[go: up one dir, main page]

WO2003030965A3 - Noeud lymphatique artificiel - Google Patents

Noeud lymphatique artificiel Download PDF

Info

Publication number
WO2003030965A3
WO2003030965A3 PCT/DE2002/003465 DE0203465W WO03030965A3 WO 2003030965 A3 WO2003030965 A3 WO 2003030965A3 DE 0203465 W DE0203465 W DE 0203465W WO 03030965 A3 WO03030965 A3 WO 03030965A3
Authority
WO
WIPO (PCT)
Prior art keywords
lymph node
module
artificial lymph
antigen
artificial
Prior art date
Application number
PCT/DE2002/003465
Other languages
German (de)
English (en)
Other versions
WO2003030965A2 (fr
Inventor
Martin Scholz
Original Assignee
Martin Scholz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Martin Scholz filed Critical Martin Scholz
Priority to DE10294532T priority Critical patent/DE10294532D2/de
Priority to AU2002349265A priority patent/AU2002349265A1/en
Publication of WO2003030965A2 publication Critical patent/WO2003030965A2/fr
Publication of WO2003030965A3 publication Critical patent/WO2003030965A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/20—Pathogenic agents
    • A61M2202/203—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/20—Pathogenic agents
    • A61M2202/206—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne un noeud lymphatique artificiel, constitué d'un module pourvu d'un orifice d'entrée et d'un orifice de sortie. Dans ce module, un complexe qui est constitué d'une cellule présentant l'antigène, du MHC et de l'antigène sont immobilisés sur un support. Le module selon l'invention peut être utilisé chez des patients (cas cliniques) présentant une réponse immunitaire cellulaire défaillante vis-à-vis, par exemple, d'agents infectieux viraux ou bactériens ou d'antigènes tumoraux.
PCT/DE2002/003465 2001-09-27 2002-09-16 Noeud lymphatique artificiel WO2003030965A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE10294532T DE10294532D2 (de) 2001-09-27 2002-09-16 Künstlicher Lymphknoten
AU2002349265A AU2002349265A1 (en) 2001-09-27 2002-09-16 Artificial lymph node

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10147639 2001-09-27
DE10147639.6 2001-09-27

Publications (2)

Publication Number Publication Date
WO2003030965A2 WO2003030965A2 (fr) 2003-04-17
WO2003030965A3 true WO2003030965A3 (fr) 2004-04-01

Family

ID=7700471

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2002/003465 WO2003030965A2 (fr) 2001-09-27 2002-09-16 Noeud lymphatique artificiel

Country Status (3)

Country Link
AU (1) AU2002349265A1 (fr)
DE (1) DE10294532D2 (fr)
WO (1) WO2003030965A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7576260B2 (en) * 2004-05-27 2009-08-18 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
ATE449161T1 (de) * 2004-03-04 2009-12-15 Leukocare Ag Leukozytenstimulations-matrix
US20090280563A1 (en) * 2005-12-12 2009-11-12 Riken Method for production of antigen-specific hybridoma using artificial lymph node with good efficiency
US9227005B2 (en) * 2013-03-14 2016-01-05 Brian J LeBerthon Method and device for treating cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020185A1 (fr) * 1992-04-01 1993-10-14 Steinman Ralph M Procede permettant de faire proliferer in vitro des precurseurs de cellules dendritiques et utilisation de celles-ci pour produire des immunogenes
WO1997003186A2 (fr) * 1995-07-12 1997-01-30 Activated Cell Therapy, Inc. Procede de proliferation in vitro de cellules dendritiques, contenant les cellules piegees dans une matrice tridimensionnelle et utilisation en immunisation
WO2000027999A2 (fr) * 1998-11-12 2000-05-18 Cell Science Therapeutics, Inc. Production de cellules lymphoides specifiques d'un tissu a partir de cellules souches hematopoietiques se trouvant dans des dispositifs tridimensionnels

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020185A1 (fr) * 1992-04-01 1993-10-14 Steinman Ralph M Procede permettant de faire proliferer in vitro des precurseurs de cellules dendritiques et utilisation de celles-ci pour produire des immunogenes
WO1997003186A2 (fr) * 1995-07-12 1997-01-30 Activated Cell Therapy, Inc. Procede de proliferation in vitro de cellules dendritiques, contenant les cellules piegees dans une matrice tridimensionnelle et utilisation en immunisation
WO2000027999A2 (fr) * 1998-11-12 2000-05-18 Cell Science Therapeutics, Inc. Production de cellules lymphoides specifiques d'un tissu a partir de cellules souches hematopoietiques se trouvant dans des dispositifs tridimensionnels

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BANCHEREAU J & STEINMAN R M: "Dendritic cells and the control of immunity", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 392, no. 6673, 19 March 1998 (1998-03-19), pages 245 - 252, XP002134557, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
AU2002349265A1 (en) 2003-04-22
WO2003030965A2 (fr) 2003-04-17
DE10294532D2 (de) 2004-08-26

Similar Documents

Publication Publication Date Title
DE60238471D1 (de) Proteosom-liposaccharid-vakzine-adjuvans
ATE306939T1 (de) Mehrstufiger kaskade-erhöhungsimpfstoff
WO2006037979A3 (fr) Nanoparticules comprenant des antigenes et des adjuvants et structures immunogenes
WO2000000616A3 (fr) Vaccin contre le virus de marburg
NO972082D0 (no) Ostomioppsamlingssystem
IL193376A0 (en) Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
CY1106400T1 (el) Συνθεση και μεθοδος ανοσοθepαπειας με καρκινικο αντιγονο
WO2003063899A3 (fr) Adjuvant de vaccin
TR199900656T2 (xx) �ndanonlar ile 262 ve 20S proteazomun engellenmesi.
WO2002008755A3 (fr) Identification de groupes d'antigenes permettant de controler l'etat general d'un systeme immunitaire
WO2003030965A3 (fr) Noeud lymphatique artificiel
WO1999064464A3 (fr) Procede de production ou d'amelioration d'une reponse des lymphocytes t contre une cellule cible a l'aide d'un complexe comprenant une molecule hla de classe i et un dispositif d'attache
WO1997011667A3 (fr) Utilisation therapeutique de serums d'animaux, en particulier du cheval, pour le traitement du sida, du cancer et d'autres maladies virales et bacteriennes
GB2376687B (en) Herpes viruses for immune modulation
WO2001040473A3 (fr) Antigenes de pseudomonas aeruginosa
BRPI0412913A (pt) meio para tratamento de infecções por leishmaniose
EP1211311A3 (fr) Lymphocytes activés issus du sang de cordon ombilical et compositions contenant ces lymphocytes
WO2003076570A3 (fr) Antigenes et leur utilisation comme agents diagnostiques et vaccins contre les especes de plasmodium
WO2003050135A3 (fr) Utilisation de proteine b2l de parapox pour modifier les reponses immunes a des antigenes administres
WO2002079396A3 (fr) Production de porteurs biologiques pour l'induction de reponses immunitaires et l'inhibition de la replication virale
WO2003054176A3 (fr) Preparation de vaccins reposant sur l'utilisation de photosensibilisant et de lumiere
CY1112424T1 (el) Πυρηνικο οξυ και αντιστοιχη πρωτεϊνη με τιτλο 238ρ1β2 χρησιμα στην αγωγη και ανιχνευση του καρκινου
AU2002303442A1 (en) Methods of mhc class ii epitope mapping, detection of autoimmune t cells and antigens, and autoimmune treatment
UA31071A (uk) Спосіб визначення рівня пошкодження лейкоцитів
UA67259A (en) Strain pestivirus bovine viraldiarrhoea "bk-1" for the preparation of vaccines and diagnosticums

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VC VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG US

121 Ep: the epo has been informed by wipo that ep was designated in this application
REF Corresponds to

Ref document number: 10294532

Country of ref document: DE

Date of ref document: 20040826

Kind code of ref document: P

WWE Wipo information: entry into national phase

Ref document number: 10294532

Country of ref document: DE

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Ref document number: JP