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WO2005113018A3 - Cancer treatment using viruses and camptothecins - Google Patents

Cancer treatment using viruses and camptothecins Download PDF

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Publication number
WO2005113018A3
WO2005113018A3 PCT/US2005/014144 US2005014144W WO2005113018A3 WO 2005113018 A3 WO2005113018 A3 WO 2005113018A3 US 2005014144 W US2005014144 W US 2005014144W WO 2005113018 A3 WO2005113018 A3 WO 2005113018A3
Authority
WO
WIPO (PCT)
Prior art keywords
virus
camptothecins
viruses
cancer treatment
treatment
Prior art date
Application number
PCT/US2005/014144
Other languages
French (fr)
Other versions
WO2005113018A2 (en
Inventor
Robert M Lorence
Michael S Roberts
Original Assignee
Wellstat Biologics Corp
Robert M Lorence
Michael S Roberts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US11/568,228 priority Critical patent/US20070207149A1/en
Priority to CN2005800130396A priority patent/CN1946421B/en
Priority to EP05779961.1A priority patent/EP1744780B1/en
Priority to NZ550430A priority patent/NZ550430A/en
Priority to HK07101289.1A priority patent/HK1096583B/en
Priority to CA2562904A priority patent/CA2562904C/en
Priority to JP2007510862A priority patent/JP5170741B2/en
Priority to AU2005244768A priority patent/AU2005244768B2/en
Application filed by Wellstat Biologics Corp, Robert M Lorence, Michael S Roberts filed Critical Wellstat Biologics Corp
Priority to MXPA06012145A priority patent/MXPA06012145A/en
Publication of WO2005113018A2 publication Critical patent/WO2005113018A2/en
Publication of WO2005113018A3 publication Critical patent/WO2005113018A3/en
Priority to ZA2006/08119A priority patent/ZA200608119B/en
Priority to IL178492A priority patent/IL178492A/en
Priority to US14/076,485 priority patent/US20140065140A1/en
Priority to US15/195,200 priority patent/US9844574B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Mammalian subjects having a neoplasm are treated with a virus and a camptothecin compound, for example irinotecan or topotecan. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus. The treatment can also include administration of a monoclonal antibody against epidermal growth factor receptor, for example cetuximab.
PCT/US2005/014144 2004-04-27 2005-04-26 Cancer treatment using viruses and camptothecins WO2005113018A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP2007510862A JP5170741B2 (en) 2004-04-27 2005-04-26 Treatment of cancer using viruses and camptothecins
EP05779961.1A EP1744780B1 (en) 2004-04-27 2005-04-26 Cancer treatment using viruses and camptothecins
NZ550430A NZ550430A (en) 2004-04-27 2005-04-26 Cancer treatment using viruses and camptothecins
HK07101289.1A HK1096583B (en) 2004-04-27 2005-04-26 Cancer treatment using viruses and camptothecins
CA2562904A CA2562904C (en) 2004-04-27 2005-04-26 Cancer treatment using viruses and camptothecins
AU2005244768A AU2005244768B2 (en) 2004-04-27 2005-04-26 Cancer treatment using viruses and camptothecins
MXPA06012145A MXPA06012145A (en) 2004-04-27 2005-04-26 Cancer treatment using viruses and camptothecins.
US11/568,228 US20070207149A1 (en) 2004-04-27 2005-04-26 Cancer treatment using viruses and camptothecins
CN2005800130396A CN1946421B (en) 2004-04-27 2005-04-26 Cancer treatment using viruses and camptothecins
ZA2006/08119A ZA200608119B (en) 2004-04-27 2006-09-29 Cancer treatment using viruses and camptothecins
IL178492A IL178492A (en) 2004-04-27 2006-10-05 Cancer treatment using viruses in combination with camptothecins
US14/076,485 US20140065140A1 (en) 2004-04-27 2013-11-11 Cancer treatment using viruses and camptothecins
US15/195,200 US9844574B2 (en) 2004-04-27 2016-06-28 Cancer treatment using viruses and camptothecins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56563104P 2004-04-27 2004-04-27
US60/565,631 2004-04-27

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/568,228 A-371-Of-International US20070207149A1 (en) 2004-04-27 2005-04-26 Cancer treatment using viruses and camptothecins
US14/076,485 Continuation US20140065140A1 (en) 2004-04-27 2013-11-11 Cancer treatment using viruses and camptothecins

Publications (2)

Publication Number Publication Date
WO2005113018A2 WO2005113018A2 (en) 2005-12-01
WO2005113018A3 true WO2005113018A3 (en) 2006-03-02

Family

ID=35428865

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/014144 WO2005113018A2 (en) 2004-04-27 2005-04-26 Cancer treatment using viruses and camptothecins

Country Status (13)

Country Link
US (3) US20070207149A1 (en)
EP (1) EP1744780B1 (en)
JP (2) JP5170741B2 (en)
KR (1) KR20070008710A (en)
CN (1) CN1946421B (en)
AU (1) AU2005244768B2 (en)
CA (1) CA2562904C (en)
IL (1) IL178492A (en)
MX (1) MXPA06012145A (en)
NZ (1) NZ550430A (en)
RU (2) RU2408387C2 (en)
WO (1) WO2005113018A2 (en)
ZA (1) ZA200608119B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1946421B (en) * 2004-04-27 2013-07-17 威尔斯达特生物制剂公司 Cancer treatment using viruses and camptothecins
MX2007010962A (en) * 2005-03-07 2008-03-10 Robarts Res Inst Use of a combination of myxoma virus and rapamycin for therapeutic treatment.
RU2435586C2 (en) * 2005-07-14 2011-12-10 Веллстат Байолоджикс Корпорейшн Cancer treatment with application of viruses fluoropyrimidines and camptothecins
WO2007143548A2 (en) 2006-06-01 2007-12-13 Robarts Research Institute Myxoma virus mutants for cancer treatment
EP2073823A1 (en) * 2006-10-13 2009-07-01 Medigene AG Use of oncolytic viruses and antiangiogenic agents in the treatment of cancer
US20110318430A1 (en) * 2008-12-18 2011-12-29 New York University Tumor therapy with antitumor agents in combination with sindbis virus-based vectors
ATE539148T1 (en) 2009-11-30 2012-01-15 United Cancer Res Inst NEW CLONE OF AVIAN PLAGUE VIRUS, PREPARATION AND APPLICATION IN MEDICAL TREATMENT OF CANCER
EP3033150A4 (en) * 2013-08-13 2017-06-28 Bionumerik Pharmaceuticals, Inc. Administration of karenitecin for the treatment of advanced ovarian cancer, including chemotherapy-resistant and/or the mucinous adenocarcinoma sub-types
CN107669707A (en) * 2017-11-16 2018-02-09 邹罡 Application of the echovirus as oncolytic virus in antitumor

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Also Published As

Publication number Publication date
JP2007534761A (en) 2007-11-29
JP2013047276A (en) 2013-03-07
MXPA06012145A (en) 2007-01-31
ZA200608119B (en) 2008-05-28
US20160303175A1 (en) 2016-10-20
AU2005244768A1 (en) 2005-12-01
CA2562904A1 (en) 2005-12-01
HK1096583A1 (en) 2007-06-08
JP5170741B2 (en) 2013-03-27
US20070207149A1 (en) 2007-09-06
RU2006141654A (en) 2008-06-27
EP1744780B1 (en) 2013-08-07
NZ550430A (en) 2009-06-26
RU2408387C2 (en) 2011-01-10
AU2005244768B2 (en) 2011-06-09
KR20070008710A (en) 2007-01-17
CN1946421B (en) 2013-07-17
EP1744780A4 (en) 2009-08-05
RU2010138887A (en) 2012-03-27
IL178492A0 (en) 2007-02-11
IL178492A (en) 2010-06-30
US20140065140A1 (en) 2014-03-06
CN1946421A (en) 2007-04-11
EP1744780A2 (en) 2007-01-24
WO2005113018A2 (en) 2005-12-01
CA2562904C (en) 2013-07-02
US9844574B2 (en) 2017-12-19

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