WO2003015810A1 - Usage medical d'un inhibiteur d'histone desacetylase et methode d'evaluation de son activite antitumorale - Google Patents

Usage medical d'un inhibiteur d'histone desacetylase et methode d'evaluation de son activite antitumorale Download PDF

Info

Publication number: WO2003015810A1
Authority: WO; WIPO (PCT)
Prior art keywords: histone deacetylase; deacetylase inhibitor; antitumor effect; medicinal use; evaluating
Prior art date: 2001-08-21

Application number

PCT/JP2002/008355

Other languages

English (en)

French (fr)

Inventor

Yuka Sasakawa

Yoshinori Naoe

Original Assignee

Fujisawa Pharmaceutical Co., Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-21

Filing date

2002-08-20

Publication date

2003-02-27

2002-08-20 Application filed by Fujisawa Pharmaceutical Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.

2002-08-20 Priority to CA002457043A priority Critical patent/CA2457043A1/en

2002-08-20 Priority to JP2003520768A priority patent/JP4238728B2/ja

2002-08-20 Priority to US10/486,833 priority patent/US8470783B2/en

2002-08-20 Priority to DK02760663.1T priority patent/DK1426054T3/da

2002-08-20 Priority to MXPA04001612A priority patent/MXPA04001612A/es

2002-08-20 Priority to HU0400668A priority patent/HU229521B1/hu

2002-08-20 Priority to AT02760663T priority patent/ATE526029T1/de

2002-08-20 Priority to EP02760663A priority patent/EP1426054B1/en

2003-02-27 Publication of WO2003015810A1 publication Critical patent/WO2003015810A1/ja

2004-02-20 Priority to NO20040731A priority patent/NO331682B1/no

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Cell Biology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Food Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
General Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Toxicology (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Hospice & Palliative Care (AREA)

PCT/JP2002/008355 2001-08-21 2002-08-20 Usage medical d'un inhibiteur d'histone desacetylase et methode d'evaluation de son activite antitumorale WO2003015810A1 (fr)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
CA002457043A CA2457043A1 (en)	2001-08-21	2002-08-20	Medicinal use of histone deacetylase inhibitor and method of evaluating antitumor effect thereof
JP2003520768A JP4238728B2 (ja)	2001-08-21	2002-08-20	ヒストンデアセチラーゼ阻害剤の医薬用途ならびにその抗腫瘍効果の評価方法
US10/486,833 US8470783B2 (en)	2001-08-21	2002-08-20	Medicinal use of histone deacetylase inhibitor and method of evaluating antitumor effect thereof
DK02760663.1T DK1426054T3 (da)	2001-08-21	2002-08-20	Medicinsk anvendelse af histon-deacetylase-inhibitor og fremgangsmåde til evaluering af antitumor virkning deraf
MXPA04001612A MXPA04001612A (es)	2001-08-21	2002-08-20	Uso medicinal de inhibidor de la histona desacetilasa y metodo para evaluar el efecto antitumoral del mismo.
HU0400668A HU229521B1 (hu)	2001-08-21	2002-08-20	A hiszton-dezacetiláz inhibitor gyógyászati alkalmazása, és eljárás tumorellenes hatásának kiértékelésére
AT02760663T ATE526029T1 (de)	2001-08-21	2002-08-20	Medizinische verwendung eines histon-deacetylase- hemmers und verfahren zur beurteilung seiner antitumoralen wirkung
EP02760663A EP1426054B1 (en)	2001-08-21	2002-08-20	Medicinal use of histone deacetylase inhibitor and method of evaluating antitumor effect thereof
NO20040731A NO331682B1 (no)	2001-08-21	2004-02-20	Medisinsk anvendelse av histon-deacetylase inhibitor.

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2001-250846		2001-08-21
JP2001250846		2001-08-21

Publications (1)

Publication Number	Publication Date
WO2003015810A1 true WO2003015810A1 (fr)	2003-02-27

Family

ID=19079582

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP2002/008355 WO2003015810A1 (fr)	2001-08-21	2002-08-20	Usage medical d'un inhibiteur d'histone desacetylase et methode d'evaluation de son activite antitumorale

Country Status (14)

Country	Link
US (1)	US8470783B2 (ja)
EP (1)	EP1426054B1 (ja)
JP (1)	JP4238728B2 (ja)
AT (1)	ATE526029T1 (ja)
CA (1)	CA2457043A1 (ja)
DK (1)	DK1426054T3 (ja)
ES (1)	ES2371630T3 (ja)
HU (1)	HU229521B1 (ja)
MX (1)	MXPA04001612A (ja)
NO (1)	NO331682B1 (ja)
PL (1)	PL210794B1 (ja)
PT (1)	PT1426054E (ja)
RU (1)	RU2298414C2 (ja)
WO (1)	WO2003015810A1 (ja)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005000332A3 (en) *	2003-06-27	2005-03-24	Fujisawa Pharmaceutical Co	Therapeutic agent for soft tissue sarcoma
WO2005059167A1 (en) *	2003-12-18	2005-06-30	Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa	Method for identifying histone deacetylase inhibitors
WO2005058298A3 (en) *	2003-12-10	2005-11-10	Wisconsin Alumni Res Found	Fk228 analogs and their use as hdac-inhibitors
WO2005079827A3 (en) *	2004-02-25	2005-12-08	Astellas Pharma Inc	Antitumor agent
JP2006000113A (ja) *	2004-05-20	2006-01-05	Masatomo Sakurai	漢方医療の診断に用いる遺伝子およびその利用方法
US7154002B1 (en)	2002-10-08	2006-12-26	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7169801B2 (en)	2003-03-17	2007-01-30	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7314862B2 (en) *	2003-09-25	2008-01-01	Astellas Pharma Inc.	Antitumor agent
US7642253B2 (en)	2005-05-11	2010-01-05	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7642275B2 (en)	2004-12-16	2010-01-05	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7732475B2 (en)	2005-07-14	2010-06-08	Takeda San Diego, Inc.	Histone deacetylase inhibitors
KR101167601B1 (ko) *	2004-02-25	2012-07-27	아스텔라스세이야쿠 가부시키가이샤	항종양제
US8691534B2 (en)	2006-12-29	2014-04-08	Celgene Corporation	Preparation of romidepsin
US8859502B2 (en)	2010-09-13	2014-10-14	Celgene Corporation	Therapy for MLL-rearranged leukemia
US8957027B2 (en)	2006-06-08	2015-02-17	Celgene Corporation	Deacetylase inhibitor therapy
US8980825B2 (en)	2010-07-12	2015-03-17	Celgene Corporation	Romidepsin solid forms and uses thereof
US9101579B2 (en)	2012-11-14	2015-08-11	Celgene Corporation	Inhibition of drug resistant cancer cells
US9134325B2 (en)	2012-09-07	2015-09-15	Celgene Corporation	Resistance biomarkers for HDAC inhibitors
US9463215B2 (en)	2013-12-27	2016-10-11	Celgene Corporation	Romidepsin formulations and uses thereof
US9539303B2 (en)	2006-04-24	2017-01-10	Celgene Corporation	Treatment of Ras-expressing tumors

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CN1649645A (zh) *	2002-04-05	2005-08-03	藤泽药品工业株式会社	用于治疗肾癌的缩酚肽
JPWO2004074478A1 (ja) *	2003-02-19	2006-06-01	アステラス製薬株式会社	ヒストンデアセチラーゼ阻害剤の抗腫瘍効果の予測方法
US20050187148A1 (en) *	2004-02-25	2005-08-25	Yoshinori Naoe	Antitumor agent
NZ599464A (en)	2005-02-03	2014-03-28	Topotarget Uk Ltd	Combination therapies using hdac inhibitors
US7604939B2 (en)	2005-03-01	2009-10-20	The Regents Of The University Of Michigan	Methods of identifying active BRM expression-promoting HDAC inhibitors
ATE542527T1 (de)	2005-05-13	2012-02-15	Topotarget Uk Ltd	Pharmazeutische formulierungen von hdac-hemmern
JP2009504751A (ja) *	2005-08-19	2009-02-05	アメリカ合衆国	ヒストンデアセチラーゼ阻害薬の局所製剤及びその使用方法
JP5377968B2 (ja)	2005-11-10	2013-12-25	トポターゲットユーケーリミテッド	癌治療のために単独で用いるまたは化学療法薬と併用するヒストンデアセチラーゼ（ｈｄａｃ）阻害剤
AU2006318652A1 (en) *	2005-11-18	2007-05-31	Gloucester Pharmaceuticals, Inc.	Metabolite derivatives of the HDAC inhibitor FK228
DK2099442T3 (en)	2006-12-26	2015-02-16	Pharmacyclics Inc	Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
WO2008083290A1 (en) *	2006-12-29	2008-07-10	Gloucester Pharmaceuticals, Inc.	Romidepsin-based treatments for cancer
AU2008210421B2 (en)	2007-01-30	2014-03-13	Pharmacyclics Llc	Methods for determining cancer resistance to histone deacetylase inhibitors
WO2009040517A2 (en)	2007-09-25	2009-04-02	Topotarget Uk Limited	Methods of synthesis of certain hydroxamic acid compounds
NZ621221A (en)	2011-09-13	2016-07-29	Pharmacyclics Llc	Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof

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EP1010705A1 (en) *	1997-09-02	2000-06-21	Japan Energy Corporation	Novel cyclic tetrapeptide derivatives and medicinal use thereof
JP2001348340A (ja) *	2000-06-07	2001-12-18	Yamanouchi Pharmaceut Co Ltd	ヒストン脱アセチル化酵素阻害剤

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JP4661782B2 (ja)	2003-06-27	2011-03-30	アステラス製薬株式会社	軟部肉腫治療剤
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2002
- 2002-08-20 US US10/486,833 patent/US8470783B2/en not_active Expired - Lifetime
- 2002-08-20 RU RU2004108137/15A patent/RU2298414C2/ru not_active IP Right Cessation
- 2002-08-20 WO PCT/JP2002/008355 patent/WO2003015810A1/ja active Application Filing
- 2002-08-20 CA CA002457043A patent/CA2457043A1/en not_active Abandoned
- 2002-08-20 ES ES02760663T patent/ES2371630T3/es not_active Expired - Lifetime
- 2002-08-20 AT AT02760663T patent/ATE526029T1/de active
- 2002-08-20 EP EP02760663A patent/EP1426054B1/en not_active Expired - Lifetime
- 2002-08-20 PT PT02760663T patent/PT1426054E/pt unknown
- 2002-08-20 PL PL368708A patent/PL210794B1/pl unknown
- 2002-08-20 JP JP2003520768A patent/JP4238728B2/ja not_active Expired - Lifetime
- 2002-08-20 HU HU0400668A patent/HU229521B1/hu not_active IP Right Cessation
- 2002-08-20 DK DK02760663.1T patent/DK1426054T3/da active
- 2002-08-20 MX MXPA04001612A patent/MXPA04001612A/es active IP Right Grant
2004
- 2004-02-20 NO NO20040731A patent/NO331682B1/no not_active IP Right Cessation

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EP1010705A1 (en) *	1997-09-02	2000-06-21	Japan Energy Corporation	Novel cyclic tetrapeptide derivatives and medicinal use thereof
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Cited By (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7154002B1 (en)	2002-10-08	2006-12-26	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7399884B2 (en)	2002-10-08	2008-07-15	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7381825B2 (en)	2003-03-17	2008-06-03	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7375228B2 (en)	2003-03-17	2008-05-20	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7169801B2 (en)	2003-03-17	2007-01-30	Takeda San Diego, Inc.	Histone deacetylase inhibitors
JP2007521259A (ja) *	2003-06-27	2007-08-02	アステラス製薬株式会社	軟部肉腫治療剤
EP2238982A3 (en) *	2003-06-27	2011-03-02	Astellas Pharma Inc.	Therapeutic agent for soft tissue sarcoma
WO2005000332A3 (en) *	2003-06-27	2005-03-24	Fujisawa Pharmaceutical Co	Therapeutic agent for soft tissue sarcoma
US7056883B2 (en)	2003-06-27	2006-06-06	Astellas Pharma Inc.	Therapeutic agent for soft tissue sarcoma
US7314862B2 (en) *	2003-09-25	2008-01-01	Astellas Pharma Inc.	Antitumor agent
WO2005058298A3 (en) *	2003-12-10	2005-11-10	Wisconsin Alumni Res Found	Fk228 analogs and their use as hdac-inhibitors
WO2005059167A1 (en) *	2003-12-18	2005-06-30	Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa	Method for identifying histone deacetylase inhibitors
WO2005079827A3 (en) *	2004-02-25	2005-12-08	Astellas Pharma Inc	Antitumor agent
US8822422B2 (en)	2004-02-25	2014-09-02	Astellas Pharma Inc.	Antitumor agent
KR101167601B1 (ko) *	2004-02-25	2012-07-27	아스텔라스세이야쿠 가부시키가이샤	항종양제
US7951780B2 (en)	2004-02-25	2011-05-31	Astellas Pharma Inc.	Antitumor agent
JP2006000113A (ja) *	2004-05-20	2006-01-05	Masatomo Sakurai	漢方医療の診断に用いる遺伝子およびその利用方法
US7642275B2 (en)	2004-12-16	2010-01-05	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7642253B2 (en)	2005-05-11	2010-01-05	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7741494B2 (en)	2005-07-14	2010-06-22	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7732475B2 (en)	2005-07-14	2010-06-08	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US9539303B2 (en)	2006-04-24	2017-01-10	Celgene Corporation	Treatment of Ras-expressing tumors
US8957027B2 (en)	2006-06-08	2015-02-17	Celgene Corporation	Deacetylase inhibitor therapy
US9259452B2 (en)	2006-06-08	2016-02-16	Gelgene Corporation	Deacetylase inhibitor therapy
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Publication number	Publication date
HUP0400668A3 (en)	2012-09-28
EP1426054B1 (en)	2011-09-28
US20050191713A1 (en)	2005-09-01
RU2298414C2 (ru)	2007-05-10
PL210794B1 (pl)	2012-03-30
RU2004108137A (ru)	2005-05-10
ES2371630T3 (es)	2012-01-05
NO331682B1 (no)	2012-02-20
EP1426054A1 (en)	2004-06-09
JPWO2003015810A1 (ja)	2004-12-02
PL368708A1 (en)	2005-04-04
HUP0400668A2 (hu)	2005-01-28
HU229521B1 (hu)	2014-01-28
NO20040731L (no)	2004-04-20
CA2457043A1 (en)	2003-02-27
JP4238728B2 (ja)	2009-03-18
PT1426054E (pt)	2011-12-06
DK1426054T3 (da)	2011-12-12
MXPA04001612A (es)	2004-07-08
ATE526029T1 (de)	2011-10-15
US8470783B2 (en)	2013-06-25
EP1426054A4 (en)	2006-09-13

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