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WO2005001411A3 - An online flow through microchip for detecting hazardous chemical and biological agents in drinking water - Google Patents

An online flow through microchip for detecting hazardous chemical and biological agents in drinking water Download PDF

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Publication number
WO2005001411A3
WO2005001411A3 PCT/US2003/037173 US0337173W WO2005001411A3 WO 2005001411 A3 WO2005001411 A3 WO 2005001411A3 US 0337173 W US0337173 W US 0337173W WO 2005001411 A3 WO2005001411 A3 WO 2005001411A3
Authority
WO
WIPO (PCT)
Prior art keywords
microchip
microbead
drinking water
monoclonal antibodies
biological agents
Prior art date
Application number
PCT/US2003/037173
Other languages
French (fr)
Other versions
WO2005001411A2 (en
Inventor
Oleksandr V Pozdin
Original Assignee
Laser Light Technologies Inc
Oleksandr V Pozdin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laser Light Technologies Inc, Oleksandr V Pozdin filed Critical Laser Light Technologies Inc
Priority to AU2003304256A priority Critical patent/AU2003304256A1/en
Publication of WO2005001411A2 publication Critical patent/WO2005001411A2/en
Publication of WO2005001411A3 publication Critical patent/WO2005001411A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A flow through microchip is disclosed having physically-registered microetched pores embedded within a wafer. The circular pores have a tapered design having an entrance diameter larger than the exit diameter. Within each pore is placed a small microbead. Each microbead will have monoclonal antibodies bound to its surfaces wherein the monoclonal antibodies are proteins designed and engineered to specifically bind pathogenic microorganisms, biotoxins, pesticides, and other contaminants. The monoclonal antibodies covering the surface of the microbead will capture the contaminants as water flows over the bead.
PCT/US2003/037173 2002-11-20 2003-11-19 An online flow through microchip for detecting hazardous chemical and biological agents in drinking water WO2005001411A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003304256A AU2003304256A1 (en) 2002-11-20 2003-11-19 An online flow through microchip for detecting hazardous chemical and biological agents in drinking water

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42781302P 2002-11-20 2002-11-20
US60/427,813 2002-11-20

Publications (2)

Publication Number Publication Date
WO2005001411A2 WO2005001411A2 (en) 2005-01-06
WO2005001411A3 true WO2005001411A3 (en) 2005-12-29

Family

ID=33551211

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/037173 WO2005001411A2 (en) 2002-11-20 2003-11-19 An online flow through microchip for detecting hazardous chemical and biological agents in drinking water

Country Status (2)

Country Link
AU (1) AU2003304256A1 (en)
WO (1) WO2005001411A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4679197B2 (en) * 2005-03-25 2011-04-27 株式会社東芝 Microbial separator
WO2011085490A1 (en) * 2010-01-14 2011-07-21 University Of British Columbia Apparatuses for determining whether a substance is carried in a fluid
KR101037099B1 (en) 2010-11-30 2011-05-25 주식회사 이바이오젠 Vibration Hybrid Biochip Reaction System Using Bead Chamber
CN112723304B (en) * 2020-12-14 2021-09-10 苏州拉索生物芯片科技有限公司 Microbead chip and preparation method thereof

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5100626A (en) * 1990-05-24 1992-03-31 Levin Andrew E Binding assay device with removable cassette and manifold
US5609826A (en) * 1995-04-17 1997-03-11 Ontogen Corporation Methods and apparatus for the generation of chemical libraries
US5714389A (en) * 1988-06-27 1998-02-03 Carter-Wallace, Inc. Test device and method for colored particle immunoassay
US6083682A (en) * 1997-12-19 2000-07-04 Glaxo Group Limited System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
US6083761A (en) * 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
US6309608B1 (en) * 1998-04-23 2001-10-30 Stephen Matson Method and apparatus for organic synthesis
US20020045272A1 (en) * 2000-01-31 2002-04-18 Mcdevitt John T. Method and apparatus for the delivery of samples to a chemical sensor array
US20020094533A1 (en) * 2000-10-10 2002-07-18 Hess Robert A. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
US6439036B1 (en) * 2000-06-13 2002-08-27 Symyx Technologics, Inc. Method for evaluating a test fluid
US6485690B1 (en) * 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714389A (en) * 1988-06-27 1998-02-03 Carter-Wallace, Inc. Test device and method for colored particle immunoassay
US5100626A (en) * 1990-05-24 1992-03-31 Levin Andrew E Binding assay device with removable cassette and manifold
US5609826A (en) * 1995-04-17 1997-03-11 Ontogen Corporation Methods and apparatus for the generation of chemical libraries
US6083761A (en) * 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
US6083682A (en) * 1997-12-19 2000-07-04 Glaxo Group Limited System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
US6309608B1 (en) * 1998-04-23 2001-10-30 Stephen Matson Method and apparatus for organic synthesis
US6485690B1 (en) * 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
US20020045272A1 (en) * 2000-01-31 2002-04-18 Mcdevitt John T. Method and apparatus for the delivery of samples to a chemical sensor array
US6439036B1 (en) * 2000-06-13 2002-08-27 Symyx Technologics, Inc. Method for evaluating a test fluid
US20020094533A1 (en) * 2000-10-10 2002-07-18 Hess Robert A. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof

Also Published As

Publication number Publication date
WO2005001411A2 (en) 2005-01-06
AU2003304256A1 (en) 2005-01-13

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