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WO2002038185A3 - Injectable sustained release delivery system with loperamide - Google Patents

Injectable sustained release delivery system with loperamide Download PDF

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Publication number
WO2002038185A3
WO2002038185A3 PCT/US2001/047116 US0147116W WO0238185A3 WO 2002038185 A3 WO2002038185 A3 WO 2002038185A3 US 0147116 W US0147116 W US 0147116W WO 0238185 A3 WO0238185 A3 WO 0238185A3
Authority
WO
WIPO (PCT)
Prior art keywords
loperamide
delivery system
sustained release
release delivery
injectable sustained
Prior art date
Application number
PCT/US2001/047116
Other languages
French (fr)
Other versions
WO2002038185A2 (en
Inventor
Richard L Dunn
David W Osborne
Original Assignee
Atrix Lab Inc
Richard L Dunn
David W Osborne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atrix Lab Inc, Richard L Dunn, David W Osborne filed Critical Atrix Lab Inc
Priority to AU2002226000A priority Critical patent/AU2002226000A1/en
Publication of WO2002038185A2 publication Critical patent/WO2002038185A2/en
Publication of WO2002038185A3 publication Critical patent/WO2002038185A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention provides for a flowable composition suitable for use as a controlled release implant, a method for forming a flowable composition for use as a controlled release implant, and methods for using the flowable composition. The composition comprises a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid; a biocompatible organic solvent that is miscible to dispersible in aqueous medium or body fluid and can effectively dissolve the thermoplastic polyester; and an antihyperalgesic opiate.
PCT/US2001/047116 2000-11-13 2001-11-13 Injectable sustained release delivery system with loperamide WO2002038185A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002226000A AU2002226000A1 (en) 2000-11-13 2001-11-13 Injectable sustained release delivery system with loperamide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71082500A 2000-11-13 2000-11-13
US09/710,825 2000-11-13

Publications (2)

Publication Number Publication Date
WO2002038185A2 WO2002038185A2 (en) 2002-05-16
WO2002038185A3 true WO2002038185A3 (en) 2003-01-16

Family

ID=24855703

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047116 WO2002038185A2 (en) 2000-11-13 2001-11-13 Injectable sustained release delivery system with loperamide

Country Status (2)

Country Link
AU (1) AU2002226000A1 (en)
WO (1) WO2002038185A2 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7875697B2 (en) 2006-06-29 2011-01-25 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US8475823B2 (en) 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US10010612B2 (en) 2007-05-25 2018-07-03 Indivior Uk Limited Sustained delivery formulations of risperidone compounds
US10022367B2 (en) 2014-03-10 2018-07-17 Indivior Uk Limited Sustained-release buprenorphine solutions
US10058554B2 (en) 2005-09-30 2018-08-28 Indivior Uk Limited Sustained release small molecule drug formulation
US10172849B2 (en) 2010-06-08 2019-01-08 Indivior Uk Limited Compositions comprising buprenorphine
US10198218B2 (en) 2010-06-08 2019-02-05 Indivior Uk Limited Injectable flowable composition comprising buprenorphine
US12433877B2 (en) 2022-05-13 2025-10-07 Durect Corporation Sustained release drug delivery systems and related methods

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
AR039729A1 (en) 2002-06-25 2005-03-09 Alza Corp SHORT-TERM DEPOSIT FORMULATIONS
DK1539101T3 (en) * 2002-07-31 2009-04-27 Alza Corp Injectable, multi-modal polymeric compositions and applications thereof
NZ539810A (en) * 2002-11-06 2008-03-28 Alza Corp Controlled release injectable depot formulations
US7202259B2 (en) 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
AU2004245022A1 (en) * 2003-05-30 2004-12-16 Alza Corporation Implantable elastomeric depot compositions, uses thereof and method of manufacturing
NZ568430A (en) 2005-11-21 2011-02-25 Purdue Pharma Lp 4-oxadiazolyl-piperidine compounds and use thereof
US8481743B2 (en) 2006-11-01 2013-07-09 Purdue Pharma L.P. Phenylpropionamide compounds and the use thereof
CN102112107A (en) 2008-06-03 2011-06-29 托马医疗科技公司 Controlled release copolymer formulation with improved release kinetics
US10350159B2 (en) 2010-05-31 2019-07-16 Laboratories Farmacéuticos Rovi, S.A. Paliperidone implant formulation
US10285936B2 (en) 2010-05-31 2019-05-14 Laboratorios Farmacéuticos Rovi, S.A. Injectable composition with aromatase inhibitor
US10335366B2 (en) 2010-05-31 2019-07-02 Laboratorios Farmacéuticos Rovi, S.A. Risperidone or paliperidone implant formulation
SMT202100679T1 (en) 2010-05-31 2022-01-10 Laboratorios Farmaceuticos Rovi S A Compositions for injectable in-situ biodegradable implants
US10881605B2 (en) 2010-05-31 2021-01-05 Laboratorios Farmaceuticos Rovi, S.A. Methods for the preparation of injectable depot compositions
US10463607B2 (en) 2010-05-31 2019-11-05 Laboratorios Farmaceutics Rofi S.A. Antipsychotic Injectable Depot Composition
PE20210047A1 (en) 2018-06-12 2021-01-08 Farm Rovi Lab Sa INJECTABLE COMPOSITION
US20220040201A1 (en) * 2018-09-25 2022-02-10 Tolmar International, Ltd. Liquid polymer delivery system for extended administration of drugs
EP4090353A4 (en) 2020-01-13 2023-08-09 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
US12318387B2 (en) 2021-07-16 2025-06-03 Laboratorios Farmaceuticos Rovi, S.A. Method of treating acute exacerbation of schizophrenia with long-acting injectable depot composition
TW202313047A (en) 2021-09-21 2023-04-01 西班牙商禾霏藥品實驗室有限公司 Antipsychotic injectable depot composition
EP4527389A1 (en) 2022-05-18 2025-03-26 Laboratorios Farmacéuticos Rovi S.A. Prolonged-release injectable compositions for use in treatment with risperidone together with cyp2d6 enzyme inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018940A1 (en) * 1990-06-04 1991-12-12 Nova Pharmaceutical Corporation Branched polyanhydrides
WO2000024374A1 (en) * 1998-10-28 2000-05-04 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
WO2001035929A2 (en) * 1999-11-16 2001-05-25 Atrix Laboratories, Inc. Biodegradable polymer composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018940A1 (en) * 1990-06-04 1991-12-12 Nova Pharmaceutical Corporation Branched polyanhydrides
WO2000024374A1 (en) * 1998-10-28 2000-05-04 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
WO2001035929A2 (en) * 1999-11-16 2001-05-25 Atrix Laboratories, Inc. Biodegradable polymer composition

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10058554B2 (en) 2005-09-30 2018-08-28 Indivior Uk Limited Sustained release small molecule drug formulation
US11110093B2 (en) 2005-09-30 2021-09-07 Indivior Uk Limited Sustained release small molecule drug formulation
US8133968B2 (en) 2006-06-29 2012-03-13 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US7875697B2 (en) 2006-06-29 2011-01-25 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US10376590B2 (en) 2007-05-25 2019-08-13 Indivior Uk Limited Sustained delivery formulations of risperidone compound
US10010612B2 (en) 2007-05-25 2018-07-03 Indivior Uk Limited Sustained delivery formulations of risperidone compounds
US11712475B2 (en) 2007-05-25 2023-08-01 Indivior Uk Limited Sustained delivery formulations of risperidone compound
US8475823B2 (en) 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8940315B2 (en) 2008-04-18 2015-01-27 Medtronic, Inc. Benzodiazepine formulation in a polyorthoester carrier
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US10172849B2 (en) 2010-06-08 2019-01-08 Indivior Uk Limited Compositions comprising buprenorphine
US10558394B2 (en) 2010-06-08 2020-02-11 Indivior Uk Limited Injectable flowable composition comprising buprenorphine
US10592168B1 (en) 2010-06-08 2020-03-17 Indivior Uk Limited Injectable flowable composition comprising buprenorphine
US10198218B2 (en) 2010-06-08 2019-02-05 Indivior Uk Limited Injectable flowable composition comprising buprenorphine
US10517864B2 (en) 2014-03-10 2019-12-31 Indivior Uk Limited Sustained-release buprenorphine solutions
US10022367B2 (en) 2014-03-10 2018-07-17 Indivior Uk Limited Sustained-release buprenorphine solutions
US12433877B2 (en) 2022-05-13 2025-10-07 Durect Corporation Sustained release drug delivery systems and related methods

Also Published As

Publication number Publication date
WO2002038185A2 (en) 2002-05-16
AU2002226000A1 (en) 2002-05-21

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