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WO2006067565A3 - Recepteur gabab tronque et procedes d'utilisation associes - Google Patents

Recepteur gabab tronque et procedes d'utilisation associes Download PDF

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Publication number
WO2006067565A3
WO2006067565A3 PCT/IB2005/003654 IB2005003654W WO2006067565A3 WO 2006067565 A3 WO2006067565 A3 WO 2006067565A3 IB 2005003654 W IB2005003654 W IB 2005003654W WO 2006067565 A3 WO2006067565 A3 WO 2006067565A3
Authority
WO
WIPO (PCT)
Prior art keywords
gabab receptor
polypeptides
truncated
methods
receptor
Prior art date
Application number
PCT/IB2005/003654
Other languages
English (en)
Other versions
WO2006067565A2 (fr
Inventor
Fu-Zon Chung
Mei Cui
Original Assignee
Warner Lambert Co
Fu-Zon Chung
Mei Cui
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co, Fu-Zon Chung, Mei Cui filed Critical Warner Lambert Co
Publication of WO2006067565A2 publication Critical patent/WO2006067565A2/fr
Publication of WO2006067565A3 publication Critical patent/WO2006067565A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention porte sur des polypeptides de sous-unité du récepteur de GABAbR2 isolés, sur des séquences nucléotidiques codant les polypeptides de l'invention et des vecteurs d'expression, et sur des lignes cellulaires associées. L'invention se rapporte aussi à une protéine du récepteur GABAb comprenant ces polypeptides. Elle concerne également un procédé d'identification d'un agent qui possède une activité de modulation du récepteur de GABAb, un agent identifié par le procédé d'identification de l'invention, un procédé de fabrication d'un récepteur de GABAb, ainsi qu'un procédé de traitement d'un trouble en réponse à la modulation d'une activité du récepteur de GABAb.
PCT/IB2005/003654 2004-12-22 2005-12-16 Recepteur gabab tronque et procedes d'utilisation associes WO2006067565A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63889104P 2004-12-22 2004-12-22
US60/638,891 2004-12-22

Publications (2)

Publication Number Publication Date
WO2006067565A2 WO2006067565A2 (fr) 2006-06-29
WO2006067565A3 true WO2006067565A3 (fr) 2006-08-10

Family

ID=36353305

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/003654 WO2006067565A2 (fr) 2004-12-22 2005-12-16 Recepteur gabab tronque et procedes d'utilisation associes

Country Status (1)

Country Link
WO (1) WO2006067565A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115137829A (zh) * 2022-08-08 2022-10-04 山东大学 用于减轻放疗诱导的肠道损伤的药物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999040114A1 (fr) * 1998-02-05 1999-08-12 Merck & Co., Inc. Nouvelles sequences d'adn codant le recepteur gaba¿b?

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999040114A1 (fr) * 1998-02-05 1999-08-12 Merck & Co., Inc. Nouvelles sequences d'adn codant le recepteur gaba¿b?

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOWERY N G ET AL: "International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function", PHARMACOLOGICAL REVIEWS, WILLIAMS AND WILKINS INC., BALTIMORE, MD,, US, vol. 54, no. 2, June 2002 (2002-06-01), pages 247 - 264, XP002289606, ISSN: 0031-6997 *
CALVER ANDREW R ET AL: "The C-terminal domains of the GABAB receptor subunits mediate intracellular trafficking but are not required for receptor signaling", JOURNAL OF NEUROSCIENCE, vol. 21, no. 4, 15 February 2001 (2001-02-15), pages 1203 - 1210, XP002382330, ISSN: 0270-6474 *
GRÜNEWALD SYLVIA ET AL: "Importance of the gamma-aminobutyric acid(B) receptor C-termini for G-protein coupling.", MOLECULAR PHARMACOLOGY. MAY 2002, vol. 61, no. 5, May 2002 (2002-05-01), pages 1070 - 1080, XP002382331, ISSN: 0026-895X *
PAGANO ADRIANA ET AL: "C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABAB receptors", JOURNAL OF NEUROSCIENCE, vol. 21, no. 4, 15 February 2001 (2001-02-15), pages 1189 - 1202, XP002382332, ISSN: 0270-6474 *

Also Published As

Publication number Publication date
WO2006067565A2 (fr) 2006-06-29

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