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WO2005000863A3 - 6, 11-4c-bicyclic 9a-azalide derivatives - Google Patents

6, 11-4c-bicyclic 9a-azalide derivatives Download PDF

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Publication number
WO2005000863A3
WO2005000863A3 PCT/US2004/015806 US2004015806W WO2005000863A3 WO 2005000863 A3 WO2005000863 A3 WO 2005000863A3 US 2004015806 W US2004015806 W US 2004015806W WO 2005000863 A3 WO2005000863 A3 WO 2005000863A3
Authority
WO
WIPO (PCT)
Prior art keywords
present
compounds
bicyclic
subject
invention further
Prior art date
Application number
PCT/US2004/015806
Other languages
French (fr)
Other versions
WO2005000863A2 (en
Inventor
Guoqiang Wang
Yat Sun Or
Ly Tam Phan
Original Assignee
Enanta Pharm Inc
Guoqiang Wang
Yat Sun Or
Ly Tam Phan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc, Guoqiang Wang, Yat Sun Or, Ly Tam Phan filed Critical Enanta Pharm Inc
Publication of WO2005000863A2 publication Critical patent/WO2005000863A2/en
Publication of WO2005000863A3 publication Critical patent/WO2005000863A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention discloses compounds of formula (I), or pharmaceutically acceptables salts, esters, or prodrugs thereof, which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
PCT/US2004/015806 2003-06-18 2004-05-19 6, 11-4c-bicyclic 9a-azalide derivatives WO2005000863A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/464,188 US6764998B1 (en) 2003-06-18 2003-06-18 6,11-4C-bicyclic 9a-azalide derivatives
US10/464,188 2003-06-18

Publications (2)

Publication Number Publication Date
WO2005000863A2 WO2005000863A2 (en) 2005-01-06
WO2005000863A3 true WO2005000863A3 (en) 2005-03-10

Family

ID=32682544

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/015806 WO2005000863A2 (en) 2003-06-18 2004-05-19 6, 11-4c-bicyclic 9a-azalide derivatives

Country Status (2)

Country Link
US (2) US6764998B1 (en)
WO (1) WO2005000863A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135573B2 (en) * 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US20060058247A1 (en) * 2004-09-16 2006-03-16 Yujiro Hata Methods and compositions for treating cystic fibrosis
US7402568B2 (en) * 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7271155B2 (en) * 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
US7212488B2 (en) * 2005-03-21 2007-05-01 Hewlett-Packard Development Company, L.P. Method and device enabling capacitive probe-based data storage readout
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US7563877B2 (en) * 2006-03-02 2009-07-21 Enanta Pharmaceuticals, Inc. Processes for the preparation of 0-(2-aminobenzo[d]oxazol-5-yl)methyl hydroxylamine for the synthesis of 6,11-bicyclic erythromycin derivative EDP-182
US20070231368A1 (en) * 2006-03-30 2007-10-04 Enanta Pharmaceuticals, Inc. Pharmaceutical formulations of 6-11 bicyclic macrolide derivative known as edp-182 and methods for preparation thereof
US20070259822A1 (en) * 2006-05-04 2007-11-08 Yat Sun Or 8a,11-bicyclic 8a-azalide derivatives
AU2007256844A1 (en) * 2006-06-05 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted erythromycin analogs
US20090053673A1 (en) * 2007-08-23 2009-02-26 Zimmer, Inc. Method for localized treatment of periodontal tissue
AU2008335668C1 (en) * 2007-09-17 2013-05-30 Enanta Pharmaceuticals, Inc. 6, 11-bridged biaryl macrolides
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
WO2009064953A1 (en) * 2007-11-15 2009-05-22 Enanta Pharmaceuticals, Inc. Use of bridged macrolides or tylosin derivatives in treating inflammatory bowel diseases
TW200946109A (en) 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
US11673910B2 (en) 2017-04-28 2023-06-13 Zikani Therapeutics, Inc. Macrolides with modified desosamine sugars and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046171A (en) * 1997-10-29 2000-04-04 Abbott Laboratories 6,11-bridged erythromycin derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960000434B1 (en) 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 Erythromycin A derivatives and preparation method thereof
IL114589A (en) 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
KR0166096B1 (en) 1990-11-28 1999-01-15 우에하라 아키라 6-0-methylerythromycin A derivative
DK0638585T3 (en) 1992-04-22 1996-12-02 Taisho Pharmaceutical Co Ltd 5-O-desosaminylerythronolide A derivatives
US5527780A (en) 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2738571B1 (en) 1995-09-11 1997-10-17 Roussel Uclaf NOVEL DERIVATIVES OF 5-0-DESOSAMINYL 6-0-METHYL- ERYTHRONOLIDE A, THEIR PREPARATION PROCESS AND THEIR APPLICATION TO THE PREPARATION OF BIOLOGICALLY ACTIVE PRODUCTS
UA51730C2 (en) 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-0-substituted ketolides having antibacterial activity
US6124269A (en) 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
WO2000062783A2 (en) 1999-04-16 2000-10-26 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
PT1206476E (en) 1999-08-24 2006-05-31 Abbott Lab 9A-AZALIDOS WITH ANTIBACTERIAL ACTIVITY
GB0127349D0 (en) 2001-11-14 2002-01-02 Glaxo Group Ltd Macrolides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046171A (en) * 1997-10-29 2000-04-04 Abbott Laboratories 6,11-bridged erythromycin derivatives

Also Published As

Publication number Publication date
WO2005000863A2 (en) 2005-01-06
US6764998B1 (en) 2004-07-20
US20050014707A1 (en) 2005-01-20

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