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WO2006067224A3 - Nouveaux composes - Google Patents

Nouveaux composes Download PDF

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Publication number
WO2006067224A3
WO2006067224A3 PCT/EP2005/057132 EP2005057132W WO2006067224A3 WO 2006067224 A3 WO2006067224 A3 WO 2006067224A3 EP 2005057132 W EP2005057132 W EP 2005057132W WO 2006067224 A3 WO2006067224 A3 WO 2006067224A3
Authority
WO
WIPO (PCT)
Prior art keywords
spiro
compounds
benzodioxole
receptor antagonists
disorders
Prior art date
Application number
PCT/EP2005/057132
Other languages
English (en)
Other versions
WO2006067224A2 (fr
Inventor
Emma Barker
Jensen Annika Jenmalm
Erik Nordling
Andrew Proud
Martin Slater
Mikael Weber
Original Assignee
Biovitrum Ab
Emma Barker
Jensen Annika Jenmalm
Erik Nordling
Andrew Proud
Martin Slater
Mikael Weber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0403160A external-priority patent/SE0403160D0/sv
Application filed by Biovitrum Ab, Emma Barker, Jensen Annika Jenmalm, Erik Nordling, Andrew Proud, Martin Slater, Mikael Weber filed Critical Biovitrum Ab
Publication of WO2006067224A2 publication Critical patent/WO2006067224A2/fr
Publication of WO2006067224A3 publication Critical patent/WO2006067224A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne des composés de formule (I) dans laquelle R1, A, Y, n et m ont la signification indiquée dans la description, des procédés de préparation desdits composés, des compositions pharmaceutiques les comprenant, et l'utilisation desdits composés et compositions dans la prophylaxie ou le traitement de troubles associés au récepteur de l'orexine 1 et de troubles associés au récepteur de l'orexine 2. A titre d'exemples pour lesdits troubles, on peut citer l'obésité et les troubles associés de type diabète de type II, la dyslipidémie et le syndrome métabolique, les maladies cardiovasculaires de type maladie vasculaire athéroscléreuse, angine de poitrine, infarctus du myocarde et AVC, la toxicomanie, et les troubles du sommeil.
PCT/EP2005/057132 2004-12-23 2005-12-22 Nouveaux composes WO2006067224A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0403160A SE0403160D0 (sv) 2004-12-23 2004-12-23 New compounds
SE0403160-5 2004-12-23
US65380305P 2005-02-17 2005-02-17
US60/653,803 2005-02-17

Publications (2)

Publication Number Publication Date
WO2006067224A2 WO2006067224A2 (fr) 2006-06-29
WO2006067224A3 true WO2006067224A3 (fr) 2006-11-02

Family

ID=36602122

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/057132 WO2006067224A2 (fr) 2004-12-23 2005-12-22 Nouveaux composes

Country Status (1)

Country Link
WO (1) WO2006067224A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007272854B2 (en) 2006-07-14 2013-08-01 Merck Sharp & Dohme Corp. Bridged diazepan orexin receptor antagonists
EP2061767B1 (fr) 2006-08-08 2014-12-17 Sanofi Imidazolidin-2,4-diones arylaminoaryl-alkyl-substituées, procédé de fabrication, médicaments les contenant et leur utilisation
PE20081229A1 (es) 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
US8030495B2 (en) 2007-05-23 2011-10-04 Coleman Paul J Cyclopropyl pyrrolidine orexin receptor antagonists
UA99620C2 (en) 2007-05-23 2012-09-10 Мерк Шарп Энд Доме Корп. Pyridyl piperidine orexin receptor antagonists
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
AR072707A1 (es) 2008-07-09 2010-09-15 Sanofi Aventis Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos
WO2010043592A1 (fr) * 2008-10-15 2010-04-22 Revotar Biopharmaceuticals Ag Inhibiteurs de la lipase destinés à être utilisés dans le traitement de l’obésité
EP2351744B1 (fr) * 2008-10-17 2015-01-07 Shionogi & Co., Ltd. Dérivé amide d'acide acétique ayant une activité inhibitrice d'une lipase endothéliale vasculaire
WO2010068601A1 (fr) 2008-12-08 2010-06-17 Sanofi-Aventis Hydrate de fluoroglycoside hétéroaromatique cristallin, ses procédés de fabrication, ses procédés d'utilisation et compositions pharmaceutiques le contenant
US8785608B2 (en) 2009-08-26 2014-07-22 Sanofi Crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
GB201021104D0 (en) * 2010-12-13 2011-01-26 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
EP2683703B1 (fr) 2011-03-08 2015-05-27 Sanofi Nouveaux dérivés phényl-oxathiazine substitués, procédé pour leur préparation, agent pharmaceutique contenant ces composés et leur utilisation
WO2012120058A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des groupes benzyle ou hétérométhylène, leur procédé de production, leur utilisation comme médicament ainsi que produits pharmaceutiques les contenant et leur utilisation
EP2683704B1 (fr) 2011-03-08 2014-12-17 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
US8809324B2 (en) 2011-03-08 2014-08-19 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120052A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
WO2012120054A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120051A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés benzyl-oxathiazine substitués avec adamantane ou noradamantane, médicaments contenant ces composés et leur utilisation
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120056A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
AU2013217323A1 (en) 2012-02-07 2014-08-28 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
US10221170B2 (en) 2014-08-13 2019-03-05 Eolas Therapeutics, Inc. Difluoropyrrolidines as orexin receptor modulators
DK3414241T3 (da) 2016-02-12 2022-08-01 Astrazeneca Ab Halogensubstituerede piperidiner som orexinreceptormodulatorer
EP3454857A1 (fr) 2016-05-10 2019-03-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement de maladies inflammatoires auto-immunes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052876A1 (fr) * 2002-12-12 2004-06-24 Janssen Pharmaceutica, N.V. 4-phenyl-[1,3]-dioxanes substitues
WO2004111056A2 (fr) * 2003-06-13 2004-12-23 Biofocus Plc Banques de composes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052876A1 (fr) * 2002-12-12 2004-06-24 Janssen Pharmaceutica, N.V. 4-phenyl-[1,3]-dioxanes substitues
WO2004111056A2 (fr) * 2003-06-13 2004-12-23 Biofocus Plc Banques de composes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
PORTER R A ET AL: "1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 11, 2001, pages 1907 - 1910, XP002269254, ISSN: 0960-894X *
PUJOL MD ROSELL G GUILLAUMET G: "Novel tricyclic spiropiperidines. Synthesis and adrenergic activity of spiro[1,3-benzodioxolopiperidines] and spiro[1,3-benzodioxanepiperidines", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 31, no. 11, 1996, pages 889 - 894, XP004063481, ISSN: 0223-5234 *
SAKURAI T ET AL: "OREXINS AND OREXIN RECEPTORS: A FAMILY OF HYPOTHALAMIC NEUROPEPTIDES AND G PROTEIN-COUPLED RECEPTORS THAT REGULATE FEEDINGBEHAVIOR", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 92, 20 February 1998 (1998-02-20), pages 573 - 585, XP002943277, ISSN: 0092-8674 *
SANCHEZ I ET AL: "SYNTHESIS OF NEW PIPERIDINE AND CYCLOHEXYLAMINO-SPIRO DERIVATIVES AS POTENTIAL ANTICALCIUM AGENTS", SCIENTIA PHARMACEUTICA, OESTERREICHISCHE APOTHEKER VERLAGSGESELLSCHAFT,, AT, vol. 70, no. 2, 2002, pages 177 - 187, XP009035726, ISSN: 0036-8709 *

Also Published As

Publication number Publication date
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