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WO2003035619A8 - Inhibiteurs de la tyrosine kinase - Google Patents

Inhibiteurs de la tyrosine kinase

Info

Publication number
WO2003035619A8
WO2003035619A8 PCT/US2002/033962 US0233962W WO03035619A8 WO 2003035619 A8 WO2003035619 A8 WO 2003035619A8 US 0233962 W US0233962 W US 0233962W WO 03035619 A8 WO03035619 A8 WO 03035619A8
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
tyrosine kinase
kinase inhibitors
present
receptor
Prior art date
Application number
PCT/US2002/033962
Other languages
English (en)
Other versions
WO2003035619A1 (fr
Inventor
B Wesley Trotter
Original Assignee
Merck & Co Inc
B Wesley Trotter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, B Wesley Trotter filed Critical Merck & Co Inc
Publication of WO2003035619A1 publication Critical patent/WO2003035619A1/fr
Publication of WO2003035619A8 publication Critical patent/WO2003035619A8/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des composés capables d'inhiber, de moduler et/ou de réguler la transduction de signal de la tyrosine kinase de type récepteur et de type non récepteur. Les composés de la présente invention possèdent une structure de base comprenant un 2-carboxamidopyrrole. La présente invention concerne également des sels de qualité pharmaceutique, des hydrates et des stéréo-isomères de ces composés.
PCT/US2002/033962 2001-10-25 2002-10-21 Inhibiteurs de la tyrosine kinase WO2003035619A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34300001P 2001-10-25 2001-10-25
US60/343,000 2001-10-25

Publications (2)

Publication Number Publication Date
WO2003035619A1 WO2003035619A1 (fr) 2003-05-01
WO2003035619A8 true WO2003035619A8 (fr) 2003-07-03

Family

ID=23344243

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/033962 WO2003035619A1 (fr) 2001-10-25 2002-10-21 Inhibiteurs de la tyrosine kinase

Country Status (1)

Country Link
WO (1) WO2003035619A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946278B2 (en) 2007-02-07 2015-02-03 Glaxosmithkline Llc Inhibitors of AkT activity

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1926996B1 (fr) 2005-09-20 2011-11-09 OSI Pharmaceuticals, Inc. Marqueurs biologiques prédictifs d'une réaction anticancéreuse aux inhibiteurs kinase du récepteur du facteur de croissance 1 analogue à l'insuline
EP2400985A2 (fr) 2009-02-25 2012-01-04 OSI Pharmaceuticals, LLC Thérapie anti-cancer combinée
US20110171124A1 (en) 2009-02-26 2011-07-14 Osi Pharmaceuticals, Inc. In situ methods for monitoring the EMT status of tumor cells in vivo
EP2401613A2 (fr) 2009-02-27 2012-01-04 OSI Pharmaceuticals, LLC Méthodes d'identification d'agents qui inhibent les cellules cancéreuses mésenchymateuses ou leur formation
JP2012519281A (ja) 2009-02-27 2012-08-23 オーエスアイ・ファーマシューティカルズ,エルエルシー 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
WO2010099138A2 (fr) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Procédés pour l'identification d'agents qui inhibent les cellules tumorales de type mésenchymateuses ou leur formation
US20100316639A1 (en) 2009-06-16 2010-12-16 Genentech, Inc. Biomarkers for igf-1r inhibitor therapy
AU2011223643A1 (en) 2010-03-03 2012-06-28 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
EP2542893A2 (fr) 2010-03-03 2013-01-09 OSI Pharmaceuticals, LLC Marqueurs biologiques prédictifs d'une réponse anticancéreuse aux inhibiteurs de kinase du récepteur du facteur de croissance insulinique 1
EP2544672A1 (fr) 2010-03-09 2013-01-16 OSI Pharmaceuticals, LLC Thérapie anticancéreuse combinatoire
WO2012116040A1 (fr) 2011-02-22 2012-08-30 OSI Pharmaceuticals, LLC Marqueurs biologiques prédictifs d'une réponse anticancéreuse aux inhibiteurs de la kinase du récepteur du facteur de croissance 1 analogue à l'insuline dans le carcinome hépatocellulaire
EP2702173A1 (fr) 2011-04-25 2014-03-05 OSI Pharmaceuticals, LLC Utilisation de signatures de gènes de tem dans la découverte de médicaments contre le cancer, diagnostics et traitement du cancer
WO2013152252A1 (fr) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Polythérapie antinéoplasique
WO2014134202A1 (fr) 2013-02-26 2014-09-04 Triact Therapeutics, Inc. Cancérothérapie
WO2015035410A1 (fr) 2013-09-09 2015-03-12 Triact Therapeutic, Inc. Traitement du cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010108063A (ko) * 1998-12-31 2001-12-07 수젠, 인크. 단백질 인산화 효소의 조절 및 암의 화학적 치료를 위한3-헤테로아릴리데닐-2-인돌리논 화합물

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946278B2 (en) 2007-02-07 2015-02-03 Glaxosmithkline Llc Inhibitors of AkT activity

Also Published As

Publication number Publication date
WO2003035619A1 (fr) 2003-05-01

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