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WO2003010184A3 - Motif conserve d'interaction de xiap dans la caspase-9 et la proteine smac/diablo pour moduler l'apoptose - Google Patents

Motif conserve d'interaction de xiap dans la caspase-9 et la proteine smac/diablo pour moduler l'apoptose Download PDF

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Publication number
WO2003010184A3
WO2003010184A3 PCT/US2002/003553 US0203553W WO03010184A3 WO 2003010184 A3 WO2003010184 A3 WO 2003010184A3 US 0203553 W US0203553 W US 0203553W WO 03010184 A3 WO03010184 A3 WO 03010184A3
Authority
WO
WIPO (PCT)
Prior art keywords
caspase
diablo
xiap
smac
conserved
Prior art date
Application number
PCT/US2002/003553
Other languages
English (en)
Other versions
WO2003010184A2 (fr
Inventor
Emad S Alnemri
Original Assignee
Univ Jefferson
Emad S Alnemri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jefferson, Emad S Alnemri filed Critical Univ Jefferson
Priority to AU2002253908A priority Critical patent/AU2002253908A1/en
Priority to IL15716802A priority patent/IL157168A0/xx
Publication of WO2003010184A2 publication Critical patent/WO2003010184A2/fr
Publication of WO2003010184A3 publication Critical patent/WO2003010184A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des peptides et des polypeptides associés à la caspase-9 et capables de se fixer à un inhibiteur de protéine d'apoptose (IAP), ainsi qu'un mutant de caspase-9, qui ne subissent pas de traitement normal et ne se fixent pas à une IAP. L'invention concerne en outre des molécules d'acide nucléique, notamment des vecteurs d'expression, qui codent lesdits peptides et polypeptides. Lesdits peptides et polypeptides sont utilisés pour provoquer l'apoptose et identifier des inhibiteurs et des amplificateurs d'apoptose.
PCT/US2002/003553 2001-02-08 2002-02-06 Motif conserve d'interaction de xiap dans la caspase-9 et la proteine smac/diablo pour moduler l'apoptose WO2003010184A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002253908A AU2002253908A1 (en) 2001-02-08 2002-02-06 A conserved xiap-interaction motif in caspase-9 and smac/diablo for mediating apoptosis
IL15716802A IL157168A0 (en) 2001-04-12 2002-03-28 Method and apparatus for measuring the position, shape, size and intensity distribution of the effective focal spot of an x-ray tube

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26796601P 2001-02-08 2001-02-08
US60/267,966 2001-02-08

Publications (2)

Publication Number Publication Date
WO2003010184A2 WO2003010184A2 (fr) 2003-02-06
WO2003010184A3 true WO2003010184A3 (fr) 2003-08-14

Family

ID=23020873

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/003553 WO2003010184A2 (fr) 2001-02-08 2002-02-06 Motif conserve d'interaction de xiap dans la caspase-9 et la proteine smac/diablo pour moduler l'apoptose

Country Status (2)

Country Link
AU (1) AU2002253908A1 (fr)
WO (1) WO2003010184A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8835393B2 (en) 2008-08-02 2014-09-16 Genentech, Inc. Inhibitors of IAP
US8907092B2 (en) 2007-04-30 2014-12-09 Genentech, Inc. Inhibitors of IAP
US9040706B2 (en) 2004-12-20 2015-05-26 Genentech, Inc. Pyrrolidine inhibitors of IAP

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1723122B1 (fr) 2004-03-01 2014-11-19 Board of Regents, The University of Texas System Petites molécules dimères inductrices d'apoptose
CA2558615C (fr) 2004-03-23 2013-10-29 Genentech, Inc. Inhibiteurs azabicyclo-octane de l'iap
NZ588799A (en) 2004-07-02 2012-06-29 Genentech Inc Inhibitors of iap
JP5155184B2 (ja) 2005-12-19 2013-02-27 ジェネンテック， インコーポレイテッド Ｉａｐのインヒビター
US8063218B2 (en) 2006-12-19 2011-11-22 Genentech, Inc. Imidazopyridine inhibitors of IAP

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE PIR [online] 16 July 1999 (1999-07-16), AHRENS C.A. ET AL., XP002962285, Database accession no. (T10375) *
KIPP R.A. ET AL.: "Molecular targeting of inhibitor of apoptosis based on small molecule mimics of natural binding partners", BIOCHEM., vol. 41, 2002, pages 7344 - 7349, XP002962287 *
LIU Z. ET AL.: "Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain", NATURE, vol. 408, no. 21, 28 December 2000 (2000-12-28), pages 1004 - 1008, XP002909550 *
SRINIVASULA S.M. ET AL.: "A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis", NATURE, vol. 410, 1 March 2001 (2001-03-01), pages 112 - 116, XP002962286 *
VIROLOGY, vol. 229, 1997, pages 381 - 399 *
WRIGHT C.W. ET AL.: "Sequence requirements of Hid binding and apoptosis regulation in the Baculovirus inhibitor of apoptosis OP-IAP", J. BIOL. CHEM., vol. 277, no. 4, 25 January 2002 (2002-01-25), pages 2454 - 2462, XP002962288 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9040706B2 (en) 2004-12-20 2015-05-26 Genentech, Inc. Pyrrolidine inhibitors of IAP
US8907092B2 (en) 2007-04-30 2014-12-09 Genentech, Inc. Inhibitors of IAP
US8835393B2 (en) 2008-08-02 2014-09-16 Genentech, Inc. Inhibitors of IAP

Also Published As

Publication number Publication date
AU2002253908A1 (en) 2003-02-17
WO2003010184A2 (fr) 2003-02-06

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