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WO2003008567A1 - Virus proliferant dans des cellules cancereuses et exprimant efficacement le facteur inhibiteur d'angiogenese tumorale, et utilisations associees - Google Patents

Virus proliferant dans des cellules cancereuses et exprimant efficacement le facteur inhibiteur d'angiogenese tumorale, et utilisations associees Download PDF

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Publication number
WO2003008567A1
WO2003008567A1 PCT/CN2002/000352 CN0200352W WO03008567A1 WO 2003008567 A1 WO2003008567 A1 WO 2003008567A1 CN 0200352 W CN0200352 W CN 0200352W WO 03008567 A1 WO03008567 A1 WO 03008567A1
Authority
WO
WIPO (PCT)
Prior art keywords
tumor
inhibitory factor
angiogenesis inhibitory
tumor cells
expressed efficiently
Prior art date
Application number
PCT/CN2002/000352
Other languages
English (en)
Chinese (zh)
Inventor
Qijun Qian
Xiaoyan Che
Shuntong Shan
Mengchao Wu
Original Assignee
Qijun Qian
Xiaoyan Che
Shuntong Shan
Mengchao Wu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qijun Qian, Xiaoyan Che, Shuntong Shan, Mengchao Wu filed Critical Qijun Qian
Publication of WO2003008567A1 publication Critical patent/WO2003008567A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne un virus proliférant dans des cellules cancéreuses et exprimant efficacement le facteur inhibiteur de l'angiogénèse tumorale, ainsi que des utilisations associées. Le virus peut proliférer dans des cellules cancéreuses, sensiblement limité à ne proliférer que dans ce type de cellules, et tue directement ces cellules par suite de l'insertion dans une région non essentielle de son génome de la séquence nucléotidique du facteur inhibiteur de l'angiogénèse. Le nombre de copies du facteur inhibiteur de l'angiogénèse augmente avec la prolifération du virus se reproduisant dans les cellules cancéreuses. Le facteur inhibiteur de l'angiogénèse est ainsi exprimé de façon efficace dans des cellules cancéreuse et permet d'inhiber l'angiogénèse tumorale, la néoplasie, le développement et les métastases.
PCT/CN2002/000352 2001-05-25 2002-05-24 Virus proliferant dans des cellules cancereuses et exprimant efficacement le facteur inhibiteur d'angiogenese tumorale, et utilisations associees WO2003008567A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN 01113003 CN1397641A (zh) 2001-05-25 2001-05-25 表达血管生成抑制因子的肿瘤细胞内增殖的病毒及其构建方法
CN01113003.2 2001-05-25

Publications (1)

Publication Number Publication Date
WO2003008567A1 true WO2003008567A1 (fr) 2003-01-30

Family

ID=4659748

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2002/000352 WO2003008567A1 (fr) 2001-05-25 2002-05-24 Virus proliferant dans des cellules cancereuses et exprimant efficacement le facteur inhibiteur d'angiogenese tumorale, et utilisations associees

Country Status (2)

Country Link
CN (1) CN1397641A (fr)
WO (1) WO2003008567A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101248912B1 (ko) * 2009-12-31 2013-03-29 한양대학교 산학협력단 항혈관신생 활성을 가지는 재조합 아데노바이러스

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999023105A1 (fr) * 1997-11-03 1999-05-14 Human Genome Sciences, Inc. Vegi, un inhibiteur de l'angiogenese et de la croissance tumorale

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999023105A1 (fr) * 1997-11-03 1999-05-14 Human Genome Sciences, Inc. Vegi, un inhibiteur de l'angiogenese et de la croissance tumorale

Also Published As

Publication number Publication date
CN1397641A (zh) 2003-02-19

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