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WO2006079999A3 - Induction d'un nouvel etat psychique a l'aide d'un agoniste de 5-ht2a et d'un antagoniste de nmda - Google Patents

Induction d'un nouvel etat psychique a l'aide d'un agoniste de 5-ht2a et d'un antagoniste de nmda Download PDF

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Publication number
WO2006079999A3
WO2006079999A3 PCT/IB2006/051080 IB2006051080W WO2006079999A3 WO 2006079999 A3 WO2006079999 A3 WO 2006079999A3 IB 2006051080 W IB2006051080 W IB 2006051080W WO 2006079999 A3 WO2006079999 A3 WO 2006079999A3
Authority
WO
WIPO (PCT)
Prior art keywords
mind
induction
nmda antagonist
ht2a agonist
novel
Prior art date
Application number
PCT/IB2006/051080
Other languages
English (en)
Other versions
WO2006079999A2 (fr
Inventor
Frederik H Barth
Original Assignee
Frederik H Barth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frederik H Barth filed Critical Frederik H Barth
Priority to PCT/IB2006/051080 priority Critical patent/WO2006079999A2/fr
Publication of WO2006079999A2 publication Critical patent/WO2006079999A2/fr
Publication of WO2006079999A3 publication Critical patent/WO2006079999A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Il a été découvert que l'administration, à un être humain, d'un agoniste de 5-HT2A hallucinogène en combinaison avec un antagoniste de NMDA induisait un état nouveau et particulier du psychisme humain. Cet état psychique est non psychotique et bénin. L'induction de cet état nouveau et particulier du psychisme humain peut être utilisé à des fins thérapeutiques, récréatives et à d'autres fins utiles.
PCT/IB2006/051080 2006-04-09 2006-04-09 Induction d'un nouvel etat psychique a l'aide d'un agoniste de 5-ht2a et d'un antagoniste de nmda WO2006079999A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IB2006/051080 WO2006079999A2 (fr) 2006-04-09 2006-04-09 Induction d'un nouvel etat psychique a l'aide d'un agoniste de 5-ht2a et d'un antagoniste de nmda

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2006/051080 WO2006079999A2 (fr) 2006-04-09 2006-04-09 Induction d'un nouvel etat psychique a l'aide d'un agoniste de 5-ht2a et d'un antagoniste de nmda

Publications (2)

Publication Number Publication Date
WO2006079999A2 WO2006079999A2 (fr) 2006-08-03
WO2006079999A3 true WO2006079999A3 (fr) 2007-04-26

Family

ID=36740888

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/051080 WO2006079999A2 (fr) 2006-04-09 2006-04-09 Induction d'un nouvel etat psychique a l'aide d'un agoniste de 5-ht2a et d'un antagoniste de nmda

Country Status (1)

Country Link
WO (1) WO2006079999A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12433904B2 (en) 2019-04-17 2025-10-07 Compass Pathfinder Limited Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
JP2023540017A (ja) 2020-08-18 2023-09-21 サイビン アイアールエル リミテッド 治療用フェネチルアミン組成物およびその使用方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006973A1 (fr) * 1990-10-15 1992-04-30 Pfizer Inc. Derives d'indole
US5902815A (en) * 1996-09-03 1999-05-11 Washington University Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction
WO2006042249A2 (fr) * 2004-10-08 2006-04-20 Neuromolecular Pharmaceuticals, Inc. Methodes et compositions de traitement de la douleur de migraine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006973A1 (fr) * 1990-10-15 1992-04-30 Pfizer Inc. Derives d'indole
US5902815A (en) * 1996-09-03 1999-05-11 Washington University Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction
WO2006042249A2 (fr) * 2004-10-08 2006-04-20 Neuromolecular Pharmaceuticals, Inc. Methodes et compositions de traitement de la douleur de migraine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FARBER NURI B ET AL: "Serotonergic agents that activate 5HT2A receptors prevent NMDA antagonist neurotoxicity", NEUROPSYCHOPHARMACOLOGY, vol. 18, no. 1, January 1998 (1998-01-01), pages 57 - 62, XP002396767, ISSN: 0893-133X *
WEST WILLIAM B ET AL: "Antagonism of a PCP drug discrimination by hallucinogens and related drugs", NEUROPSYCHOPHARMACOLOGY, vol. 22, no. 6, June 2000 (2000-06-01), pages 618 - 625, XP002396768, ISSN: 0893-133X *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12433904B2 (en) 2019-04-17 2025-10-07 Compass Pathfinder Limited Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin

Also Published As

Publication number Publication date
WO2006079999A2 (fr) 2006-08-03

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