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WO2006065590A3 - Pyridine and pyrimidine antiviral compositions - Google Patents

Pyridine and pyrimidine antiviral compositions Download PDF

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Publication number
WO2006065590A3
WO2006065590A3 PCT/US2005/044206 US2005044206W WO2006065590A3 WO 2006065590 A3 WO2006065590 A3 WO 2006065590A3 US 2005044206 W US2005044206 W US 2005044206W WO 2006065590 A3 WO2006065590 A3 WO 2006065590A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyridine
antiviral compositions
pyrimidine
pyrimidine antiviral
methods
Prior art date
Application number
PCT/US2005/044206
Other languages
French (fr)
Other versions
WO2006065590A2 (en
Inventor
C Richard Wobbe
Original Assignee
Xtl Biopharmaceuticals Inc
C Richard Wobbe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xtl Biopharmaceuticals Inc, C Richard Wobbe filed Critical Xtl Biopharmaceuticals Inc
Publication of WO2006065590A2 publication Critical patent/WO2006065590A2/en
Publication of WO2006065590A3 publication Critical patent/WO2006065590A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to pyridines and pyrimidine derivatives of formula (I) wherein R1, R2, R3, R4 and R5 are as defined herein, and their pharmaceutical compositions useful as antiviral compounds, and their methods of preparation and methods for use in the treatment as antiviral agents.
PCT/US2005/044206 2004-12-16 2005-12-05 Pyridine and pyrimidine antiviral compositions WO2006065590A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63710804P 2004-12-16 2004-12-16
US60/637,108 2004-12-16

Publications (2)

Publication Number Publication Date
WO2006065590A2 WO2006065590A2 (en) 2006-06-22
WO2006065590A3 true WO2006065590A3 (en) 2006-09-21

Family

ID=36337452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/044206 WO2006065590A2 (en) 2004-12-16 2005-12-05 Pyridine and pyrimidine antiviral compositions

Country Status (1)

Country Link
WO (1) WO2006065590A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
US8957046B2 (en) 2007-03-30 2015-02-17 Gilead Pharmasset Llc Nucleoside phosphoramidate prodrugs
US9549941B2 (en) 2011-11-29 2017-01-24 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200904437A (en) 2007-02-14 2009-02-01 Janssen Pharmaceutica Nv 2-aminopyrimidine modulators of the histamine H4 receptor
EP2142215B1 (en) 2007-05-04 2012-03-07 Vertex Pharmceuticals Incorporated Combination therapy for the treatment of hcv infection
CA2734489C (en) * 2008-08-20 2016-11-08 Southern Research Institute Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
CA2734488A1 (en) 2008-08-20 2010-02-25 Southern Research Institute Azo-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
WO2010022121A1 (en) * 2008-08-20 2010-02-25 Schering Corporation Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
AR072940A1 (en) 2008-08-20 2010-09-29 Schering Corp PIRIDINE AND PYRIMIDINE DERIVATIVES REPLACED WITH ETHYLLIN AND ITS USE IN THE TREATMENT OF VIRAL INFECTIONS
EP2376515A1 (en) 2008-12-23 2011-10-19 Pharmasset, Inc. Synthesis of purine nucleosides
PT2376088T (en) 2008-12-23 2017-05-02 Gilead Pharmasset Llc 6-o-substituted-2-amino-purine nucleoside phosphoramidates
NZ593649A (en) 2008-12-23 2013-11-29 Gilead Pharmasset Llc Nucleoside analogs
TWI576352B (en) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 Nucleoside phosphoramidates
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
AP2012006535A0 (en) 2010-03-31 2012-10-31 Gilead Pharmasset Llc Stereoselective synthesis of phosphorous containing actives
UY33312A (en) 2010-03-31 2011-10-31 Pharmasset Inc PURINE NUCLEOSIDE PHOSPHORAMIDATE
CN105517540B (en) 2013-08-27 2019-08-23 吉利德制药有限责任公司 Compound preparation of two antiviral compounds
US10774064B2 (en) 2016-06-02 2020-09-15 Cadent Therapeutics, Inc. Potassium channel modulators
JP6997197B2 (en) 2017-01-23 2022-01-17 カデント セラピューティクス，インコーポレーテッド Potassium channel modulator
MX2021004647A (en) 2018-10-22 2021-08-16 Novartis Ag Crystalline forms of potassium channel modulators.
CN116507611A (en) * 2020-11-06 2023-07-28 佩勒梅德有限公司 Novel capsid assembly inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001078648A2 (en) * 2000-04-17 2001-10-25 Dong Wha Pharm. Ind. Co., Ltd. 6-methylnicotinamide derivatives as antiviral agents
WO2003078427A1 (en) * 2002-03-15 2003-09-25 Vertex Pharmaceuticals, Inc. Azolylaminoazines as inhibitors of protein kinases
WO2003084953A1 (en) * 2002-04-04 2003-10-16 B & C Biopharm 6-(4-substituted-anilino)pyrimidine derivatives, method for the preparation thereof and antiviral pharmaceutical composition comprising the same
US20050192294A1 (en) * 2004-02-27 2005-09-01 Bayer Pharmaceuticals Corporation Heteroarylaminopyrazole derivatives useful for the treatment of diabetes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001078648A2 (en) * 2000-04-17 2001-10-25 Dong Wha Pharm. Ind. Co., Ltd. 6-methylnicotinamide derivatives as antiviral agents
WO2003078427A1 (en) * 2002-03-15 2003-09-25 Vertex Pharmaceuticals, Inc. Azolylaminoazines as inhibitors of protein kinases
WO2003084953A1 (en) * 2002-04-04 2003-10-16 B & C Biopharm 6-(4-substituted-anilino)pyrimidine derivatives, method for the preparation thereof and antiviral pharmaceutical composition comprising the same
US20050192294A1 (en) * 2004-02-27 2005-09-01 Bayer Pharmaceuticals Corporation Heteroarylaminopyrazole derivatives useful for the treatment of diabetes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ROUCHAUD, J. ET AL: "Soil metabolism of flupyrsulfuron in winter wheat crops", WEED RESEARCH , 42(1), 14-25 CODEN: WEREAT; ISSN: 0043-1737, 2002, XP002383028 *
ROUCHAUD, JEAN ET AL: "Flupyrsulfuron Soil Dissipation and Mobility in Winter Wheat Crops", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 47(9), 3872-3878 CODEN: JAFCAU; ISSN: 0021-8561, 1999, XP002383029 *
ROUCHAUD, JEAN ET AL: "The cyclization transformation of the sulfonylurea herbicide flupyrsulfuron in the soil of winter wheat crops", PEST MANAGEMENT SCIENCE , 59(8), 940-948 CODEN: PMSCFC; ISSN: 1526-498X, 2003, XP002383027 *
SINGLES, SUZANNE KOCH ET AL: "Fate and behavior of flupyrsulfuron-methyl in soil and aquatic systems", PESTICIDE SCIENCE , 55(3), 288-300 CODEN: PSSCBG; ISSN: 0031-613X, 1999, XP002383030 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8957046B2 (en) 2007-03-30 2015-02-17 Gilead Pharmasset Llc Nucleoside phosphoramidate prodrugs
US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
US9549941B2 (en) 2011-11-29 2017-01-24 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus

Also Published As

Publication number Publication date
WO2006065590A2 (en) 2006-06-22

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