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WO2004069990A3 - Composes oligomeres pour la modulation de l'expression de thioredoxine - Google Patents

Composes oligomeres pour la modulation de l'expression de thioredoxine Download PDF

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Publication number
WO2004069990A3
WO2004069990A3 PCT/DK2004/000095 DK2004000095W WO2004069990A3 WO 2004069990 A3 WO2004069990 A3 WO 2004069990A3 DK 2004000095 W DK2004000095 W DK 2004000095W WO 2004069990 A3 WO2004069990 A3 WO 2004069990A3
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Prior art keywords
trx
expression
oligonucleotides
modulation
lung
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PCT/DK2004/000095
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English (en)
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WO2004069990A2 (fr
Inventor
Bo Hansen
Charlotte Albaek Thrue
Kamille Dumong Petersen
Majken Westergaard
Margit Wissenbach
Original Assignee
Santaris Pharma As
Bo Hansen
Charlotte Albaek Thrue
Kamille Dumong Petersen
Majken Westergaard
Margit Wissenbach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Santaris Pharma As, Bo Hansen, Charlotte Albaek Thrue, Kamille Dumong Petersen, Majken Westergaard, Margit Wissenbach filed Critical Santaris Pharma As
Priority to JP2006501523A priority Critical patent/JP2006518999A/ja
Priority to CA002515554A priority patent/CA2515554A1/fr
Priority to EP04709581A priority patent/EP1592794A2/fr
Priority to AU2004209597A priority patent/AU2004209597A1/en
Publication of WO2004069990A2 publication Critical patent/WO2004069990A2/fr
Publication of WO2004069990A3 publication Critical patent/WO2004069990A3/fr

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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Abstract

L'invention concerne des oligonucléotides dirigés contre le gène TRX afin de moduler l'expression de TRX. Ces compositions contiennent des oligonucléotides ciblés vers des acides nucléiques codant TRX. L'invention porte aussi sur des procédés d'utilisation de ces composés pour la modulation de l'expression de TRX et pour le traitement de maladies associées soit à la surexpression de TRX, soit à l'expression de TRX muté, ou aux deux. Parmi ces maladies figurent le cancer tel le cancer des poumons, du sein, du colon, de la prostate, du pancréas, du foie, de la thyroïde, des reins, du cerveau, des testicules, de l'estomac, de l'intestin, de la moelle épinière, des sinus, de la vessie, du tractus urinaire ou des ovaires. Ces oligonucléotides peuvent être composés deoxyribonucléosides ou d'un acide nucléique analogue tel un acide nucléique verrouillé ou une combinaison des deux.
PCT/DK2004/000095 2003-02-10 2004-02-10 Composes oligomeres pour la modulation de l'expression de thioredoxine WO2004069990A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2006501523A JP2006518999A (ja) 2003-02-10 2004-02-10 チオレドキシン発現の改変のためのオリゴマー化合物
CA002515554A CA2515554A1 (fr) 2003-02-10 2004-02-10 Composes oligomeres pour la modulation de l'expression de thioredoxine
EP04709581A EP1592794A2 (fr) 2003-02-10 2004-02-10 Composes oligomeres pour la modulation de l'expression de thioredoxine
AU2004209597A AU2004209597A1 (en) 2003-02-10 2004-02-10 Oligomeric compounds for the modulation of thioredoxin expression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200300188 2003-02-10
DKPA200300188 2003-02-10

Publications (2)

Publication Number Publication Date
WO2004069990A2 WO2004069990A2 (fr) 2004-08-19
WO2004069990A3 true WO2004069990A3 (fr) 2004-09-16

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PCT/DK2004/000095 WO2004069990A2 (fr) 2003-02-10 2004-02-10 Composes oligomeres pour la modulation de l'expression de thioredoxine

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EP (1) EP1592794A2 (fr)
JP (1) JP2006518999A (fr)
AU (1) AU2004209597A1 (fr)
CA (1) CA2515554A1 (fr)
WO (1) WO2004069990A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2456990T3 (es) * 2007-11-26 2014-04-24 Santaris Pharma A/S Antagonistas basados en LNA dirigidos al receptor de andrógenos
JP6429264B2 (ja) * 2013-11-12 2018-11-28 学校法人東京理科大学 ボラノホスフェート化合物、及び核酸オリゴマー

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999038963A1 (fr) * 1998-01-30 1999-08-05 Genesense Technologies, Inc. Sequences oligonucleotidiques complementaires des genes de la thioredoxine reductase et leurs procedes d'utilisation pour la modulation de la croissance cellulaire
WO2001048190A2 (fr) * 1999-12-23 2001-07-05 Exiqon A/S Utilisations therapeutiques d'oligonucleotides a lna modifie

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999038963A1 (fr) * 1998-01-30 1999-08-05 Genesense Technologies, Inc. Sequences oligonucleotidiques complementaires des genes de la thioredoxine reductase et leurs procedes d'utilisation pour la modulation de la croissance cellulaire
WO2001048190A2 (fr) * 1999-12-23 2001-07-05 Exiqon A/S Utilisations therapeutiques d'oligonucleotides a lna modifie

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
ALTMANN K.-H. ET AL.: "NOVEL CHEMISTRY", 1998, APPLIED ANTISENSE OLIGONUCLEOTIDE TECHNOLOGY; STEIN C.A. AND KRIEG A.M. EDS. WILEY-LISS INC., US, ISBN: 0-471-17279-0, XP002119324 *
ANDOH T. ET AL.: "The roles of Thioredoxin in protection against oxidative stress-induced apoptosis in SH-SY5Y cells", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 12, 22 March 2002 (2002-03-22), pages 9655 - 0660, XP002290398 *
BIESSEN E.A.L. ET AL.: "Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepatocytes", BIOCONJUGATE CHEMISTRY, vol. 13, 2002, pages 295 - 302, XP002290397 *
BRAASCH D.A . ET AL.: "Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA", CHEMISTRY AND BIOLOGY, vol. 8, no. 1, January 2001 (2001-01-01), pages 1 - 7, XP002255827, ISSN: 1074-5521 *
BRAASCH D.A. ET AL.: "Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design", NUCLEIC ACIDS RESEARCH, vol. 30, no. 23, 2002, pages 5160 - 5167, XP002290400 *
FLUITER K. ET AL.: "In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides", NUCLEIC ACIDS RESEARCH, vol. 31, no. 3, 1 February 2003 (2003-02-01), pages 953 - 962, XP002290401 *
HORI K. ET AL.: "Expression of Adult T Cell Leukemia-derived Factor / Human Thioredoxin in human gliomas", MIE MEDICAL JOURNAL, vol. 44, no. 1, 1994, pages 19 - 24, XP008033406 *
KOJI MORITA ET AL.: "2'-O,4'-C-ethylene-bridged nucleic acid (ENA): highly nuclease resistant and thermodinamically stable oligonucleotides for antisense drug", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 12, 2002, pages 73 - 76, XP002290399 *
KURRECK J. ET AL.: "Design of antisense oligonucleotides stabilized by locked nucleic acids", NUCLEIC ACIDS RESEARCH, vol. 30, no. 9, 1 May 2002 (2002-05-01), pages 1911 - 1918, XP002281375, ISSN: 0305-1048 *
OERUM H. ET AL.: "Locked nucleic acids: a promising molecular family for gene-function analysis and antisense drug development", CURRENT OPINION IN MOLECULAR THERAPEUTICS, vol. 3, no. 3, June 2001 (2001-06-01), pages 239 - 243, XP001179829, ISSN: 1464-8431 *
RAIT A.S. ET AL.: "Inhibitory effects of the combination of HER-2 antisense oligonucleotide and chemotherapeutic agents used for the treatment of human breast cancer", CANCER GENE THERAPY, vol. 8, no. 10, 2001, pages 728 - 739, XP008005112, ISSN: 0929-1903 *
SAITOH M ET AL: "Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1", EMBO JOURNAL, vol. 17, no. 9, 1 May 1998 (1998-05-01), pages 2596 - 2606, XP002106020, ISSN: 0261-4189 *

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Publication number Publication date
EP1592794A2 (fr) 2005-11-09
WO2004069990A2 (fr) 2004-08-19
AU2004209597A1 (en) 2004-08-19
JP2006518999A (ja) 2006-08-24
CA2515554A1 (fr) 2004-08-19

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