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WO2005113598A3 - Membres de la superfamille des tnf avec immunogenicite modifiee - Google Patents

Membres de la superfamille des tnf avec immunogenicite modifiee Download PDF

Info

Publication number
WO2005113598A3
WO2005113598A3 PCT/US2005/018130 US2005018130W WO2005113598A3 WO 2005113598 A3 WO2005113598 A3 WO 2005113598A3 US 2005018130 W US2005018130 W US 2005018130W WO 2005113598 A3 WO2005113598 A3 WO 2005113598A3
Authority
WO
WIPO (PCT)
Prior art keywords
super family
family members
altered immunogenicity
tnf super
relates
Prior art date
Application number
PCT/US2005/018130
Other languages
English (en)
Other versions
WO2005113598A2 (fr
Inventor
Shannon Alicia Marshall
Gregory L Moore
Arthur J Chirino
John R Desjarlais
Original Assignee
Xencor Inc
Shannon Alicia Marshall
Gregory L Moore
Arthur J Chirino
John R Desjarlais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc, Shannon Alicia Marshall, Gregory L Moore, Arthur J Chirino, John R Desjarlais filed Critical Xencor Inc
Publication of WO2005113598A2 publication Critical patent/WO2005113598A2/fr
Publication of WO2005113598A3 publication Critical patent/WO2005113598A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Cette invention concerne des protéines variantes existant à l'état naturel membres de la superfamille des facteurs de nécrose tumorale avec immunogénicité réduite. Cette invention concerne plus spécifiquement les protéines variantes BAFF, RANKL, TRAIL, CD40L et APRIL avec immunogénicité réduite.
PCT/US2005/018130 2004-05-21 2005-05-23 Membres de la superfamille des tnf avec immunogenicite modifiee WO2005113598A2 (fr)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US57320604P 2004-05-21 2004-05-21
US57339504P 2004-05-21 2004-05-21
US57330104P 2004-05-21 2004-05-21
US60/573,395 2004-05-21
US60/573,206 2004-05-21
US60/573,301 2004-05-21
US58831404P 2004-07-14 2004-07-14
US60/588,314 2004-07-14
US60739704P 2004-09-02 2004-09-02
US60739604P 2004-09-02 2004-09-02
US60/607,396 2004-09-02
US60/607,397 2004-09-02

Publications (2)

Publication Number Publication Date
WO2005113598A2 WO2005113598A2 (fr) 2005-12-01
WO2005113598A3 true WO2005113598A3 (fr) 2006-06-01

Family

ID=35428917

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/018130 WO2005113598A2 (fr) 2004-05-21 2005-05-23 Membres de la superfamille des tnf avec immunogenicite modifiee

Country Status (1)

Country Link
WO (1) WO2005113598A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070086979A1 (en) 2005-10-13 2007-04-19 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
EP2517723B1 (fr) 2006-09-18 2019-11-06 The Board of Trustees of The University of Arkansas Compositions et procédés d'amélioration des réponses immunitaires
EP2214840B1 (fr) 2007-10-30 2015-05-06 The Board Of Trustees Of The University Of Arkansas Compositions et procédés pour améliorer les réponses immunitaires dirigées contre une bactérie flagellée
CA3156538C (fr) 2007-11-01 2023-12-12 The Board Of Trustees Of The University Of Arkansas Compositions et procedes pour amplifier des reponses immunitaires a l'eimeria
CN102811734B (zh) 2010-01-21 2016-02-10 阿肯色大学评议会 增强免疫应答的疫苗载体和方法
JP5746333B2 (ja) 2010-06-09 2015-07-08 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー カンピロバクター感染を減少させるワクチン及び方法
EP3610887B8 (fr) 2013-02-14 2024-01-24 The Board of Trustees of the University of Arkansas Compositions et procédés pour renforcer des réponses immunitaires vis-à-vis d'eimeria ou limiter une infection par eimeria
KR102239207B1 (ko) 2013-03-15 2021-04-09 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 장내 병원균에 대한 면역 반응을 증진시키는 조성물 및 방법
SG11201809686SA (en) 2016-05-03 2018-11-29 Univ Arkansas Yeast vaccine vector including immunostimulatory and antigenic polypeptides and methods of using the same
IL303992A (en) * 2020-12-29 2023-08-01 Cemm Forschungszentrum F?R Molekulare Medizin Gmbh Antibodies against APRIL and uses thereof

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012965A2 (fr) * 1997-09-12 1999-03-18 Biogen, Inc. Nouveaux ligands de la famille des tnf
WO2000067034A1 (fr) * 1999-04-30 2000-11-09 Immunex Corporation Methodes d'utilisation de l'interaction taci/taci-l
WO2002018445A2 (fr) * 2000-09-01 2002-03-07 Biogen, Inc. Structure co-cristalline de l'anticorps monoclonal 5c8 et cd154, et utilisation de cette structure dans la mise au point de medicaments
WO2002036141A2 (fr) * 2000-11-02 2002-05-10 Immunex Corporation Methode permettant d'ameliorer des reponses immunitaires induites par des lymphocytes
US20020061525A1 (en) * 2000-05-16 2002-05-23 Rodrigo Yelin Sequences of trail variants
WO2003006154A2 (fr) * 2001-07-10 2003-01-23 Xencor, Inc. Automatisation de conception de proteines pour la conception de bibliotheques de proteines a antigenicite modifiee
WO2003029420A2 (fr) * 2001-10-02 2003-04-10 Genentech, Inc. Variants de ligands apo-2 et leurs utilisations
WO2003059281A2 (fr) * 2002-01-04 2003-07-24 Xencor Nouveaux variants de proteines rankl
WO2004081043A2 (fr) * 2003-01-06 2004-09-23 Xencor, Inc. Variants de baff et leurs methodes d'utilisation
WO2004089982A2 (fr) * 2003-01-06 2004-10-21 Xencor Variantes april et leurs procedes
WO2005035570A2 (fr) * 2003-10-10 2005-04-21 Xencor, Inc. Nouveaux variants de la proteine cd40l

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012965A2 (fr) * 1997-09-12 1999-03-18 Biogen, Inc. Nouveaux ligands de la famille des tnf
WO2000067034A1 (fr) * 1999-04-30 2000-11-09 Immunex Corporation Methodes d'utilisation de l'interaction taci/taci-l
US20020061525A1 (en) * 2000-05-16 2002-05-23 Rodrigo Yelin Sequences of trail variants
WO2002018445A2 (fr) * 2000-09-01 2002-03-07 Biogen, Inc. Structure co-cristalline de l'anticorps monoclonal 5c8 et cd154, et utilisation de cette structure dans la mise au point de medicaments
WO2002036141A2 (fr) * 2000-11-02 2002-05-10 Immunex Corporation Methode permettant d'ameliorer des reponses immunitaires induites par des lymphocytes
WO2003006154A2 (fr) * 2001-07-10 2003-01-23 Xencor, Inc. Automatisation de conception de proteines pour la conception de bibliotheques de proteines a antigenicite modifiee
WO2003029420A2 (fr) * 2001-10-02 2003-04-10 Genentech, Inc. Variants de ligands apo-2 et leurs utilisations
WO2003059281A2 (fr) * 2002-01-04 2003-07-24 Xencor Nouveaux variants de proteines rankl
WO2004081043A2 (fr) * 2003-01-06 2004-09-23 Xencor, Inc. Variants de baff et leurs methodes d'utilisation
WO2004089982A2 (fr) * 2003-01-06 2004-10-21 Xencor Variantes april et leurs procedes
WO2005035570A2 (fr) * 2003-10-10 2005-04-21 Xencor, Inc. Nouveaux variants de la proteine cd40l

Also Published As

Publication number Publication date
WO2005113598A2 (fr) 2005-12-01

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