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WO2003000191A3 - Composition comprenant des glycosaminoglycanes et des inhibiteurs d'hyaluronidase destinee au traitement d'articulations arthritiques - Google Patents

Composition comprenant des glycosaminoglycanes et des inhibiteurs d'hyaluronidase destinee au traitement d'articulations arthritiques Download PDF

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Publication number
WO2003000191A3
WO2003000191A3 PCT/US2002/019718 US0219718W WO03000191A3 WO 2003000191 A3 WO2003000191 A3 WO 2003000191A3 US 0219718 W US0219718 W US 0219718W WO 03000191 A3 WO03000191 A3 WO 03000191A3
Authority
WO
WIPO (PCT)
Prior art keywords
hyaluronic acid
composition
hyaluronidase inhibitor
preferred
hyaluronidase
Prior art date
Application number
PCT/US2002/019718
Other languages
English (en)
Other versions
WO2003000191A2 (fr
Inventor
Jonathan Thompson
Anna Gosiewska
Susan Niemiec
Sridevi Dhanaraj
Original Assignee
Depuy
Jonathan Thompson
Anna Gosiewska
Susan Niemiec
Sridevi Dhanaraj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Depuy, Jonathan Thompson, Anna Gosiewska, Susan Niemiec, Sridevi Dhanaraj filed Critical Depuy
Priority to JP2003506637A priority Critical patent/JP2005521629A/ja
Priority to CA002451248A priority patent/CA2451248A1/fr
Priority to EP02739947A priority patent/EP1423081A4/fr
Publication of WO2003000191A2 publication Critical patent/WO2003000191A2/fr
Publication of WO2003000191A3 publication Critical patent/WO2003000191A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne une composition et une méthode de traitement de l'arthrite, ladite composition comprenant au moins un glycosaminoglycane combiné à au moins un inhibiteur d'hyaluronidase. Dans un mode de réalisation préféré, la présente invention concerne une composition et une méthode de traitement de l'arthrite, ladite composition comprenant au moins un glycosaminoglycane qui comprend au moins de l'acide hyaluronique combiné à au moins un inhibiteur d'hyaluronidase sélectionné dans le groupe constitué d'héparane sulfate, de dextrane sulfate et de xylose sulphate. Dans un autre mode de réalisation préféré encore, la présente invention concerne une composition et une méthode de traitement de l'arthrite, ladite composition comprenant de l'acide hyaluronique co-encapsulé avec un inhibiteur d'hyaluronidase présent dans les liposomes. L'acide hyaluronique présent dans la composition confère les propriétés de viscosupplément à l'articulation. La fonction de l'inhibiteur d'hyaluronidase est d'agir en tant qu'un conservateur, et de protéger l'acide hyaluronique contre la dégradation prématurée au niveau de l'articulation. L'encapsulation liposomale et la libération de ladite composition sert de dépôt à libération lente pour l'acide hyaluronique et de l'inhibiteur d'hyaluronidase. Ladite invention concerne par conséquent un moyen d'administration stable et de longue durée d'acide hyaluronique (HA) de poids moléculaire élevé au niveau de l'articulation. L'efficacité thérapeutique de l'acide hyaluronique encapsulé dans le liposome avec l'inhibiteur d'hyaluronidase est supérieur à une simple injection d'acide hyaluronique. La méthode de traitement préférée est une injection intra-articulaire d'un mélange d'acide hyaluronique et d'un inhibiteur d'hyaluronidase, éventuellement encapsulés dans des liposomes. Le traitement est plus efficace que les traitements actuellement disponibles reposant sur le seul HA.
PCT/US2002/019718 2001-06-25 2002-06-20 Composition comprenant des glycosaminoglycanes et des inhibiteurs d'hyaluronidase destinee au traitement d'articulations arthritiques WO2003000191A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2003506637A JP2005521629A (ja) 2001-06-25 2002-06-20 関節炎の関節を治療するためのグリコサミノグリカンとヒアルロニダーゼ阻害剤を含んで成る組成物
CA002451248A CA2451248A1 (fr) 2001-06-25 2002-06-20 Composition comprenant des glycosaminoglycanes et des inhibiteurs d'hyaluronidase destinee au traitement d'articulations arthritiques
EP02739947A EP1423081A4 (fr) 2001-06-25 2002-06-20 Composition comprenant des glycosaminoglycanes et des inhibiteurs d'hyaluronidase destinee au traitement d'articulations arthritiques

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30073401P 2001-06-25 2001-06-25
US60/300,734 2001-06-25
US74102A 2002-06-06 2002-06-06
USDEP-741 2002-06-06

Publications (2)

Publication Number Publication Date
WO2003000191A2 WO2003000191A2 (fr) 2003-01-03
WO2003000191A3 true WO2003000191A3 (fr) 2004-03-11

Family

ID=26668090

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/019718 WO2003000191A2 (fr) 2001-06-25 2002-06-20 Composition comprenant des glycosaminoglycanes et des inhibiteurs d'hyaluronidase destinee au traitement d'articulations arthritiques

Country Status (4)

Country Link
EP (1) EP1423081A4 (fr)
JP (1) JP2005521629A (fr)
CA (1) CA2451248A1 (fr)
WO (1) WO2003000191A2 (fr)

Cited By (1)

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CN109758607A (zh) * 2019-03-08 2019-05-17 宁夏妙朗生物科技有限公司 抵抗透明质酸酶水解的交联透明质酸凝胶

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JP4703948B2 (ja) * 2003-05-20 2011-06-15 丸善製薬株式会社 抗アレルギー剤、抗老化剤及び抗老化用皮膚外用剤
WO2006020994A2 (fr) * 2004-08-13 2006-02-23 Angiotech International Ag Compositions et methodes utilisant de l'acide hyaluronique
ES2747978T3 (es) 2005-10-03 2020-03-12 Mark A Pinsky Liposomas no fosfolipídicos que comprenden ácido hialurónico
AU2013270451B2 (en) * 2005-10-03 2016-05-12 Mark A. Pinsky Compositions and methods for improved skin care
EP2543340A1 (fr) * 2006-05-19 2013-01-09 Trustees Of Boston University Nouveaux polymères hydrophiles utilisés en tant que gels et lubrifiants à usage médical
WO2008139122A2 (fr) * 2007-05-11 2008-11-20 Galderma Research & Development Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations
EP2155154A2 (fr) * 2007-05-11 2010-02-24 Galderma Research & Development Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
ITMI20072348A1 (it) 2007-12-17 2009-06-18 Medichem Srl Metodo per la rigenerazione cellulare di acido ialuronico e relativa composizione cosmetica
JP2011520962A (ja) * 2008-05-19 2011-07-21 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 新規カチオン性脂質を含む方法及び組成物
ITMI20090779A1 (it) * 2009-05-08 2010-11-08 Vitrupharm Srl Composizioni nutrizionali a base di resveratrolo cisteina o suoi derivati o metaboliti e astaxantina
US9402857B2 (en) 2009-07-23 2016-08-02 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using low molecular weight hyaluronic acid and astaxanthin
US9913810B2 (en) 2009-07-23 2018-03-13 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using phospholipids and astaxanthin
US9399047B2 (en) 2009-07-23 2016-07-26 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using phospholipids and roe extract
US9238043B2 (en) 2009-07-23 2016-01-19 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using algae based oils
US9216164B2 (en) 2009-07-23 2015-12-22 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA
US8481072B2 (en) 2009-07-23 2013-07-09 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain
US8557275B2 (en) 2009-07-23 2013-10-15 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA
US8637569B2 (en) 2009-10-22 2014-01-28 Api Genesis, Llc Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds
US9889098B2 (en) * 2009-10-22 2018-02-13 Vizuri Health Sciences Llc Methods of making and using compositions comprising flavonoids
WO2011160146A1 (fr) * 2010-06-23 2011-12-29 Croma-Pharma Gesellschaft M.B.H. Préparation pharmaceutique contenant du dextrane et de l'hyaluronate de sodium pour le traitement de troubles articulaires
US8716204B2 (en) 2010-07-27 2014-05-06 Zimmer, Inc. Synthetic synovial fluid compositions and methods for making the same
ITRM20100614A1 (it) * 2010-11-24 2012-05-25 D M G Italia S R L Preparazioni farmaceutiche dell acido 18 beta glicirretico e/o di suoi derivati per infiltrazioni intrarticolari per il trattamento delle artropatie infiammatorie
FR2991876B1 (fr) 2012-06-13 2014-11-21 Vivacy Lab Composition, en milieu aqueux, comprenant au moins un acide hyaluronique et au moins un sel hydrosoluble de sucrose octasulfate
US20190000874A1 (en) * 2015-08-13 2019-01-03 Newven Sprl Composition for the Treatment of Joint Conditions
DE102016208567A1 (de) * 2016-05-19 2017-11-23 Heraeus Medical Gmbh Polymerlösung zur Viscosupplementation
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WO2000074662A2 (fr) * 1999-06-07 2000-12-14 University Of Sheffield Traitement de l'arthrite

Patent Citations (4)

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US4239754A (en) * 1976-10-23 1980-12-16 Choay, S.A. Liposomes containing heparin and a process for obtaining them
US4743596A (en) * 1987-06-16 1988-05-10 Lapin Alfred R Anti-arthritic preparation
US6232315B1 (en) * 1998-09-28 2001-05-15 Merck & Co., Inc. Method for treating inflammatory diseases by administering a thrombin inhibitor
US6136795A (en) * 1998-11-18 2000-10-24 Omni Nutraceuticals, Inc Dietary regimen of nutritional supplements for relief of symptoms of arthritis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109758607A (zh) * 2019-03-08 2019-05-17 宁夏妙朗生物科技有限公司 抵抗透明质酸酶水解的交联透明质酸凝胶
CN109758607B (zh) * 2019-03-08 2021-07-27 宁夏妙朗生物科技有限公司 抵抗透明质酸酶水解的交联透明质酸凝胶

Also Published As

Publication number Publication date
CA2451248A1 (fr) 2003-01-03
EP1423081A2 (fr) 2004-06-02
WO2003000191A2 (fr) 2003-01-03
EP1423081A4 (fr) 2005-05-25
JP2005521629A (ja) 2005-07-21

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