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WO2003033709A3 - Regulation of human serine/threonine protein kinase - Google Patents

Regulation of human serine/threonine protein kinase Download PDF

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Publication number
WO2003033709A3
WO2003033709A3 PCT/EP2002/011551 EP0211551W WO03033709A3 WO 2003033709 A3 WO2003033709 A3 WO 2003033709A3 EP 0211551 W EP0211551 W EP 0211551W WO 03033709 A3 WO03033709 A3 WO 03033709A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein kinase
threonine protein
human serine
regulation
reagents
Prior art date
Application number
PCT/EP2002/011551
Other languages
French (fr)
Other versions
WO2003033709A2 (en
Inventor
Zhimin Zhu
Original Assignee
Bayer Healthcare Ag
Zhimin Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Zhimin Zhu filed Critical Bayer Healthcare Ag
Publication of WO2003033709A2 publication Critical patent/WO2003033709A2/en
Publication of WO2003033709A3 publication Critical patent/WO2003033709A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01037—Protein kinase (2.7.1.37)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents that regulate human serine/threonine protein kinase and reagents which bind to human serine/threonine protein kinase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, diabetes, CNS disorders or COPD.
PCT/EP2002/011551 2001-10-17 2002-10-16 Regulation of human serine/threonine protein kinase WO2003033709A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32950201P 2001-10-17 2001-10-17
US60/329,502 2001-10-17

Publications (2)

Publication Number Publication Date
WO2003033709A2 WO2003033709A2 (en) 2003-04-24
WO2003033709A3 true WO2003033709A3 (en) 2003-12-24

Family

ID=23285715

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/011551 WO2003033709A2 (en) 2001-10-17 2002-10-16 Regulation of human serine/threonine protein kinase

Country Status (1)

Country Link
WO (1) WO2003033709A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020243623A1 (en) * 2019-05-31 2020-12-03 The Council Of The Queensland Institute Of Medical Research Activating anti-gal9 binding molecules
WO2020237320A1 (en) * 2019-05-31 2020-12-03 The Council Of The Queensland Institute Of Medical Research Anti-gal9 immune-inhibiting binding molecules

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0894863A1 (en) * 1997-07-28 1999-02-03 Smithkline Beecham Corporation A YAK-1 related serine/threonine protein kinase-HTLAR33
WO2001029564A1 (en) * 1999-10-15 2001-04-26 Human Genome Sciences, Inc. Protein tyrosine kinase receptor polynucleotides, polypeptides, and antibodies
WO2002022660A2 (en) * 2000-09-11 2002-03-21 Hyseq, Inc. Novel nucleic acids and polypeptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0894863A1 (en) * 1997-07-28 1999-02-03 Smithkline Beecham Corporation A YAK-1 related serine/threonine protein kinase-HTLAR33
WO2001029564A1 (en) * 1999-10-15 2001-04-26 Human Genome Sciences, Inc. Protein tyrosine kinase receptor polynucleotides, polypeptides, and antibodies
WO2002022660A2 (en) * 2000-09-11 2002-03-21 Hyseq, Inc. Novel nucleic acids and polypeptides

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 2 July 2001 (2001-07-02), XP002256102, Database accession no. AAD03990 *
DATABASE EMBL [online] 27 June 2002 (2002-06-27), XP002256103, Database accession no. ABB97344 *
LUMENG CAREY ET AL: "Interactions between beta2-syntrophin and a family of microtubule-associated serine/threonine kinases.", NATURE NEUROSCIENCE, vol. 2, no. 7, July 1999 (1999-07-01), pages 611 - 617, XP002256003, ISSN: 1097-6256 *
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. XI. THE COMPLETE SEQUENCES OF 100 NEW CDNA CLONES FROM BRAIN WHICH CODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 5, 1998, pages 277 - 286, XP000828191, ISSN: 1340-2838 *
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. XIII. THE COMPLETE SEQUENCES OF 100 NEW CDNA CLONES FROM BRAIN WHICH CODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 6, 1999, pages 63 - 70, XP001000446, ISSN: 1340-2838 *

Also Published As

Publication number Publication date
WO2003033709A2 (en) 2003-04-24

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