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WO2003000729A3 - Secreted polypeptide and their use in the treatment of bone disorders - Google Patents

Secreted polypeptide and their use in the treatment of bone disorders Download PDF

Info

Publication number
WO2003000729A3
WO2003000729A3 PCT/US2001/048938 US0148938W WO03000729A3 WO 2003000729 A3 WO2003000729 A3 WO 2003000729A3 US 0148938 W US0148938 W US 0148938W WO 03000729 A3 WO03000729 A3 WO 03000729A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
bone disorders
secreted polypeptide
polypeptide
disorders
Prior art date
Application number
PCT/US2001/048938
Other languages
French (fr)
Other versions
WO2003000729A2 (en
Inventor
Audrey Goddard
William I Wood
Weilan Ye
Zemin Zhang
Original Assignee
Genentech Inc
Audrey Goddard
William I Wood
Weilan Ye
Zemin Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2001/019692 external-priority patent/WO2002000690A2/en
Priority claimed from PCT/US2001/021735 external-priority patent/WO2002008284A2/en
Application filed by Genentech Inc, Audrey Goddard, William I Wood, Weilan Ye, Zemin Zhang filed Critical Genentech Inc
Priority to EP01990229A priority Critical patent/EP1397383A2/en
Priority to AU2002229091A priority patent/AU2002229091A1/en
Publication of WO2003000729A2 publication Critical patent/WO2003000729A2/en
Publication of WO2003000729A3 publication Critical patent/WO2003000729A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention is directed to a novel polypeptide and to nucleic acid molecules encoding that polypeptide. Also provided herein are methods of treating and diagnosing bone disorders.
PCT/US2001/048938 2001-06-20 2001-12-13 Secreted polypeptide and their use in the treatment of bone disorders WO2003000729A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01990229A EP1397383A2 (en) 2001-06-20 2001-12-13 Secreted polypeptide and their use in the treatment of bone disorders
AU2002229091A AU2002229091A1 (en) 2001-06-20 2001-12-13 Secreted polypeptide and their use in the treatment of bone disorders

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
USPCT/US01/19692 2001-06-20
PCT/US2001/019692 WO2002000690A2 (en) 2000-06-23 2001-06-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
USPCT/US01/21735 2001-07-09
PCT/US2001/021735 WO2002008284A2 (en) 2000-07-20 2001-07-09 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis

Publications (2)

Publication Number Publication Date
WO2003000729A2 WO2003000729A2 (en) 2003-01-03
WO2003000729A3 true WO2003000729A3 (en) 2003-03-06

Family

ID=26680506

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/048938 WO2003000729A2 (en) 2001-06-20 2001-12-13 Secreted polypeptide and their use in the treatment of bone disorders

Country Status (3)

Country Link
EP (1) EP1397383A2 (en)
AU (1) AU2002229091A1 (en)
WO (1) WO2003000729A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998054963A2 (en) * 1997-06-06 1998-12-10 Human Genome Sciences, Inc. 207 human secreted proteins
WO2000056889A2 (en) * 1999-03-23 2000-09-28 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2000063382A1 (en) * 1999-04-15 2000-10-26 Osiris Therapeutics, Inc. Genes and expression products from hematopoietic cells
WO2001062891A2 (en) * 2000-02-24 2001-08-30 Human Genome Sciences, Inc. 207 human secreted proteins
WO2002000690A2 (en) * 2000-06-23 2002-01-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998054963A2 (en) * 1997-06-06 1998-12-10 Human Genome Sciences, Inc. 207 human secreted proteins
WO2000056889A2 (en) * 1999-03-23 2000-09-28 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2000063382A1 (en) * 1999-04-15 2000-10-26 Osiris Therapeutics, Inc. Genes and expression products from hematopoietic cells
WO2001062891A2 (en) * 2000-02-24 2001-08-30 Human Genome Sciences, Inc. 207 human secreted proteins
WO2002000690A2 (en) * 2000-06-23 2002-01-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 9 June 2001 (2001-06-09), KUMAR, S. ET AL: "HOA2-G-8 HOA (Human Osteoarthritic Cartilage) Homo sapiens cDNA, mRNA sequence", XP002218581, Database accession no. BG897954 *
KUMAR, S. ET AL.: "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries.", OSTEOARTHRITIS AND CARTILAGE, vol. 9, no. 7, October 2001 (2001-10-01), pages 641 - 53, XP008009844 *

Also Published As

Publication number Publication date
WO2003000729A2 (en) 2003-01-03
EP1397383A2 (en) 2004-03-17
AU2002229091A1 (en) 2003-01-08

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