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WO2003068150A3 - Methods of treating and diagnosing arthritis - Google Patents

Methods of treating and diagnosing arthritis Download PDF

Info

Publication number
WO2003068150A3
WO2003068150A3 PCT/US2003/003708 US0303708W WO03068150A3 WO 2003068150 A3 WO2003068150 A3 WO 2003068150A3 US 0303708 W US0303708 W US 0303708W WO 03068150 A3 WO03068150 A3 WO 03068150A3
Authority
WO
WIPO (PCT)
Prior art keywords
treating
methods
diagnosing arthritis
diagnosing
arthritis
Prior art date
Application number
PCT/US2003/003708
Other languages
French (fr)
Other versions
WO2003068150A2 (en
Inventor
Christophe O Benoist
Diane J Mathis
Original Assignee
Joslin Diabetes Center Inc
Christophe O Benoist
Diane J Mathis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joslin Diabetes Center Inc, Christophe O Benoist, Diane J Mathis filed Critical Joslin Diabetes Center Inc
Priority to AU2003209049A priority Critical patent/AU2003209049A1/en
Publication of WO2003068150A2 publication Critical patent/WO2003068150A2/en
Publication of WO2003068150A3 publication Critical patent/WO2003068150A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0325—Animal model for autoimmune diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Methods of diagnosing, screening and treating a subject having an autoimmune disorder include evaluating of modulating the alternative pathway of complement activation.
PCT/US2003/003708 2002-02-11 2003-02-06 Methods of treating and diagnosing arthritis WO2003068150A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003209049A AU2003209049A1 (en) 2002-02-11 2003-02-06 Methods of treating and diagnosing arthritis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35604102P 2002-02-11 2002-02-11
US60/356,041 2002-02-11
US35777502P 2002-02-19 2002-02-19
US60/357,775 2002-02-19

Publications (2)

Publication Number Publication Date
WO2003068150A2 WO2003068150A2 (en) 2003-08-21
WO2003068150A3 true WO2003068150A3 (en) 2004-01-08

Family

ID=27737514

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/003708 WO2003068150A2 (en) 2002-02-11 2003-02-06 Methods of treating and diagnosing arthritis

Country Status (2)

Country Link
AU (1) AU2003209049A1 (en)
WO (1) WO2003068150A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9248162B2 (en) 2013-03-14 2016-02-02 Baxalta Incorporated Factor H for treatment of rheumatoid arthritis

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007095154A2 (en) 2006-02-10 2007-08-23 The Brigham And Women's Hospital, Inc. Lectin complement pathway assays and related compositions and methods
US8580735B2 (en) * 2007-02-05 2013-11-12 Apellis Pharmaceuticals, Inc. Local complement inhibition for treatment of complement-mediated disorders
JP7156827B2 (en) * 2018-06-08 2022-10-19 デンカ株式会社 Reagent for measuring complement titer and method for stabilizing measured value of complement titer using the same
EP3771468A1 (en) * 2019-07-31 2021-02-03 Universitätsklinikum Hamburg-Eppendorf C3/c5 convertase assays

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053824A1 (en) * 2000-01-18 2001-07-26 The General Hospital Corporation Mouse model for rheumatoid arthritis
US6319897B1 (en) * 1996-03-13 2001-11-20 John D. Lambris Peptides which inhibit complement activation
US20020081293A1 (en) * 1998-02-20 2002-06-27 Tanox, Inc., Delaware Corporation Inhibitors of complement activation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319897B1 (en) * 1996-03-13 2001-11-20 John D. Lambris Peptides which inhibit complement activation
US20020081293A1 (en) * 1998-02-20 2002-06-27 Tanox, Inc., Delaware Corporation Inhibitors of complement activation
WO2001053824A1 (en) * 2000-01-18 2001-07-26 The General Hospital Corporation Mouse model for rheumatoid arthritis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JI H. ET AL.: "Arthritis critically dependent on innate immune system players", IMMUNITY, vol. 16, February 2002 (2002-02-01), pages 157 - 168, XP002968950 *
MCGRATH Y. ET AL.: "Development of adenovirus vectors encoding rat complement regulators for use in therapy in rodent models of inflammatory diseases", J. IMMUNOL., vol. 163, 1999, pages 6834 - 6840, XP002968951 *
YOSHIDA K. ET AL.: "An immunochemical method for assessing the function of the alternative complement pathway", INT. ARCHS. ALLERGY APPL. IMMUN., vol. 75, 1984, pages 173 - 178 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9248162B2 (en) 2013-03-14 2016-02-02 Baxalta Incorporated Factor H for treatment of rheumatoid arthritis

Also Published As

Publication number Publication date
AU2003209049A8 (en) 2003-09-04
AU2003209049A1 (en) 2003-09-04
WO2003068150A2 (en) 2003-08-21

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