[go: up one dir, main page]

WO2004058135A1 - Attenuateur d'ondes ultrasonores - Google Patents

Attenuateur d'ondes ultrasonores Download PDF

Info

Publication number
WO2004058135A1
WO2004058135A1 PCT/JP2003/016551 JP0316551W WO2004058135A1 WO 2004058135 A1 WO2004058135 A1 WO 2004058135A1 JP 0316551 W JP0316551 W JP 0316551W WO 2004058135 A1 WO2004058135 A1 WO 2004058135A1
Authority
WO
WIPO (PCT)
Prior art keywords
ultrasonic
frequency
slimming
ultrasonic wave
irradiation
Prior art date
Application number
PCT/JP2003/016551
Other languages
English (en)
Japanese (ja)
Inventor
Yuko Matsumura
Yasuhiro Sato
Original Assignee
Matsushita Electric Works, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matsushita Electric Works, Ltd. filed Critical Matsushita Electric Works, Ltd.
Priority to AU2003292743A priority Critical patent/AU2003292743A1/en
Publication of WO2004058135A1 publication Critical patent/WO2004058135A1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A61H23/02Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
    • A61H23/0245Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive with ultrasonic transducers, e.g. piezoelectric
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N2007/0004Applications of ultrasound therapy
    • A61N2007/0008Destruction of fat cells

Definitions

  • the present invention relates to an ultrasonic slimming device for locally slimming a whole body or a region to be thinned using ultrasonic waves.
  • Patent Document 1 Japanese Patent Application Laid-Open No. Hei 4-189058
  • Patent Document 2 Japanese Patent Application Laid-Open No. 3-123595
  • Patent Document 3 International Patent Publication No. WO 99/93967 7
  • the present invention has been made in view of such problems of the prior art, and has an effect on slimming and has a safe frequency and output power which does not affect internal organs in the deep part of the body. It is intended to provide an ultrasonic slimming device that irradiates ultrasonic waves within a range.
  • the present invention provides an ultrasonic transducer, An ultrasonic generator that irradiates an ultrasonic wave toward the desired part in a state where the ultrasonic wave is applied to the desired part, and a controller that controls an ultrasonic vibrator.
  • frequency sound waves characterized by 1. 3 ⁇ 3 MH Z 0 the irradiation power when in the range of. 5 W // C H1 2 or 3 W / cm 2 or less and the possible.
  • the irradiation morphism power when the frequency of the ultrasonic waves irradiated from the ultrasonic wave generator is greater than 3 MH z 0. 0 5 W / cm 2 or more 0. Set to less than 5 W / cm 2, basically It can also irradiate relatively shallow parts of the body.
  • a switch that can switch the frequency of the ultrasonic wave to be irradiated is provided so that the frequency of the ultrasonic wave irradiated by the switch can be selected from the range of 1.3 to 3 MHz or the range of 3 MHz or more. Then, the convenience of the ultrasonic slimming device is improved.
  • a detection unit that detects the distance from the skin surface of the body to the internal organs and bones is provided, and the control of the ultrasonic vibrator by the control unit irradiates ultrasonic waves at a frequency and irradiation pattern corresponding to the result of the detection unit.
  • the distance detected by the detection unit is smaller than a predetermined value, it is preferable to stop the irradiation of the ultrasonic wave from the viewpoint of safety.
  • FIG. 1 is a block diagram showing a basic configuration of Embodiment 1 of the present invention.
  • FIG. 2 is a block diagram showing a basic configuration of Embodiment 2 of the present invention.
  • FIG. 3 is a block diagram showing a basic configuration of the third embodiment of the present invention.
  • FIG. 4 is an explanatory diagram showing the difference in catecholamine secretion between no stimulation and after stimulation with ultrasound.
  • Catecholamine is a collective term for three substances, dopamine, noradrenaline, and adrenaline, and secretes catecholamines from sympathetic nerve endings and adrenal glands by stimulating the sympathetic nerves in the body's particularly lean areas with ultrasound. And promote this secretion.
  • the six average of the results of human monitoring experiment as shown in FIG. 4 the irradiation power 0.1 at a frequency 1 MHz to a site desired to ⁇ 5 ⁇ 0. 8 W / cm 2 of that the catecholamine to ultrasonic irradiation (noradrenaline ) has been confirmed to be secreted.
  • UCP 3 of the Uncoupling Protein (UCP) in the fat layer and muscle layer is specifically activated by ultrasonic stimulation, the decomposed fat is burned. I know it will be easier.
  • UCP 3 of the Uncoupling Protein (UCP) in the fat layer and muscle layer is specifically activated by ultrasonic stimulation, the decomposed fat is burned. I know it will be easier.
  • the sympathetic nerve endings exist in the deep part of the skin (dermis layer), and the depth from the skin surface is about 1 to 2 mm.
  • the fat and muscle layers are at a depth of about 2 to 3 cm from the skin surface.
  • irradiating ultrasonic waves with a frequency around 1 MHz can reach a depth of about 5 cm to reduce the slimming effect. That's enough to get.
  • the frequency of the ultrasonic waves must be 1.3 MHz or more.
  • Table 1 shows the difference in the half-value layer depending on the frequency for each living tissue
  • Tables 2 and 3 show that the ultrasound power of lWZcm 2 and 0.8 WZ cm 2
  • the decay of the irradiation power when irradiating the surface is calculated based on the half-value layer in Table 1, respectively.
  • the irradiation power at the time of reaching the internal organs and the like deeper than the muscles becomes smaller as the frequency becomes higher if the irradiation power at the time of irradiation is the same.
  • the frequency is constant, the larger the irradiation power at the time of irradiation, the larger the irradiation power.
  • Ultrasonic irradiation conditions such as frequency and irradiation power, are not only set to a frequency of 1.3 MHz or more as described above, but also affect the sympathetic nerve and uncoupled protein family in consideration of the half-value layer.
  • the irradiation power is set to 0.5 to 3 W / cm 2 .
  • the irradiation power should be in the range of 0.5 to 3 WZcm2 in consideration of the effect of supersonic waves on internal organs, etc.
  • Frequency 3 When it exceeds MH z, for the purpose of illuminating a relatively shallow portion in essentially the body as described later, the irradiation power so as to set to 0.0 5 to 0. Of 5 WZ cm 2 range You may.
  • ultrasound can be applied to the lower scapula, axilla, back neck, etc., where brown fat cells that control heat production in the whole body are present, so that a high overall slimming effect can be obtained.
  • heat production means to produce (produce) heat in the body. If the heat production power is high, energy consumption is large, so fat does not accumulate and it does not become fat. Conversely, low energy consumption leads to fat accumulation and fatness. Heat production also acts to maintain body temperature homeostasis.
  • an ultrasonic slimming device 1 including an ultrasonic generator 3 having an ultrasonic vibrator 2 and a controller 4 for controlling the ultrasonic vibrator 2 is used. Then, ultrasonic waves are irradiated while the ultrasonic wave generating section 3 is in contact with the surface of the desired portion 6 where the user wants to lose weight.
  • a jewel 7 as an ultrasonic transmission medium between the ultrasonic generator 3 and the desired site 6. This jewel 7 is similar to that used in ordinary ultrasound diagnosis, for example, hydrophilic one in which water is retained in lipoxyl methyl cellulose, and caffeine is contained in the inside.
  • a substance that promotes lipolysis, such as capsaicin, or a substance that can provide a slimming effect may be included.
  • the ultrasonic waves emitted from the ultrasonic generator 3 of the ultrasonic slimming device 1 pass through the jewel 7, stimulate the sensory organs in the skin at the desired site 6, and enhance the sympathetic nerve.
  • catecholamines are secreted to cause lipolysis.
  • the ultrasound reaches the fat layer and the muscle layer, and activates the uncoupled protein family (heat-producing protein) in the fat layer and the muscle layer by the stimulation of the ultrasound, and as a result, breaks down the decomposed fat.
  • High efficiency slimming effect can be obtained by burning efficiently Things.
  • the ultrasonic generator 3 is applied to the surface of a desired part for slimming the whole body such as the lower scapula, axilla, and back neck where brown fat cells are present.
  • a desired part for slimming the whole body such as the lower scapula, axilla, and back neck where brown fat cells are present.
  • the brown fat cells can be enhanced to increase the heat productivity of the whole body, that is, the ultrasonic slimming device 1 can be used for slimming the whole body.
  • the control unit 4 irradiates the ultrasonic waves in the mode set by the user with the switch 4a.
  • the ultrasonic slimming device 1 is used to reduce fat inside the body and muscles, and to reduce fat located relatively shallower (near the epidermis). Mode can be switched by switch 4a.
  • the frequency is selected in the range of 1.3 to 3 MHz, and the irradiation power is selected in the range of 0.5 W / cm 2 or more and 3 W / cm 2 or less.
  • the control unit 4 controls the ultrasonic vibrator 2 so that a sound wave is emitted.
  • the frequency is selected in the range of 3 to 15 MHz, and the irradiation power is in the range of 0.05 WZ cm 2 or more and less than 0.5 W / cm 2 .
  • the control unit 4 controls the ultrasonic vibrator 2 so that the ultrasonic wave selected in the step is irradiated.
  • an ultrasonic generator 13a having an ultrasonic oscillator 12a
  • an ultrasonic generator 13b having an ultrasonic oscillator 12b
  • each ultrasonic oscillator 1 Using an ultrasonic slimming device 11 having a control unit 14 for controlling 3a and 13b, one ultrasonic generating unit 13a is applied to the surface of a desired part 6 of the body 5 which is desired to be thin.
  • the other ultrasonic generator 13b is applied to the surface of the desired part 16 for whole body slimming, such as the lower scapula, axillary part, and back neck, where the brown luster cells are located, and the ultrasonic wave is applied. Is irradiated.
  • a jewel 7 similar to that shown in the first embodiment is provided. Applying power S Preferred.
  • the ultrasonic waves emitted from the ultrasonic generator 13a of the ultrasonic slimming device 11 pass through the jewel 7, and stimulate the sensory organs in the skin at the desired site 6 to enhance the sympathetic nerve.
  • catecholamines are secreted to cause lipolysis.
  • the ultrasound reaches the fat layer and the muscle layer, and the uncoupled protein family in the fat layer and the muscle layer is activated by the stimulation of the ultrasound, and as a result, the decomposed fat is efficiently burned.
  • a high slimming effect can be obtained locally.
  • the ultrasonic waves emitted from the ultrasonic wave generating section 13b pass through the jewel 7, and enhance brown fat cells existing at the desired site 16 to thereby increase the heat productivity of the whole body.
  • the ultrasonic apparatus 11 of the present embodiment can perform both partial slimming and whole body slimming at the same time, but both ultrasonic generators 13a and 13b can be used for whole body slimming. Yes, it can be used for partial slimming of different parts. Furthermore, it is also possible to further provide the same ultrasonic wave generating sections 13a and 13b so as to perform slimming of a plurality of parts simultaneously with slimming of the whole body.
  • the control unit 14 emits ultrasonic waves in a mode set by the user via the switch 14a.
  • Ultrasound slimming device 1 is a “deep mode” for reducing fat inside the body and muscles, and a fat for relatively shallower portions (near the epidermis). “Shallow mode” can be switched by switch 14a.
  • the frequency is selected in the range of 1.. 3 to 3 MHz
  • the irradiation power ultrasonic selected is irradiated with 0. 5W / cm 2 or more 3W / / cm 2 or less in the range
  • the control unit 14 controls the ultrasonic vibrator 12 as described above.
  • the frequency is selected in the range of 3 to 1 5 MHz, the irradiation power is at 0. 0 5W / C m 2 or more 0. 5 W / cm 2 less than the range
  • the control unit 14 controls the ultrasonic vibrator 12 so that the selected ultrasonic wave is emitted.
  • the vibrator 12a is used for the "deep mode” and the vibrator 12b is used for the “shallow mode” so that it can be used selectively during use. You may do it.
  • an ultrasonic irradiation unit 25 including an ultrasonic generator 23 having an ultrasonic vibrator 22 and a control unit 24 for controlling the ultrasonic vibrator 22 detects a distance to internal organs and bones. and a sensor unit 26 and the detection unit 28 to the detection result to the control unit 24 and a control unit 2 7 for which full Eid back of the sensor unit 26 which, using the ultrasonic slimming device 2 1, comprising, in the body 5 Ultrasonic irradiation on the surface of the desired part 6 where you want to lose weight Ultrasonic waves are emitted while the ultrasonic generating section 23 of the section 25 and the sensor section 26 of the detecting section 28 are in contact with each other.
  • the detection unit 28 of the present embodiment detects the distance to the internal organs and bones by using the difference in the reflectivity of ultrasonic waves depending on the substance.
  • the distance from the skin surface of the desired part 6 of the body 5 to the skin and bone is detected by the sensor part 26 of the detection part 28 of the ultrasonic slimming device 21 and the detection result is controlled by the control part 27.
  • the correlation between the distance to the internal organs and bones and the safe and efficient ultrasonic output and frequency (regression equation) is input to the control unit 27 in advance, and the appropriate frequency and irradiation corresponding to the results of the detection unit 28 Irradiate the ultrasonic wave to the ultrasonic wave irradiating section 25 in a single step. Correlation between ultrasonic power and frequency
  • the data is determined based on the concept of the half-value layer and the ultrasonic energy. For example, if the distance from the skin surface to the internal organ is detected as 3 to 5 cm, the data is set in advance and the data is determined. Control is performed to reduce the irradiation power by half.
  • the irradiation conditions of the ultrasonic wave can be selected according to the mode selected by the switch 24a, and when the frequency is 1.3 to 3 MHz, the irradiation power is 0.5 W / cm 2 or more. 3 W cm 2 while following ultrasonic selected in the range is irradiated, when the frequency is 3 to 1 5 MH z, irradiation power is 0. 0 5 W / cm 2 or more 0. 5 WZ cm 2 less than
  • the irradiation condition is selected based on the results of the detection unit 28 so that the irradiation conditions are determined so that the ultrasonic waves do not affect the internal organs and bones. And safety has been assured.
  • the control to reduce the irradiation power further than specified or to stop the ultrasonic irradiation is detected. It may be performed in part 28. That is, when it is determined that the distance from the skin surface to the internal organs and bones is 0.5 to 2 cm, the detection unit 28 narrows the irradiation path further than specified, and the distance from the skin surface to the internal organs and bones is 0. If it is determined that the distance is less than 5 cm, the detection unit 28 can also perform control for stopping irradiation of the ultrasonic wave.
  • the ultrasonic generator 23 of the ultrasonic slimming device 21 for partial slimming as described above, it is desirable to use for the whole body slimming such as the lower scapula, axilla, and back neck where brown fat cells are present.
  • brown fat cells can be enhanced to increase the heat productivity of the whole body, that is, the ultrasonic slimming device 21 can be used for slimming the whole body.
  • a plurality of ultrasonic generators 23 and detectors 28 are provided, respectively, to simultaneously perform partial slimming of multiple parts, simultaneously irradiate ultrasonic waves to multiple desired parts for slimming whole body, It is also possible to perform slimming and one or more partial slimming at the same time.

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Rehabilitation Therapy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Percussion Or Vibration Massage (AREA)

Abstract

L'invention concerne un atténuateur d'ondes ultrasonores (1) comprenant un générateur d'ondes ultrasonores (3) équipé d'un vibreur ultrasonore (2) permettant de diffuser une onde ultrasonore vers une partie prédéterminée (6) du corps (5) lorsqu'il est appliqué contre celle-ci, et d'une unité de commande (4) permettant de commander le vibreur ultrasonore (2). La puissance d'irradiation, lorsque la fréquence d'une onde ultrasonore émise par le générateur d'ondes ultrasonores (3) est comprise entre 1,3 et 3 MHz, est comprise entre 0,5 W/cm2 et 3 W/cm2.
PCT/JP2003/016551 2002-12-24 2003-12-24 Attenuateur d'ondes ultrasonores WO2004058135A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003292743A AU2003292743A1 (en) 2002-12-24 2003-12-24 Ultrasonic wave weight reducing device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002373135A JP2004201839A (ja) 2002-12-24 2002-12-24 超音波痩身装置
JP2002-373135 2002-12-24

Publications (1)

Publication Number Publication Date
WO2004058135A1 true WO2004058135A1 (fr) 2004-07-15

Family

ID=32677252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/016551 WO2004058135A1 (fr) 2002-12-24 2003-12-24 Attenuateur d'ondes ultrasonores

Country Status (3)

Country Link
JP (1) JP2004201839A (fr)
AU (1) AU2003292743A1 (fr)
WO (1) WO2004058135A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019008573A1 (fr) * 2017-07-06 2019-01-10 Slender Medical Ltd. Applicateur d'énergie ultrasonore

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200722068A (en) * 2005-07-29 2007-06-16 Shunkosha Kk Apparatus for body slimming
TW201531290A (zh) * 2013-10-18 2015-08-16 Ya Man Ltd 超音波美容器具、電壓施加方法及超音波頭
US20150174387A1 (en) * 2013-12-23 2015-06-25 L'oreal Combined sonic and ultrasonic skin care device

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0489058A (ja) * 1990-07-31 1992-03-23 Ya Man Ltd 接触温度を可変できる超音波美容装置
JPH09248213A (ja) * 1996-01-12 1997-09-22 Hoomaa Ion Kenkyusho:Kk 超音波を応用した美容・痩身器
WO1998053787A1 (fr) * 1997-05-26 1998-12-03 Miwa Science Laboratory Inc. Agent de decomposition du tissu adipeux utilisant des ondes ultra sonores
WO1999039677A1 (fr) * 1998-02-05 1999-08-12 Miwa Science Laboratory Inc. Appareil de rayonnement d'ondes ultrasoniques
JP2000217854A (ja) * 1999-01-29 2000-08-08 Toshihiko Yayama 超音波治療装置
JP2001170128A (ja) * 1999-12-22 2001-06-26 Matsushita Electric Works Ltd 痩身器具
JP2001314473A (ja) * 2000-05-12 2001-11-13 Heiwa Tokei Mfg Co Ltd 超音波美顔器
JP2002248451A (ja) * 2001-02-23 2002-09-03 Kurimoto Ltd 車載式圧縮成形装置

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0489058A (ja) * 1990-07-31 1992-03-23 Ya Man Ltd 接触温度を可変できる超音波美容装置
JPH09248213A (ja) * 1996-01-12 1997-09-22 Hoomaa Ion Kenkyusho:Kk 超音波を応用した美容・痩身器
WO1998053787A1 (fr) * 1997-05-26 1998-12-03 Miwa Science Laboratory Inc. Agent de decomposition du tissu adipeux utilisant des ondes ultra sonores
WO1999039677A1 (fr) * 1998-02-05 1999-08-12 Miwa Science Laboratory Inc. Appareil de rayonnement d'ondes ultrasoniques
JP2000217854A (ja) * 1999-01-29 2000-08-08 Toshihiko Yayama 超音波治療装置
JP2001170128A (ja) * 1999-12-22 2001-06-26 Matsushita Electric Works Ltd 痩身器具
JP2001314473A (ja) * 2000-05-12 2001-11-13 Heiwa Tokei Mfg Co Ltd 超音波美顔器
JP2002248451A (ja) * 2001-02-23 2002-09-03 Kurimoto Ltd 車載式圧縮成形装置

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019008573A1 (fr) * 2017-07-06 2019-01-10 Slender Medical Ltd. Applicateur d'énergie ultrasonore

Also Published As

Publication number Publication date
JP2004201839A (ja) 2004-07-22
AU2003292743A1 (en) 2004-07-22

Similar Documents

Publication Publication Date Title
JP4723707B2 (ja) 痩身器具
US5413550A (en) Ultrasound therapy system with automatic dose control
US10556123B2 (en) Method and apparatus for treatment of cutaneous and subcutaneous conditions
KR102696429B1 (ko) 내부 장기, 부상 및 통증 처리 방법
EP1603507B1 (fr) Traitement par ultrasons de la cellulite
CN100441250C (zh) 超声波经皮透过装置、超声波经皮透过配套产品和超声波经皮透过方法
JP3416909B2 (ja) 超音波照射装置
KR101605527B1 (ko) 초음파 치료 시스템
CN103919638A (zh) 一种便携式治疗器械及其使用方法
KR101472983B1 (ko) 고주파 온열 치료 장치
JP2002306614A (ja) リッツ線コイルを用いた磁気刺激装置
KR102214521B1 (ko) 미용에 사용하는 복합 전극패드를 이용한 미용기기와 그 방법
WO2004058135A1 (fr) Attenuateur d'ondes ultrasonores
JP2005253501A (ja) 複合処理装置
Bissell Therapeutic modalities in hand surgery
EP1569722B1 (fr) Appareil permettant de traiter des patients souffrant de maladies vasculaires au moyen d'ondes infra, audibles et ultrasons
KR20050024353A (ko) 피부 및 피하 상태 치료 방법 및 장치
IL257938A (en) A method for non-invasive mastopexy
RU2830461C1 (ru) Излучающее ультразвук устройство для селективного воздействия на жировую ткань в процессах омоложения/коррекции тела
HK1082927B (en) An apparatus for treating patients suffering from vascular disease by means of infra-, audibel- and ultrasound waves

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS KE KG KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase