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WO2003104814A3 - Procedes et systemes a canaux ouverts d'extraction en phase solide de biomolecules - Google Patents

Procedes et systemes a canaux ouverts d'extraction en phase solide de biomolecules Download PDF

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Publication number
WO2003104814A3
WO2003104814A3 PCT/US2003/014503 US0314503W WO03104814A3 WO 2003104814 A3 WO2003104814 A3 WO 2003104814A3 US 0314503 W US0314503 W US 0314503W WO 03104814 A3 WO03104814 A3 WO 03104814A3
Authority
WO
WIPO (PCT)
Prior art keywords
solid phase
extraction
phase extraction
biomolecule
methods
Prior art date
Application number
PCT/US2003/014503
Other languages
English (en)
Other versions
WO2003104814A2 (fr
Inventor
Douglas T Gjerde
Christopher P Hanna
Original Assignee
Phynexus Inc
Douglas T Gjerde
Christopher P Hanna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phynexus Inc, Douglas T Gjerde, Christopher P Hanna filed Critical Phynexus Inc
Priority to EP03728775A priority Critical patent/EP1518115A2/fr
Priority to JP2004511834A priority patent/JP2005529335A/ja
Priority to AU2003233498A priority patent/AU2003233498A1/en
Publication of WO2003104814A2 publication Critical patent/WO2003104814A2/fr
Publication of WO2003104814A3 publication Critical patent/WO2003104814A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34—Purifying; Cleaning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/08—Preparation using an enricher
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N2030/009—Extraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N2030/062—Preparation extracting sample from raw material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Dispositif possédant des canaux capillaires ouverts servant à effectuer l'extraction en phase solide de molécules capables de produire un facteur d'enrichissement tubulaire d'au moins 1. Ce dispositif est composé d'un canal (2, 12, 18, 42, 68, 98, 128, 200) dont une extrémité est reliée à une pompe (44, 70,100, 218) servant à pomper le liquide et le gaz et dans l'autre extrémité peut être reliée à une interface (26) d'applicateur (32) de spécimen protéique sous forme de puce ou de spectromètre de masse. La surface intérieure (4) de ce canal, surface d'extraction, peut être revêtue d'un agent d'affinité par fixation, tel qu'un métal chélaté, une protéine, un sucre ou un acide nucléique. Ce procédé met en application ce dispositif afin de fixer les molécules de substance à analyser provenant d'une solution spécimen à la surface d'extraction par affinité et d'effectuer la désorption de la substance à analyser de la surface d'extraction au moyen d'un liquide de désorption selon un facteur d'extraction supérieur à 1.
PCT/US2003/014503 2002-01-01 2003-05-08 Procedes et systemes a canaux ouverts d'extraction en phase solide de biomolecules WO2003104814A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP03728775A EP1518115A2 (fr) 2002-06-10 2003-05-08 Procedes et systemes a canaux ouverts d'extraction en phase solide de biomolecules
JP2004511834A JP2005529335A (ja) 2002-06-10 2003-05-08 開放チャンネルを使って生体分子を固体相として抽出するシステムと方法
AU2003233498A AU2003233498A1 (en) 2002-06-10 2003-05-08 Biomolecule open channel solid phase extraction systems and methods

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US38812002P 2002-06-10 2002-06-10
US60/388,120 2002-06-10
US41913602P 2002-10-16 2002-10-16
US60/419,136 2002-10-16
US43406102P 2002-12-17 2002-12-17
US60/434,061 2002-12-17
US44760503P 2003-02-14 2003-02-14
US60/447,605 2003-02-14

Publications (2)

Publication Number Publication Date
WO2003104814A2 WO2003104814A2 (fr) 2003-12-18
WO2003104814A3 true WO2003104814A3 (fr) 2004-11-11

Family

ID=29741060

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/014503 WO2003104814A2 (fr) 2002-01-01 2003-05-08 Procedes et systemes a canaux ouverts d'extraction en phase solide de biomolecules

Country Status (5)

Country Link
US (1) US20040126890A1 (fr)
EP (1) EP1518115A2 (fr)
JP (1) JP2005529335A (fr)
AU (1) AU2003233498A1 (fr)
WO (1) WO2003104814A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980093B2 (en) 2003-09-30 2015-03-17 Yuri P. Belov Multicapillary device for sample preparation

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7151167B2 (en) 2002-06-10 2006-12-19 Phynexus, Inc. Open channel solid phase extraction systems and methods
US7879621B2 (en) 2003-05-08 2011-02-01 Phynexus, Inc. Open channel solid phase extraction systems and methods
US7122640B2 (en) 2002-06-10 2006-10-17 Phynexus, Inc. Open channel solid phase extraction systems and methods
US20040180449A1 (en) * 2003-03-11 2004-09-16 Gilson, Inc. Multidimensional chromatography with ion exchange solid phase extraction
US7667010B2 (en) * 2003-11-18 2010-02-23 Phynexus, Inc. Open channel solid phase extraction systems and methods
AU2004202003B8 (en) * 2003-05-13 2008-10-02 Corning Incorporated Method and apparatus for purifying and desalting biological samples
US7231839B2 (en) * 2003-08-11 2007-06-19 The Board Of Trustees Of The Leland Stanford Junior University Electroosmotic micropumps with applications to fluid dispensing and field sampling
US7429356B2 (en) * 2003-08-19 2008-09-30 Fujifilm Corporation Extracting apparatus
US20060115384A1 (en) * 2003-09-16 2006-06-01 Vici Gig Harbor Group, Inc. Pipette tip surface sorption extraction
US20050142565A1 (en) * 2003-12-30 2005-06-30 Agency For Science, Technology And Research Nucleic acid purification chip
JP4522105B2 (ja) * 2004-02-02 2010-08-11 キヤノン株式会社 物質の液体からの分離方法
US7122791B2 (en) * 2004-09-03 2006-10-17 Agilent Technologies, Inc. Capillaries for mass spectrometry
US8187441B2 (en) * 2004-10-19 2012-05-29 Evans Christine E Electrochemical pump
US7964380B2 (en) * 2005-01-21 2011-06-21 Argylia Technologies Nanoparticles for manipulation of biopolymers and methods of thereof
US7612165B2 (en) 2005-03-03 2009-11-03 Phynexus, Inc. Solid-phase synthesis is a capillary
US7655187B2 (en) 2005-03-11 2010-02-02 Waters Technologies Corporation Systems for isolating toxins and collecting eluates for testing for toxins and methods using the same
FR2885898B1 (fr) * 2005-05-17 2007-07-06 Commissariat Energie Atomique Composant microfluidique comprenant au moins un canal rempli de nanotubes et procede de fabrication d'un tel composant microfluidique.
DE102006004165A1 (de) * 2006-01-30 2007-08-09 Bruker Daltonik Gmbh Breitbandextraktion aus Blut für massenspektrometrische Proteinprofile
US20080026373A1 (en) * 2006-07-26 2008-01-31 Rodionova Natalia A Assays Based On Light Emission From Analyte Complexes Within A Cassette
AU2006348443A1 (en) * 2006-09-20 2008-03-27 Chromba, Inc. Multicapillary device for sample preparation
EP2503330A3 (fr) * 2006-09-20 2013-04-17 Chromba, Inc. Dispositif multicapillaire pour la préparation d'échantillons
US10434492B2 (en) * 2007-01-26 2019-10-08 Sigma-Aldrich Co. Llc Compositions and methods for solid phase extraction of lipids
US10928366B2 (en) * 2007-01-26 2021-02-23 Sigma-Aldrich Co. Llc Compositions and methods for combining protein precipitation and solid phase extraction
US20100151465A1 (en) * 2008-03-27 2010-06-17 Jingyue Ju Selective Capture and Release of Analytes
US9103782B2 (en) 2008-12-02 2015-08-11 Malvern Instruments Incorporated Automatic isothermal titration microcalorimeter apparatus and method of use
US9090663B2 (en) * 2009-04-21 2015-07-28 The Trustees Of Columbia University In The City Of New York Systems and methods for the capture and separation of microparticles
US9500572B2 (en) 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
DE102010011560B4 (de) * 2010-03-16 2021-09-16 Gilupi Gmbh Biodetektor
US20120160038A1 (en) * 2010-12-22 2012-06-28 Agilent Technologies, Inc. Large-area solid phase extraction apparatus and methods
CN102564805B (zh) * 2010-12-31 2014-05-28 同方威视技术股份有限公司 用于痕量探测仪的进样装置以及具有该进样装置的痕量探测仪
WO2013019714A1 (fr) 2011-07-29 2013-02-07 The Trustees Of Columbia University In The City Of New York Capteur d'affinité mems pour surveillance ininterrompue de substances à analyser
JP2012123014A (ja) * 2012-02-20 2012-06-28 Chromba Inc 試料調製のためのマルチキャピラリー装置
DE112013002108T5 (de) * 2012-04-19 2014-12-31 New Objective, Inc. Verfahren und Vorrichtung für die kombinierte Probenvorbereitung und Nanoelektrospray-Ionisierungsmassenspektrometrie
CN108287209B (zh) 2013-01-31 2021-01-26 普度研究基金会 分析原油的方法
WO2014120411A1 (fr) 2013-01-31 2014-08-07 Purdue Research Foundation Systèmes et procédés pour analyser un échantillon extrait
EP4099363A1 (fr) 2013-06-25 2022-12-07 Purdue Research Foundation Analyse par spectrométrie de masse de micro-organismes dans des échantillons
USD724196S1 (en) * 2013-12-17 2015-03-10 Stingray Group, Llc Heater block for pressure digestion vessels
CN103816695B (zh) * 2014-02-25 2015-10-07 东南大学 一种样品中酚类内分泌干扰物的固相萃取法
WO2016022696A1 (fr) 2014-08-05 2016-02-11 The Trustees Of Columbia University In The City Of New York Procédé d'isolement d'aptamères pour détecter une maladie résiduelle minimale
JP6744302B2 (ja) 2014-11-03 2020-08-19 ザ ジェネラル ホスピタル コーポレイション ミクロ流体装置における粒子の分類
US9786478B2 (en) 2014-12-05 2017-10-10 Purdue Research Foundation Zero voltage mass spectrometry probes and systems
CN104458999B (zh) * 2014-12-26 2016-08-17 力合科技（湖南）股份有限公司 有机物自动分析仪
CN107960130A (zh) 2015-02-06 2018-04-24 普度研究基金会 探针、系统、盒及其使用方法
EP3465138B1 (fr) * 2016-06-03 2023-12-27 Purdue Research Foundation Systèmes et procédés d'analyse d'un analyte extrait d'un échantillon à l'aide d'un matériau adsorbant
CA3043329A1 (fr) 2016-11-09 2018-05-17 Healthtell Inc. Revetements a densite d'amine reglable
EP3538536A4 (fr) 2016-11-09 2020-05-13 Healthtell Inc. Lieurs chimiosélectifs pré-assemblés, protégés, chimiquement stables
CN109865315A (zh) * 2017-12-05 2019-06-11 中国科学院大连化学物理研究所 一种用作色谱固定相的有机-无机杂化介孔材料涂层制备方法
EP3735281B1 (fr) 2018-01-05 2024-11-27 Path Ex, Inc. Dispositif pour la capture et l'élimination de matériel de maladie à partir de fluides
CN112272859B (zh) * 2018-06-29 2024-03-26 Dh科技发展私人贸易有限公司 用于质谱法的取样探针和取样界面
EP3870969A4 (fr) * 2018-10-24 2022-07-27 Path Ex, Inc. Procédé de capture et d'isolement de substances pathologiques à partir de matière en écoulement
EP3969877A1 (fr) 2019-06-03 2022-03-23 Entech Instruments Inc. Récupération améliorée de composés organiques dans des échantillons liquides à l'aide d'une extraction sous vide par évaporation complète, d'une désorption thermique et d'une analyse par chromatographie en phase gazeuse-spectrometrie de masse (gcms)
JP7627909B2 (ja) 2021-08-10 2025-02-07 国立大学法人埼玉大学 揮発性有機化合物の分析方法及び分析システム
GB202218893D0 (en) * 2022-12-14 2023-01-25 Watercycle Tech Ltd Method
CN116407873B (zh) * 2023-03-31 2025-08-22 方圆标志检验检测(山东)有限公司 一种正压固相萃取仪的塞柱移动和液体流速控制装置及其使用方法
CN119757611B (zh) * 2025-03-06 2025-06-13 中国科学院昆明植物研究所 一种基于生物质谱与Tycho仪分析独脚金内酯类激素与受体蛋白互作的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097927A (en) * 1959-07-21 1963-07-16 Technicon Instr Chromatography analysis apparatus and method
US4028056A (en) * 1976-04-20 1977-06-07 Technicon Instruments Corporation Substance separation technique
EP0183950A1 (fr) * 1984-10-18 1986-06-11 Hewlett-Packard GmbH Procédé de traitement d'un liquide à l'intérieur d'un tube
WO1996012194A1 (fr) * 1994-10-14 1996-04-25 Bjarne Holmbom Procede et appareil d'extraction en direct de constituants recuperables presents dans des liquides
US5565622A (en) * 1994-09-15 1996-10-15 Hewlett-Packard Co., Legal Dept. Reduced solvent solid phase extraction
WO1998041855A1 (fr) * 1997-03-14 1998-09-24 Pawliszyn Janusz B Procede et dispositif de microextraction en phase solide et desorption

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2017540A (en) * 1931-01-27 1935-10-15 Kemp Joseph Process of treating zinciferous solutions
US3807389A (en) * 1971-12-29 1974-04-30 M Sturman Medical instrument for measuring fluid pressure
US4634679A (en) * 1982-11-10 1987-01-06 Becton Dickinson And Company Method of determining adhesion of a liquid sample
EP0149168B1 (fr) * 1983-12-19 1991-04-24 Daiichi Pure Chemicals Co. Ltd. Dosage immunologique
US4882275A (en) * 1984-02-29 1989-11-21 The Children's Medical Center Corporation Method of purifying endothelial cell growth factors using immobilized heparin
CA1304886C (fr) * 1986-07-10 1992-07-07 Heinz Dobeli Resines chelatant des metaux
DE69007006T2 (de) * 1989-09-29 1994-08-25 Rohm & Haas Ligand enthaltendes Medium für chromatographische Trennung, Verfahren zur dessen Herstellung und dessen Verwendung zur Isolierung von synthetischen oder natürlichen Molekülen von einer Fluidmischung.
DE69305947T2 (de) * 1992-09-18 1997-03-13 Amersham Int Plc Vorrichtung und Methode zur Affinitätstrennung
US5561097A (en) * 1994-04-28 1996-10-01 Minnesota Mining And Manufacturing Company Method of controlling density of ligand coupled onto supports and products produced therefrom
US5772874A (en) * 1995-11-02 1998-06-30 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
US5962641A (en) * 1996-08-16 1999-10-05 Clontech Laboratories, Inc. Method for purification of recombinant proteins
US6048457A (en) * 1997-02-26 2000-04-11 Millipore Corporation Cast membrane structures for sample preparation
US6020209A (en) * 1997-04-28 2000-02-01 The United States Of America As Represented By The Secretary Of The Navy Microcapillary-based flow-through immunosensor and displacement immunoassay using the same
US5771810A (en) * 1997-06-25 1998-06-30 Eastman Kodak Company Continuous tone microfluidic display and printing
EP1329513B1 (fr) * 1998-08-25 2011-12-07 University of Washington Analyse quantitative rapide de protéines ou de fonction protéique dans des mélanges complexes
US6514700B1 (en) * 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6294392B1 (en) * 1999-07-21 2001-09-25 The Regents Of The University Of California Spatially-encoded analyte detection
US6149815A (en) * 1999-11-23 2000-11-21 Sauter; Andrew D. Precise electrokinetic delivery of minute volumes of liquid(s)
US6610499B1 (en) * 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
US6416716B1 (en) * 2001-04-20 2002-07-09 Ashok Kumar Shukla Sample preparation device with embedded separation media
US20020164824A1 (en) * 2001-02-16 2002-11-07 Jianming Xiao Method and apparatus based on bundled capillaries for high throughput screening
US20030007897A1 (en) * 2001-07-06 2003-01-09 Andrew Creasey Pipette tips

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097927A (en) * 1959-07-21 1963-07-16 Technicon Instr Chromatography analysis apparatus and method
US4028056A (en) * 1976-04-20 1977-06-07 Technicon Instruments Corporation Substance separation technique
EP0183950A1 (fr) * 1984-10-18 1986-06-11 Hewlett-Packard GmbH Procédé de traitement d'un liquide à l'intérieur d'un tube
US5565622A (en) * 1994-09-15 1996-10-15 Hewlett-Packard Co., Legal Dept. Reduced solvent solid phase extraction
WO1996012194A1 (fr) * 1994-10-14 1996-04-25 Bjarne Holmbom Procede et appareil d'extraction en direct de constituants recuperables presents dans des liquides
WO1998041855A1 (fr) * 1997-03-14 1998-09-24 Pawliszyn Janusz B Procede et dispositif de microextraction en phase solide et desorption

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A. ZLATKIS ET AL.: "rapid analysis of trace organics in aqueous solutions by enrichment in uncoated capillary columns", CHROMATOGRAPHIA, vol. 30, no. 3/4, August 1990 (1990-08-01), WIESBADEN, DE, pages 149 - 154, XP008026102, ISSN: 0009-5893 *
EISERT R ET AL: "AUTOMATED IN-TUBE SOLID-PHASE MICROEXTRACTION COUPLED TO HIGH-PERFORMACE LIQUID CHROMATOGRAPHY", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 69, no. 16, 15 August 1997 (1997-08-15), pages 3140 - 3147, XP000699501, ISSN: 0003-2700 *
HENNION M-C: "Solid-phase extraction: method development, sorbents, and coupling with liquid chromatography", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER SCIENCE, NL, vol. 856, no. 1-2, 24 September 1999 (1999-09-24), pages 3 - 54, XP004180074, ISSN: 0021-9673 *
MA M ET AL: "SOLVENT MICROEXTRACTION WITH SIMULTANEOUS BACK-EXTRACTION FOR SAMPLE CLEANUP AND PRECONCENTRATION: PRECONCENTRATION INTO A SINGLE MICRODROP", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 71, no. 2, 15 January 1999 (1999-01-15), pages 388 - 393, XP000825700, ISSN: 0003-2700 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980093B2 (en) 2003-09-30 2015-03-17 Yuri P. Belov Multicapillary device for sample preparation

Also Published As

Publication number Publication date
US20040126890A1 (en) 2004-07-01
AU2003233498A8 (en) 2003-12-22
JP2005529335A (ja) 2005-09-29
WO2003104814A2 (fr) 2003-12-18
AU2003233498A1 (en) 2003-12-22
EP1518115A2 (fr) 2005-03-30

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