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WO2006118990A3 - Method and device for organ perfusion - Google Patents

Method and device for organ perfusion Download PDF

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Publication number
WO2006118990A3
WO2006118990A3 PCT/US2006/016163 US2006016163W WO2006118990A3 WO 2006118990 A3 WO2006118990 A3 WO 2006118990A3 US 2006016163 W US2006016163 W US 2006016163W WO 2006118990 A3 WO2006118990 A3 WO 2006118990A3
Authority
WO
WIPO (PCT)
Prior art keywords
organ
fluid
perfusion
perfusion fluid
oxygenator
Prior art date
Application number
PCT/US2006/016163
Other languages
French (fr)
Other versions
WO2006118990A2 (en
Inventor
Marlin L Alford
Robert M Dowben
Original Assignee
Transplan Inc
Marlin L Alford
Robert M Dowben
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transplan Inc, Marlin L Alford, Robert M Dowben filed Critical Transplan Inc
Priority to EP06751728A priority Critical patent/EP1879997A2/en
Publication of WO2006118990A2 publication Critical patent/WO2006118990A2/en
Publication of WO2006118990A3 publication Critical patent/WO2006118990A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/143—Apparatus for organ perfusion
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A portable organ perfusion device has an organ chamber for supporting an organ immersed in a perfusion fluid. A pump circulates the perfusion fluid around a circuit containing a pump, a heat exchanger for cooling the perfusion fluid, an oxygenator for oxygenation of the perfusion fluid, and a pressure head device for ensuring a constant head supply to the vasculature of the organ. A bypass channel forms a fluid connection from upstream of the oxygenator to the organ chamber allowing excess fluid to bypass the organ. The device also includes an oxygen source, sensors, a power source and a control unit for receiving information from the sensors and providing control instructions to control elements.
PCT/US2006/016163 2005-04-29 2006-04-28 Method and device for organ perfusion WO2006118990A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06751728A EP1879997A2 (en) 2005-04-29 2006-04-28 Method and device for organ perfusion

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67632905P 2005-04-29 2005-04-29
US60/676,329 2005-04-29

Publications (2)

Publication Number Publication Date
WO2006118990A2 WO2006118990A2 (en) 2006-11-09
WO2006118990A3 true WO2006118990A3 (en) 2007-01-25

Family

ID=37308518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/016163 WO2006118990A2 (en) 2005-04-29 2006-04-28 Method and device for organ perfusion

Country Status (2)

Country Link
EP (1) EP1879997A2 (en)
WO (1) WO2006118990A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9060507B2 (en) * 2010-09-01 2015-06-23 Perfusion Fluid Technologies Inc Perfusion solution
US9119392B2 (en) * 2010-11-09 2015-09-01 Biomedinnovations, Llc Articulating organ support
US9756848B2 (en) 2011-09-02 2017-09-12 Organ Assist B.V. Apparatus, system and method for conditioning and preserving an organ from a donor
BR112014011358B1 (en) 2011-11-10 2021-04-06 Organox Limited DISPOSABLE SET OF COMPONENTS FOR AN ORGAN PERFUSION SYSTEM, SYSTEM AND SUPPORT PANEL
US20140308654A1 (en) 2011-11-10 2014-10-16 Organox Limited Organ perfusion systems
GB201119420D0 (en) 2011-11-10 2011-12-21 Organox Ltd Oxygen supply for organ perfusion systems
US20140370490A1 (en) * 2013-06-12 2014-12-18 Medtronic, Inc. Heart-lung preparation and method of use
SE1330158A1 (en) * 2013-12-30 2015-07-01 Vivoline Medical Ab Insert for an organ transport device
WO2017134192A1 (en) * 2016-02-04 2017-08-10 Xvivo Perfusion Ab Ex vivo lung simulator
CN106754355A (en) * 2016-11-23 2017-05-31 厦门大学 A kind of organ vitro culture system
CN110122474B (en) * 2019-04-26 2021-08-10 浙江机电职业技术学院 Human body broken limb protection box based on non-contact sensing control perfusion technology
GB2587350B (en) * 2019-09-23 2021-12-15 Royal Papworth Hospital Nhs Found Trust Organ perfusion system and method
GB2626275B (en) * 2020-02-20 2024-10-30 Deka Products Lp System and method for organ maintenance and transport
CN111657268A (en) * 2020-03-31 2020-09-15 同济大学 Small animal heart imaging perfusion hose system
JP2024500116A (en) 2020-12-22 2024-01-04 ポルビオニツァ エスペー・ゾオ Systems for storage or culture of organ or tissue models and their use
CN116369305A (en) * 2021-02-08 2023-07-04 苏州心擎医疗技术有限公司 Blood warming organ transfer platform and exhaust method

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002965A (en) * 1989-05-09 1991-03-26 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Use of ginkgolides to prevent reperfusion injury in organ transplantation
DE4201259A1 (en) * 1992-01-18 1993-07-22 Sachs Elektronik Kg Hugo DEVICE FOR PERFUSING AN INSULATED HEART
US5405742A (en) * 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
US5693462A (en) * 1994-12-12 1997-12-02 Charlotte-Mecklenburg Hospital Authority Organ transplant solutions and method for transplanting an organ
US5702881A (en) * 1993-03-16 1997-12-30 Alliance Pharmaceutical Corp. Method and solution for organ preservation comprising retinal-derived growth factor, cyclodextrin, mucopolysaccharide and fluorocarbon
US5965433A (en) * 1996-05-29 1999-10-12 Trans D.A.T.A. Service, Inc. Portable perfusion/oxygenation module having mechanically linked dual pumps and mechanically actuated flow control for pulsatile cycling of oxygenated perfusate
US6046046A (en) * 1997-09-23 2000-04-04 Hassanein; Waleed H. Compositions, methods and devices for maintaining an organ
US6582375B2 (en) * 2001-10-11 2003-06-24 University Of Cincinnati System for study of global uni-or bi-ventricular function of an explanted, reperfused heart
US6673594B1 (en) * 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002965A (en) * 1989-05-09 1991-03-26 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Use of ginkgolides to prevent reperfusion injury in organ transplantation
DE4201259A1 (en) * 1992-01-18 1993-07-22 Sachs Elektronik Kg Hugo DEVICE FOR PERFUSING AN INSULATED HEART
US5702881A (en) * 1993-03-16 1997-12-30 Alliance Pharmaceutical Corp. Method and solution for organ preservation comprising retinal-derived growth factor, cyclodextrin, mucopolysaccharide and fluorocarbon
US5405742A (en) * 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
US5693462A (en) * 1994-12-12 1997-12-02 Charlotte-Mecklenburg Hospital Authority Organ transplant solutions and method for transplanting an organ
US5965433A (en) * 1996-05-29 1999-10-12 Trans D.A.T.A. Service, Inc. Portable perfusion/oxygenation module having mechanically linked dual pumps and mechanically actuated flow control for pulsatile cycling of oxygenated perfusate
US6046046A (en) * 1997-09-23 2000-04-04 Hassanein; Waleed H. Compositions, methods and devices for maintaining an organ
US6673594B1 (en) * 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US6582375B2 (en) * 2001-10-11 2003-06-24 University Of Cincinnati System for study of global uni-or bi-ventricular function of an explanted, reperfused heart

Also Published As

Publication number Publication date
WO2006118990A2 (en) 2006-11-09
EP1879997A2 (en) 2008-01-23

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