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WO2003048198A3 - Polypeptides inducing apoptosis, polynucleotides encoding them and therapeutic uses thereof - Google Patents

Polypeptides inducing apoptosis, polynucleotides encoding them and therapeutic uses thereof Download PDF

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Publication number
WO2003048198A3
WO2003048198A3 PCT/FR2002/004211 FR0204211W WO03048198A3 WO 2003048198 A3 WO2003048198 A3 WO 2003048198A3 FR 0204211 W FR0204211 W FR 0204211W WO 03048198 A3 WO03048198 A3 WO 03048198A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotides encoding
therapeutic uses
inducing apoptosis
polypeptides
polypeptides inducing
Prior art date
Application number
PCT/FR2002/004211
Other languages
French (fr)
Other versions
WO2003048198A2 (en
Inventor
Monique Lafon
Christophe Prehaud
Stephanie Lay
Mireille Lafage
Maria-Isabel Thoulouze
Original Assignee
Pasteur Institut
Monique Lafon
Christophe Prehaud
Stephanie Lay
Mireille Lafage
Maria-Isabel Thoulouze
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Monique Lafon, Christophe Prehaud, Stephanie Lay, Mireille Lafage, Maria-Isabel Thoulouze filed Critical Pasteur Institut
Priority to AU2002364431A priority Critical patent/AU2002364431A1/en
Publication of WO2003048198A2 publication Critical patent/WO2003048198A2/en
Publication of WO2003048198A3 publication Critical patent/WO2003048198A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20111—Lyssavirus, e.g. rabies virus
    • C12N2760/20122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention concerns an isolated or purified polypeptide and the polynucleotide encoding it inducing, through activation of initiator caspase 8, the formation of apoptotic bodies capable of stimulating in a vertebrate a humoral immune response and preferably, a B-dependent humoral immune response.
PCT/FR2002/004211 2001-12-07 2002-12-06 Polypeptides inducing apoptosis, polynucleotides encoding them and therapeutic uses thereof WO2003048198A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002364431A AU2002364431A1 (en) 2001-12-07 2002-12-06 Polypeptides inducing apoptosis, polynucleotides encoding them and therapeutic uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA2,364,150 2001-12-07
CA002364150A CA2364150A1 (en) 2001-12-07 2001-12-07 Polypeptides inducing apoptosis, polynucleotides that code for them and their therapeutic applications

Publications (2)

Publication Number Publication Date
WO2003048198A2 WO2003048198A2 (en) 2003-06-12
WO2003048198A3 true WO2003048198A3 (en) 2004-04-22

Family

ID=4170716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/004211 WO2003048198A2 (en) 2001-12-07 2002-12-06 Polypeptides inducing apoptosis, polynucleotides encoding them and therapeutic uses thereof

Country Status (3)

Country Link
AU (1) AU2002364431A1 (en)
CA (1) CA2364150A1 (en)
WO (1) WO2003048198A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2239330A1 (en) 2009-04-07 2010-10-13 Institut Pasteur Neuron generation, regeneration and protection
EP2581384A1 (en) 2011-10-11 2013-04-17 Institut Pasteur Products useful for the treatment of malignant neoplasms of the human nervous system
EP2592091B1 (en) 2011-11-08 2017-09-20 Institut Pasteur High MAST2-affinity polypeptides and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0162757A1 (en) * 1984-04-25 1985-11-27 Transgene S.A. Vaccine for rabies and process for its preparation
WO1989000861A1 (en) * 1987-07-30 1989-02-09 The Wistar Institute Vaccination against rabies-related viruses
WO1997012981A1 (en) * 1995-10-05 1997-04-10 Microbix Biosystems Inc. Rabies recombinant adenovirus
WO2001070932A2 (en) * 2000-03-23 2001-09-27 Thomas Jefferson University Genetically engineered rabies recombinant vaccine for immunization of stray dogs and wildlife

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0162757A1 (en) * 1984-04-25 1985-11-27 Transgene S.A. Vaccine for rabies and process for its preparation
WO1989000861A1 (en) * 1987-07-30 1989-02-09 The Wistar Institute Vaccination against rabies-related viruses
WO1997012981A1 (en) * 1995-10-05 1997-04-10 Microbix Biosystems Inc. Rabies recombinant adenovirus
WO2001070932A2 (en) * 2000-03-23 2001-09-27 Thomas Jefferson University Genetically engineered rabies recombinant vaccine for immunization of stray dogs and wildlife

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FODOR I ET AL: "Nucleotide and deduced amino acid sequences of the glycoprotein gene of rabies virus vaccine strain Vnukovo-32.", ARCHIVES OF VIROLOGY, vol. 135, no. 3-4, 1994, pages 451 - 459, XP009009912, ISSN: 0304-8608 *
MORIMOTO KINJIRO ET AL: "Pathogenicity of different rabies virus variants inversely correlates with apoptosis and rabies virus glycoprotein expression in infected primary neuron cultures.", JOURNAL OF VIROLOGY, vol. 73, no. 1, January 1999 (1999-01-01), pages 510 - 518, XP002239719, ISSN: 0022-538X *
THOULOUZE MARIA-ISABEL ET AL: "Rabies virus infects mouse and human lymphocytes and induces apoptosis.", JOURNAL OF VIROLOGY, vol. 71, no. 10, 1997, pages 7372 - 7380, XP002239720, ISSN: 0022-538X *

Also Published As

Publication number Publication date
CA2364150A1 (en) 2003-06-07
AU2002364431A1 (en) 2003-06-17
WO2003048198A2 (en) 2003-06-12

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