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WO2003015710A3 - Combined drug and csf removal therapies and systems - Google Patents

Combined drug and csf removal therapies and systems Download PDF

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Publication number
WO2003015710A3
WO2003015710A3 PCT/US2002/026435 US0226435W WO03015710A3 WO 2003015710 A3 WO2003015710 A3 WO 2003015710A3 US 0226435 W US0226435 W US 0226435W WO 03015710 A3 WO03015710 A3 WO 03015710A3
Authority
WO
WIPO (PCT)
Prior art keywords
csf
space
systems
implantable
combined drug
Prior art date
Application number
PCT/US2002/026435
Other languages
French (fr)
Other versions
WO2003015710A2 (en
Inventor
Dawn Mcguire
Tom Saul
Denise F Gottfried
Original Assignee
Eunoe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eunoe Inc filed Critical Eunoe Inc
Priority to AU2002313778A priority Critical patent/AU2002313778A1/en
Publication of WO2003015710A2 publication Critical patent/WO2003015710A2/en
Publication of WO2003015710A3 publication Critical patent/WO2003015710A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0233—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
    • A61M3/0254—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped
    • A61M3/0258—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped by means of electric pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/006—Cerebrospinal drainage; Accessories therefor, e.g. valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0464—Cerebrospinal fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • External Artificial Organs (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Diseases and other conditions of the central nervous system are treated by concurrently or sequentially delivering a therapeutic agent to a cerebrospinal fluid (CSF) space and draining CSF from the CSF space. Systems (70) include one or more implantable catheters (52, 60, 66)for accessing the CSF space, typically in a ventricle or lumbar space, in one catheters for draining the CSF to another location, such as the peritoneal cavity. Implantable pumps (54) provided for delivering the therapeutic agent through the CSF space access catheter and implantable flow control mechanisms (64) are provided for controlling the rate and volume of CSF drainage from the CSF space.
PCT/US2002/026435 2001-08-21 2002-08-19 Combined drug and csf removal therapies and systems WO2003015710A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002313778A AU2002313778A1 (en) 2001-08-21 2002-08-19 Combined drug and csf removal therapies and systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31393801P 2001-08-21 2001-08-21
US60/313,938 2001-08-21

Publications (2)

Publication Number Publication Date
WO2003015710A2 WO2003015710A2 (en) 2003-02-27
WO2003015710A3 true WO2003015710A3 (en) 2004-02-12

Family

ID=23217836

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/026435 WO2003015710A2 (en) 2001-08-21 2002-08-19 Combined drug and csf removal therapies and systems

Country Status (2)

Country Link
AU (1) AU2002313778A1 (en)
WO (1) WO2003015710A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11278657B2 (en) 2019-04-11 2022-03-22 Enclear Therapies, Inc. Methods of amelioration of cerebrospinal fluid and devices and systems therefor
US11419921B2 (en) 2018-07-23 2022-08-23 Enclear Therapies, Inc. Methods of treating neurological disorders
US11752200B2 (en) 2018-07-23 2023-09-12 Enclear Therapies Inc. Methods of treating neurological disorders
US12329930B2 (en) 2020-09-29 2025-06-17 Enclear Therapies, Inc. Subarachnoid fluid management method and system

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1324800T3 (en) 2000-09-11 2008-11-10 Csf Dynamics As Liquid hunt system for treatment of hydrocephalus
ES2307396B1 (en) * 2006-09-14 2009-09-30 Fundacion Para Investigaciones Neurologicas (Fin) SYSTEMS FOR THE ELIMINATION OF NEUROTOXIC SUBSTANCES CAUSING NEURODEGENERATIVE DISEASES THROUGH THEIR SELECTIVE ATTACKING BY IMMUNOFINITY IN THE CIRCULATING CEPHALO-RAQUIDEO LIQUID.
US10632237B2 (en) 2006-10-09 2020-04-28 Minnetronix, Inc. Tangential flow filter system for the filtration of materials from biologic fluids
US10850235B2 (en) 2006-10-09 2020-12-01 Minnetronix, Inc. Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow
ES2845146T3 (en) 2006-10-09 2021-07-26 Neurofluidics Inc Cerebrospinal fluid purification system
WO2011114260A1 (en) 2010-03-19 2011-09-22 Pfizer Inc. Cerebrospinal fluid purification system
US20150038948A1 (en) * 2013-07-31 2015-02-05 G-Tech Electronic Research & Development, LLC Apparatus and use of a neurochemisrty regulator device insertable in the cranium for the treatment of cerebral cortical disorders
WO2015049588A2 (en) * 2013-10-01 2015-04-09 Md Start Sa Systems and methods for moving and circulating fluid to treat alzheimer's disease
US11147540B2 (en) 2015-07-01 2021-10-19 Minnetronix, Inc. Introducer sheath and puncture tool for the introduction and placement of a catheter in tissue
EP3714915B1 (en) 2015-08-05 2021-11-03 Minnetronix Inc. Tangential flow filter system for the filtration of materials from biologic fluids
CN108778355B (en) 2015-12-04 2021-04-30 米奈特朗尼克斯有限公司 Systems and methods for regulating cerebrospinal fluid
CN107088257B (en) * 2017-04-27 2023-06-09 哈尔滨医科大学 A Y-type dual-purpose double-cavity and two-bag drainage device
US11559626B2 (en) 2020-04-08 2023-01-24 Medtronic, Inc. Means to treat Alzheimer's disease via flushing of brain parenchyma

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5957912A (en) * 1998-04-16 1999-09-28 Camino Neurocare, Inc. Catheter having distal stylet opening and connector
US6193691B1 (en) * 1999-03-30 2001-02-27 Depuy Orthopaedics, Inc. Catheter system
US6210346B1 (en) * 1989-10-11 2001-04-03 Edwards Lifesciences Corp. Method for inserting an intracranial catheter and for monitoring intracranial pressure in a mammal
US20030135148A1 (en) * 2002-01-14 2003-07-17 Dextradeur Alan J. Multi-catheter insertion device and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6210346B1 (en) * 1989-10-11 2001-04-03 Edwards Lifesciences Corp. Method for inserting an intracranial catheter and for monitoring intracranial pressure in a mammal
US5957912A (en) * 1998-04-16 1999-09-28 Camino Neurocare, Inc. Catheter having distal stylet opening and connector
US6193691B1 (en) * 1999-03-30 2001-02-27 Depuy Orthopaedics, Inc. Catheter system
US20030135148A1 (en) * 2002-01-14 2003-07-17 Dextradeur Alan J. Multi-catheter insertion device and method

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11419921B2 (en) 2018-07-23 2022-08-23 Enclear Therapies, Inc. Methods of treating neurological disorders
US11752200B2 (en) 2018-07-23 2023-09-12 Enclear Therapies Inc. Methods of treating neurological disorders
US11278657B2 (en) 2019-04-11 2022-03-22 Enclear Therapies, Inc. Methods of amelioration of cerebrospinal fluid and devices and systems therefor
US12350416B2 (en) 2019-04-11 2025-07-08 Enclear Therapies, Inc. Methods of amelioration of cerebrospinal fluid and devices and systems therefor
US12329930B2 (en) 2020-09-29 2025-06-17 Enclear Therapies, Inc. Subarachnoid fluid management method and system
US12337140B2 (en) 2020-09-29 2025-06-24 Enclear Therapies, Inc. Subarachnoid fluid management method and system with varying rates

Also Published As

Publication number Publication date
AU2002313778A1 (en) 2003-03-03
WO2003015710A2 (en) 2003-02-27

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