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WO2003055589A3 - Plaque de microtitration pour l'execution en parallele de plusieurs microsyntheses, en particulier a temperatures elevees - Google Patents

Plaque de microtitration pour l'execution en parallele de plusieurs microsyntheses, en particulier a temperatures elevees Download PDF

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Publication number
WO2003055589A3
WO2003055589A3 PCT/EP2002/014763 EP0214763W WO03055589A3 WO 2003055589 A3 WO2003055589 A3 WO 2003055589A3 EP 0214763 W EP0214763 W EP 0214763W WO 03055589 A3 WO03055589 A3 WO 03055589A3
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
high temperatures
microtiter plate
intermediate walls
micro
Prior art date
Application number
PCT/EP2002/014763
Other languages
German (de)
English (en)
Other versions
WO2003055589A2 (fr
Inventor
Jens Albert
Guenter Mayer
Andreas Schober
Alexander Gross
Original Assignee
Inst Physikalische Hochtech Ev
Jens Albert
Guenter Mayer
Andreas Schober
Alexander Gross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Physikalische Hochtech Ev, Jens Albert, Guenter Mayer, Andreas Schober, Alexander Gross filed Critical Inst Physikalische Hochtech Ev
Publication of WO2003055589A2 publication Critical patent/WO2003055589A2/fr
Publication of WO2003055589A3 publication Critical patent/WO2003055589A3/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50857—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using arrays or bundles of open capillaries for holding samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00331—Details of the reactor vessels
    • B01J2219/00333—Closures attached to the reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

L'invention concerne une plaque de microtitration permettant l'exécution simultanée de plusieurs microsynthèses à des températures élevées, cette plaque pouvant être utilisée à l'échelle nanométrique. Ladite plaque doit être conçue de telle sorte que les différentes microchambres de la matrice à microchambres ou nanochambres puissent être hermétiquement fermées et que la fermeture et l'ouverture de ces microchambres, respectivement avant et après une réaction, puissent être automatisées. Selon l'invention, les substances de remplissage se trouvent dans des chambres ouvertes sur le dessus et le dessous, ces chambres étant séparées les unes des autres par des cloisons et pouvant être fermées par des couvercles. La plaque présente, au moins dans la zone des chambres, une structure multicouche étanche et l'épaisseur des cloisons au niveau des ouvertures des chambres est réduite par rapport à leur épaisseur à l'intérieur de celles-ci. Entre les zones de cloison d'épaisseur différente sont formées des arêtes saillantes.
PCT/EP2002/014763 2001-12-31 2002-12-27 Plaque de microtitration pour l'execution en parallele de plusieurs microsyntheses, en particulier a temperatures elevees WO2003055589A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10164575.9 2001-12-31
DE10164575 2001-12-31

Publications (2)

Publication Number Publication Date
WO2003055589A2 WO2003055589A2 (fr) 2003-07-10
WO2003055589A3 true WO2003055589A3 (fr) 2003-11-06

Family

ID=7711206

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/014763 WO2003055589A2 (fr) 2001-12-31 2002-12-27 Plaque de microtitration pour l'execution en parallele de plusieurs microsyntheses, en particulier a temperatures elevees

Country Status (1)

Country Link
WO (1) WO2003055589A2 (fr)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001559A2 (fr) * 1993-07-02 1995-01-12 Evotec Biosystems Gmbh Porte-echantillons et son utilisation
WO1999034920A1 (fr) * 1998-01-12 1999-07-15 Massachusetts Institute Of Technology Procede pour effectuer des dosages microscopiques
US6044981A (en) * 1994-03-07 2000-04-04 The Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
US6157456A (en) * 1997-03-11 2000-12-05 Hvass; Per Cuvette for spectrophotometrical analysis
WO2001014063A1 (fr) * 1999-08-25 2001-03-01 Alphahelix Ab Dispositif et procede permettant de manipuler et de traiter des echantillons et/ou des melanges reactionnels de petit volume
WO2001061054A2 (fr) * 2000-02-18 2001-08-23 Board Of Trustees Of The Leland Stanford Junior University Appareils et procedes de conduite en parallele de reactions sur des microvolumes
US20010036674A1 (en) * 2000-02-23 2001-11-01 Indermuhle Pierre F. Chips having elevated sample surfaces
DE10025698A1 (de) * 2000-05-23 2001-11-29 Merck Patent Gmbh Vorrichtung für die parallele Mikrosynthese
WO2002049763A2 (fr) * 2000-12-18 2002-06-27 Institut für Physikalische Hochtechnologie e.V. Dispositif d'extraction et d'emission de substances liquides
WO2002087760A1 (fr) * 2001-04-30 2002-11-07 Epr Labautomation Ag Procede et dispositif pour stocker et doser de petites quantites de liquide

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001559A2 (fr) * 1993-07-02 1995-01-12 Evotec Biosystems Gmbh Porte-echantillons et son utilisation
US6044981A (en) * 1994-03-07 2000-04-04 The Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
US6157456A (en) * 1997-03-11 2000-12-05 Hvass; Per Cuvette for spectrophotometrical analysis
WO1999034920A1 (fr) * 1998-01-12 1999-07-15 Massachusetts Institute Of Technology Procede pour effectuer des dosages microscopiques
WO2001014063A1 (fr) * 1999-08-25 2001-03-01 Alphahelix Ab Dispositif et procede permettant de manipuler et de traiter des echantillons et/ou des melanges reactionnels de petit volume
WO2001061054A2 (fr) * 2000-02-18 2001-08-23 Board Of Trustees Of The Leland Stanford Junior University Appareils et procedes de conduite en parallele de reactions sur des microvolumes
US20010036674A1 (en) * 2000-02-23 2001-11-01 Indermuhle Pierre F. Chips having elevated sample surfaces
DE10025698A1 (de) * 2000-05-23 2001-11-29 Merck Patent Gmbh Vorrichtung für die parallele Mikrosynthese
WO2002049763A2 (fr) * 2000-12-18 2002-06-27 Institut für Physikalische Hochtechnologie e.V. Dispositif d'extraction et d'emission de substances liquides
WO2002087760A1 (fr) * 2001-04-30 2002-11-07 Epr Labautomation Ag Procede et dispositif pour stocker et doser de petites quantites de liquide

Also Published As

Publication number Publication date
WO2003055589A2 (fr) 2003-07-10

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