WO2003037180A1 - Appareil permettant de determiner la vitesse du flux sanguin et le rapport de vitesse du flux sanguin - Google Patents
Appareil permettant de determiner la vitesse du flux sanguin et le rapport de vitesse du flux sanguin Download PDFInfo
- Publication number
- WO2003037180A1 WO2003037180A1 PCT/CN2002/000747 CN0200747W WO03037180A1 WO 2003037180 A1 WO2003037180 A1 WO 2003037180A1 CN 0200747 W CN0200747 W CN 0200747W WO 03037180 A1 WO03037180 A1 WO 03037180A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- blood
- flow velocity
- catheter
- blood flow
- points
- Prior art date
Links
- 239000008280 blood Substances 0.000 title claims description 17
- 210000004369 blood Anatomy 0.000 title claims description 17
- 230000017531 blood circulation Effects 0.000 claims description 48
- 239000007924 injection Substances 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 7
- 239000000523 sample Substances 0.000 claims description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 5
- 210000001367 artery Anatomy 0.000 abstract description 5
- 210000003462 vein Anatomy 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract 2
- 239000011148 porous material Substances 0.000 abstract 2
- 210000004204 blood vessel Anatomy 0.000 description 11
- 238000000034 method Methods 0.000 description 9
- 229940090044 injection Drugs 0.000 description 6
- 229940093181 glucose injection Drugs 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 241001552669 Adonis annua Species 0.000 description 2
- 239000008355 dextrose injection Substances 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 210000001147 pulmonary artery Anatomy 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/026—Measuring blood flow
- A61B5/0275—Measuring blood flow using tracers, e.g. dye dilution
- A61B5/028—Measuring blood flow using tracers, e.g. dye dilution by thermo-dilution
Definitions
- the invention relates to a device for measuring a blood flow velocity and a blood flow velocity ratio thereof from a blood vessel cavity.
- a commonly used method for measuring blood flow velocity from a blood vessel cavity is an ultrasonic Doppler method.
- This method uses an ultrasonic probe of an ultrasonic Doppler apparatus as a catheter to be placed in a blood vessel cavity, and uses the principle of ultrasonic Doppler to detect blood. Flow velocity, but due to the complicated manufacturing process and expensive price of this probe, it is difficult to promote in basic and clinical research work.
- Another method for measuring the blood flow velocity from the blood vessel cavity is the blood temperature change sensing method. This method locates a Swan-Ganz catheter with a thermistor at the front end of the catheter in the pulmonary artery, and generates a potential by sensing the change in blood temperature.
- This blood flow velocity measurement method can only measure the average pulmonary blood flow velocity, and the calculation process of calculating the pulmonary blood flow velocity from the temperature dilution curve is complicated.
- the object of the present invention is to provide a device for more easily determining the blood flow velocity and the ratio of blood flow velocity of large, medium-sized arteries and venous blood vessels from the inside of a blood vessel cavity based on the principle of sensing blood temperature changes, so that the arterial
- the system is used in large and medium vascular and clinical research work, and has the characteristics of simple structure and low safety cost.
- the device for measuring the blood flow velocity and the blood flow velocity ratio is a catheter that can be placed in the lumen of a blood vessel, and its surface has four places (a known distance from each other).
- a thermocouple that can detect changes in blood temperature, which can be connected to the interface through a wire, and the interface can be connected to an instrument that detects and records temperature changes.
- There are two openings on both sides of the place where the thermocouple is placed (the end hole at the front end of the catheter and the side hole at the rear end of the catheter), and connected to the injection port through a pipe.
- thermocouple When measuring the blood flow velocity and the change ratio of the blood flow velocity, when the catheter is placed against the blood flow direction, a 5% glucose injection solution of 0-5- ° C is injected from the front opening of the catheter, and the blood temperature drops there, and The blood that has dropped in temperature passes through the four parts of the catheter where the thermocouple is placed.
- the catheter When the catheter is placed in the direction of blood flow, the 5% glucose injection solution of 0-5 ° C is inserted from the rear side hole of the catheter.
- the temperature of the blood drops at this place, and the blood of which the temperature drops also flows along the blood through the four parts where the thermocouple is placed on the catheter; use the blood flow to pass through two selected combinations of the four points (in the place where the thermocouple is placed).
- the two parts of the four parts in the selected combination) are divided by the known distance between the two points to calculate the instantaneous blood flow of the artery or vein speed. Because there are thermocouples that can detect changes in blood temperature at four places on the surface of the catheter (a known distance), the instantaneous blood flow velocity (instantaneous blood flow velocity A and Instantaneous blood flow velocity B). Divide the instant blood flow velocity A by the instant blood flow velocity B to obtain the instant blood flow velocity ratio.
- the invention only needs to replace the thermistor at the original Swan-Ganz catheter thermistor place with a thermocouple, and install three sets of temperature change sensing circuits (including the thermocouple and the wires connected to it) at the rear end of the thermistor.
- the blood flow velocity and the blood flow velocity ratio can be directly detected from the vascular cavity of the large and medium arteries and veins, and the calculation process of the blood flow velocity and the blood flow velocity ratio can be simplified. At the same time, it has the characteristics of simple operation, safety, reliability and low cost.
- FIG. 1 The drawing is a perspective view (FIG. 1) and a working principle diagram (FIG. 2, FIG. 3) of a device for measuring blood flow velocity and a blood flow velocity change rate according to the present invention.
- FIG. 2 a working principle diagram
- This device is a special catheter with one end hole (1) at the front end, which is connected to the injection hole (2) through a pipe, and thermocouples (3, 4, 5, respectively) are arranged at different distances from the end hole of the catheter. 6)
- the wires connected to it are connected to the interface (7, 8, 9, 10), and the interface can be connected to the instrument that detects and records the temperature change.
- thermocouple On the other side of the conduit where the thermocouple is located, there is a side hole (11), which is connected to the liquid injection hole (12) through a pipe ( Figure 1).
- a certain amount of 0-5 ° C 5% glucose injection solution is injected from the catheter injection port (2), and the glucose injection solution is opened through the front end of the catheter (1) Entering the blood vessel, the temperature of the blood drops there, and the blood with the temperature decreasing passes through the four parts (3, 4, 5, 6) where the thermocouple is placed;
- Figure 3 an amount of injection from the injection port of the catheter (12) 0- 5 ° C in 5% dextrose injection, dextrose injection rear end side of the hole (11) through the catheter into the blood vessel, where the blood temperature drop And the temperature of the blood that has dropped has also flowed through the four parts (6, 5, 4, 3) where the thermocouple is located; through the connection line through the interface (10
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physiology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
La présente invention concerne un appareil, permettant de déterminer la vitesse du flux sanguin et le rapport de vitesse, qui comprend un cathéter et quatre thermocouples adjacents à l'extérieur dudit cathéter, celui-ci étant placé dans une artère ou une veine. Lorsqu'on injecte 5 % de solution de dextrose à 0∩5° C à travers l'alésage terminal ou le pore latéral du cathéter, le mélange de sang et de produits injectés à une température inférieure s'écoule successivement à travers quatre points, chacun ayant un thermocouple. Deux des quatre points sont sélectionnés. Il est alors possible de calculer les vitesses simultanées A et B des deux points d'après la distance connue séparant les deux points et la durée d'écoulement du mélange de sang et de produits injectés entre les deux points. On peut également obtenir le rapport de vitesses instantanées selon les vitesses instantanées du flux sanguin A et B.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01129820 CN1358478A (zh) | 2001-10-29 | 2001-10-29 | 一种测定血流速度及其血流速度比值的装置 |
| CN01129820.0 | 2001-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2003037180A1 true WO2003037180A1 (fr) | 2003-05-08 |
Family
ID=4669475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2002/000747 WO2003037180A1 (fr) | 2001-10-29 | 2002-10-23 | Appareil permettant de determiner la vitesse du flux sanguin et le rapport de vitesse du flux sanguin |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN1358478A (fr) |
| WO (1) | WO2003037180A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103561641B (zh) * | 2011-06-01 | 2016-09-28 | 皇家飞利浦有限公司 | 用于分布式血流测量的系统 |
| US11564584B2 (en) * | 2016-09-28 | 2023-01-31 | Koninklijke Philips N.V. | System for determining blood flow |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2108675A (en) * | 1981-10-23 | 1983-05-18 | Draegerwerk Ag | Measuring probe |
| US4901734A (en) * | 1987-08-17 | 1990-02-20 | Nova Medical Specialties | Dual-thermistor thermodilution catheter |
| WO1993015652A1 (fr) * | 1992-02-07 | 1993-08-19 | Interflo Medical, Inc. | Catheter de thermodilution pourvu d'un element chauffant flexible fiable |
| CN2424743Y (zh) * | 2000-02-29 | 2001-03-28 | 邱汉婴 | 一种测定血流速度的装置 |
| CN2432891Y (zh) * | 2000-02-29 | 2001-06-06 | 邱汉婴 | 一种测定左心输出量的装置 |
-
2001
- 2001-10-29 CN CN 01129820 patent/CN1358478A/zh active Pending
-
2002
- 2002-10-23 WO PCT/CN2002/000747 patent/WO2003037180A1/fr not_active Application Discontinuation
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2108675A (en) * | 1981-10-23 | 1983-05-18 | Draegerwerk Ag | Measuring probe |
| US4901734A (en) * | 1987-08-17 | 1990-02-20 | Nova Medical Specialties | Dual-thermistor thermodilution catheter |
| WO1993015652A1 (fr) * | 1992-02-07 | 1993-08-19 | Interflo Medical, Inc. | Catheter de thermodilution pourvu d'un element chauffant flexible fiable |
| CN2424743Y (zh) * | 2000-02-29 | 2001-03-28 | 邱汉婴 | 一种测定血流速度的装置 |
| CN2432891Y (zh) * | 2000-02-29 | 2001-06-06 | 邱汉婴 | 一种测定左心输出量的装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1358478A (zh) | 2002-07-17 |
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