WO2003018590A1 - Process for producing thienopyridine derivative - Google Patents
Process for producing thienopyridine derivative Download PDFInfo
- Publication number
- WO2003018590A1 WO2003018590A1 PCT/JP2002/008445 JP0208445W WO03018590A1 WO 2003018590 A1 WO2003018590 A1 WO 2003018590A1 JP 0208445 W JP0208445 W JP 0208445W WO 03018590 A1 WO03018590 A1 WO 03018590A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ring
- producing
- salt
- formula
- derivative
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical class C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
A process for industrially advantageously producing either a thienopyridine derivative represented by the formula (V) (wherein G is halogeno, hydroxy, etc.; X is lower alkylene, etc.; n is 2 to 4; Y is oxygen or optionally oxidized sulfur; ring A is an optionally substituted benzene ring; and ring B is a five- to eight-membered ring) or a salt of the derivative, which comprises causing a compound represented by the formula (IV) (IV) (wherein R is hydrogen or lower alkyl and the other symbols have the same meanings as defined above) or a salt thereof to undergo ring closure in the presence of a base.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001254598 | 2001-08-24 | ||
| JP2001-254598 | 2001-08-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2003018590A1 true WO2003018590A1 (en) | 2003-03-06 |
Family
ID=19082740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2002/008445 WO2003018590A1 (en) | 2001-08-24 | 2002-08-22 | Process for producing thienopyridine derivative |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2003018590A1 (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996014319A1 (en) * | 1994-11-08 | 1996-05-17 | Takeda Chemical Industries, Ltd. | Thienopyridine or thienopyrimidine derivatives and their use |
| WO1997040050A1 (en) * | 1996-04-25 | 1997-10-30 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives and their use |
| WO1999065916A1 (en) * | 1998-06-15 | 1999-12-23 | Takeda Chemical Industries, Ltd. | Thienodipyridine derivatives, production and use thereof |
| WO2000016776A1 (en) * | 1998-09-18 | 2000-03-30 | Takeda Chemical Industries, Ltd. | Sustained release oral preparations |
| WO2001064685A2 (en) * | 2000-02-29 | 2001-09-07 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives and their use as anti-inflammatory agents |
-
2002
- 2002-08-22 WO PCT/JP2002/008445 patent/WO2003018590A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996014319A1 (en) * | 1994-11-08 | 1996-05-17 | Takeda Chemical Industries, Ltd. | Thienopyridine or thienopyrimidine derivatives and their use |
| WO1997040050A1 (en) * | 1996-04-25 | 1997-10-30 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives and their use |
| WO1999065916A1 (en) * | 1998-06-15 | 1999-12-23 | Takeda Chemical Industries, Ltd. | Thienodipyridine derivatives, production and use thereof |
| WO2000016776A1 (en) * | 1998-09-18 | 2000-03-30 | Takeda Chemical Industries, Ltd. | Sustained release oral preparations |
| WO2001064685A2 (en) * | 2000-02-29 | 2001-09-07 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives and their use as anti-inflammatory agents |
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