule R-CO-NHOH.X, où R représente un radical sélectionné parmi: (i) H2N-CH(COY)-(CH2)n-; (ii) H2N-CH(COOH)-CH2-S-CH2-; et (iii) pyridyle, pipéridyle ou tétrahydro-isoquinolinyle, où n représente 1, 2 ou 3, et Y représente OH ou NH2; et X est un composé de vanadium sélectionné parmi un sel de vanadyle (VO2+), de métavanadate (VO¿3?-) ou de vanadate (VO¿4?3-).
PCT/IL2001/001004 2000-11-01 2001-10-30 Compositions pharmaceutiques comprenant des complexes de vanadium organiques pour le traitement de l'ischemie WO2002036066A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002214222A AU2002214222A1 (en) 2000-11-01 2001-10-30 Pharmaceutical compositions comprising organic vanadium complexes for treatment of ischemia

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IL13939900A IL139399A0 (en) 2000-11-01 2000-11-01 Pharmaceutical compositions comprising vanadium complexes of hydroxamates
IL139399 2000-11-01
IL141182 2001-01-30
IL14118201A IL141182A0 (en) 2001-01-30 2001-01-30 Pharmaceutical compositions comprising organic vanadium complexes

Publications (2)

Publication Number Publication Date
WO2002036066A2 WO2002036066A2 (fr) 2002-05-10
WO2002036066A3 true WO2002036066A3 (fr) 2002-08-01

Family

ID=26323987

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2001/001004 WO2002036066A2 (fr) 2000-11-01 2001-10-30 Compositions pharmaceutiques comprenant des complexes de vanadium organiques pour le traitement de l'ischemie

Country Status (2)

Country Link
AU (1) AU2002214222A1 (fr)
WO (1) WO2002036066A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI712591B (zh) 2015-02-02 2020-12-11 美商佛瑪治療公司 作為ｈｄａｃ抑制劑之3-烷基-4-醯胺基-雙環[4,5,0]羥肟酸
AR103598A1 (es) 2015-02-02 2017-05-24 Forma Therapeutics Inc Ácidos bicíclicos[4,6,0]hidroxámicos como inhibidores de hdac
US10555935B2 (en) 2016-06-17 2020-02-11 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors
NL2019605B1 (en) * 2017-09-22 2019-03-28 Cfm Pharma Holding B V Vanadyl and vanadate for use in reducing stress-induced metabolic derangement

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039385A1 (fr) * 1995-06-06 1996-12-12 Pfizer Inc. (indole-2-carbonyl-)-amides substitues en n et leurs derives, servant d'inhibiteurs de la glycogene phosphorylase
WO1999012875A1 (fr) * 1997-09-11 1999-03-18 Yeda Research And Development Co. Ltd. Complexes de vanadium de monohydroxamates et compositions pharmaceutiques les renfermant

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039385A1 (fr) * 1995-06-06 1996-12-12 Pfizer Inc. (indole-2-carbonyl-)-amides substitues en n et leurs derives, servant d'inhibiteurs de la glycogene phosphorylase
WO1999012875A1 (fr) * 1997-09-11 1999-03-18 Yeda Research And Development Co. Ltd. Complexes de vanadium de monohydroxamates et compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
AU2002214222A1 (en) 2002-05-15
WO2002036066A2 (fr) 2002-05-10

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