[go: up one dir, main page]

WO2003048144A3 - Procede de monosulfonylation d'un compose de type aminobenzofuranne. - Google Patents

Procede de monosulfonylation d'un compose de type aminobenzofuranne. Download PDF

Info

Publication number
WO2003048144A3
WO2003048144A3 PCT/FR2002/004091 FR0204091W WO03048144A3 WO 2003048144 A3 WO2003048144 A3 WO 2003048144A3 FR 0204091 W FR0204091 W FR 0204091W WO 03048144 A3 WO03048144 A3 WO 03048144A3
Authority
WO
WIPO (PCT)
Prior art keywords
monosulphonylation
aminobenzofuran
compound
invention concerns
pka
Prior art date
Application number
PCT/FR2002/004091
Other languages
English (en)
Other versions
WO2003048144A2 (fr
Inventor
Philippe Karrer
Original Assignee
Rhodia Chimie Sa
Philippe Karrer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodia Chimie Sa, Philippe Karrer filed Critical Rhodia Chimie Sa
Priority to AU2002361357A priority Critical patent/AU2002361357A1/en
Publication of WO2003048144A2 publication Critical patent/WO2003048144A2/fr
Publication of WO2003048144A3 publication Critical patent/WO2003048144A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La présente invention a pour objet un procédé de monosulfonylation d'un composé de type aminobenzofuranne.L'invention vise plus particulièrement un procédé de monosulfonylation de 2-n-alkyl-5-aminobenzofuranne. Le procédé de l'invention est un procédé de monosulfonylation d'un composé de type aminobenzofuranne caractérisé par le fait qu'il consiste à faire réagir ledit composé, avec un agent sulfonylant, en présence d'une base dont l'acide associé a un pka au moins supérieur ou égal à 5 et inférieur à 10.
PCT/FR2002/004091 2001-12-06 2002-11-28 Procede de monosulfonylation d'un compose de type aminobenzofuranne. WO2003048144A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002361357A AU2002361357A1 (en) 2001-12-06 2002-11-28 Method for monosulphonylation of an aminobenzofuran compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR01/15781 2001-12-06
FR0115781A FR2833262A1 (fr) 2001-12-06 2001-12-06 Procede de monosulfonylation d'un compose de type aminobenzofuranne ou aminobenzothiophene

Publications (2)

Publication Number Publication Date
WO2003048144A2 WO2003048144A2 (fr) 2003-06-12
WO2003048144A3 true WO2003048144A3 (fr) 2003-12-11

Family

ID=8870180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/004091 WO2003048144A2 (fr) 2001-12-06 2002-11-28 Procede de monosulfonylation d'un compose de type aminobenzofuranne.

Country Status (3)

Country Link
AU (1) AU2002361357A1 (fr)
FR (1) FR2833262A1 (fr)
WO (1) WO2003048144A2 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9174959B2 (en) 2011-03-29 2015-11-03 Sanofi Process for preparation of dronedarone by N-butylation
US9174958B2 (en) 2010-06-18 2015-11-03 Sanofi Process for the preparation of dronedarone
US9193703B2 (en) 2011-03-29 2015-11-24 Sanofi Process for preparation of dronedarone by mesylation
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9221777B2 (en) 2012-01-20 2015-12-29 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9238636B2 (en) 2012-05-31 2016-01-19 Sanofi Process for preparation of dronedarone by Grignard reaction
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9334254B2 (en) 2010-03-30 2016-05-10 Sanofi Process for preparing sulfonamidobenzofuran derivatives
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
US9499507B2 (en) 2011-11-29 2016-11-22 Sanofi Method for preparing 5-amino-benzoyl-benzofuran derivatives

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
CN102276561A (zh) 2010-06-09 2011-12-14 江苏恒瑞医药股份有限公司 决奈达隆及其盐的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471609A1 (fr) * 1990-08-06 1992-02-19 Sanofi Dérivés de Benzofuranne, Benzothiophène, Indole ou Indolizine, leur procédé de préparation ainsi que les compositions les contenant

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471609A1 (fr) * 1990-08-06 1992-02-19 Sanofi Dérivés de Benzofuranne, Benzothiophène, Indole ou Indolizine, leur procédé de préparation ainsi que les compositions les contenant

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
E. SAWICKI ET AL.: "Some Nitrogen Derivatives of Dibenzothiophene", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 75, 1953, DC US, pages 1752 - 1753, XP002207949 *
J. BOSCH ET AL.: "A Convergent Route to 5-(Arylsulfanyl)-6-sulfonamido-3-benzofuranones", SYNTHESIS, no. 5, 2000, STUTTGART DE, pages 721 - 725, XP002207971 *
W.A. BOGGUST ET AL.: "Experiments in the Chemistry of Benzthiazole", JOURNAL OF THE CHEMICAL SOCIETY., 1949, LETCHWORTH GB, pages 355 - 362, XP002207950 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9334254B2 (en) 2010-03-30 2016-05-10 Sanofi Process for preparing sulfonamidobenzofuran derivatives
US9174958B2 (en) 2010-06-18 2015-11-03 Sanofi Process for the preparation of dronedarone
US9193703B2 (en) 2011-03-29 2015-11-24 Sanofi Process for preparation of dronedarone by mesylation
US9174959B2 (en) 2011-03-29 2015-11-03 Sanofi Process for preparation of dronedarone by N-butylation
US9611242B2 (en) 2011-03-29 2017-04-04 Sanofi Process for preparation of dronedarone by N-butylation
US9499507B2 (en) 2011-11-29 2016-11-22 Sanofi Method for preparing 5-amino-benzoyl-benzofuran derivatives
US9221777B2 (en) 2012-01-20 2015-12-29 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9708281B2 (en) 2012-01-20 2017-07-18 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9701654B2 (en) 2012-02-13 2017-07-11 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
US9238636B2 (en) 2012-05-31 2016-01-19 Sanofi Process for preparation of dronedarone by Grignard reaction

Also Published As

Publication number Publication date
AU2002361357A1 (en) 2003-06-17
AU2002361357A8 (en) 2003-06-17
WO2003048144A2 (fr) 2003-06-12
FR2833262A1 (fr) 2003-06-13

Similar Documents

Publication Publication Date Title
WO2002074293A3 (fr) Methodes permettant de retablir la fonction cognitive suite a un stress systemique
WO2003048144A3 (fr) Procede de monosulfonylation d'un compose de type aminobenzofuranne.
MXPA03009565A (es) Derivado de acido carboxilico y una sal del mismo.
IL153508A0 (en) 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
EP1440709A3 (fr) Combinaisons comprenant des inhibiteurs de cGMP PDE5.
MY134077A (en) Cross-linking of starch
MXPA03006117A (es) Cojinete de brida.
WO2002102586A3 (fr) Composites cellulose et polymere et procede de fabrication
WO2002079358A3 (fr) Composition d'huile lubrifiante
AU1408900A (en) Method for synthesizing cdna
ZA200302020B (en) Gaseous acid catalysis.
WO2002028950A3 (fr) Composition retardant le grillage
MXPA03006533A (es) Composicion catalizadora y proceso que utiliza la misma.
EP1073449A4 (fr) Amidinohydrazones d'acide amine, alcoxyguanidines et aminoguanidines utilises comme inhibiteurs de l'enzyme protease
AU2002308805A1 (en) Magnesium-based alloy and method for the production thereof
MXPA03008441A (es) Delta 1-pirrolinas.
AU2001267855A1 (en) Intermediate and process for producing fluorinated carboxylic acid derivative from the same
IL144063A0 (en) Process for the preparation of 1,1-cyclohexanediacetic acid
WO2003048145A3 (fr) Procede de preparation d'un compose de type aminobenzofuranne.
AUPR414701A0 (en) Alpha 1,3 galactosyltransferase
WO2004026821A3 (fr) Agents antibacteriens non halogenes et procedes permettant de produire ces agents
WO2002060933A3 (fr) INHIBITION DE L'ACTIVATION NF-λB
WO2002074953A3 (fr) Bibliotheque genetique et procede de fabrication
WO2002091134A3 (fr) Systeme d'exploitation oriente objet pour regulateur de pulverisation
WO2003072842A3 (fr) Dispositif a utiliser lors d'un durcissement

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP