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WO2005058298A3 - Analogues de fk228 et methodes de production et d'utilisation desdits analogues - Google Patents

Analogues de fk228 et methodes de production et d'utilisation desdits analogues Download PDF

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Publication number
WO2005058298A3
WO2005058298A3 PCT/US2004/041678 US2004041678W WO2005058298A3 WO 2005058298 A3 WO2005058298 A3 WO 2005058298A3 US 2004041678 W US2004041678 W US 2004041678W WO 2005058298 A3 WO2005058298 A3 WO 2005058298A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogs
inhibitors
hdac
tissues
making
Prior art date
Application number
PCT/US2004/041678
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English (en)
Other versions
WO2005058298B1 (fr
WO2005058298A2 (fr
Inventor
Scott R Rajski
David A Wassarman
Jose A Restituyo
Original Assignee
Wisconsin Alumni Res Found
Scott R Rajski
David A Wassarman
Jose A Restituyo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found, Scott R Rajski, David A Wassarman, Jose A Restituyo filed Critical Wisconsin Alumni Res Found
Priority to EP04813928A priority Critical patent/EP1713460A2/fr
Publication of WO2005058298A2 publication Critical patent/WO2005058298A2/fr
Publication of WO2005058298A3 publication Critical patent/WO2005058298A3/fr
Publication of WO2005058298B1 publication Critical patent/WO2005058298B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Analogues de FK228 et méthodes de production et d'utilisation desdits analogues. Ces analogues sont de puissants inhibiteurs de l'histone désacétylase et, dans certains modes de réalisation, sont capables de cibler spécifiquement des cellules et tissus cancéreux. Dans des modes de réalisation préférés, ces analogues sont caractérisés par un motif disulfure cyclique.
PCT/US2004/041678 2003-12-10 2004-12-10 Analogues de fk228 et methodes de production et d'utilisation desdits analogues WO2005058298A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04813928A EP1713460A2 (fr) 2003-12-10 2004-12-10 Analogues de fk228 et leur utilisation comme inhibiteurs de hdac

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52850103P 2003-12-10 2003-12-10
US60/528,501 2003-12-10

Publications (3)

Publication Number Publication Date
WO2005058298A2 WO2005058298A2 (fr) 2005-06-30
WO2005058298A3 true WO2005058298A3 (fr) 2005-11-10
WO2005058298B1 WO2005058298B1 (fr) 2005-12-08

Family

ID=34699874

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/041678 WO2005058298A2 (fr) 2003-12-10 2004-12-10 Analogues de fk228 et methodes de production et d'utilisation desdits analogues

Country Status (2)

Country Link
EP (1) EP1713460A2 (fr)
WO (1) WO2005058298A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7375228B2 (en) 2003-03-17 2008-05-20 Takeda San Diego, Inc. Histone deacetylase inhibitors
JP2008520682A (ja) * 2004-11-17 2008-06-19 ザ ユニヴァーシティー オヴ シカゴ ヒストンデアセチラーゼ阻害剤およびその使用方法
WO2006066133A2 (fr) 2004-12-16 2006-06-22 Takeda San Diego, Inc. Inhibiteurs d'histone desacetylase
EP1896436A2 (fr) 2005-05-11 2008-03-12 Takeda San Diego, Inc. Inhibiteurs d'histone deacetylase
EP1904452A2 (fr) 2005-07-14 2008-04-02 Takeda San Diego, Inc. Inhibiteurs de l'histone deacetylase
CA2650520A1 (fr) 2006-04-24 2008-01-31 Gloucester Pharmaceuticals Traitement de tumeurs exprimant ras
US8957027B2 (en) 2006-06-08 2015-02-17 Celgene Corporation Deacetylase inhibitor therapy
WO2008083288A2 (fr) 2006-12-29 2008-07-10 Gloucester Pharmaceuticals Préparation de la romidepsine
WO2008083290A1 (fr) 2006-12-29 2008-07-10 Gloucester Pharmaceuticals, Inc. Traitements du cancer à base de romidepsine
US8828924B2 (en) * 2009-05-14 2014-09-09 University Of Maryland, Baltimore Methods of treating a diabetic embryopathy
MX342913B (es) 2010-07-12 2016-10-19 Celgene Corp * Formas solidas de romidepsina y sus usos.
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
AU2013202507B9 (en) 2012-11-14 2015-08-13 Celgene Corporation Inhibition of drug resistant cancer cells
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
CN113861267B (zh) * 2021-10-25 2023-06-27 深圳湾实验室坪山生物医药研发转化中心 一种缩酯环肽类化合物lzg-pku-h及其合成方法和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0352646A2 (fr) * 1988-07-26 1990-01-31 Fujisawa Pharmaceutical Co., Ltd. Substance FR901228 et sa préparation
WO2002062773A1 (fr) * 2001-01-27 2002-08-15 F. Hoffmann-La Roche Ag Derives de sultames et de lactames tricycliques, utilisation de ces derniers en tant qu'inhibiteurs de l'histone deacetylase
US20020183513A1 (en) * 2001-04-23 2002-12-05 Adelbert Grossmann Tricyclic alkylhydroxamate derivatives
WO2003015810A1 (fr) * 2001-08-21 2003-02-27 Fujisawa Pharmaceutical Co., Ltd. Usage medical d'un inhibiteur d'histone desacetylase et methode d'evaluation de son activite antitumorale
EP1302476A1 (fr) * 2000-07-17 2003-04-16 Fujisawa Pharmaceutical Co., Ltd. Fk228 reduit et son utilisation
WO2003084611A1 (fr) * 2002-04-05 2003-10-16 Fujisawa Pharmaceutical Co., Ltd. Depsipeptide pour la therapie du cancer du rein

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0352646A2 (fr) * 1988-07-26 1990-01-31 Fujisawa Pharmaceutical Co., Ltd. Substance FR901228 et sa préparation
EP1302476A1 (fr) * 2000-07-17 2003-04-16 Fujisawa Pharmaceutical Co., Ltd. Fk228 reduit et son utilisation
WO2002062773A1 (fr) * 2001-01-27 2002-08-15 F. Hoffmann-La Roche Ag Derives de sultames et de lactames tricycliques, utilisation de ces derniers en tant qu'inhibiteurs de l'histone deacetylase
US20020183513A1 (en) * 2001-04-23 2002-12-05 Adelbert Grossmann Tricyclic alkylhydroxamate derivatives
WO2003015810A1 (fr) * 2001-08-21 2003-02-27 Fujisawa Pharmaceutical Co., Ltd. Usage medical d'un inhibiteur d'histone desacetylase et methode d'evaluation de son activite antitumorale
WO2003084611A1 (fr) * 2002-04-05 2003-10-16 Fujisawa Pharmaceutical Co., Ltd. Depsipeptide pour la therapie du cancer du rein

Also Published As

Publication number Publication date
WO2005058298B1 (fr) 2005-12-08
EP1713460A2 (fr) 2006-10-25
WO2005058298A2 (fr) 2005-06-30

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