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WO2003048185A3 - Angiopioetin related factors - Google Patents

Angiopioetin related factors Download PDF

Info

Publication number
WO2003048185A3
WO2003048185A3 PCT/US2002/037660 US0237660W WO03048185A3 WO 2003048185 A3 WO2003048185 A3 WO 2003048185A3 US 0237660 W US0237660 W US 0237660W WO 03048185 A3 WO03048185 A3 WO 03048185A3
Authority
WO
WIPO (PCT)
Prior art keywords
wild
domain
amino acid
acid sequence
fusion proteins
Prior art date
Application number
PCT/US2002/037660
Other languages
French (fr)
Other versions
WO2003048185A2 (en
Inventor
Paul D Kessler
Imre Kovesdi
Original Assignee
Genvec Inc
Paul D Kessler
Imre Kovesdi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genvec Inc, Paul D Kessler, Imre Kovesdi filed Critical Genvec Inc
Priority to AU2002359464A priority Critical patent/AU2002359464A1/en
Publication of WO2003048185A2 publication Critical patent/WO2003048185A2/en
Publication of WO2003048185A3 publication Critical patent/WO2003048185A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides fusion proteins comprising a fibrinogen-like domain comprising an amino acid sequence identical or homologous to the amino acid sequence of the fibrinogen-like domain of a first wild-type angiopoietin-related factor and a coiled-coil domain comprising an amino acid sequence identical or homologous to the coiled-coil domain of a second wild-type angiopoietin-related factor, where the first and second wild-type angiopoietin related factors are different. The invention further provides polynucleotides encoding such fusion proteins, vectors comprising such polynucleotides, and methods of making and administering such fusion proteins, polynucleotides, and vectors.
PCT/US2002/037660 2001-11-30 2002-11-21 Angiopioetin related factors WO2003048185A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002359464A AU2002359464A1 (en) 2001-11-30 2002-11-21 Angiopioetin related factors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33448801P 2001-11-30 2001-11-30
US60/334,488 2001-11-30

Publications (2)

Publication Number Publication Date
WO2003048185A2 WO2003048185A2 (en) 2003-06-12
WO2003048185A3 true WO2003048185A3 (en) 2004-06-24

Family

ID=23307442

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/037660 WO2003048185A2 (en) 2001-11-30 2002-11-21 Angiopioetin related factors

Country Status (2)

Country Link
AU (1) AU2002359464A1 (en)
WO (1) WO2003048185A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7081443B2 (en) * 2002-05-21 2006-07-25 Korea Advanced Institutes Of Science And Technology (Kaist) Chimeric comp-ang1 molecule
DK1781698T3 (en) 2004-07-20 2016-10-03 Genentech Inc COMPOSITIONS AND METHODS FOR THE USE OF Angiopoietin-like-4-PROTEIN
ES2339789T3 (en) 2004-07-20 2010-05-25 Genentech, Inc. PROTEIN 4 INHIBITORS OF ANGIOPOYETINE TYPE, COMBINATIONS AND ITS USE.
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
EP2457578B1 (en) * 2004-09-28 2015-08-19 Aprogen, Inc. Chimeric molecule comprising angiopoietin-1 and a coiled-coil domain for use in treating penile erectile dysfunction
EP2446897A1 (en) 2005-01-06 2012-05-02 Novo Nordisk A/S Anti-KIR combination treatments and methods
IL296666A (en) 2005-03-23 2022-11-01 Genmab As Antibodies against 38cd for the treatment of multiple myeloma
MX347514B (en) 2011-05-25 2017-04-28 Innate Pharma Sa ANTI-RECEIVING ANTIBODIES TYPE IMMUNOGLOBULIN CITOLITICOS (KIR) FOR THE TREATMENT OF INFLAMMATORY DISORDERS.
WO2013154744A1 (en) * 2012-04-13 2013-10-17 Cornell University Development of a highly efficient second generation nicotine-conjugate vaccine to treat nicotine addiction
US9540428B2 (en) 2012-07-03 2017-01-10 Ecole Polytechnique Federale De Lausanne (Epfl) Extracellular matrix heparin-binding domains
GB202108761D0 (en) * 2021-06-18 2021-08-04 Ikarovec Ltd Ocular disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6074873A (en) * 1997-09-19 2000-06-13 Genentech, Inc. Nucleic acids encoding NL-3
US6265564B1 (en) * 1996-08-02 2001-07-24 Regeneron Pharmaceuticals, Inc. Expressed ligand-vascular intercellular signalling molecule
US6406693B1 (en) * 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265564B1 (en) * 1996-08-02 2001-07-24 Regeneron Pharmaceuticals, Inc. Expressed ligand-vascular intercellular signalling molecule
US20030092891A1 (en) * 1996-08-02 2003-05-15 Samuel Davis Expressed ligand - vascular intercellular signalling molecule
US6074873A (en) * 1997-09-19 2000-06-13 Genentech, Inc. Nucleic acids encoding NL-3
US6406693B1 (en) * 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids

Also Published As

Publication number Publication date
WO2003048185A2 (en) 2003-06-12
AU2002359464A8 (en) 2003-06-17
AU2002359464A1 (en) 2003-06-17

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