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WO2003052064A3 - Lignees de cellules clonales de myelomes utilisables pour la production de proteines dans un milieu defini chimiquement - Google Patents

Lignees de cellules clonales de myelomes utilisables pour la production de proteines dans un milieu defini chimiquement Download PDF

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Publication number
WO2003052064A3
WO2003052064A3 PCT/US2002/039496 US0239496W WO03052064A3 WO 2003052064 A3 WO2003052064 A3 WO 2003052064A3 US 0239496 W US0239496 W US 0239496W WO 03052064 A3 WO03052064 A3 WO 03052064A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell lines
chemically defined
defined media
myeloma cell
present
Prior art date
Application number
PCT/US2002/039496
Other languages
English (en)
Other versions
WO2003052064A2 (fr
Inventor
Chichang Lee
Celia Ly
Gordon Moore
Edward Savino
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Priority to JP2003552931A priority Critical patent/JP2005512538A/ja
Priority to CA002470026A priority patent/CA2470026A1/fr
Priority to EP02797264A priority patent/EP1490481A4/fr
Priority to AU2002362130A priority patent/AU2002362130A1/en
Publication of WO2003052064A2 publication Critical patent/WO2003052064A2/fr
Publication of WO2003052064A3 publication Critical patent/WO2003052064A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C12N5/0694—Cells of blood, e.g. leukemia cells, myeloma cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C12N2500/95—Protein-free medium and culture conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention porte: sur des lignées de cellules clonales de myélomes pouvant croître continuellement dans un milieu défini chimiquement; sur la production de protéines dans des lignées cellules clonales de myélomes et toute lignée en dérivant; sur des procédés d'identification de lignées de cellules pouvant croître dans un milieu défini chimiquement; et sur des méthodes commerciales permettant de fournir à des clients les cellules, lignées de cellules et cultures de cellules de la présente invention.
PCT/US2002/039496 2001-12-14 2002-12-11 Lignees de cellules clonales de myelomes utilisables pour la production de proteines dans un milieu defini chimiquement WO2003052064A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2003552931A JP2005512538A (ja) 2001-12-14 2002-12-11 無血清培地中でタンパク質を製造するのに有用なクローン性骨髄腫細胞系
CA002470026A CA2470026A1 (fr) 2001-12-14 2002-12-11 Lignees de cellules clonales de myelomes utilisables pour la production de proteines dans un milieu defini chimiquement
EP02797264A EP1490481A4 (fr) 2001-12-14 2002-12-11 Lignees de cellules clonales de myelomes utilisables pour la production de proteines dans un milieu defini chimiquement
AU2002362130A AU2002362130A1 (en) 2001-12-14 2002-12-11 Clonal myeloma cell lines useful for manufacturing proteins in chemically defined media

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33942901P 2001-12-14 2001-12-14
US60/339,429 2001-12-14

Publications (2)

Publication Number Publication Date
WO2003052064A2 WO2003052064A2 (fr) 2003-06-26
WO2003052064A3 true WO2003052064A3 (fr) 2004-10-28

Family

ID=23328968

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/039496 WO2003052064A2 (fr) 2001-12-14 2002-12-11 Lignees de cellules clonales de myelomes utilisables pour la production de proteines dans un milieu defini chimiquement

Country Status (5)

Country Link
EP (1) EP1490481A4 (fr)
JP (1) JP2005512538A (fr)
AU (1) AU2002362130A1 (fr)
CA (1) CA2470026A1 (fr)
WO (1) WO2003052064A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2426523B (en) * 2004-03-01 2008-10-22 Kitakyushu Foundation Human cell strains for protein production,provided by selecting strains with high intracellular protein and mutating with carcinogens
CA2576464C (fr) * 2004-07-23 2014-09-09 Immunomedics, Inc. Compositions et methodes d'accroissement de la duree de vie et du rendement en proteines de cultures de cellules
US7531327B2 (en) * 2004-07-23 2009-05-12 Immunomedics, Inc. Methods and compositions for increasing longevity and protein yield from a cell culture
JP6873530B2 (ja) * 2013-03-15 2021-05-19 イン3バイオ・リミテッドIn3Bio Ltd. 自己組織化合成タンパク質（Ｓｅｌｆ−Ａｓｓｅｍｂｌｉｎｇ Ｓｙｎｔｈｅｔｉｃ Ｐｒｏｔｅｉｎｓ）

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4504469A (en) * 1982-12-21 1985-03-12 Ferring Ab Vasotocin derivatives
US4780313A (en) * 1985-12-24 1988-10-25 Takeda Chemical Industries, Ltd. Method of stimulating the immune system with a mixture of substances having IL-2 activity and muramyldipeptide
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5723441A (en) * 1993-11-15 1998-03-03 Celtrix Pharmaceuticals, Inc. Method of treating renal disease by administering IGF-I and IGFBP-3
US5759996A (en) * 1994-04-13 1998-06-02 La Jolla Cancer Research Center Peptides useful for altering αv β3 -mediated binding
US5877148A (en) * 1994-08-05 1999-03-02 The United States Of America As Represented By The Department Of Health And Human Services Treatment of cancer with human chorionic gonadotropin
US6008195A (en) * 1996-02-16 1999-12-28 The Regents Of University Of California Antimicrobial peptides and methods of use
US6274335B1 (en) * 1982-05-05 2001-08-14 Genentech, Inc. Method of treatment using recombinant human tissue plasminogen activator
US6306648B1 (en) * 1996-06-03 2001-10-23 St. Jude Children's Research Hospital Cyclin-C variants, and diagnostic and therapeutic uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE420945T1 (de) * 2001-02-15 2009-01-15 Centocor Inc Chemisch definiertes medium für kultivierte säugerzellen

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274335B1 (en) * 1982-05-05 2001-08-14 Genentech, Inc. Method of treatment using recombinant human tissue plasminogen activator
US4504469A (en) * 1982-12-21 1985-03-12 Ferring Ab Vasotocin derivatives
US4780313A (en) * 1985-12-24 1988-10-25 Takeda Chemical Industries, Ltd. Method of stimulating the immune system with a mixture of substances having IL-2 activity and muramyldipeptide
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5723441A (en) * 1993-11-15 1998-03-03 Celtrix Pharmaceuticals, Inc. Method of treating renal disease by administering IGF-I and IGFBP-3
US5759996A (en) * 1994-04-13 1998-06-02 La Jolla Cancer Research Center Peptides useful for altering αv β3 -mediated binding
US5877148A (en) * 1994-08-05 1999-03-02 The United States Of America As Represented By The Department Of Health And Human Services Treatment of cancer with human chorionic gonadotropin
US6008195A (en) * 1996-02-16 1999-12-28 The Regents Of University Of California Antimicrobial peptides and methods of use
US6306648B1 (en) * 1996-06-03 2001-10-23 St. Jude Children's Research Hospital Cyclin-C variants, and diagnostic and therapeutic uses thereof

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
BIOTECHNOLOGY PROGRESS, vol. 16, no. 5, September 2000 (2000-09-01) - October 2000 (2000-10-01), pages 682 - 687 *
BLOOD, vol. 96, no. 11, PART 2, 16 November 2000 (2000-11-16), pages 278B *
CLINICAL THERAPEUTICS, vol. 21, no. 6, June 1999 (1999-06-01), pages 932 - 942 *
CYTOTECHNOLOGY, vol. 22, no. 1-3, January 1996 (1996-01-01), pages 239 - 250 *
DATABASE BIOSIS [online] BIOLOGICAL ABSTRACTS INC. (COLUMBUS, OH USA); HILL M.: "Adaptive state of mammalian cells and its nonseparability suggestive of a quantum system", XP002972612, accession no. STN Database accession no. 2001:152166 *
DATABASE BIOSIS [online] BIOLOGICAL ABSTRACTS INC. (COLUMBUS, OH USA); LOUIS ET AL.: "Maintenance of clonotypic myeloma cells in serum-free media", XP002972615, accession no. STN Database accession no. 2001:311437 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (BETHESDA, MD, USA); FAULDS ET AL.: "Abciximab (c7E3 Fab). A review of its pharmacology and therapeutic potential in ischaemic heart disease", XP002972617, accession no. STN Database accession no. 95094637 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (BETHESDA, MD, USA); MOUSER ET AL.: "Infliximab: a novel chimeric monoclonal antibody for the treatment of Crohn's disease", XP002972616, accession no. STN Database accession no. 1999367230 *
DATABASE SCISEARCH [online] THOMSON ISI (COLUMBUS, OH, USA); GORFIEN ET AL.: "Growth of NSO cells in protein-free, chemically defined medium", XP002972614, accession no. STN Database accession no. 2000:780843 *
DATABASE SCISEARCH [online] THOMSON ISI (COLUMBUS, OH, USA); ZHOU ET AL.: "Large scale production of recombinant mouse and rat growth hormone by fed-batch GS-NS0 cell cultures", XP002972618, accession no. STN Database accession no. 97:138896 *
DRUGS, vol. 48, no. 4, October 1994 (1994-10-01), pages 583 - 598 *
FRESHNEY R. IAN, 1994, WILEY-LISS, NEW YORK, article "Culture of animal cells", pages: 92 - 93, XP002972613 *
SCRIPTA MEDICA (BRNO), vol. 73, no. 4, 2000, pages 211 - 222 *
See also references of EP1490481A4 *

Also Published As

Publication number Publication date
JP2005512538A (ja) 2005-05-12
CA2470026A1 (fr) 2003-06-26
WO2003052064A2 (fr) 2003-06-26
EP1490481A4 (fr) 2005-12-07
AU2002362130A1 (en) 2003-06-30
EP1490481A2 (fr) 2004-12-29

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