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WO2003036298A3 - Closed substrate platforms suitable for analysis of biomolecules - Google Patents

Closed substrate platforms suitable for analysis of biomolecules Download PDF

Info

Publication number
WO2003036298A3
WO2003036298A3 PCT/IB2002/004726 IB0204726W WO03036298A3 WO 2003036298 A3 WO2003036298 A3 WO 2003036298A3 IB 0204726 W IB0204726 W IB 0204726W WO 03036298 A3 WO03036298 A3 WO 03036298A3
Authority
WO
WIPO (PCT)
Prior art keywords
analysis
container
biomolecules
sample analysis
closed substrate
Prior art date
Application number
PCT/IB2002/004726
Other languages
French (fr)
Other versions
WO2003036298A2 (en
Inventor
Mikkel Norholm
Soren Moller
Lars Kongsbak
Mogens Havsteen Jakobsen
Original Assignee
Exiqon As
Mikkel Norholm
Soren Moller
Lars Kongsbak
Mogens Havsteen Jakobsen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2001/002902 external-priority patent/WO2002097398A2/en
Priority claimed from US10/057,841 external-priority patent/US20030138969A1/en
Application filed by Exiqon As, Mikkel Norholm, Soren Moller, Lars Kongsbak, Mogens Havsteen Jakobsen filed Critical Exiqon As
Priority to AU2002348982A priority Critical patent/AU2002348982A1/en
Publication of WO2003036298A2 publication Critical patent/WO2003036298A2/en
Publication of WO2003036298A3 publication Critical patent/WO2003036298A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to a closed substrate platform comprising: a container comprising an area for sample analysis and a microfluidic analysis platform, the container comprising (i) at least one inlet for the introduction of fluid to the sample analysis area and (ii) an outlet for removal of fluid to the sample analysis area; and a vent for expulsion of air from the container. The substrate platform may be used for covalent immobilization of polypeptides and nucleic acids and may be used in conjunction with any type of equipment typically used to manipulate or evaluate a standard microscope slide, such as a scanner.
PCT/IB2002/004726 2001-10-25 2002-10-25 Closed substrate platforms suitable for analysis of biomolecules WO2003036298A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002348982A AU2002348982A1 (en) 2001-10-25 2002-10-25 Closed substrate platforms suitable for analysis of biomolecules

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
PCT/IB2001/002902 WO2002097398A2 (en) 2000-10-25 2001-10-25 Closed substrate platforms suitable for analysis of biomolecules
US10/032,381 US20030152927A1 (en) 2000-10-25 2001-10-25 Closed substrate platforms suitable for analysis of biomolecules
IBPCT/IB01/02902 2001-10-25
US10/032,381 2001-10-25
US10/057,841 2002-01-24
US10/057,841 US20030138969A1 (en) 2002-01-24 2002-01-24 Closed substrate platforms suitable for analysis of biomolecules
DKPA200200133 2002-01-25
DKPA200200133 2002-01-25

Publications (2)

Publication Number Publication Date
WO2003036298A2 WO2003036298A2 (en) 2003-05-01
WO2003036298A3 true WO2003036298A3 (en) 2003-10-16

Family

ID=27439854

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/004726 WO2003036298A2 (en) 2001-10-25 2002-10-25 Closed substrate platforms suitable for analysis of biomolecules

Country Status (2)

Country Link
AU (1) AU2002348982A1 (en)
WO (1) WO2003036298A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524672B2 (en) 2004-09-22 2009-04-28 Sandia Corporation Microfluidic microarray systems and methods thereof
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5254040B2 (en) 2006-01-18 2013-08-07 アルゴス セラピューティクス，インコーポレイティド System and method for processing samples in a closed container and associated apparatus
WO2008066164A1 (en) * 2006-11-30 2008-06-05 Arkray, Inc. Primer set for amplification of obesity gene, reagent for amplification of obesity gene comprising the primer set, and use of the primer set
JP2011124253A (en) 2009-12-08 2011-06-23 Sony Corp Method of manufacturing semiconductor laser, semiconductor laser, optical disk device, method of manufacturing semiconductor device and semiconductor device
CN101817495B (en) * 2010-03-25 2012-03-14 湖南大学 Micro fluid control chip and preparation method and application thereof
CH703278B1 (en) * 2010-06-15 2016-11-15 Csem Centre Suisse D'electronique Et De Microtechnique Sa - Rech Et Développement Device and platform for multiplex analysis.
US10222391B2 (en) 2011-12-07 2019-03-05 The Johns Hopkins University System and method for screening a library of samples
CN110465342B (en) * 2016-06-15 2022-10-04 汉密尔顿公司 Pipetting devices, pipette tip couplers and pipette tips: devices and methods
CN111304058B (en) * 2020-03-26 2023-11-28 河南科技大学 Microfluidic chip for detecting gram-negative bacteria genes and detection method
MX2021013866A (en) * 2021-11-11 2023-05-12 Jesus Raul Beltran Ramirez Biological sample reading device.

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225163A (en) * 1989-08-18 1993-07-06 Angenics, Inc. Reaction apparatus employing gravitational flow
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5731212A (en) * 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
WO2001026813A2 (en) * 1999-10-08 2001-04-19 Micronics, Inc. Microfluidics without electrically of mechanically operated pumps
US20010006785A1 (en) * 1997-04-28 2001-07-05 J. Michael Ramsey Method and apparatus for analyzing nucleic acids
WO2001054813A2 (en) * 2000-01-11 2001-08-02 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
EP1201304A2 (en) * 2000-10-25 2002-05-02 MICROPARTS GESELLSCHAFT FÜR MIKROSTRUKTURTECHNIK mbH Microstructured platform for examining a liquid
WO2002072264A1 (en) * 2001-03-09 2002-09-19 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225163A (en) * 1989-08-18 1993-07-06 Angenics, Inc. Reaction apparatus employing gravitational flow
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5731212A (en) * 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
US20010006785A1 (en) * 1997-04-28 2001-07-05 J. Michael Ramsey Method and apparatus for analyzing nucleic acids
WO2001026813A2 (en) * 1999-10-08 2001-04-19 Micronics, Inc. Microfluidics without electrically of mechanically operated pumps
WO2001054813A2 (en) * 2000-01-11 2001-08-02 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
EP1201304A2 (en) * 2000-10-25 2002-05-02 MICROPARTS GESELLSCHAFT FÜR MIKROSTRUKTURTECHNIK mbH Microstructured platform for examining a liquid
WO2002072264A1 (en) * 2001-03-09 2002-09-19 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524672B2 (en) 2004-09-22 2009-04-28 Sandia Corporation Microfluidic microarray systems and methods thereof
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis

Also Published As

Publication number Publication date
WO2003036298A2 (en) 2003-05-01
AU2002348982A1 (en) 2003-05-06

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